GPCR crystal structures: Medicinal chemistry in the pocket

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 14, 2015, Pages 3880-3906

  Shonberg, Jeremy ^a   Kling, Ralf C ^a   Gmeiner, Peter ^a   Löber, Stefan ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Crystal structure; Drug discovery; GPCR; Ligand receptor interactions; Medicinal chemistry; Receptor activation; Receptor selectivity

Indexed keywords

ADENOSINE; ADENOSINE A2A RECEPTOR; BETA ADRENERGIC RECEPTOR; CARAZOLOL; CARMOTEROL; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; CYANOPINDOLOL; DIHYDROERGOTAMINE; DOBUTAMINE; DOPAMINE 3 RECEPTOR; DOXEPIN; ETICLOPRIDE; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 40; HISTAMINE H1 RECEPTOR; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 5; MUSCARINIC RECEPTOR; NEUROTENSIN RECEPTOR; NOCICEPTIN RECEPTOR; OPIATE RECEPTOR; PROTEINASE ACTIVATED RECEPTOR 1; PURINERGIC P2Y12 RECEPTOR; SALBUTAMOL; SEROTONIN RECEPTOR; SMOOTHENED PROTEIN; SPHINGOSINE 1 PHOSPHATE RECEPTOR; TIOTROPIUM BROMIDE; UNINDEXED DRUG; LIGAND;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLIZATION; HUMAN; LIGAND BINDING; MEDICINAL CHEMISTRY; NONHUMAN; PROTEIN INTERACTION; PROTEIN LOCALIZATION; RECEPTOR INTRINSIC ACTIVITY; CHEMISTRY; DRUG DESIGN; METABOLISM; PROCEDURES; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; LIGANDS; PROTEIN CONFORMATION; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84930868579     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.12.034     Document Type: Article

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