A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptor

Journal of Biological Chemistry

Volumn 285, Issue 23, 2010, Pages 17954-17964

  Hurst, Dow P ^a   Grossfield, Alan ^b   Lynch, Diane L ^a   Feller, Scott ^c   Romo, Tod D ^b   Gawrisch, Klaus ^d   Pitman, Michael C ^e   Reggio, Patricia H ^a  

^a UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c WABASH COLLEGE   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

^e IBM T J WATSON RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING POCKETS; BULK LIPIDS; CLASS A; COVALENT LABELING; G PROTEIN COUPLED RECEPTORS; ISOTHIOCYANATES; LIGAND BINDING; MOLECULAR DYNAMICS SIMULATIONS; PHOSPHATIDYLCHOLINE; RECEPTOR BINDING; TIME-SCALES; TOGGLE SWITCH; TRANSMEMBRANES;

IONIZATION OF LIQUIDS; LIGANDS; MOLECULAR DYNAMICS; PROTEINS;

LIPID BILAYERS;

2 ARACHIDONOYLGLYCEROL; CANNABINOID 2 RECEPTOR; DIPALMITOYLPHOSPHATIDYLCHOLINE; G PROTEIN COUPLED RECEPTOR; LIPID; PROTON; WATER;

ALPHA HELIX; ARTICLE; CHEMICAL INTERACTION; CONTROLLED STUDY; LIGAND BINDING; LIPID BILAYER; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTON TRANSPORT; RECEPTOR BINDING; RECEPTOR UPREGULATION; SIMULATION; TIME; WATER TRANSPORT;

ANIMALS; ARACHIDONIC ACIDS; BIOPHYSICS; CANNABINOIDS; CATTLE; COMPUTER SIMULATION; EICOSANOIDS; GLYCERIDES; HYDROGEN BONDING; IONS; LIGANDS; LIPID BILAYERS; LIPIDS; PROTEIN BINDING; RECEPTORS, G-PROTEIN-COUPLED; RHODOPSIN; SOLVENTS;

EID: 77952921531     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.041590     Document Type: Article

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