Fibroblast growth factor 21 is regulated by the IRE1α-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis

Journal of Biological Chemistry

Volumn 289, Issue 43, 2014, Pages 29751-29765

  Jiang, Shan ^a   Yan, Cheng ^b   Fang, Qi Chen ^a   Shao, Meng Le ^b   Zhang, Yong Liang ^b   Liu, Yong ^b,b   Deng, Yi Ping ^b   Shan, Bo ^b   Liu, Jing Qi ^b   Li, Hua Ting ^a   Yong, Liu ^b   Zhou, Jian ^c   Dai, Zhi ^c   Jia, Wei Ping ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; CELL CULTURE; CELL MEMBRANES; FIBROBLASTS; MAMMALS; NUTRITION; PHYSIOLOGY; PROTEINS;

ENDOPLASMIC RETICULUM STRESS; FEEDBACK EFFECTS; FIBROBLAST GROWTH FACTOR; HEPATIC STEATOSIS; INTRAPERITONEAL ADMINISTRATION; LIPID METABOLISMS; NON-ALCOHOLIC FATTY LIVER DISEASE; UNFOLDED PROTEIN RESPONSE;

METABOLISM;

FIBROBLAST GROWTH FACTOR 21; IRE1 ALPHA PROTEIN; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; DNA BINDING PROTEIN; ERN1 PROTEIN, HUMAN; ERN1 PROTEIN, MOUSE; FIBROBLAST GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; RECOMBINANT PROTEIN; REGULATORY FACTOR X TRANSCRIPTION FACTORS; RIBONUCLEASE; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; FGF21 GENE; HUMAN; HUMAN TISSUE; LIPID METABOLISM; LIPID OXIDATION; LIPOGENESIS; MALE; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; UNFOLDED PROTEIN RESPONSE; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; ANTIBODY SPECIFICITY; C57BL MOUSE; DIET; DRUG EFFECTS; ENZYME ACTIVATION; FATTY LIVER; GENETIC TRANSCRIPTION; GENETICS; HEPG2 CELL LINE; LIVER CELL; METABOLISM; MOLECULAR GENETICS; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; PATHOLOGY; PROMOTER REGION;

ANIMALS; BASE SEQUENCE; DIET; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM STRESS; ENDORIBONUCLEASES; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FATTY LIVER; FIBROBLAST GROWTH FACTORS; HEP G2 CELLS; HEPATOCYTES; HUMANS; MALE; MICE, INBRED C57BL; MICE, OBESE; MOLECULAR SEQUENCE DATA; NON-ALCOHOLIC FATTY LIVER DISEASE; ORGAN SPECIFICITY; PROMOTER REGIONS, GENETIC; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION; UNFOLDED PROTEIN RESPONSE;

EID: 84908200877     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.565960     Document Type: Article

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