-
1
-
-
42149181885
-
Structural diversity of G protein-coupled receptors and significance for drug discovery
-
Lagerstrom M.C., and Schioth H.B. Structural diversity of G protein-coupled receptors and significance for drug discovery. Nat. Rev. Drug Discov. 7 (2008) 339-357
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 339-357
-
-
Lagerstrom, M.C.1
Schioth, H.B.2
-
2
-
-
0345791508
-
Sequential binding of agonists to the β2 adrenoceptor. Kinetic evidence for intermediate conformational states
-
Swaminath G., et al. Sequential binding of agonists to the β2 adrenoceptor. Kinetic evidence for intermediate conformational states. J. Biol. Chem. 279 (2004) 686-691
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 686-691
-
-
Swaminath, G.1
-
3
-
-
65449161390
-
Ligand binding and micro-switches in 7TM receptor structures
-
Nygaard R., et al. Ligand binding and micro-switches in 7TM receptor structures. Trends Pharmacol. Sci. 30 (2009) 249-259
-
(2009)
Trends Pharmacol. Sci.
, vol.30
, pp. 249-259
-
-
Nygaard, R.1
-
4
-
-
66249144426
-
The structure and function of G-protein-coupled receptors
-
Rosenbaum D.M., et al. The structure and function of G-protein-coupled receptors. Nature 459 (2009) 356-363
-
(2009)
Nature
, vol.459
, pp. 356-363
-
-
Rosenbaum, D.M.1
-
5
-
-
33747802375
-
Building functional modules from molecular interactions
-
Hofmann K.P., et al. Building functional modules from molecular interactions. Trends Biochem. Sci. 31 (2006) 497-508
-
(2006)
Trends Biochem. Sci.
, vol.31
, pp. 497-508
-
-
Hofmann, K.P.1
-
6
-
-
0034604451
-
Crystal structure of rhodopsin: a G protein-coupled receptor
-
Palczewski K., et al. Crystal structure of rhodopsin: a G protein-coupled receptor. Science 289 (2000) 739-745
-
(2000)
Science
, vol.289
, pp. 739-745
-
-
Palczewski, K.1
-
7
-
-
4344581120
-
The retinal conformation and its environment in rhodopsin in light of a new 2.2 Å crystal structure
-
Okada T., et al. The retinal conformation and its environment in rhodopsin in light of a new 2.2 Å crystal structure. J. Mol. Biol. 342 (2004) 571-583
-
(2004)
J. Mol. Biol.
, vol.342
, pp. 571-583
-
-
Okada, T.1
-
8
-
-
6344248639
-
Structure of bovine rhodopsin in a trigonal crystal form
-
Li J., et al. Structure of bovine rhodopsin in a trigonal crystal form. J. Mol. Biol. 343 (2004) 1409-1438
-
(2004)
J. Mol. Biol.
, vol.343
, pp. 1409-1438
-
-
Li, J.1
-
9
-
-
0035336676
-
Activation of rhodopsin: new insights from structural and biochemical studies
-
Okada T., et al. Activation of rhodopsin: new insights from structural and biochemical studies. Trends Biochem. Sci. 26 (2001) 318-324
-
(2001)
Trends Biochem. Sci.
, vol.26
, pp. 318-324
-
-
Okada, T.1
-
10
-
-
67249125561
-
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex
-
Yao X.J., et al. The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex. Proc. Natl. Acad. Sci. U. S. A. 106 (2009) 9501-9506
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 9501-9506
-
-
Yao, X.J.1
-
11
-
-
2942617209
-
Dark adaptation and the retinoid cycle of vision
-
Lamb T.D., and Pugh Jr. E.N. Dark adaptation and the retinoid cycle of vision. Prog. Retin. Eye Res. 23 (2004) 307-380
-
(2004)
Prog. Retin. Eye Res.
, vol.23
, pp. 307-380
-
-
Lamb, T.D.1
Pugh Jr., E.N.2
-
12
-
-
0343580431
-
A comparison of the efficiency of G protein activation by ligand-free and light-activated forms of rhodopsin
-
Melia Jr. T.J., et al. A comparison of the efficiency of G protein activation by ligand-free and light-activated forms of rhodopsin. Biophys. J. 73 (1997) 3182-3191
-
(1997)
Biophys. J.
, vol.73
, pp. 3182-3191
-
-
Melia Jr., T.J.1
-
13
-
-
0028005422
-
Bleached pigment activates transduction in isolated rods of the salamander retina
-
Cornwall M.C., and Fain G.L. Bleached pigment activates transduction in isolated rods of the salamander retina. J. Physiol. 480 (1994) 261-279
-
(1994)
J. Physiol.
, vol.480
, pp. 261-279
-
-
Cornwall, M.C.1
Fain, G.L.2
-
14
-
-
43749109187
-
Crystal structure of squid rhodopsin
-
Murakami M., and Kouyama T. Crystal structure of squid rhodopsin. Nature 453 (2008) 363-367
-
(2008)
Nature
, vol.453
, pp. 363-367
-
-
Murakami, M.1
Kouyama, T.2
-
15
-
-
47949129742
-
Structure of a beta1-adrenergic G-protein-coupled receptor
-
Warne T., et al. Structure of a beta1-adrenergic G-protein-coupled receptor. Nature 454 (2008) 486-491
-
(2008)
Nature
, vol.454
, pp. 486-491
-
-
Warne, T.1
-
16
-
-
36448995359
-
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor
-
Cherezov V., et al. High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science 318 (2007) 1258-1265
-
(2007)
Science
, vol.318
, pp. 1258-1265
-
-
Cherezov, V.1
-
17
-
-
36248970132
-
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
-
Rasmussen S.G., et al. Crystal structure of the human β2 adrenergic G-protein-coupled receptor. Nature 450 (2007) 383-387
-
(2007)
Nature
, vol.450
, pp. 383-387
-
-
Rasmussen, S.G.1
-
18
-
-
56749103466
-
The 2.6 Å crystal structure of a human A2A adenosine receptor bound to an antagonist
-
Jaakola V.P., et al. The 2.6 Å crystal structure of a human A2A adenosine receptor bound to an antagonist. Science 322 (2008) 1211-1217
-
(2008)
Science
, vol.322
, pp. 1211-1217
-
-
Jaakola, V.P.1
-
19
-
-
58149203324
-
Discovery of new GPCR biology: one receptor structure at a time
-
Hanson M.A., and Stevens R.C. Discovery of new GPCR biology: one receptor structure at a time. Structure 17 (2009) 8-14
-
(2009)
Structure
, vol.17
, pp. 8-14
-
-
Hanson, M.A.1
Stevens, R.C.2
-
20
-
-
65549111760
-
Modeling small molecule-compound binding to G-protein-coupled receptors
-
Vaidehi N., et al. Modeling small molecule-compound binding to G-protein-coupled receptors. Methods Enzymol. 460 (2009) 263-288
-
(2009)
Methods Enzymol.
, vol.460
, pp. 263-288
-
-
Vaidehi, N.1
-
21
-
-
57049178915
-
Structural insights into G-protein-coupled receptor activation
-
Weis W.I., and Kobilka B.K. Structural insights into G-protein-coupled receptor activation. Curr. Opin. Struct. Biol. 18 (2008) 734-740
-
(2008)
Curr. Opin. Struct. Biol.
, vol.18
, pp. 734-740
-
-
Weis, W.I.1
Kobilka, B.K.2
-
22
-
-
58849094130
-
Topology of class A G protein-coupled receptors: insights gained from crystal structures of rhodopsins, adrenergic and adenosine receptors
-
Mustafi D., and Palczewski K. Topology of class A G protein-coupled receptors: insights gained from crystal structures of rhodopsins, adrenergic and adenosine receptors. Mol. Pharmacol. 75 (2009) 1-12
-
(2009)
Mol. Pharmacol.
, vol.75
, pp. 1-12
-
-
Mustafi, D.1
Palczewski, K.2
-
23
-
-
33846302070
-
The role of internal water molecules in the structure and function of the rhodopsin family of G protein-coupled receptors
-
Pardo L., et al. The role of internal water molecules in the structure and function of the rhodopsin family of G protein-coupled receptors. ChemBiochem 8 (2007) 19-24
-
(2007)
ChemBiochem
, vol.8
, pp. 19-24
-
-
Pardo, L.1
-
24
-
-
66649096395
-
Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors
-
Angel T.E., et al. Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors. Proc. Natl. Acad. Sci. U. S. A. 106 (2009) 8555-8560
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 8555-8560
-
-
Angel, T.E.1
-
25
-
-
0035800850
-
Activation of the β2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6
-
Ballesteros J.A., et al. Activation of the β2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6. J. Biol. Chem. 276 (2001) 29171-29177
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 29171-29177
-
-
Ballesteros, J.A.1
-
26
-
-
63849294621
-
Identification of two distinct inactive conformations of the β2-adrenergic receptor reconciles structural and biochemical observations
-
Dror R.O., et al. Identification of two distinct inactive conformations of the β2-adrenergic receptor reconciles structural and biochemical observations. Proc. Natl. Acad. Sci. U. S. A. 106 (2009) 4689-4694
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 4689-4694
-
-
Dror, R.O.1
-
27
-
-
0037174606
-
β2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch
-
Shi L., et al. β2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch. J. Biol. Chem. 277 (2002) 40989-40996
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 40989-40996
-
-
Shi, L.1
-
28
-
-
0037452868
-
Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin
-
Mirzadegan T., et al. Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin. Biochemistry 42 (2003) 2759-2767
-
(2003)
Biochemistry
, vol.42
, pp. 2759-2767
-
-
Mirzadegan, T.1
-
29
-
-
17644402459
-
Transduction of receptor signals by β-arrestins
-
Lefkowitz R.J., and Shenoy S.K. Transduction of receptor signals by β-arrestins. Science 308 (2005) 512-517
-
(2005)
Science
, vol.308
, pp. 512-517
-
-
Lefkowitz, R.J.1
Shenoy, S.K.2
-
30
-
-
34447633368
-
Conformational complexity of G-protein-coupled receptors
-
Kobilka B.K., and Deupi X. Conformational complexity of G-protein-coupled receptors. Trends Pharmacol. Sci. 28 (2007) 397-406
-
(2007)
Trends Pharmacol. Sci.
, vol.28
, pp. 397-406
-
-
Kobilka, B.K.1
Deupi, X.2
-
31
-
-
25144510053
-
The role of Glu181 in the photoactivation of rhodopsin
-
Ludeke S., et al. The role of Glu181 in the photoactivation of rhodopsin. J. Mol. Biol. 353 (2005) 345-356
-
(2005)
J. Mol. Biol.
, vol.353
, pp. 345-356
-
-
Ludeke, S.1
-
32
-
-
34247228082
-
Coupling of protonation switches during rhodopsin activation
-
Vogel R., et al. Coupling of protonation switches during rhodopsin activation. Photochem. Photobiol. 83 (2007) 286-292
-
(2007)
Photochem. Photobiol.
, vol.83
, pp. 286-292
-
-
Vogel, R.1
-
33
-
-
47049130668
-
Crystal structure of the ligand-free G-protein-coupled receptor opsin
-
Park J.H., et al. Crystal structure of the ligand-free G-protein-coupled receptor opsin. Nature 454 (2008) 183-187
-
(2008)
Nature
, vol.454
, pp. 183-187
-
-
Park, J.H.1
-
34
-
-
52949102889
-
Crystal structure of opsin in its G-protein-interacting conformation
-
Scheerer P., et al. Crystal structure of opsin in its G-protein-interacting conformation. Nature 455 (2008) 497-502
-
(2008)
Nature
, vol.455
, pp. 497-502
-
-
Scheerer, P.1
-
35
-
-
0023716027
-
Site of G protein binding to rhodopsin mapped with synthetic peptides from the α subunit
-
Hamm H.E., et al. Site of G protein binding to rhodopsin mapped with synthetic peptides from the α subunit. Science 241 (1988) 832-835
-
(1988)
Science
, vol.241
, pp. 832-835
-
-
Hamm, H.E.1
-
36
-
-
30044447642
-
The carboxyl terminus of the Gα-subunit is the latch for triggered activation of heterotrimeric G proteins
-
Nanoff C., et al. The carboxyl terminus of the Gα-subunit is the latch for triggered activation of heterotrimeric G proteins. Mol. Pharmacol. 69 (2006) 397-405
-
(2006)
Mol. Pharmacol.
, vol.69
, pp. 397-405
-
-
Nanoff, C.1
-
37
-
-
33748352984
-
Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins
-
Oldham W.M., et al. Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins. Nat. Struct. Mol. Biol. 13 (2006) 772-777
-
(2006)
Nat. Struct. Mol. Biol.
, vol.13
, pp. 772-777
-
-
Oldham, W.M.1
-
38
-
-
37549016836
-
Heterotrimeric G protein activation by G-protein-coupled receptors
-
Oldham W.M., and Hamm H.E. Heterotrimeric G protein activation by G-protein-coupled receptors. Nat. Rev. Mol. Cell. Biol. 9 (2008) 60-71
-
(2008)
Nat. Rev. Mol. Cell. Biol.
, vol.9
, pp. 60-71
-
-
Oldham, W.M.1
Hamm, H.E.2
-
39
-
-
0038549048
-
G protein-coupled receptor rhodopsin: a prospectus
-
Filipek S., et al. G protein-coupled receptor rhodopsin: a prospectus. Annu. Rev. Physiol. 65 (2003) 851-879
-
(2003)
Annu. Rev. Physiol.
, vol.65
, pp. 851-879
-
-
Filipek, S.1
-
40
-
-
0038037706
-
Stability of dark state rhodopsin is mediated by a conserved ion pair in intradiscal loop E-2
-
Janz J.M., et al. Stability of dark state rhodopsin is mediated by a conserved ion pair in intradiscal loop E-2. J. Biol. Chem. 278 (2003) 16982-16991
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 16982-16991
-
-
Janz, J.M.1
-
41
-
-
0035498937
-
Receptor activation: what does the rhodopsin structure tell us? Trends Pharmacol
-
Meng E.C., and Bourne H.R. Receptor activation: what does the rhodopsin structure tell us? Trends Pharmacol. Sci. 22 (2001) 587-593
-
(2001)
Sci.
, vol.22
, pp. 587-593
-
-
Meng, E.C.1
Bourne, H.R.2
-
42
-
-
0041629657
-
Retinal counterion switch in the photoactivation of the G protein-coupled receptor rhodopsin
-
Yan E.C., et al. Retinal counterion switch in the photoactivation of the G protein-coupled receptor rhodopsin. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 9262-9267
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 9262-9267
-
-
Yan, E.C.1
-
43
-
-
44649152217
-
Structural impact of the E113Q counterion mutation on the activation and deactivation pathways of the G protein-coupled receptor rhodopsin
-
Standfuss J., et al. Structural impact of the E113Q counterion mutation on the activation and deactivation pathways of the G protein-coupled receptor rhodopsin. J. Mol. Biol. 380 (2008) 145-157
-
(2008)
J. Mol. Biol.
, vol.380
, pp. 145-157
-
-
Standfuss, J.1
-
44
-
-
0019137579
-
A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled β-adrenergic receptor
-
De Lean A., et al. A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled β-adrenergic receptor. J. Biol. Chem. 255 (1980) 7108-7117
-
(1980)
J. Biol. Chem.
, vol.255
, pp. 7108-7117
-
-
De Lean, A.1
-
45
-
-
0037465339
-
An opsin mutant with increased thermal stability
-
Xie G., et al. An opsin mutant with increased thermal stability. Biochemistry 42 (2003) 1995-2001
-
(2003)
Biochemistry
, vol.42
, pp. 1995-2001
-
-
Xie, G.1
-
46
-
-
34548529916
-
Crystal structure of a thermally stable rhodopsin mutant
-
Standfuss J., et al. Crystal structure of a thermally stable rhodopsin mutant. J. Mol. Biol. 372 (2007) 1179-1188
-
(2007)
J. Mol. Biol.
, vol.372
, pp. 1179-1188
-
-
Standfuss, J.1
-
47
-
-
84887212404
-
A ligand channel through the G protein coupled receptor opsin
-
Hildebrand P.W., et al. A ligand channel through the G protein coupled receptor opsin. PLoS ONE 4 (2009) e4382
-
(2009)
PLoS ONE
, vol.4
-
-
Hildebrand, P.W.1
-
48
-
-
0038729667
-
Signaling states of rhodopsin. Formation of the storage form, metarhodopsin III, from active metarhodopsin II
-
Heck M., et al. Signaling states of rhodopsin. Formation of the storage form, metarhodopsin III, from active metarhodopsin II. J. Biol. Chem. 278 (2003) 3162-3169
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 3162-3169
-
-
Heck, M.1
-
49
-
-
0035914463
-
Conformations of the active and inactive states of opsin
-
Vogel R., and Siebert F. Conformations of the active and inactive states of opsin. J. Biol. Chem. 276 (2001) 38487-38493
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38487-38493
-
-
Vogel, R.1
Siebert, F.2
-
50
-
-
0035046325
-
Role of noncovalent binding of 11-cis-retinal to opsin in dark adaptation of rod and cone photoreceptors
-
Kefalov V.J., et al. Role of noncovalent binding of 11-cis-retinal to opsin in dark adaptation of rod and cone photoreceptors. Neuron 29 (2001) 749-755
-
(2001)
Neuron
, vol.29
, pp. 749-755
-
-
Kefalov, V.J.1
-
51
-
-
33748079137
-
Local peptide movement in the photoreaction intermediate of rhodopsin
-
Nakamichi H., and Okada T. Local peptide movement in the photoreaction intermediate of rhodopsin. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 12729-12734
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 12729-12734
-
-
Nakamichi, H.1
Okada, T.2
-
52
-
-
33746321096
-
Crystallographic analysis of primary visual photochemistry
-
Nakamichi H., and Okada T. Crystallographic analysis of primary visual photochemistry. Angew. Chem. Int. Ed. 45 (2006) 4270-4273
-
(2006)
Angew. Chem. Int. Ed.
, vol.45
, pp. 4270-4273
-
-
Nakamichi, H.1
Okada, T.2
-
53
-
-
52149103169
-
Activity switches of rhodopsin
-
Ritter E., et al. Activity switches of rhodopsin. Photochem. Photobiol. 84 (2008) 911-920
-
(2008)
Photochem. Photobiol.
, vol.84
, pp. 911-920
-
-
Ritter, E.1
-
54
-
-
0027715151
-
Interaction between photoactivated rhodopsin and its kinase: stability and kinetics of complex formation
-
Pulvermüller A., et al. Interaction between photoactivated rhodopsin and its kinase: stability and kinetics of complex formation. Biochemistry 32 (1993) 14082-14088
-
(1993)
Biochemistry
, vol.32
, pp. 14082-14088
-
-
Pulvermüller, A.1
-
55
-
-
22744435933
-
Direct observation of the complex formation of GDP-bound transducin with the rhodopsin intermediate having a visible absorption maximum in rod outer segment membranes
-
Morizumi T., et al. Direct observation of the complex formation of GDP-bound transducin with the rhodopsin intermediate having a visible absorption maximum in rod outer segment membranes. Biochemistry 44 (2005) 9936-9943
-
(2005)
Biochemistry
, vol.44
, pp. 9936-9943
-
-
Morizumi, T.1
-
56
-
-
0027317273
-
Two different forms of metarhodopsin II: Schiff base deprotonation precedes proton uptake and signaling state
-
Arnis S., and Hofmann K.P. Two different forms of metarhodopsin II: Schiff base deprotonation precedes proton uptake and signaling state. Proc. Natl. Acad. Sci. U. S. A. 90 (1993) 7849-7853
-
(1993)
Proc. Natl. Acad. Sci. U. S. A.
, vol.90
, pp. 7849-7853
-
-
Arnis, S.1
Hofmann, K.P.2
-
57
-
-
33846543250
-
Lumi I→Lumi II: the last detergent independent process in rhodopsin photoexcitation
-
Epps J., et al. Lumi I→Lumi II: the last detergent independent process in rhodopsin photoexcitation. Photochem. Photobiol. 82 (2006) 1436-1441
-
(2006)
Photochem. Photobiol.
, vol.82
, pp. 1436-1441
-
-
Epps, J.1
-
58
-
-
0028061193
-
A conserved carboxylic acid group mediates light-dependent proton uptake and signaling by rhodopsin
-
Arnis S., et al. A conserved carboxylic acid group mediates light-dependent proton uptake and signaling by rhodopsin. J. Biol. Chem. 269 (1994) 23879-23881
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 23879-23881
-
-
Arnis, S.1
-
59
-
-
38049100706
-
Sequence of late molecular events in the activation of rhodopsin
-
Knierim B., et al. Sequence of late molecular events in the activation of rhodopsin. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 20290-20295
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 20290-20295
-
-
Knierim, B.1
-
60
-
-
45649083187
-
Functional role of the "ionic lock" - an interhelical hydrogen-bond network in family A heptahelical receptors
-
Vogel R., et al. Functional role of the "ionic lock" - an interhelical hydrogen-bond network in family A heptahelical receptors. J. Mol. Biol. 380 (2008) 648-655
-
(2008)
J. Mol. Biol.
, vol.380
, pp. 648-655
-
-
Vogel, R.1
-
61
-
-
0025181491
-
The dynamic aspects of proton-transfer processes
-
Gutman M., and Nachliel E. The dynamic aspects of proton-transfer processes. Biochim. Biophys. Acta 1015 (1990) 391-414
-
(1990)
Biochim. Biophys. Acta
, vol.1015
, pp. 391-414
-
-
Gutman, M.1
Nachliel, E.2
-
62
-
-
0027050784
-
Mechanism of activation and inactivation of opsin: role of Glu113 and Lys296
-
Cohen G.B., et al. Mechanism of activation and inactivation of opsin: role of Glu113 and Lys296. Biochemistry 31 (1992) 12592-12601
-
(1992)
Biochemistry
, vol.31
, pp. 12592-12601
-
-
Cohen, G.B.1
-
63
-
-
0027298812
-
Constitutive activation of opsin: influence of charge at position 134 and size at position 296
-
Cohen G.B., et al. Constitutive activation of opsin: influence of charge at position 134 and size at position 296. Biochemistry 32 (1993) 6111-6115
-
(1993)
Biochemistry
, vol.32
, pp. 6111-6115
-
-
Cohen, G.B.1
-
64
-
-
0030614337
-
The activation process of the α1B-adrenergic receptor: potential role of protonation and hydrophobicity of a highly conserved aspartate
-
Scheer A., et al. The activation process of the α1B-adrenergic receptor: potential role of protonation and hydrophobicity of a highly conserved aspartate. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 808-813
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 808-813
-
-
Scheer, A.1
-
65
-
-
0027716597
-
Photoactivated conformational changes in rhodopsin: a time-resolved spin label study
-
Farahbakhsh Z.T., et al. Photoactivated conformational changes in rhodopsin: a time-resolved spin label study. Science 262 (1993) 1416-1419
-
(1993)
Science
, vol.262
, pp. 1416-1419
-
-
Farahbakhsh, Z.T.1
-
66
-
-
0029907599
-
Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin
-
Farrens D.L., et al. Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin. Science 274 (1996) 768-770
-
(1996)
Science
, vol.274
, pp. 768-770
-
-
Farrens, D.L.1
-
67
-
-
0029778268
-
Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F
-
Sheikh S.P., et al. Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F. Nature 383 (1996) 347-350
-
(1996)
Nature
, vol.383
, pp. 347-350
-
-
Sheikh, S.P.1
-
68
-
-
44949236117
-
High-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation
-
Altenbach C., et al. High-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 7439-7444
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 7439-7444
-
-
Altenbach, C.1
-
69
-
-
56649097496
-
Two protonation switches control rhodopsin activation in membranes
-
Mahalingam M., et al. Two protonation switches control rhodopsin activation in membranes. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 17795-17800
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 17795-17800
-
-
Mahalingam, M.1
-
70
-
-
55249090879
-
Monitoring the conformational changes of photoactivated rhodopsin from microseconds to seconds by transient fluorescence spectroscopy
-
Hoersch D., et al. Monitoring the conformational changes of photoactivated rhodopsin from microseconds to seconds by transient fluorescence spectroscopy. Biochemistry 47 (2008) 11518-11527
-
(2008)
Biochemistry
, vol.47
, pp. 11518-11527
-
-
Hoersch, D.1
-
71
-
-
59649112109
-
Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation
-
Ahuja S., et al. Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation. Nat. Struct. Mol. Biol. 16 (2009) 168-175
-
(2009)
Nat. Struct. Mol. Biol.
, vol.16
, pp. 168-175
-
-
Ahuja, S.1
-
72
-
-
65649142570
-
Location of the retinal chromophore in the activated state of rhodopsin*
-
Ahuja S., et al. Location of the retinal chromophore in the activated state of rhodopsin*. J. Biol. Chem. 284 (2009) 10190-10201
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 10190-10201
-
-
Ahuja, S.1
-
73
-
-
33750836895
-
Crystal structure of a photoactivated deprotonated intermediate of rhodopsin
-
Salom D., et al. Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 16123-16128
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 16123-16128
-
-
Salom, D.1
-
74
-
-
41949093679
-
Rhodopsin and 9-demethyl-retinal analog: effect of a partial agonist on displacement of transmembrane helix 6 in class A G protein-coupled receptors
-
Knierim B., et al. Rhodopsin and 9-demethyl-retinal analog: effect of a partial agonist on displacement of transmembrane helix 6 in class A G protein-coupled receptors. J. Biol. Chem. 283 (2008) 4967-4974
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 4967-4974
-
-
Knierim, B.1
-
75
-
-
33644772378
-
Location of Trp265 in metarhodopsin II: implications for the activation mechanism of the visual receptor rhodopsin
-
Crocker E., et al. Location of Trp265 in metarhodopsin II: implications for the activation mechanism of the visual receptor rhodopsin. J. Mol. Biol. 357 (2006) 163-172
-
(2006)
J. Mol. Biol.
, vol.357
, pp. 163-172
-
-
Crocker, E.1
-
76
-
-
26644452318
-
Partial agonism in a G protein-coupled receptor: role of the retinal ring structure in rhodopsin activation
-
Bartl F.J., et al. Partial agonism in a G protein-coupled receptor: role of the retinal ring structure in rhodopsin activation. J. Biol. Chem. 280 (2005) 34259-34267
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 34259-34267
-
-
Bartl, F.J.1
-
77
-
-
0040141552
-
Signaling states of rhodopsin. Retinal provides a scaffold for activating proton transfer switches
-
Meyer C.K., et al. Signaling states of rhodopsin. Retinal provides a scaffold for activating proton transfer switches. J. Biol. Chem. 275 (2000) 19713-19718
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 19713-19718
-
-
Meyer, C.K.1
-
78
-
-
32344443931
-
Agonists and partial agonists of rhodopsin: retinal polyene methylation affects receptor activation
-
Vogel R., et al. Agonists and partial agonists of rhodopsin: retinal polyene methylation affects receptor activation. Biochemistry 45 (2006) 1640-1652
-
(2006)
Biochemistry
, vol.45
, pp. 1640-1652
-
-
Vogel, R.1
-
79
-
-
0042473251
-
Deactivation of rhodopsin in the transition from the signaling state meta II to meta III involves a thermal isomerization of the retinal chromophore C{A figure is presented}D
-
Vogel R., et al. Deactivation of rhodopsin in the transition from the signaling state meta II to meta III involves a thermal isomerization of the retinal chromophore C{A figure is presented}D. Biochemistry 42 (2003) 9863-9874
-
(2003)
Biochemistry
, vol.42
, pp. 9863-9874
-
-
Vogel, R.1
-
80
-
-
9144265807
-
Transition of rhodopsin into the active metarhodopsin II state opens a new light-induced pathway linked to Schiff base isomerization
-
Ritter E., et al. Transition of rhodopsin into the active metarhodopsin II state opens a new light-induced pathway linked to Schiff base isomerization. J. Biol. Chem. 279 (2004) 48102-48111
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 48102-48111
-
-
Ritter, E.1
-
81
-
-
33645535034
-
G protein-coupled receptor rhodopsin
-
Palczewski K. G protein-coupled receptor rhodopsin. Annu. Rev. Biochem. 75 (2006) 743-767
-
(2006)
Annu. Rev. Biochem.
, vol.75
, pp. 743-767
-
-
Palczewski, K.1
-
82
-
-
34547434085
-
Monomeric G protein-coupled receptor rhodopsin in solution activates its G protein transducin at the diffusion limit
-
Ernst O.P., et al. Monomeric G protein-coupled receptor rhodopsin in solution activates its G protein transducin at the diffusion limit. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 10859-10864
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 10859-10864
-
-
Ernst, O.P.1
-
83
-
-
34447509986
-
Transducin activation by nanoscale lipid bilayers containing one and two rhodopsins
-
Bayburt T.H., et al. Transducin activation by nanoscale lipid bilayers containing one and two rhodopsins. J. Biol. Chem. 282 (2007) 14875-14881
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 14875-14881
-
-
Bayburt, T.H.1
-
84
-
-
42949164679
-
Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer
-
Whorton M.R., et al. Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer. J. Biol. Chem. 283 (2008) 4387-4394
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 4387-4394
-
-
Whorton, M.R.1
-
85
-
-
40849130624
-
Rapid incorporation of functional rhodopsin into nanoscale apolipoprotein bound bilayer (NABB) particles
-
Banerjee S., et al. Rapid incorporation of functional rhodopsin into nanoscale apolipoprotein bound bilayer (NABB) particles. J. Mol. Biol. 377 (2008) 1067-1081
-
(2008)
J. Mol. Biol.
, vol.377
, pp. 1067-1081
-
-
Banerjee, S.1
-
86
-
-
33750619233
-
NMR analysis of rhodopsin-transducin interactions
-
Ridge K.D., et al. NMR analysis of rhodopsin-transducin interactions. Vision Res. 46 (2006) 4482-4492
-
(2006)
Vision Res.
, vol.46
, pp. 4482-4492
-
-
Ridge, K.D.1
-
87
-
-
0344406765
-
5,6F motif in the rhodopsin ground state and during activation
-
5,6F motif in the rhodopsin ground state and during activation. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 2290-2295
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 2290-2295
-
-
Fritze, O.1
-
88
-
-
67649743779
-
Structural and kinetic modeling of an activating helix switch in the rhodopsin-transducin interface
-
Scheerer P., et al. Structural and kinetic modeling of an activating helix switch in the rhodopsin-transducin interface. Proc. Natl. Acad. Sci. U. S. A. 106 (2009) 10660-10665
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 10660-10665
-
-
Scheerer, P.1
-
89
-
-
65249138168
-
Helix dipole movement and conformational variability contribute to allosteric GDP release in Gαi subunits
-
Preininger A., et al. Helix dipole movement and conformational variability contribute to allosteric GDP release in Gαi subunits. Biochemistry 48 (2009) 2630-2642
-
(2009)
Biochemistry
, vol.48
, pp. 2630-2642
-
-
Preininger, A.1
-
90
-
-
30144445932
-
Functional waters in intraprotein proton transfer monitored by FTIR difference spectroscopy
-
Garczarek F., and Gerwert K. Functional waters in intraprotein proton transfer monitored by FTIR difference spectroscopy. Nature 439 (2006) 109-112
-
(2006)
Nature
, vol.439
, pp. 109-112
-
-
Garczarek, F.1
Gerwert, K.2
-
91
-
-
44049094995
-
Hydrogen-bonding and packing features of membrane proteins: functional implications
-
Hildebrand P.W., et al. Hydrogen-bonding and packing features of membrane proteins: functional implications. Biophys. J. 94 (2008) 1945-1953
-
(2008)
Biophys. J.
, vol.94
, pp. 1945-1953
-
-
Hildebrand, P.W.1
-
92
-
-
34547516861
-
Hydrophobic association of α-helices, steric dewetting, and enthalpic barriers to protein folding
-
MacCallum J.L., et al. Hydrophobic association of α-helices, steric dewetting, and enthalpic barriers to protein folding. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 6206-6210
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 6206-6210
-
-
MacCallum, J.L.1
-
93
-
-
64849111005
-
Sending signals dynamically
-
Smock R.G., and Gierasch L.M. Sending signals dynamically. Science 324 (2009) 198-203
-
(2009)
Science
, vol.324
, pp. 198-203
-
-
Smock, R.G.1
Gierasch, L.M.2
-
94
-
-
77957055780
-
Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors
-
Ballesteros J.A., and Weinstein H. Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors. Methods Neurosci. 25 (1995) 366-428
-
(1995)
Methods Neurosci.
, vol.25
, pp. 366-428
-
-
Ballesteros, J.A.1
Weinstein, H.2
-
95
-
-
34249661141
-
Common structural requirements for heptahelical domain function in class A and class C G protein-coupled receptors
-
Binet V., et al. Common structural requirements for heptahelical domain function in class A and class C G protein-coupled receptors. J. Biol. Chem. 282 (2007) 12154-12163
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 12154-12163
-
-
Binet, V.1
-
96
-
-
0037184031
-
Conserved helix 7 tyrosine acts as a multistate conformational switch in the 5HT2C receptor. Identification of a novel "locked-on" phenotype and double revertant mutations
-
Prioleau C., et al. Conserved helix 7 tyrosine acts as a multistate conformational switch in the 5HT2C receptor. Identification of a novel "locked-on" phenotype and double revertant mutations. J. Biol. Chem. 277 (2002) 36577-36584
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 36577-36584
-
-
Prioleau, C.1
-
97
-
-
0025036350
-
Rhodopsin mutants that bind but fail to activate transducin
-
Franke R.R., et al. Rhodopsin mutants that bind but fail to activate transducin. Science 250 (1990) 123-125
-
(1990)
Science
, vol.250
, pp. 123-125
-
-
Franke, R.R.1
-
98
-
-
0028946950
-
Characterization of rhodopsin mutants that bind transducin but fail to induce GTP nucleotide uptake. Classification of mutant pigments by fluorescence, nucleotide release, and flash-induced light-scattering assays
-
Ernst O.P., et al. Characterization of rhodopsin mutants that bind transducin but fail to induce GTP nucleotide uptake. Classification of mutant pigments by fluorescence, nucleotide release, and flash-induced light-scattering assays. J. Biol. Chem. 270 (1995) 10580-10586
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 10580-10586
-
-
Ernst, O.P.1
-
99
-
-
0032516098
-
Light-activated rhodopsin induces structural binding motif in G protein alpha subunit
-
Kisselev O.G., et al. Light-activated rhodopsin induces structural binding motif in G protein alpha subunit. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 4270-4275
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 4270-4275
-
-
Kisselev, O.G.1
-
100
-
-
0036385914
-
Structure and orientation of a G protein fragment in the receptor bound state from residual dipolar couplings
-
Koenig B.W., et al. Structure and orientation of a G protein fragment in the receptor bound state from residual dipolar couplings. J. Mol. Biol. 322 (2002) 441-461
-
(2002)
J. Mol. Biol.
, vol.322
, pp. 441-461
-
-
Koenig, B.W.1
-
101
-
-
5044235587
-
Electron crystallography reveals the structure of metarhodopsin I
-
Ruprecht J.J., et al. Electron crystallography reveals the structure of metarhodopsin I. EMBO J. 23 (2004) 3609-3620
-
(2004)
EMBO J.
, vol.23
, pp. 3609-3620
-
-
Ruprecht, J.J.1
-
102
-
-
47249130441
-
11-cis- and all-trans-retinols can activate rod opsin: rational design of the visual cycle
-
Kono M., et al. 11-cis- and all-trans-retinols can activate rod opsin: rational design of the visual cycle. Biochemistry 47 (2008) 7567-7571
-
(2008)
Biochemistry
, vol.47
, pp. 7567-7571
-
-
Kono, M.1
-
103
-
-
0029829057
-
Mechanisms of opsin activation
-
Buczylko J., et al. Mechanisms of opsin activation. J. Biol. Chem. 271 (1996) 20621-20630
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 20621-20630
-
-
Buczylko, J.1
-
104
-
-
0033609101
-
Signal transfer from rhodopsin to the G-protein: evidence for a two-site sequential fit mechanism
-
Kisselev O.G., et al. Signal transfer from rhodopsin to the G-protein: evidence for a two-site sequential fit mechanism. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 4898-4903
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 4898-4903
-
-
Kisselev, O.G.1
-
105
-
-
33144459843
-
Molecular mechanism of 7TM receptor activation - a global toggle switch model
-
Schwartz T.W., et al. Molecular mechanism of 7TM receptor activation - a global toggle switch model. Annu. Rev. Pharmacol. Toxicol. 46 (2006) 481-519
-
(2006)
Annu. Rev. Pharmacol. Toxicol.
, vol.46
, pp. 481-519
-
-
Schwartz, T.W.1
|