SCOPUS 정보 검색 플랫폼

ChemMedChem

Volumn 6, Issue 7, 2011, Pages 1152-1162

Recent Advances in the Development of DopamineD3 Receptor Antagonists: A Medicinal Chemistry Perspective

(1) Micheli, Fabrizio a

a Aptuit Inc (United States)

Author keywords

Antagonists; Dopamine d3 receptors; HERG; Medicinal chemistry; Neurological agents; Positron emission tomography (PET)

Indexed keywords

AROMATIC COMPOUND; AVE 5997; DOPAMINE 3 RECEPTOR BLOCKING AGENT; FERROCENE; GLYCOPROTEIN P; GSK 598809; MOLECULAR SCAFFOLD; NITROGEN; PG 01037; RIBOSOMAL SPACER DNA; SULFONAMIDE; UNCLASSIFIED DRUG;

BINDING AFFINITY; CENTRAL NERVOUS SYSTEM; CHEMICAL PARAMETERS; DRUG DEPENDENCE; ENANTIOSELECTIVITY; EXECUTIVE FUNCTION; HUMAN; HYDROGEN BOND; INVOLUNTARY MOVEMENT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PARKINSON DISEASE; PERMEABILITY; PHARMACOPHORE; PHYSICAL CHEMISTRY; POSITRON EMISSION TOMOGRAPHY; PREMATURE EJACULATION; PRIORITY JOURNAL; REVIEW; SCHIZOPHRENIA; SOLUBILITY;

ANIMALS; AZABICYCLO COMPOUNDS; CHEMISTRY, PHARMACEUTICAL; DOPAMINE ANTAGONISTS; HUMANS; PIPERAZINES; RECEPTORS, DOPAMINE D3; TRIAZOLES;

EID: 79959712583 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201000538 Document Type: Review

Times cited : (43)

References (126)

1
- 0025179967
- P. Sokoloff, B. Giros, M. P. Martres, L. Marie, J. C. Schwartz, Nature 1990, 347, 146-151.
- (1990) Nature , vol.347 , pp. 146-151
- Sokoloff, P.¹ Giros, B.² Martres, M.P.³ Marie, L.⁴ Schwartz, J.C.⁵

2
- 33646694071
- P. Sokoloff, J. Dias, B. LeFoll, O. Guillin, L. Lerich, E. Bezard, C. Gueremy, CNS Neurol. Disord. Drug Targets 2006, 5, 25-43.
- (2006) CNS Neurol. Disord. Drug Targets , vol.5 , pp. 25-43
- Sokoloff, P.¹ Dias, J.² LeFoll, B.³ Guillin, O.⁴ Lerich, L.⁵ Bezard, E.⁶ Gueremy, C.⁷

3
- 51049090956
- F. Micheli, C. Heidbreder, Expert Opin. Ther. Pat. 2008, 18, 821-840.
- (2008) Expert Opin. Ther. Pat. , vol.18 , pp. 821-840
- Micheli, F.¹ Heidbreder, C.²

4
- 77949300041
- C. Heidbreder, A. Newman, Ann. N. Y. Acad. Sci. 2010, 1187, 4-34.
- (2010) Ann. N. Y. Acad. Sci. , vol.1187 , pp. 4-34
- Heidbreder, C.¹ Newman, A.²

5
- 0037019828
- A. E. Hackling, H. Stark, ChemBioChem 2002, 3, 946-961.
- (2002) ChemBioChem , vol.3 , pp. 946-961
- Hackling, A.E.¹ Stark, H.²

6
- 79959771091
- BASF AK, Ludwigshafen, Germany), WO/1996/002519, Chem. Abstr. 1996, 124, 261048].
- B. Hellendahl, A. Lansky, R. Munschauer, S. Bialojan, L. Unger, H.-J. Teschendorf, K. Wicke, K. Drescher, (BASF AK, Ludwigshafen, Germany), WO/1996/002519, 1996; [ Chem. Abstr. 1996, 124, 261048].
- (1996)
- Hellendahl, B.¹ Lansky, A.² Munschauer, R.³ Bialojan, S.⁴ Unger, L.⁵ Teschendorf, H.-J.⁶ Wicke, K.⁷ Drescher, K.⁸

7
- 79959703940
- Neurogen Corporation, Branford, USA), WO/1997/010229, Chem. Abstr. 1997, 126, 293366].
- J. Yuan, X. Chen, (Neurogen Corporation, Branford, USA), WO/1997/010229, 1997; [ Chem. Abstr. 1997, 126, 293366].
- (1997)
- Yuan, J.¹ Chen, X.²

8
- 0037057547
- L. Bettinetti, K. Schlotter, H. Huebner, P. Gmeiner, J. Med. Chem. 2002, 45, 4594-4597.
- (2002) J. Med. Chem. , vol.45 , pp. 4594-4597
- Bettinetti, L.¹ Schlotter, K.² Huebner, H.³ Gmeiner, P.⁴

9
- 0034089063
- M. J. Millan, A. Gobert, A. Newman-Tancredi, F. Lejeune, D. Cussac, J.-M. Rivet, V. Audinot, T. Dubuffet, G. Lavielle, J. Pharm. Exp.Ther. 2000, 293, 1048-1062.
- (2000) J. Pharm. Exp.Ther. , vol.293 , pp. 1048-1062
- Millan, M.J.¹ Gobert, A.² Newman-Tancredi, A.³ Lejeune, F.⁴ Cussac, D.⁵ Rivet, J.-M.⁶ Audinot, V.⁷ Dubuffet, T.⁸ Lavielle, G.⁹

10
- 79959733979
- Aventis Pharmaceuticals Inc., Bridgewater, USA), WO/2002/066468, Chem. Abstr. 2002, 137, 201306].
- J. A. Hendrix, J. T. Strupczewski, K. J. Bordeau, S. Brooks, H. Hemmerle, M. Urmann, X.-Y. Zhao, P. J. Mueller, (Aventis Pharmaceuticals Inc., Bridgewater, USA), WO/2002/066468, 2002; [ Chem. Abstr. 2002, 137, 201306].
- (2002)
- Hendrix, J.A.¹ Strupczewski, J.T.² Bordeau, K.J.³ Brooks, S.⁴ Hemmerle, H.⁵ Urmann, M.⁶ Zhao, X.-Y.⁷ Mueller, P.J.⁸

11
- 13844318790
- P. Heidler, V. Zohrabi-Kalantari, T. Calmels, M. Capet, I. Berrebi-Bertrand, J.-C. Schwartz, H. Stark, A. Linka, Bioorg. Med. Chem. 2005, 13, 2009-2014;
- (2005) Bioorg. Med. Chem. , vol.13 , pp. 2009-2014
- Heidler, P.¹ Zohrabi-Kalantari, V.² Calmels, T.³ Capet, M.⁴ Berrebi-Bertrand, I.⁵ Schwartz, J.-C.⁶ Stark, H.⁷ Linka, A.⁸

12
- 49649088197
- A. Böcker, B. C. Sasse, M. Nietert, H. Stark, G. Schneider, ChemMedChem 2007, 2, 1000-1005.
- (2007) ChemMedChem , vol.2 , pp. 1000-1005
- Böcker, A.¹ Sasse, B.C.² Nietert, M.³ Stark, H.⁴ Schneider, G.⁵

13
- 0033595283
- M. Pilla, S. Perachon, F. Sautel, F. Garrido, A. Mann, C. G. Wermuth, J.-C. Schwartz, B. J. Everitt, P. Sokoloff, Nature 1999, 400, 371-375.
- (1999) Nature , vol.400 , pp. 371-375
- Pilla, M.¹ Perachon, S.² Sautel, F.³ Garrido, F.⁴ Mann, A.⁵ Wermuth, C.G.⁶ Schwartz, J.-C.⁷ Everitt, B.J.⁸ Sokoloff, P.⁹

14
- 0041919650
- A. Hackling, R. Ghosh, S. Perachon, A. Mann, H.-D. Höltje, C. G. Wermuth, J.-C. Schwartz, W. Sippl, P. Sokoloff, H. Stark, J. Med. Chem. 2003, 46, 3883-3899.
- (2003) J. Med. Chem. , vol.46 , pp. 3883-3899
- Hackling, A.¹ Ghosh, R.² Perachon, S.³ Mann, A.⁴ Höltje, H.-D.⁵ Wermuth, C.G.⁶ Schwartz, J.-C.⁷ Sippl, W.⁸ Sokoloff, P.⁹ Stark, H.¹⁰

15
- 68149129503
- P. Gleeson, G. Bravi, S. Modi, D. Lowe, Bioorg. Med. Chem. 2009, 17, 5906-5919.
- (2009) Bioorg. Med. Chem. , vol.17 , pp. 5906-5919
- Gleeson, P.¹ Bravi, G.² Modi, S.³ Lowe, D.⁴

16
- 39749181550
- M. P. Gleeson, J. Med. Chem. 2008, 51, 817-834.
- (2008) J. Med. Chem. , vol.51 , pp. 817-834
- Gleeson, M.P.¹

17
- 33846230530
- M. P. Gleeson, J. Med. Chem. 2007, 50, 101-112.
- (2007) J. Med. Chem. , vol.50 , pp. 101-112
- Gleeson, M.P.¹

18
- 33645404135
- M. P. Gleeson, N. J. Waters, S. W. Paine, A. M. Davis, J. Med. Chem. 2006, 49, 1953-1963.
- (2006) J. Med. Chem. , vol.49 , pp. 1953-1963
- Gleeson, M.P.¹ Waters, N.J.² Paine, S.W.³ Davis, A.M.⁴

19
- 9744232909
- P. D. Leeson, A. M. Davis, J. Med. Chem. 2004, 47, 6338-6348.
- (2004) J. Med. Chem. , vol.47 , pp. 6338-6348
- Leeson, P.D.¹ Davis, A.M.²

20
- 0037468884
- M. C. Wenlock, R. P. Austin, P. Barton, A. M. Davis, P. D. Leeson, J. Med. Chem. 2003, 46, 1250-1256.
- (2003) J. Med. Chem. , vol.46 , pp. 1250-1256
- Wenlock, M.C.¹ Austin, R.P.² Barton, P.³ Davis, A.M.⁴ Leeson, P.D.⁵

21
- 13244266921
- C. A. Lipinski, Drug Discovery Today: Technol. 2004, 1, 337-341.
- (2004) Drug Discovery Today: Technol. , vol.1 , pp. 337-341
- Lipinski, C.A.¹

22
- 0035289779
- C. A. Lipinski, F. Lombardo, B. W. Dominy, P. J. Feeney, Adv. Drug Delivery Rev. 2001, 46, 3-26.
- (2001) Adv. Drug Delivery Rev. , vol.46 , pp. 3-26
- Lipinski, C.A.¹ Lombardo, F.² Dominy, B.W.³ Feeney, P.J.⁴

23
- 34247282794
- J. L. Martelle, R. Claytor, J. T. Ross, B. A. Reboussin, A. H. Newman, M. A. Nader, J. Pharm. Exp.Ther. 2007, 321, 573-582.
- (2007) J. Pharm. Exp.Ther. , vol.321 , pp. 573-582
- Martelle, J.L.¹ Claytor, R.² Ross, J.T.³ Reboussin, B.A.⁴ Newman, A.H.⁵ Nader, M.A.⁶

24
- 33745193915
- Gardner
- Z.-X. Xi, A. H. Newman, J. G. Gilbert, A. C. Pak, X.-Q. Peng, C. R. Ashby Jr., L. Gitajn, E. L. Gardner, Neuropsychopharmacology 2005, 31, 1393-1405.
- (2005) Neuropsychopharmacology , vol.31 , pp. 1393-1405
- Xi, Z.-X.¹ Newman, A.H.² Gilbert, J.G.³ Pak, A.C.⁴ Peng X.-Q.C., R.⁵ Ashby Jr., L.⁶ Gitajn, E.L.⁷

25
- 35348923397
- F. Micheli, C. Heidbreder, Recent Pat. CNS Drug Discovery 2006, 1, 271-288.
- (2006) Recent Pat. CNS Drug Discovery , vol.1 , pp. 271-288
- Micheli, F.¹ Heidbreder, C.²

26
- 79959691906
- Neurogen Corporation, Branford, USA), US/2001/6175015, Chem. Abstr. 2001, 134, 100888].
- J. Yuan, J. Wasley, (Neurogen Corporation, Branford, USA), US/2001/6175015, 2001; [ Chem. Abstr. 2001, 134, 100888].
- (2001)
- Yuan, J.¹ Wasley, J.²

27
- 79959711578
- Gedeon Richter, Budapest, Hungary), WO/2003/028728, Chem. Abstr. 2003, 138, 287700].
- K. Nógrádi, J. Galambos, T. Ács, I. Borza, A. Bielik, G. Domány, B. Kiss, I. Gyertyán, I. Laszlovszky, A. Horváth, (Gedeon Richter, Budapest, Hungary), WO/2003/028728, 2003; [ Chem. Abstr. 2003, 138, 287700].
- (2003)
- Nógrádi, K.¹ Galambos, J.² Ács, T.³ Borza, I.⁴ Bielik, A.⁵ Domány, G.⁶ Kiss, B.⁷ Gyertyán, I.⁸ Laszlovszky, I.⁹ Horváth, A.¹⁰

28
- 20144375764
- K. Schlotter, F. Boeckler, H. Hubner, P. Gmeiner, J. Med. Chem. 2005, 48, 3696-3699.
- (2005) J. Med. Chem. , vol.48 , pp. 3696-3699
- Schlotter, K.¹ Boeckler, F.² Hubner, H.³ Gmeiner, P.⁴

29
- 13444287717
- P. Grundt, E. E. Carlson, J. Cao, C. J. Bennett, E. McElveen, M. Taylor, R. R. Luedtke, A. H. Newman, J. Med. Chem. 2005, 48, 839-848.
- (2005) J. Med. Chem. , vol.48 , pp. 839-848
- Grundt, P.¹ Carlson, E.E.² Cao, J.³ Bennett, C.J.⁴ McElveen, E.⁵ Taylor, M.⁶ Luedtke, R.R.⁷ Newman, A.H.⁸

30
- 79959747586
- Aventis Pharmaceuticals Inc., Bridgewater, USA; J.P. Carey, Cincinnati, USA; G.E. Lee, Somerville, USA), WO/2002/066446, Chem. Abstr. 2002, 137, 201331].
- J. A. Hendrix, H. Hemmerle, M. Urmann, G. Shutske, J. T. Strupczewski, K. J. Bordeau, J. G. Jurcak, T. Nieduzak, S. A. Jackson, P. Angell, D. M. Fink, J.-F. Sabuco, Y. Chiang, N. Collar, (Aventis Pharmaceuticals Inc., Bridgewater, USA; J.P. Carey, Cincinnati, USA; G.E. Lee, Somerville, USA), WO/2002/066446, 2002; [ Chem. Abstr. 2002, 137, 201331].
- (2002)
- Hendrix, J.A.¹ Hemmerle, H.² Urmann, M.³ Shutske, G.⁴ Strupczewski, J.T.⁵ Bordeau, K.J.⁶ Jurcak, J.G.⁷ Nieduzak, T.⁸ Jackson, S.A.⁹ Angell, P.¹⁰ Fink, D.M.¹¹ Sabuco, J.-F.¹² Chiang, Y.¹³ Collar, N.¹⁴

31
- 79959765119
- Aventis Pharmaceuticals Inc., Bridgewater, USA), WO/2002/066469, Chem. Abstr. 2002, 137, 201342].
- J. A. Hendrix, J. T. Strupczewski, K. J. Bordeau, M. Urmann, G. Shutske, H. Hemmerle, J. G. Jurcak, H. Gill, F. Weiberth, Jr., T. Nieduzak, S. A. Jackson, X.-Y. Zhao, P. J. Mueller, (Aventis Pharmaceuticals Inc., Bridgewater, USA), WO/2002/066469, 2002; [ Chem. Abstr. 2002, 137, 201342].
- (2002)
- Hendrix, J.A.¹ Strupczewski, J.T.² Bordeau, K.J.³ Urmann, M.⁴ Shutske, G.⁵ Hemmerle, H.⁶ Jurcak, J.G.⁷ Gill, H.⁸ Weiberth Jr, F.⁹ Nieduzak, T.¹⁰ Jackson, S.A.¹¹ Zhao, X.-Y.¹² Mueller, P.J.¹³

32
- 18344391187
- M. Y. Cha, B. C. Choi, K. H. Kang, Bioorg. Med. Chem. Lett. 2002, 12, 1327-1330.
- (2002) Bioorg. Med. Chem. Lett. , vol.12 , pp. 1327-1330
- Cha, M.Y.¹ Choi, B.C.² Kang, K.H.³

33
- 79959706625
- BASF AK, Ludwigshafen, Germany), WO/2001/072306, Chem. Abstr. 2001, 135, 267256].
- D. Starck, H. Treiber, L. Unger, H.-J. Teschendorf, G. Gross (BASF AK, Ludwigshafen, Germany), WO/2001/072306, 2001; [ Chem. Abstr. 2001, 135, 267256].
- (2001)
- Starck, D.¹ Treiber, H.² Unger, L.³ Teschendorf, H.-J.⁴ Gross, G.⁵

34
- 79959742551
- Smithkline Beecham PLC, Brentford, UK), WO/2002/040471, Chem. Abstr. 2002, 136, 386120];
- M. Hadley, A. Lightfoot, G. Macdonald, G. Stemp (Smithkline Beecham PLC, Brentford, UK), WO/2002/040471, 2001; [ Chem. Abstr. 2002, 136, 386120];
- (2001)
- Hadley, M.¹ Lightfoot, A.² Macdonald, G.³ Stemp, G.⁴

35
- 79959770157
- Glaxo Group Ltd., Greenford, USA), WO/2005/087764, Chem. Abstr. 2005, 143, 326368 ];
- L. Arista, G. Bonanomi, F. Damiani, D. Hamprecht, F. Micheli, L. Tarsi, G. Tedesco (Glaxo Group Ltd., Greenford, USA), WO/2005/087764, 2005; [ Chem. Abstr. 2005, 143, 326368 ];
- (2005)
- Arista, L.¹ Bonanomi, G.² Damiani, F.³ Hamprecht, D.⁴ Micheli, F.⁵ Tarsi, L.⁶ Tedesco, G.⁷

36
- 79959724154
- Glaxo Group Ltd., Greenford, UK), WO/2005/118549, Chem. Abstr. 2005, 144, 88295].,[ Chem. Abstr. 2005, 144, 51588]; Glaxo Group Ltd., Greenford, UK), WO/2005/123717, 2005
- G. Bonanomi, F. Damiani, G. Gentile, D. W. Hamprecht, F. Micheli, L. Tarsi, G. Tedesco, S. Terreni (Glaxo Group Ltd., Greenford, UK), WO/2005/118549, 2005; [ Chem. Abstr. 2005, 144, 51588]; D. Hamprecht, F. Micheli, L. Tarsi, G. Tedesco (Glaxo Group Ltd., Greenford, UK), WO/2005/123717, 2005; [ Chem. Abstr. 2005, 144, 88295].
- (2005)
- Bonanomi, G.¹ Damiani, F.² Gentile, G.³ Hamprecht, D.W.⁴ Micheli, F.⁵ Tarsi, L.⁶ Tedesco, G.⁷ Terreni, S.⁸ Hamprecht, D.⁹ Micheli, F.¹⁰ Tarsi, L.¹¹ Tedesco, G.¹²

37
- 0033838517
- C. Reavill, S. G. Taylor, M. D. Wood, T. Ashmeade, N. E. Austin, K. Y. Avenell, I. Boyfield, C. L. Branch, J. Cilia, M. C. Coldwell, M. S. Hadley, A. J. Hunter, P. Jeffrey, F. Jewitt, C. N. Johnson, D. N. Jones, A. D. Medhurst, D. N. Middlemiss, D. J. Nash, G. J. Riley, C. Routledge, G. Stemp, K. M. Thewlis, D. Trail, A. K. Vong, J. J. Hagan, J. Pharmacol. Exp. Ther. 2000, 294, 1154-1165.
- (2000) J. Pharmacol. Exp. Ther. , vol.294 , pp. 1154-1165
- Reavill, C.¹ Taylor, S.G.² Wood, M.D.³ Ashmeade, T.⁴ Austin, N.E.⁵ Avenell, K.Y.⁶ Boyfield, I.⁷ Branch, C.L.⁸ Cilia, J.⁹ Coldwell, M.C.¹⁰ Hadley, M.S.¹¹ Hunter, A.J.¹² Jeffrey, P.¹³ Jewitt, F.¹⁴ Johnson, C.N.¹⁵ Jones, D.N.¹⁶ Medhurst, A.D.¹⁷ Middlemiss, D.N.¹⁸ Nash, D.J.¹⁹ Riley, G.J.²⁰ more..

38
- 78650379608
- D. C. Pryde, D. Dalvie, Q. Hu, P. Jones, R. S. Obach, T.-D. Tran, J. Med. Chem. 2010, 53, 8441-8460.
- (2010) J. Med. Chem. , vol.53 , pp. 8441-8460
- Pryde, D.C.¹ Dalvie, D.² Hu, Q.³ Jones, P.⁴ Obach, R.S.⁵ Tran, T.-D.⁶

39
- 0141992809
- J. Varady, X. Wu, X. Fang, J. Min, Z. Hu, B. Levant, S. Wang, J. Med. Chem. 2003, 46, 4377-4392.
- (2003) J. Med. Chem. , vol.46 , pp. 4377-4392
- Varady, J.¹ Wu, X.² Fang, X.³ Min, J.⁴ Hu, Z.⁵ Levant, B.⁶ Wang, S.⁷

40
- 24744465202
- J. Elsner, F. Boeckler, F. W. Heinemann, H. Hubner, P. Gmeiner, J. Med. Chem. 2005, 48, 5771-5779.
- (2005) J. Med. Chem. , vol.48 , pp. 5771-5779
- Elsner, J.¹ Boeckler, F.² Heinemann, F.W.³ Hubner, H.⁴ Gmeiner, P.⁵

41
- 31044451129
- H.-J. Kim, Y. S. Cho, H. Y. Koh, J. Y. Kong, K. T. Nob, A. N. Pae, Bioorg. Med. Chem. 2006, 14, 1454-1461.
- (2006) Bioorg. Med. Chem. , vol.14 , pp. 1454-1461
- Kim, H.-J.¹ Cho, Y.S.² Koh, H.Y.³ Kong, J.Y.⁴ Nob, K.T.⁵ Pae, A.N.⁶

42
- 21544439847
- J. N. Joyce, M. J. Millan, Drug Discovery Today 2005, 10, 917-925.
- (2005) Drug Discovery Today , vol.10 , pp. 917-925
- Joyce, J.N.¹ Millan, M.J.²

43
- 20144378943
- A. H. Newman, P. Grundt, M. A. Nader, J. Med. Chem. 2005, 48, 3663-3679.
- (2005) J. Med. Chem. , vol.48 , pp. 3663-3679
- Newman, A.H.¹ Grundt, P.² Nader, M.A.³

44
- 79959697501
- Abbott Gmbh & Co., Wiesbaden, Germany), WO/2005/056546, Chem. Abstr. 2005, 143, 78097].
- W. Lubisch, A. Haupt, W. Braje, H. Geneste, (Abbott Gmbh & Co., Wiesbaden, Germany), WO/2005/056546, 2005; [ Chem. Abstr. 2005, 143, 78097].
- (2005)
- Lubisch, W.¹ Haupt, A.² Braje, W.³ Geneste, H.⁴

45
- 79959702204
- Abbott Gmbh & Co., Wiesbaden, Germany), US/2005/137186, Chem. Abstr. 2005, 143, 78097].
- W. M. Braje, A. Haupt, W. Lubisch, R. Grandel, K. Drescher, H. Geneste, L. Unger, D. R. Sauer, (Abbott Gmbh & Co., Wiesbaden, Germany), US/2005/137186, 2005; [ Chem. Abstr. 2005, 143, 78097].
- (2005)
- Braje, W.M.¹ Haupt, A.² Lubisch, W.³ Grandel, R.⁴ Drescher, K.⁵ Geneste, H.⁶ Unger, L.⁷ Sauer, D.R.⁸

46
- 79959769533
- Abbott Gmbh & Co., Wiesbaden, Germany), WO/2005/058328, Chem. Abstr. 2005, 143, 97282].
- W. Braje, A. Haupt, W. Lubisch, R. Grandel, K. Drescher, H. Geneste, L. Unger, D. R. Sauer, (Abbott Gmbh & Co., Wiesbaden, Germany), WO/2005/058328, 2005; [ Chem. Abstr. 2005, 143, 97282].
- (2005)
- Braje, W.¹ Haupt, A.² Lubisch, W.³ Grandel, R.⁴ Drescher, K.⁵ Geneste, H.⁶ Unger, L.⁷ Sauer, D.R.⁸

47
- 79959760750
- Abbott Gmbh & Co., Wiesbaden, Germany), WO/2005/118558, Chem. Abstr. 2005, 144, 51603].
- H. Geneste, A. Haupt, W. Braje, W. Lubisch, G. Steiner, L. Unger, (Abbott Gmbh & Co., Wiesbaden, Germany), WO/2005/118558, 2005; [ Chem. Abstr. 2005, 144, 51603].
- (2005)
- Geneste, H.¹ Haupt, A.² Braje, W.³ Lubisch, W.⁴ Steiner, G.⁵ Unger, L.⁶

48
- 79959709835
- Abbott Gmbh & Co., Wiesbaden, Germany), WO/2005/118571, Chem. Abstr. 2005, 144, 36378].
- H. Geneste, W. Braje, A. Haupt, (Abbott Gmbh & Co., Wiesbaden, Germany), WO/2005/118571, 2005; [ Chem. Abstr. 2005, 144, 36378].
- (2005)
- Geneste, H.¹ Braje, W.² Haupt, A.³

49
- 79959762022
- Abbott Gmbh & Co., Wiesbaden, Germany), WO/2006/015842, Chem. Abstr. 2006, 144, 212808].
- A. Haupt, L. Unger, K. Drescher, A. L. Jongen-Relo, R. Grandel, W. Braje, H. Geneste, (Abbott Gmbh & Co., Wiesbaden, Germany), WO/2006/015842, 2006; [ Chem. Abstr. 2006, 144, 212808].
- (2006)
- Haupt, A.¹ Unger, L.² Drescher, K.³ Jongen-Relo, A.L.⁴ Grandel, R.⁵ Braje, W.⁶ Geneste, H.⁷

50
- 79959732168
- Abbott Gmbh & Co., Wiesbaden, Germany), WO/2006/040176, Chem. Abstr. 2006, 144, 390732].
- K. Drescher, A. Haupt, L. Unger, S. C. Turner, W. Braje, R. Grandel, (Abbott Gmbh & Co., Wiesbaden, Germany), WO/2006/040176, 2006; [ Chem. Abstr. 2006, 144, 390732].
- (2006)
- Drescher, K.¹ Haupt, A.² Unger, L.³ Turner, S.C.⁴ Braje, W.⁵ Grandel, R.⁶

51
- 79959756266
- Abbott Gmbh & Co., Wiesbaden, Germany), WO/2006/040180, Chem. Abstr. 2006, 144, 412362].
- K. Drescher, A. Haupt, L. Unger, S. C. Turner, W. Braje, R. Grandel, (Abbott Gmbh & Co., Wiesbaden, Germany), WO/2006/040180, 2006; [ Chem. Abstr. 2006, 144, 412362].
- (2006)
- Drescher, K.¹ Haupt, A.² Unger, L.³ Turner, S.C.⁴ Braje, W.⁵ Grandel, R.⁶

52
- 79959707971
- Abbott Gmbh & Co., Wiesbaden, Germany), WO/2006/040177, Chem. Abstr. 2006, 144, 412245].
- K. Drescher, A. Haupt, L. Unger, S. C. Turner, W. Braje, R. Grandel, (Abbott Gmbh & Co., Wiesbaden, Germany), WO/2006/040177, 2006; [ Chem. Abstr. 2006, 144, 412245].
- (2006)
- Drescher, K.¹ Haupt, A.² Unger, L.³ Turner, S.C.⁴ Braje, W.⁵ Grandel, R.⁶

53
- 79959733978
- Abbott Gmbh & Co., Wiesbaden, Germany), WO/2006/040179, Chem. Abstr. 2006, 144, 412241].
- K. Drescher, A. Haupt, L. Unger, S. C. Turner, W. Braje, R. Grandel, (Abbott Gmbh & Co., Wiesbaden, Germany), WO/2006/040179, 2006; [ Chem. Abstr. 2006, 144, 412241].
- (2006)
- Drescher, K.¹ Haupt, A.² Unger, L.³ Turner, S.C.⁴ Braje, W.⁵ Grandel, R.⁶

54
- 79959725961
- Abbott Gmbh & Co., Wiesbaden, Germany), WO/2006/040178, Chem. Abstr. 2006, 144, 412247].
- K. Drescher, A. Haupt, L. Unger, S. C. Turner, W. Braje, R. Grandel, C. Henry, (Abbott Gmbh & Co., Wiesbaden, Germany), WO/2006/040178, 2006; [ Chem. Abstr. 2006, 144, 412247].
- (2006)
- Drescher, K.¹ Haupt, A.² Unger, L.³ Turner, S.C.⁴ Braje, W.⁵ Grandel, R.⁶ Henry, C.⁷

55
- 79959739460
- Abbott Gmbh & Co., Wiesbaden, Germany), WO/2006/058753, Chem. Abstr. 2006, 145, 46089].
- L. Unger, A. Haupt, A. Beyerbach, K. Drescher, W. Braje, J. Darbyshire, S. C. Turner, G. Backfisch, (Abbott Gmbh & Co., Wiesbaden, Germany), WO/2006/058753, 2006; [ Chem. Abstr. 2006, 145, 46089].
- (2006)
- Unger, L.¹ Haupt, A.² Beyerbach, A.³ Drescher, K.⁴ Braje, W.⁵ Darbyshire, J.⁶ Turner, S.C.⁷ Backfisch, G.⁸

56
- 79959691905
- Abbott Gmbh & Co., Wiesbaden, Germany), DE/102004061593, Chem. Abstr. 2006, 145, 83384].
- H. Geneste, D. R. Sauer, (Abbott Gmbh & Co., Wiesbaden, Germany), DE/102004061593, 2006; [ Chem. Abstr. 2006, 145, 83384].
- (2006)
- Geneste, H.¹ Sauer, D.R.²

57
- 79959710704
- Abbott Gmbh & Co., Wiesbaden, Germany), US/2006/160809, Chem. Abstr. 2006, 145, 145753].
- W. M. Braje, A. Haupt, W. Lubisch, R. Grandel, K. Drescher, H. Geneste, L. Unger, D. R. Sauer, S. C. Turner, (Abbott Gmbh & Co., Wiesbaden, Germany), US/2006/160809, 2006; [ Chem. Abstr. 2006, 145, 145753].
- (2006)
- Braje, W.M.¹ Haupt, A.² Lubisch, W.³ Grandel, R.⁴ Drescher, K.⁵ Geneste, H.⁶ Unger, L.⁷ Sauer, D.R.⁸ Turner, S.C.⁹

58
- 79959703939
- Abbott Gmbh & Co., Wiesbaden, Germany), WO/2007/118859, Chem. Abstr. 2007, 147, 486332].
- R. Grandel, W. Braje, M. Wilfried, A. Haupt, S. C. Turner, U. Lange, K. Drescher, L. Unger, (Abbott Gmbh & Co., Wiesbaden, Germany), WO/2007/118859, 2007; [ Chem. Abstr. 2007, 147, 486332].
- (2007)
- Grandel, R.¹ Braje, W.² Wilfried, M.³ Haupt, A.⁴ Turner, S.C.⁵ Lange, U.⁶ Drescher, K.⁷ Unger, L.⁸

59
- 79959709834
- Glaxo Group Ltd., Greenford, UK), WO/2005/080382, Chem. Abstr. 2005, 143, 266934].
- L. Arista, G. Bonanomi, A. M. Capelli, F. Damiani, R. DiFabio, G. Gentile, D. Hamprecht, F. Micheli, L. Tarsi, G. Tedesco, S. Terreni, (Glaxo Group Ltd., Greenford, UK), WO/2005/080382, 2005; [ Chem. Abstr. 2005, 143, 266934].
- (2005)
- Arista, L.¹ Bonanomi, G.² Capelli, A.M.³ Damiani, F.⁴ DiFabio, R.⁵ Gentile, G.⁶ Hamprecht, D.⁷ Micheli, F.⁸ Tarsi, L.⁹ Tedesco, G.¹⁰ Terreni, S.¹¹

60
- 79959761219
- Glaxo Group Ltd., Greenford, UK), WO/2005/087764, Chem. Abstr. 2005, 143, 326368].
- L. Arista, G. Bonanomi, F. Damiani, D. Hamprecht, F. Micheli, L. Tarsi, G. Tedesco, (Glaxo Group Ltd., Greenford, UK), WO/2005/087764, 2005; [ Chem. Abstr. 2005, 143, 326368].
- (2005)
- Arista, L.¹ Bonanomi, G.² Damiani, F.³ Hamprecht, D.⁴ Micheli, F.⁵ Tarsi, L.⁶ Tedesco, G.⁷

61
- 79959707573
- Glaxo Group Ltd., Greenford, UK), WO/2005/118549, Chem. Abstr. 2005, 144, 51588].
- G. Bonanomi, F. Damiani, G. Gentile, D. W. Hamprecht, F. Micheli, L. Tarsi, G. Tedesco, S. Terreni, (Glaxo Group Ltd., Greenford, UK), WO/2005/118549, 2005; [ Chem. Abstr. 2005, 144, 51588].
- (2005)
- Bonanomi, G.¹ Damiani, F.² Gentile, G.³ Hamprecht, D.W.⁴ Micheli, F.⁵ Tarsi, L.⁶ Tedesco, G.⁷ Terreni, S.⁸

62
- 79959718664
- Glaxo Group Ltd., Greenford, UK), WO/2005/123717, Chem. Abstr. 2005, 144, 88295].
- D. Hamprecht, F. Micheli, L. Tarsi, G. Tedesco, (Glaxo Group Ltd., Greenford, UK), WO/2005/123717, 2005; [ Chem. Abstr. 2005, 144, 88295].
- (2005)
- Hamprecht, D.¹ Micheli, F.² Tarsi, L.³ Tedesco, G.⁴

63
- 79959725039
- Glaxo Group Ltd., Greenford, UK), WO/2006/002928, Chem. Abstr. 2006, 144, 128979].
- G. Bonanomi, F. Cardullo, F. Damiani, G. Gentile, D. Hamprecht, F. Micheli, L. Tarsi, (Glaxo Group Ltd., Greenford, UK), WO/2006/002928, 2006; [ Chem. Abstr. 2006, 144, 128979].
- (2006)
- Bonanomi, G.¹ Cardullo, F.² Damiani, F.³ Gentile, G.⁴ Hamprecht, D.⁵ Micheli, F.⁶ Tarsi, L.⁷

64
- 79959758987
- Glaxo Group Ltd., Greenford, UK), WO/2006/108700, Chem. Abstr. 2006, 145, 438625].
- D. Andreotti, A. Checchia, D. Hamprecht, F. Micheli, (Glaxo Group Ltd., Greenford, UK), WO/2006/108700, 2006; [ Chem. Abstr. 2006, 145, 438625].
- (2006)
- Andreotti, D.¹ Checchia, A.² Hamprecht, D.³ Micheli, F.⁴

65
- 79959746268
- Glaxo Group Ltd., Greenford, UK), WO/2006/108701, Chem. Abstr. 2006, 145, 438626].
- G. Bonanomi, A. Checchia, E. Fazzolari, D. Hamprecht, F. Micheli, L. Tarsi, Luca; S. Terreni, (Glaxo Group Ltd., Greenford, UK), WO/2006/108701, 2006; [ Chem. Abstr. 2006, 145, 438626].
- (2006)
- Bonanomi, G.¹ Checchia, A.² Fazzolari, E.³ Hamprecht, D.⁴ Micheli, F.⁵ Tarsi, L.⁶ Terreni, L.S.⁷

66
- 79959740804
- Glaxo Group Ltd., Greenford, UK), WO/2006/133945, Chem. Abstr. 2006, 146, 62722].
- L. Arista, G. Bonanomi, D. Hamprecht, F. Micheli, (Glaxo Group Ltd., Greenford, UK), WO/2006/133945, 2006; [ Chem. Abstr. 2006, 146, 62722].
- (2006)
- Arista, L.¹ Bonanomi, G.² Hamprecht, D.³ Micheli, F.⁴

67
- 79959713943
- Glaxo Group Ltd., Greenford, UK), WO/2006/133946, Chem. Abstr. 2006, 146, 62584].
- L. Arista, F. Cardullo, A. Checchia, D. Hamprecht, F. Micheli, G. Tedesco, S. Terreni, (Glaxo Group Ltd., Greenford, UK), WO/2006/133946, 2006; [ Chem. Abstr. 2006, 146, 62584].
- (2006)
- Arista, L.¹ Cardullo, F.² Checchia, A.³ Hamprecht, D.⁴ Micheli, F.⁵ Tedesco, G.⁶ Terreni, S.⁷

68
- 79959752199
- Glaxo Group Ltd., Greenford, UK), WO/2006/136223, Chem. Abstr. 2006, 146, 100551].
- D. Hamprecht, C. Mazzoni, F. Micheli, (Glaxo Group Ltd., Greenford, UK), WO/2006/136223, 2006; [ Chem. Abstr. 2006, 146, 100551].
- (2006)
- Hamprecht, D.¹ Mazzoni, C.² Micheli, F.³

69
- 79959690255
- Glaxo Group Ltd., Greenford, UK), WO/2007/022933, Chem. Abstr. 2007, 146, 295933].
- G. Bonanomi, R. DiFabio, E. Fazzolari, D. Hamprecht, F. Micheli, L. Tarsi, S. Terreni, (Glaxo Group Ltd., Greenford, UK), WO/2007/022933, 2007; [ Chem. Abstr. 2007, 146, 295933].
- (2007)
- Bonanomi, G.¹ DiFabio, R.² Fazzolari, E.³ Hamprecht, D.⁴ Micheli, F.⁵ Tarsi, L.⁶ Terreni, S.⁷

70
- 79959720646
- Glaxo Group Ltd., Greenford, UK), WO/2007/022936, Chem. Abstr. 2007, 146, 274406].
- A. M. Capelli, E. Fazzolari, F. Micheli, G. Tedesco, S. Terreni, (Glaxo Group Ltd., Greenford, UK), WO/2007/022936, 2007; [ Chem. Abstr. 2007, 146, 274406].
- (2007)
- Capelli, A.M.¹ Fazzolari, E.² Micheli, F.³ Tedesco, G.⁴ Terreni, S.⁵

71
- 79959687647
- Glaxo Group Ltd., Greenford, UK), WO/2007/022935, Chem. Abstr. 2007, 146, 295765].
- G. Gentile, D. Hamprecht, F. Micheli, A. Prandi, S. Terreni, (Glaxo Group Ltd., Greenford, UK), WO/2007/022935, 2007; [ Chem. Abstr. 2007, 146, 295765].
- (2007)
- Gentile, G.¹ Hamprecht, D.² Micheli, F.³ Prandi, A.⁴ Terreni, S.⁵

72
- 79959691904
- Glaxo Group Ltd., Greenford, UK), WO/2007/022980, Chem. Abstr. 2007, 146, 295767].
- D. Hamprecht, C. Heidbreder, S. Melotto, F. Micheli, T. Yamada, (Glaxo Group Ltd., Greenford, UK), WO/2007/022980, 2007; [ Chem. Abstr. 2007, 146, 295767].
- (2007)
- Hamprecht, D.¹ Heidbreder, C.² Melotto, S.³ Micheli, F.⁴ Yamada, T.⁵

73
- 79959765551
- Glaxo Group Ltd., Greenford, UK), WO/2007/022934, Chem. Abstr. 2007, 146, 274392].
- L. Arista, A. Checchia, G. Gentile, D. Hamprecht, F. Micheli, (Glaxo Group Ltd., Greenford, UK), WO/2007/022934, 2007; [ Chem. Abstr. 2007, 146, 274392].
- (2007)
- Arista, L.¹ Checchia, A.² Gentile, G.³ Hamprecht, D.⁴ Micheli, F.⁵

74
- 79959758540
- Glaxo Group Ltd., Greenford, UK), WO/2007113258, Chem. Abstr. 2007, 147, 448641 ].
- B. Bertani, F. Micheli, A. Pasquarello, S. Terreni, (Glaxo Group Ltd., Greenford, UK), WO/2007113258, 2007; [ Chem. Abstr. 2007, 147, 448641 ].
- (2007)
- Bertani, B.¹ Micheli, F.² Pasquarello, A.³ Terreni, S.⁴

75
- 79959743025
- Glaxo Group Ltd., Greenford, UK), WO/2007/113232, Chem. Abstr. 2007, 147, 448793].
- B. Bertani, G. Bonanomi, A. M. Capelli, A. Checchia, R. DiFabio, G. Gentile, F. Micheli, A. Pasquarello, G. Tedesco, S. Terreni, (Glaxo Group Ltd., Greenford, UK), WO/2007/113232, 2007; [ Chem. Abstr. 2007, 147, 448793].
- (2007)
- Bertani, B.¹ Bonanomi, G.² Capelli, A.M.³ Checchia, A.⁴ DiFabio, R.⁵ Gentile, G.⁶ Micheli, F.⁷ Pasquarello, A.⁸ Tedesco, G.⁹ Terreni, S.¹⁰

76
- 79959725960
- Glaxo Group Ltd., Greenford, UK), WO/2007/125061, Chem. Abstr. 2007, 147, 522251].
- B. Bertani, R. DiFabio, F. Micheli, A. Pasquarello, L. Tarsi, S. Terreni, (Glaxo Group Ltd., Greenford, UK), WO/2007/125061, 2007; [ Chem. Abstr. 2007, 147, 522251].
- (2007)
- Bertani, B.¹ DiFabio, R.² Micheli, F.³ Pasquarello, A.⁴ Tarsi, L.⁵ Terreni, S.⁶

77
- 79959712963
- Abbott Gmbh & Co., Wiesbaden, Germany), WO/2009/056600, Chem. Abstr. 2009, 150, 472759].
- S. C. Turner, A. Haupt, W. Braje, U. Lange, K. Drescher, L. Unger, (Abbott Gmbh & Co., Wiesbaden, Germany), WO/2009/056600, 2009; [ Chem. Abstr. 2009, 150, 472759].
- (2009)
- Turner, S.C.¹ Haupt, A.² Braje, W.³ Lange, U.⁴ Drescher, K.⁵ Unger, L.⁶

78
- 79959707068
- Abbott Gmbh & Co., Wiesbaden, Germany), WO/2009/056625, Chem. Abstr. 2009, 150, 494901].
- W. Braje, S. C. Turner, A. Haupt, U. Lange, H. Geneste, K. Drescher, L. Unger, A. L. Jongen-Relo, A. Bespalov, (Abbott Gmbh & Co., Wiesbaden, Germany), WO/2009/056625, 2009; [ Chem. Abstr. 2009, 150, 494901].
- (2009)
- Braje, W.¹ Turner, S.C.² Haupt, A.³ Lange, U.⁴ Geneste, H.⁵ Drescher, K.⁶ Unger, L.⁷ Jongen-Relo, A.L.⁸ Bespalov, A.⁹

79
- 79959732593
- Glaxo Group Ltd., Greenford, UK), WO/2009/043883, Chem. Abstr. 2009, 150, 398576].
- B. Bertani, F. Cardullo, P. Dambruoso, P. Marzorati, F. Micheli, A. Pasquarello, C. Seri, G. Tedesco, (Glaxo Group Ltd., Greenford, UK), WO/2009/043883, 2009; [ Chem. Abstr. 2009, 150, 398576].
- (2009)
- Bertani, B.¹ Cardullo, F.² Dambruoso, P.³ Marzorati, P.⁴ Micheli, F.⁵ Pasquarello, A.⁶ Seri, C.⁷ Tedesco, G.⁸

80
- 79959765118
- Glaxo Group Ltd., Greenford, UK), WO/2009/043884, Chem. Abstr. 2009, 150, 398584].
- B. Bertani, S. Cremonesi, S. Fontana, A. Pasquarello, (Glaxo Group Ltd., Greenford, UK), WO/2009/043884, 2009; [ Chem. Abstr. 2009, 150, 398584].
- (2009)
- Bertani, B.¹ Cremonesi, S.² Fontana, S.³ Pasquarello, A.⁴

81
- 79959749773
- Glaxo Group Ltd., Greenford, UK), WO/2008/022994, Chem. Abstr. 2008, 148, 285197].
- A. Anderton, S. Bacchi, S. Beato, F. Sartor (Glaxo Group Ltd., Greenford, UK), WO/2008/022994, 2008; [ Chem. Abstr. 2008, 148, 285197].
- (2008)
- Anderton, A.¹ Bacchi, S.² Beato, S.³ Sartor, F.⁴

82
- 79959712040
- Hoffmann-La Roche, Inc., Nutley, USA), US/2010/075985, Chem. Abstr. 2010, 152, 381449].
- K. J. Prior, G. Jaeschke, R. M. Rodriguez Sarmiento, L. Steward, (Hoffmann-La Roche, Inc., Nutley, USA), US/2010/075985, 2010; [ Chem. Abstr. 2010, 152, 381449].
- (2010)
- Prior, K.J.¹ Jaeschke, G.² Sarmiento, R.M.R.³ Steward, L.⁴

83
- 79959736799
- Hoffmann-La Roche, Inc., Nutley, USA), US/2010/075981, Chem. Abstr. 2010, 152, 381447].
- L. Gobbi, G. Jaeschke, R. M. Rodriguez Sarmiento, L. Steward, (Hoffmann-La Roche, Inc., Nutley, USA), US/2010/075981, 2010; [ Chem. Abstr. 2010, 152, 381447].
- (2010)
- Gobbi, L.¹ Jaeschke, G.² Sarmiento, R.M.R.³ Steward, L.⁴

84
- 79959759835
- Hoffmann-La Roche, Inc., Nutley, USA), US/2010/075979, Chem. Abstr. 2010, 152, 381446].
- L. Gobbi, G. Jaeschke, R. M. Rodriguez Sarmiento, L. Steward, (Hoffmann-La Roche, Inc., Nutley, USA), US/2010/075979, 2010; [ Chem. Abstr. 2010, 152, 381446].
- (2010)
- Gobbi, L.¹ Jaeschke, G.² Sarmiento, R.M.R.³ Steward, L.⁴

85
- 79959751267
- Pfizer Products Inc., Groton, USA), WO/2008/026046, Chem. Abstr. 2008, 148, 331693].
- T. T. Wager, R. Y. Chandrasekaran, T. W. Butler, (Pfizer Products Inc., Groton, USA), WO/2008/026046, 2008; [ Chem. Abstr. 2008, 148, 331693].
- (2008)
- Wager, T.T.¹ Chandrasekaran, R.Y.² Butler, T.W.³

86
- 79959762470
- The Government of the United States of America as Represented by the Secretary of the Department of Health and Human Services, Rockville, USA), WO/2008/153573, Chem. Abstr. 2008, 150, 56199].
- A. H. Newman, P. Grundt, G. C. Cyriac, R. Luedtke, J. Cao (The Government of the United States of America as Represented by the Secretary of the Department of Health and Human Services, Rockville, USA), WO/2008/153573, 2008; [ Chem. Abstr. 2008, 150, 56199].
- (2008)
- Newman, A.H.¹ Grundt, P.² Cyriac, G.C.³ Luedtke, R.⁴ Cao, J.⁵

87
- 79959703086
- University of Michigan, Ann Arbor, USA), WO/2010/025235, Chem. Abstr. 2010, 152, 311596].
- S. Wang, J. Chen, G. Collins, J. H. Woods, B. Levant, (University of Michigan, Ann Arbor, USA), WO/2010/025235, 2010; [ Chem. Abstr. 2010, 152, 311596].
- (2010)
- Wang, S.¹ Chen, J.² Collins, G.³ Woods, J.H.⁴ Levant, B.⁵

88
- 29544431769
- H. Geneste, G. Backfisch, W. Braje, J. Delzer, A. Haupt, C. W. Hutchins, L. L. King, A. Kling, H.-J. Teschendorf, L. Unger, W. Werneta, Bioorg. Med. Chem. Lett. 2006, 16, 490-494.
- (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 490-494
- Geneste, H.¹ Backfisch, G.² Braje, W.³ Delzer, J.⁴ Haupt, A.⁵ Hutchins, C.W.⁶ King, L.L.⁷ Kling, A.⁸ Teschendorf, H.-J.⁹ Unger, L.¹⁰ Werneta, W.¹¹

89
- 29544433208
- H. Geneste, G. Backfisch, W. Braje, J. Delzer, A. Haupt, C. W. Hutchins, L. L. King, W. Lubisch, G. Steiner, H.-J. Teschendorf, L. Unger, W. Wernet, Bioorg. Med. Chem. Lett. 2006, 16, 658-662.
- (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 658-662
- Geneste, H.¹ Backfisch, G.² Braje, W.³ Delzer, J.⁴ Haupt, A.⁵ Hutchins, C.W.⁶ King, L.L.⁷ Lubisch, W.⁸ Steiner, G.⁹ Teschendorf, H.-J.¹⁰ Unger, L.¹¹ Wernet, W.¹²

90
- 0028039636
- C. Hutchins, Endocr. J. 1994, 2, 7-23;
- (1994) Endocr. J. , vol.2 , pp. 7-23
- Hutchins, C.¹

91
- 12644255702
- Eds.: T.W. Schwartz, S.A. Hjorth, J.S. Kastrup), Munksgaard, Copenhagen
- C. Hutchins in Structure and Function of 7TM Receptors, (Eds.: T.W. Schwartz, S.A. Hjorth, J.S. Kastrup), Munksgaard, Copenhagen, 1996, pp.213-216.
- (1996) Structure and Function of 7TM Receptors , pp. 213-216
- Hutchins, C.¹

92
- 33144464648
- H. Geneste, W. Amberg, G. Backfisch, A. Beyerbach, W. M. Braje, J. Delzer, A. Haupt, C. W. Hutchins, L. L. King, D. R. Sauer, L. Unger, W. Wernet, Bioorg. Med. Chem. Lett. 2006, 16, 1934-1937.
- (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 1934-1937
- Geneste, H.¹ Amberg, W.² Backfisch, G.³ Beyerbach, A.⁴ Braje, W.M.⁵ Delzer, J.⁶ Haupt, A.⁷ Hutchins, C.W.⁸ King, L.L.⁹ Sauer, D.R.¹⁰ Unger, L.¹¹ Wernet, W.¹²

93
- 34548138905
- P. Grundt, K. M. Prevatt, J. Cao, M. Taylor, C. Z. Floresca, J.-K. Choi, B. G. Jenkins, R. R. Luedtke, A. H. Newman, J. Med. Chem. 2007, 50, 4135-4146;
- (2007) J. Med. Chem. , vol.50 , pp. 4135-4146
- Grundt, P.¹ Prevatt, K.M.² Cao, J.³ Taylor, M.⁴ Floresca, C.Z.⁵ Choi, J.-K.⁶ Jenkins, B.G.⁷ Luedtke, R.R.⁸ Newman, A.H.⁹

94
- 77952343819
- C. W. Mason, H. E. Hassan, K.-P. Kim, J. Cao, N. D. Eddington, A. H. Newman, P. J. Voulalas, J. Pharmacol. Exp. Ther. 2010, 333, 854-864.
- (2010) J. Pharmacol. Exp. Ther. , vol.333 , pp. 854-864
- Mason, C.W.¹ Hassan, H.E.² Kim, K.-P.³ Cao, J.⁴ Eddington, N.D.⁵ Newman, A.H.⁶ Voulalas, P.J.⁷

95
- 35348917640
- F. Micheli, G. Bonanomi, F. E. Blaney, S. Braggio, A. M. Capelli, A. Checchia, O. Curcuruto, F. Damiani, R. DiFabio, D. Donati, G. Gentile, A. Gribble, D. Hamprecht, G. Tedesco, S. Terreni, L. Tarsi, A. Lightfoot, G. Stemp, G. MacDonald, A. Smith, M. Pecoraro, M. Petrone, O. Perini, J. Piner, T. Rossi, A. Worby, M. Pilla, E. Valerio, C. Griffante, M. Mugnaini, M. Wood, C. Scott, M. Andreoli, L. Lacroix, A. Schwarz, A. Gozzi, A. Bifone, C. R. Ashby, Jr., J. J. Hagan, C. Heidbreder, J. Med. Chem. 2007, 50, 5076-5089.
- (2007) J. Med. Chem. , vol.50 , pp. 5076-5089
- Micheli, F.¹ Bonanomi, G.² Blaney, F.E.³ Braggio, S.⁴ Capelli, A.M.⁵ Checchia, A.⁶ Curcuruto, O.⁷ Damiani, F.⁸ DiFabio, R.⁹ Donati, D.¹⁰ Gentile, G.¹¹ Gribble, A.¹² Hamprecht, D.¹³ Tedesco, G.¹⁴ Terreni, S.¹⁵ Tarsi, L.¹⁶ Lightfoot, A.¹⁷ Stemp, G.¹⁸ MacDonald, G.¹⁹ Smith, A.²⁰ more..

96
- 38849203201
- F. Micheli, G. Bonanomi, S. Braggio, A. M. Capelli, P. Celestini, F. Damiani, R. DiFabio, D. Donati, S. Gagliardi, G. Gentile, D. Hamprecht, M. Petrone, S. Radaelli, G. Tedesco, S. Terreni, A. Worby, C. Heidbreder, Bioorg. Med. Chem. Lett. 2008, 18, 901-907.
- (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 901-907
- Micheli, F.¹ Bonanomi, G.² Braggio, S.³ Capelli, A.M.⁴ Celestini, P.⁵ Damiani, F.⁶ DiFabio, R.⁷ Donati, D.⁸ Gagliardi, S.⁹ Gentile, G.¹⁰ Hamprecht, D.¹¹ Petrone, M.¹² Radaelli, S.¹³ Tedesco, G.¹⁴ Terreni, S.¹⁵ Worby, A.¹⁶ Heidbreder, C.¹⁷

97
- 38749096639
- F. Micheli, G. Bonanomi, S. Braggio, A. M. Capelli, F. Damiani, R. DiFabio, D. Donati, G. Gentile, D. Hamprecht, O. Perini, M. Petrone, G. Tedesco, S. Terreni, A. Worby, C. Heidbreder, Bioorg. Med. Chem. Lett. 2008, 18, 908-912.
- (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 908-912
- Micheli, F.¹ Bonanomi, G.² Braggio, S.³ Capelli, A.M.⁴ Damiani, F.⁵ DiFabio, R.⁶ Donati, D.⁷ Gentile, G.⁸ Hamprecht, D.⁹ Perini, O.¹⁰ Petrone, M.¹¹ Tedesco, G.¹² Terreni, S.¹³ Worby, A.¹⁴ Heidbreder, C.¹⁵

98
- 74849137482
- F. Micheli, L. Arista, G. Bonanomi, F. E. Blaney, S. Braggio, A. M. Capelli, A. Checchia, F. Damiani, R. Di-Fabio, S. Fontana, G. Gentile, C. Griffante, D. Hamprecht, C. Marchioro, M. Mugnaini, J. Piner, E. Ratti, G. Tedesco, L. Tarsi, S. Terreni, A. Worby, C. R. Ashby Jr., C. Heidbreder, J. Med. Chem. 2010, 53, 374-391.
- (2010) J. Med. Chem. , vol.53 , pp. 374-391
- Micheli, F.¹ Arista, L.² Bonanomi, G.³ Blaney, F.E.⁴ Braggio, S.⁵ Capelli, A.M.⁶ Checchia, A.⁷ Damiani, F.⁸ Di-Fabio, R.⁹ Fontana, S.¹⁰ Gentile, G.¹¹ Griffante, C.¹² Hamprecht, D.¹³ Marchioro, C.¹⁴ Mugnaini, M.¹⁵ Piner, J.¹⁶ Ratti, E.¹⁷ Tedesco, G.¹⁸ Tarsi, L.¹⁹ Terreni, S.²⁰ more..

99
- 77951690761
- G. Bonanomi, S. Braggio, A. M. Capelli, A. Checchia, R. DiFabio, C. Marchioro, L. Tarsi, G. Tedesco, S. Terreni, A. Worby, C. Heibreder, F. Micheli, ChemMedChem 2010, 5, 705- 715.
- (2010) ChemMedChem , vol.5 , pp. 705-715
- Bonanomi, G.¹ Braggio, S.² Capelli, A.M.³ Checchia, A.⁴ DiFabio, R.⁵ Marchioro, C.⁶ Tarsi, L.⁷ Tedesco, G.⁸ Terreni, S.⁹ Worby, A.¹⁰ Heibreder, C.¹¹ Micheli, F.¹²

100
- 77957909271
- F. Micheli, L. Arista, B. Bertani, S. Braggio, A. M. Capelli, S. Cremonesi, R. Di-Fabio, G. Gelardi, G. Gentile, C. Marchioro, A. Pasquarello, S. Provera, G. Tedesco, L. Tarsi, S. Terreni, A. Worby, C. Heidbreder, J. Med. Chem. 2010, 53, 7129-7139.
- (2010) J. Med. Chem. , vol.53 , pp. 7129-7139
- Micheli, F.¹ Arista, L.² Bertani, B.³ Braggio, S.⁴ Capelli, A.M.⁵ Cremonesi, S.⁶ Di-Fabio, R.⁷ Gelardi, G.⁸ Gentile, G.⁹ Marchioro, C.¹⁰ Pasquarello, A.¹¹ Provera, S.¹² Tedesco, G.¹³ Tarsi, L.¹⁴ Terreni, S.¹⁵ Worby, A.¹⁶ Heidbreder, C.¹⁷

101
- 65249161020
- A. H. Newman, P. Grundt, G. Cyriac, J. R. Deschamps, M. Taylor, R. Kumar, D. Ho, R. R. Luedtke, J. Med. Chem. 2009, 52, 2559-2570.
- (2009) J. Med. Chem. , vol.52 , pp. 2559-2570
- Newman, A.H.¹ Grundt, P.² Cyriac, G.³ Deschamps, J.R.⁴ Taylor, M.⁵ Kumar, R.⁶ Ho, D.⁷ Luedtke, R.R.⁸

102
- 71049142202
- D. Huber, H. Hubner, P. Gmeiner, J. Med. Chem. 2009, 52, 6860-6870.
- (2009) J. Med. Chem. , vol.52 , pp. 6860-6870
- Huber, D.¹ Hubner, H.² Gmeiner, P.³

103
- 79959727740
- Abstracts of Papers, MEDI-142; 226th American Chemical Society National Meeting, New York, NY (USA), September 7-11.
- J.A. Hendrix, S. Kongsamut, K.J. Bordeau, J.T. Strupczewski, H. Hemmerle, M. Urmann, F. Messing, T.J. Corbett, S. Kafka, D. Rampe, N. Huebert, Abstracts of Papers, MEDI-142; 226th American Chemical Society National Meeting, New York, NY (USA), September 7-11, 2003.
- (2003)
- Hendrix, J.A.¹ Kongsamut, S.² Bordeau, K.J.³ Strupczewski, J.T.⁴ Hemmerle, H.⁵ Urmann, M.⁶ Messing, F.⁷ Corbett, T.J.⁸ Kafka, S.⁹ Rampe, D.¹⁰ Huebert, N.¹¹

104
- 79959753876
- For details of the phaseI clinical trial visit: (Last accessed: February 7, 2011).
- For details of the phaseI clinical trial visit: (Last accessed: February 7, 2011).

105
- 77955710668
- G. Searle, J. D. Beaver, R. A. Comley, M. Bani, A. Tziortzi, M. Slifstein, M. Mugnaini, C. Griffante, A. A. Wilson, E. Merlo-Pich, S. Houle, R. Gunn, E. A. Rabiner, M. Laruelle, Biol. Psychiatry 2010, 68, 392-399.
- (2010) Biol. Psychiatry , vol.68 , pp. 392-399
- Searle, G.¹ Beaver, J.D.² Comley, R.A.³ Bani, M.⁴ Tziortzi, A.⁵ Slifstein, M.⁶ Mugnaini, M.⁷ Griffante, C.⁸ Wilson, A.A.⁹ Merlo-Pich, E.¹⁰ Houle, S.¹¹ Gunn, R.¹² Rabiner, E.A.¹³ Laruelle, M.¹⁴

106
- 24144473428
- J. Sovago, L. Farde, C. Halldin, E. Schukin, M. Schou, I. Laszlovszky, B. Kiss, B. Gulyas, Brain Res. Bull. 2005, 67, 219-224.
- (2005) Brain Res. Bull. , vol.67 , pp. 219-224
- Sovago, J.¹ Farde, L.² Halldin, C.³ Schukin, E.⁴ Schou, M.⁵ Laszlovszky, I.⁶ Kiss, B.⁷ Gulyas, B.⁸

107
- 25144504927
- C. Hocke, O. Prante, S. Lober, H. Hubner, P. Gmeiner, T. Kuwerta, Bioorg. Med. Chem. Lett. 2005, 15, 4819-4823.
- (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 4819-4823
- Hocke, C.¹ Prante, O.² Lober, S.³ Hubner, H.⁴ Gmeiner, P.⁵ Kuwerta, T.⁶

108
- 30444439721
- M. Leopoldo, E. Lacivita, P. DeGiorgio, N. A. Colabufo, M. Niso, F. Berardi, R. Perrone, J. Med. Chem. 2006, 49, 358-365.
- (2006) J. Med. Chem. , vol.49 , pp. 358-365
- Leopoldo, M.¹ Lacivita, E.² DeGiorgio, P.³ Colabufo, N.A.⁴ Niso, M.⁵ Berardi, F.⁶ Perrone, R.⁷

109
- 33846930565
- I. Salama, C. Hocke, W. Utz, O. Prante, F. Boeckler, H. Hubner, T. Kuwert, P. Gmeiner, J. Med. Chem. 2007, 50, 489-500.
- (2007) J. Med. Chem. , vol.50 , pp. 489-500
- Salama, I.¹ Hocke, C.² Utz, W.³ Prante, O.⁴ Boeckler, F.⁵ Hubner, H.⁶ Kuwert, T.⁷ Gmeiner, P.⁸

110
- 47649127702
- C. Hocke, O. Prante, I. Salama, H. Hübner, S. Lober, T. Kuwert, P. Gmeiner, ChemMedChem 2008, 3, 788-793.
- (2008) ChemMedChem , vol.3 , pp. 788-793
- Hocke, C.¹ Prante, O.² Salama, I.³ Hübner, H.⁴ Lober, S.⁵ Kuwert, T.⁶ Gmeiner, P.⁷

111
- 53549088596
- M. Gao, M. Wang, G. D. Hutchins, Q.-H. Zheng, Appl. Radiat. Isot. 2008, 66, 1891-1897.
- (2008) Appl. Radiat. Isot. , vol.66 , pp. 1891-1897
- Gao, M.¹ Wang, M.² Hutchins, G.D.³ Zheng, Q.-H.⁴

112
- 58549088678
- M. Leopoldo, E. Lacivita, P. DeGiorgio, M. Contino, F. Berardi, R. Perrone, Bioorg. Med. Chem. 2009, 17, 758-766.
- (2009) Bioorg. Med. Chem. , vol.17 , pp. 758-766
- Leopoldo, M.¹ Lacivita, E.² DeGiorgio, P.³ Contino, M.⁴ Berardi, F.⁵ Perrone, R.⁶

113
- 67651108948
- I. P. Holmes, F. Micheli, S. Gaines, O. Lorthioir, S. P. Watson, R. DiFabio, G. Gentile, C. Heidbreder, C. Savoia, A. Worby, Bioorg. Med. Chem. Lett. 2009, 19, 4799-4801.
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 4799-4801
- Holmes, I.P.¹ Micheli, F.² Gaines, S.³ Lorthioir, O.⁴ Watson, S.P.⁵ DiFabio, R.⁶ Gentile, G.⁷ Heidbreder, C.⁸ Savoia, C.⁹ Worby, A.¹⁰

114
- 67650102585
- F. Micheli, I. Holmes, L. Arista, G. Bonanomi, S. Braggio, F. Cardullo, R. DiFabio, D. Donati, G. Gentile, D. Hamprecht, S. Terreni, C. Heidbreder, C. Savoia, C. Griffante, A. Worby, Bioorg. Med. Chem. Lett. 2009, 19, 4011-4013.
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 4011-4013
- Micheli, F.¹ Holmes, I.² Arista, L.³ Bonanomi, G.⁴ Braggio, S.⁵ Cardullo, F.⁶ DiFabio, R.⁷ Donati, D.⁸ Gentile, G.⁹ Hamprecht, D.¹⁰ Terreni, S.¹¹ Heidbreder, C.¹² Savoia, C.¹³ Griffante, C.¹⁴ Worby, A.¹⁵

115
- 68349127060
- I. Bennacef, C. A. Salinas, T. A. Bonasera, R. N. Gunn, H. Audrain, S. Jakobsen, N. Nabulsi, D. Weinzimmer, R. E. Carson, Y. Huang, I. Holmes, F. Micheli, C. Heidbreder, G. Gentile, T. Rossi, M. Laruelle, Bioorg. Med. Chem. Lett. 2009, 19, 5056-5059.
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 5056-5059
- Bennacef, I.¹ Salinas, C.A.² Bonasera, T.A.³ Gunn, R.N.⁴ Audrain, H.⁵ Jakobsen, S.⁶ Nabulsi, N.⁷ Weinzimmer, D.⁸ Carson, R.E.⁹ Huang, Y.¹⁰ Holmes, I.¹¹ Micheli, F.¹² Heidbreder, C.¹³ Gentile, G.¹⁴ Rossi, T.¹⁵ Laruelle, M.¹⁶

116
- 77953089656
- C. Hocke, S. Maschauer, H. Hübner, S. Löber, W. Utz, T. Kuwert, P. Gmeiner, O. Prante, ChemMedChem 2010, 5, 941-948.
- (2010) ChemMedChem , vol.5 , pp. 941-948
- Hocke, C.¹ Maschauer, S.² Hübner, H.³ Löber, S.⁴ Utz, W.⁵ Kuwert, T.⁶ Gmeiner, P.⁷ Prante, O.⁸

117
- 34447545521
- A. J. Schwarz, A. Gozzi, T. Reese, C. A. Heidbreder, A. Bifone, Magnetic Resonance Imaging 2007, 25, 811-820.
- (2007) Magnetic Resonance Imaging , vol.25 , pp. 811-820
- Schwarz, A.J.¹ Gozzi, A.² Reese, T.³ Heidbreder, C.A.⁴ Bifone, A.⁵

118
- 77955774783
- J.-K. Choi, J. B. Mandeville, Y. I. Chen, P. Grundt, S. K. Sarkar, A. H. Newman, B. G. Jenkins, Psychopharmacology 2010, 212, 59-72.
- (2010) Psychopharmacology , vol.212 , pp. 59-72
- Choi, J.-K.¹ Mandeville, J.B.² Chen, Y.I.³ Grundt, P.⁴ Sarkar, S.K.⁵ Newman, A.H.⁶ Jenkins, B.G.⁷

119
- 77549083431
- I. P. Holmes, R. J. Blunt, O. E. Lorthioir, S. M. Blowers, A. Gribble, A. H. Payne, I. G. Stansfield, M. Wood, P. M. Woollard, C. Reavill, C. M. Howes, F. Micheli, R. DiFabio, D. Donati, S. Terreni, D. Hamprecht, L. Arista, A. Worby, S. P. Watson, Bioorg. Med. Chem. Lett. 2010, 20, 2013-2016.
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 2013-2016
- Holmes, I.P.¹ Blunt, R.J.² Lorthioir, O.E.³ Blowers, S.M.⁴ Gribble, A.⁵ Payne, A.H.⁶ Stansfield, I.G.⁷ Wood, M.⁸ Woollard, P.M.⁹ Reavill, C.¹⁰ Howes, C.M.¹¹ Micheli, F.¹² DiFabio, R.¹³ Donati, D.¹⁴ Terreni, S.¹⁵ Hamprecht, D.¹⁶ Arista, L.¹⁷ Worby, A.¹⁸ Watson, S.P.¹⁹

120
- 77956176225
- F. Micheli, D. Hamprecht, G. Bonanomi, R. DiFabio, D. Donati, G. Gentile, C. Heidbreder, A. Prandi, L. Tarsi, S. Terreni, Bioorg. Med. Chem. Lett. 2010, 20, 5491-5494.
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 5491-5494
- Micheli, F.¹ Hamprecht, D.² Bonanomi, G.³ DiFabio, R.⁴ Donati, D.⁵ Gentile, G.⁶ Heidbreder, C.⁷ Prandi, A.⁸ Tarsi, L.⁹ Terreni, S.¹⁰

121
- 79959738637
- Abstracts of Papers, MEDI-553; 239th American Chemical Society National Meeting, San Francisco, CA (USA), March 21-25.
- S.C. Turner, Abstracts of Papers, MEDI-553; 239th American Chemical Society National Meeting, San Francisco, CA (USA), March 21-25, 2010.
- (2010)
- Turner, S.C.¹

122
- 77957243152
- M. J. Millan, J. J. Buccafusco, F. Loiseau, D. J. G. Watson, E. Decamp, K. C. F. Fone, N. Thomasson-Perret, M. Hill, E. Mocaer, J. S. Schneider, Int. J. Neuropsychopharmacology 2010, 13, 1035-1051.
- (2010) Int. J. Neuropsychopharmacology , vol.13 , pp. 1035-1051
- Millan, M.J.¹ Buccafusco, J.J.² Loiseau, F.³ Watson, D.J.G.⁴ Decamp, E.⁵ Fone, K.C.F.⁶ Thomasson-Perret, N.⁷ Hill, M.⁸ Mocaer, E.⁹ Schneider, J.S.¹⁰

123
- 77949654291
- M. A. T. M. Khaled, K. F. Araki, B. Li, K. M. Coen, P. W. Marinelli, J. Varga, J. Gaal, B. LeFoll, Int. J. Neuropsychopharmacology 2009, 13, 181-190.
- (2009) Int. J. Neuropsychopharmacology , vol.13 , pp. 181-190
- Khaled, M.A.T.M.¹ Araki, K.F.² Li, B.³ Coen, K.M.⁴ Marinelli, P.W.⁵ Varga, J.⁶ Gaal, J.⁷ LeFoll, B.⁸

124
- 67349158011
- R. Kumar, L. Riddle, S. A. Griffin, P. Grundt, A. H. Newman, R. R. Luedtke, Neuropharmacology 2009, 56, 944-955.
- (2009) Neuropharmacology , vol.56 , pp. 944-955
- Kumar, R.¹ Riddle, L.² Griffin, S.A.³ Grundt, P.⁴ Newman, A.H.⁵ Luedtke, R.R.⁶

125
- 64149109693
- P. Clément, C. Pozzato, C. Heidbreder, L. Alexandre, F. Giuliano, S. Melotto, J. Sex. Med. 2009, 6, 980-988.
- (2009) J. Sex. Med. , vol.6 , pp. 980-988
- Clément, P.¹ Pozzato, C.² Heidbreder, C.³ Alexandre, L.⁴ Giuliano, F.⁵ Melotto, S.⁶

126
- 78449305788
- E. Y. T. Chien, W. Liu, Q. Zhao, V. Katritch, G. W. Han, M. A. Hanson, L. Shi, A. H. Newman, J. A. Javitch, V. Cherezov, R. C. Stevens, J. Science. 2010, 330, 1091-1095.
- (2010) J. Science. , vol.330 , pp. 1091-1095
- Chien, E.Y.T.¹ Liu, W.² Zhao, Q.³ Katritch, V.⁴ Han, G.W.⁵ Hanson, M.A.⁶ Shi, L.⁷ Newman, A.H.⁸ Javitch, J.A.⁹ Cherezov, V.¹⁰ Stevens, R.C.¹¹

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.