Analogues of (3 R)-7-hydroxy- N -[(1 S)-1-{[(3 R,4 R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3- isoquinolinecarboxamide (JDTic). Synthesis and in vitro and in vivo opioid receptor antagonist activity

Journal of Medicinal Chemistry

Volumn 53, Issue 14, 2010, Pages 5290-5301

  Runyon, Scott P ^a   Brieaddy, Lawrence E ^a   Mascarella, S Wayne ^a   Thomas, James B ^a   Navarro, Hernán A ^a   Howard, James L ^b   Pollard, Gerald T ^b   Carroll, F Ivy ^a  

^a RTI INTERNATIONAL   (United States)

^b Howard Associates LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; 6 HYDROXY 1,2,3,4 TETRAHYDRONAPHTHALENE 2 CARBOXYLIC ACID [1 [4 (3 HYDROXYPHENYL)DIMETHYLPIPERIDINYLMETHYL]METHYLPROPYL]AMIDE; 7 HYDROXY N [1 [[4 (3 HYDROXYPHENYL) 3,4 DIMETHYL 1 PIPERIDINYL]METHYL] 2 METHYLPROPYL] 1,2,3,4 TETRAHYDRO 3 ISOQUINOLINECARBOXAMIDE; DELTA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; OPIATE ANTAGONIST; UNCLASSIFIED DRUG; 6 HYDROXY 1,2,3,4 TETRAHYDRONAPHTHALENE 2 CARBOXYLIC ACID (1 (4 (3 HYDROXYPHENYL)DIMETHYLPIPERIDINYLMETHYL)METHYLPROPYL)AMIDE; 6-HYDROXY-1,2,3,4-TETRAHYDRONAPHTHALENE-2-CARBOXYLIC ACID-(1-(4-(3-HYDROXYPHENYL)DIMETHYLPIPERIDINYLMETHYL)METHYLPROPYL)AMIDE; ISOQUINOLINE DERIVATIVE; PIPERIDINE DERIVATIVE; TETRALIN DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIURESIS; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG DOSE COMPARISON; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; MALE; NONHUMAN; RAT; ANIMAL; CHEMISTRY; CHO CELL; CRICETULUS; DRUG EFFECT; DRUG POTENTIATION; HAMSTER; RADIOASSAY; SPRAGUE DAWLEY RAT; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TIME;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DIURESIS; HUMANS; ISOQUINOLINES; MALE; PIPERIDINES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDRONAPHTHALENES; TIME FACTORS;

EID: 77954752369     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1004978     Document Type: Article

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