SCOPUS 정보 검색 플랫폼

Volumn 43, Issue 9, 2000, Pages 1878-1885

Design and synthesis of trans-N-[4-[2-(6-cyano-1,2,3,4- tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB- 277011): A potent and selective dopamine D3 receptor antagonist with high oral bioavailability and CNS penetration in the rat

(19) Stemp, Geoffrey a Ashmeade, Tracey a Branch, Clive L a Hadley, Michael S a Hunter, A Jacqueline a Johnson, Christopher N a Nash, David J a Thewlis, Kevin M a Vong, Antonio K K a Austin, Nigel E a Jeffrey, Phillip a Avenell, Kim Y a Boyfield, Izzy a Hagan, Jim J a Middlemiss, Derek N a Reavill, Charlie a Riley, Graham J a Routledge, Carole a Wood, Martyn a

a GLAXOSMITHKLINE (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE 3 RECEPTOR; DOPAMINE 3 RECEPTOR BLOCKING AGENT; N [4 [2 (6 CYANO 1,2,3,4 TETRAHYDRO 2 ISOQUINOLINYL)ETHYL]CYCLOHEXYL] 4 QUINOLINECARBOXAMIDE; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHO CELL; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DESIGN; DRUG MECHANISM; DRUG PENETRATION; DRUG POTENCY; DRUG SYNTHESIS; MALE; NONHUMAN; PSYCHOSIS; RAT;

ANIMALS; BIOLOGICAL AVAILABILITY; BRAIN; CATALEPSY; CENTRAL NERVOUS SYSTEM; CHO CELLS; CRICETINAE; DOPAMINE ANTAGONISTS; HALF-LIFE; HUMANS; MALE; MICRODIALYSIS; NITRILES; PROLACTIN; QUINOLINES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; TETRAHYDROISOQUINOLINES;

EID: 0034066880 PISSN: 00222623 EISSN: None Source Type: Journal
DOI: 10.1021/jm000090i Document Type: Article

Times cited : (123)

References (23)

1
- 0025179967
- 3) as a target for neuroleptic drugs
- 3) as a target for neuroleptic drugs. Nature 1990, 347, 146-151.
- (1990) Nature , vol.347 , pp. 146-151
- Sokoloff, P.¹ Giros, B.² Martres, M.-P.³ Bouthenet, M.-L.⁴ Schwartz, J.-C.⁵

2
- 0027337821
- 3 receptor: Basic and clinical aspects
- 3 receptor: basic and clinical aspects. Clin. Neuropharmacol. 1993, 16, 295-314.
- (1993) Clin. Neuropharmacol. , vol.16 , pp. 295-314
- Schwartz, J.-C.¹ Levesque, D.² Martres, M.-P.³ Sokoloff, P.⁴

3
- 0031594765
- 3 dopamine receptor in cellular and organismal function
- 3 dopamine receptor in cellular and organismal function. Psychopharmacology 1998, 135, 1-16.
- (1998) Psychopharmacology , vol.135 , pp. 1-16
- Shafer, R.A.¹ Levant, B.²

4
- 0030610748
- 2 receptors to neuronal circuits in human brain: Insights into schizophrenia
- 2 receptors to neuronal circuits in human brain: insights into schizophrenia. Neuropsychopharmacology 1997, 16, 375-384.
- (1997) Neuropsychopharmacology , vol.16 , pp. 375-384
- Joyce, J.N.¹ Meador-Woodruff, J.H.²

5
- 0033595283
- 3 receptor agonist
- 3 receptor agonist. Nature 1999, 400, 371-375.
- (1999) Nature , vol.400 , pp. 371-375
- Pilla, M.¹ Perachon, S.² Sautel, F.³ Garrido, F.⁴ Mann, A.⁵ Wermuth, C.G.⁶ Schwartz, J.-C.⁷ Everitt, B.J.⁸ Sokoloff, P.⁹

6
- 0032798705
- 3 receptors: From anatomy to neuropsychiatry
- 3 receptors: from anatomy to neuropsychiatry. NeuroSci. News 1999, 2, 11-21.
- (1999) NeuroSci. News , vol.2 , pp. 11-21
- Joyce, J.N.¹ Gurevich, E.V.²

7
- 0032773336
- 4.4 receptors expressed in Chinese hamster ovary cells
- 4.4 receptors expressed in Chinese hamster ovary cells. Br. J. Pharmacol. 1999, 127, 1135-1144.
- (1999) Br. J. Pharmacol. , vol.127 , pp. 1135-1144
- Coldwell, M.C.¹ Boyfield, I.² Brown, A.M.³ Stemp, G.⁴ Middlemiss, D.N.⁵

8
- 0027521571
- 3 receptor: A postsynaptic receptor inhibitory on rat locomotor activity
- 3 receptor: a postsynaptic receptor inhibitory on rat locomotor activity. J. Neur. Trams. 1993, 94, 11-19.
- (1993) J. Neur. Trams. , vol.94 , pp. 11-19
- Waters, N.¹ Svensson, K.² Haandsma-Svensson, S.R.³ Smith, M.W.⁴ Carlsson, A.⁵

9
- 0029549966
- 3 receptor antagonist, activates locomotion in rodents
- 3 receptor antagonist, activates locomotion in rodents. J. Pharmacol. Exp. Ther. 1995, 275, 1239-1246.
- (1995) J. Pharmacol. Exp. Ther. , vol.275 , pp. 1239-1246
- Sautel, F.¹ Griffon, N.² Sokoloff, P.³ Schwartz, J.-P.⁴ Launey, C.⁵ Simon, P.⁶ Costentin, J.⁷ Schoenfelder, A.⁸ Garrido, F.⁹ Mann, A.¹⁰ Wermuth, C.G.¹¹

10
- 0031576837
- 3
- 3 receptor, Bioorg. Med. Chem. Lett. 1997. 7, 485-488.
- (1997) Bioorg. Med. Chem. Lett. , vol.7 , pp. 485-488
- Bolton, D.¹ Boyfield, I.² Coldwell, M.C.³ Hadley, M.S.⁴ Johns, A.⁵ Johnson, C.N.⁶ Markwell, R.E.⁷ Nash, D.J.⁸ Riley, G.J.⁹ Scott, E.E.¹⁰ Smith, S.A.¹¹ Stemp, G.¹² Wadsworth, H.J.¹³ Watts, E.A.¹⁴

11
- 0028847688
- 3 receptor
- 3 receptor. Bioorg. Med. Chem. Lett. 1995, 5, 219-222.
- (1995) Bioorg. Med. Chem. Lett. , vol.5 , pp. 219-222
- Murray, P.J.¹ Harrison, L.E.² Johnson, M.R.³ Robertson, G.M.⁴ Scopes, D.I.C.⁵ Bull, D.R.⁶ Graham, E.A.⁷ Hayes, A.G.⁸ Kilpatrick, G.J.⁹ Den Dass, I.¹⁰ Large, C.¹¹ Sheehan, M.J.¹² Stubbs, C.M.¹³ Turpin, M.P.¹⁴

12
- 0030799247
- 3 dopamine receptor ligands
- 3 dopamine receptor ligands. Bioorg. Med. Chem. Lett. 1997, 7, 2403-2408.
- (1997) Bioorg. Med. Chem. Lett. , vol.7 , pp. 2403-2408
- Belliotti, T.R.¹ Kesten, S.R.² Rubin, J.R.³ Wustrow, D.J.⁴ Georgic, L.M.⁵ Zoski, K.T.⁶ Akunne, H.C.⁷ Wise, L.D.⁸

13
- 0032491245
- 3 receptor antagonists
- 3 receptor antagonists. Bioorg. Med. Chem. Lett. 1998, 8, 2715-2718.
- (1998) Bioorg. Med. Chem. Lett. , vol.8 , pp. 2715-2718
- Yuan, J.¹ Chen, X.² Brodbeck, R.³ Primus, R.⁴ Braun, J.⁵ Wasley, J.W.F.⁶ Thurkauf, A.⁷

14
- 17144437584
- 3 receptor
- 3 receptor. Bioorg. Med. Chem. Lett. 1996, 6, 403-8.
- (1996) Bioorg. Med. Chem. Lett. , vol.6 , pp. 403-408
- Murray, P.J.¹ Helden, R.M.² Johnson, M.R.³ Robertson, G.M.⁴ Scopes, D.I.C.⁵ Stokes, M.⁶ Wadman, S.⁷ Whitehead, J.W.F.⁸ Hayes, A.G.⁹ Kilpatrick, G.J.¹⁰ Large, C.¹¹ Stubbs, C.M.¹² Turpin, M.P.¹³

15
- 0030802322
- 3 receptor
- 3 receptor. Bioorg. Med. Chem. Lett. 1997, 7, 1995-1998.
- (1997) Bioorg. Med. Chem. Lett. , vol.7 , pp. 1995-1998
- Boyfield, I.¹ Coldwell, M.C.² Hadley, M.S.³ Johnson, C.N.⁴ Riley, G.J.⁵ Scott, E.E.⁶ Stacey, R.⁷ Stemp, G.⁸ Thewlis, K.⁹

16
- 0033584162
- 3 receptor antagonists
- 3 receptor antagonists. Bioorg. Med. Chem. Lett. 1999, 9, 2059-2064.
- (1999) Bioorg. Med. Chem. Lett. , vol.9 , pp. 2059-2064
- Dubuffet, T.¹ Newman-Tancredi, A.² Cussac, D.³ Audinot, V.⁴ Loutz, A.⁵ Millan, M.J.⁶ Lavielle, G.⁷

17
- 0033579921
- 3 receptor
- 3 receptor. Bioorg. Med. Chem. Lett. 1999, 9, 179-184.
- (1999) Bioorg. Med. Chem. Lett. , vol.9 , pp. 179-184
- Austin, N.E.¹ Avenell, K.Y.² Boyfield, I.³ Branch, C.L.⁴ Coldwell, M.C.⁵ Hadley, M.S.⁶ Jeffrey, P.⁷ Johns, A.⁸ Johnson, C.N.⁹ Nash, D.J.¹⁰ Riley, G.J.¹¹ Smith, S.A.¹² Stacey, R.C.¹³ Stemp, G.¹⁴ Thewlis, K.M.¹⁵ Vong, A.K.K.¹⁶

18
- 0013641351
- 3 receptors
- 3 receptors. Soc. Neurosci. Abstr. 1999, 25, 1467.
- (1999) Soc. Neurosci. Abstr. , vol.25 , pp. 1467
- Cussac, D.¹ Newman-Tancredi, A.² LeJeune, F.³ Gobert, A.⁴ Audinot, V.⁵ Rivet, J.M.⁶ Dubuffet, T.⁷ Lavielle, G.⁸ Millan, M.J.⁹

19
- 0033103064
- 3 receptor selective agonists and antagonists
- 3 receptor selective agonists and antagonists. Synapse 1999, 31, 210-215.
- (1999) Synapse , vol.31 , pp. 210-215
- Xu, M.¹ Koeltzow, T.E.² Cooper, D.C.³ Tonegawa, S.⁴ White, F.J.⁵

20
- 14444273648
- 1B receptor inverse agonist 1′-methyl-5-[[2′-methyl-4′-(5-methyl-1,2,4-oxadiazol-3-yl) biphenyl-4-yl]carbonyl-2,3,6,7-tetrahydrospiro]furo[2,3-f]indole-3, 4′-piperidine (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo
- 1B receptor inverse agonist 1′-methyl-5-[[2′-methyl-4′-(5-methyl-1,2,4-oxadiazol-3-yl) biphenyl-4-yl]carbonyl-2,3,6,7-tetrahydrospiro]furo[2,3-f]indole-3, 4′-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo. J. Med. Chem. 1998, 41, 1218-1235.
- (1998) J. Med. Chem. , vol.41 , pp. 1218-1235
- Gaster, L.M.¹ Blaney, F.E.² Davies, S.³ Duckworth, D.M.⁴ Ham, P.⁵ Jenkins, S.⁶ Jennings, A.J.⁷ Joiner, G.F.⁸ King, F.D.⁹ Mulholland, K.R.¹⁰ Wyman, P.A.¹¹ Hagan, J.J.¹² Hatcher, J.¹³ Jones, B.J.¹⁴ Middlemiss, D.N.¹⁵ Price, G.W.¹⁶ Riley, G.J.¹⁷ Roberts, C.¹⁸ Routlcdge, C.¹⁹ Selkirk, J.²⁰ Slade, P.D.²¹ more..

21
- 0017339896
- 1-(trans-4-methylcyclohexyl)-N-nitrosourea for evaluation as anticancer agents
- 1-(trans-4-methylcyclohexyl)-N-nitrosourea for evaluation as anticancer agents. J. Med. Chem. 1977, 20, 279-290.
- (1977) J. Med. Chem. , vol.20 , pp. 279-290
- Johnston, T.P.¹ McCalet, G.S.² Clayton, S.D.³ Frye, J.L.⁴ Krauth, C.A.⁵ Montgomery, J.A.⁶

22
- 0029665116
- 3 receptors mediate inhibition of dopamine neuronal activity?
- 3 receptors mediate inhibition of dopamine neuronal activity? Biochem. Soc. Trans. 1996, 24, 199-201.
- (1996) Biochem. Soc. Trans. , vol.24 , pp. 199-201
- Routledge, C.¹ Thorn, L.² Ashmeade, T.³ Taylor, S.⁴

23
- 0025918637
- 2 receptor mRNA
- 2 receptor mRNA. Brain Res. 1991, 564, 203-19.
- (1991) Brain Res. , vol.564 , pp. 203-219
- Bouthenet, M.L.¹ Souil, E.² Martres, M.P.³ Sokoloff, P.⁴ Giros, B.⁵ Schwartz, J.-C.⁶

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.