SCOPUS 정보 검색 플랫폼

Volumn 22, Issue 21, 2014, Pages 5790-5803

AFQ056/mavoglurant, a novel clinically effective mGluR5 antagonist: Identification, SAR and pharmacological characterization

(10) Vranesic, Ivo a Ofner, Silvio a Flor, Peter Josef a,b Bilbe, Graeme a,c Bouhelal, Rochdi a Enz, Albert a Desrayaud, Sandrine a McAllister, Kevin a Kuhn, Rainer a,d Gasparini, Fabrizio a

a NOVARTIS PHARMA AG (Switzerland)

b UNIVERSITY OF REGENSBURG (Germany)

c Drugs for Neglected Diseases Initiative DNDi (Switzerland)

d EVOTEC AG (Germany)

Author keywords

Allosteric; Antagonist; mGluR5; Non competitive

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; BENZODIAZEPINE CHLORDIAZEPOXIDE; BENZODIAZEPINE DERIVATIVE; MAVOGLURANT; METABOTROPIC RECEPTOR 5; UNCLASSIFIED DRUG; 6-METHYL-2-(PHENYLETHYNYL)PYRIDINE; INDOLE DERIVATIVE; LEVODOPA; PROTEIN BINDING; PYRIDINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG SELECTIVITY; DRUG STRUCTURE; HIGH THROUGHPUT SCREENING; HYPERTHERMIA; IC50; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; RAT; RECEPTOR BLOCKING; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION; TIME TO MAXIMUM PLASMA CONCENTRATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; CHEMISTRY; DRUG EFFECTS; DYSKINESIA, DRUG-INDUCED; HALF LIFE TIME; HUMAN; HYPERTHERMIC THERAPY; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; BRAIN; DYSKINESIA, DRUG-INDUCED; HALF-LIFE; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; HYPERTHERMIA, INDUCED; INDOLES; LEVODOPA; MALE; MICE; PROTEIN BINDING; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, METABOTROPIC GLUTAMATE 5; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84908433180 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2014.09.033 Document Type: Article

Times cited : (47)

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