CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding

Molecular Pharmacology

Volumn 55, Issue 3, 1999, Pages 453-461

  Litschig, Stephane ^a   Gasparini, Fabrizio ^a   Rueegg, Doris ^a   Stoehr, Natacha ^a   Flor, Peter Josef ^a   Vranesic, Ivo ^a   Prezeau, Laurent ^b   Pin, Jean Philippe ^b   Thomsen, Christian ^c   Kuhn, Rainer ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b CNRS   (France)

^c NOVO NORDISK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; 1 AMINO 1,5 INDANDICARBOXYLIC ACID; 2 AMINO 4 PHOSPHONOBUTYRIC ACID; 7 (HYDROXYIMINO)CYCLOPROPAN[B]CHROMEN 1A CARBOXYLIC ACID ETHYL ESTER; ALANINE; AMINO ACID; FORSKOLIN; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; METABOTROPIC RECEPTOR; PHOSPHATIDYLINOSITIDE; QUISQUALIC ACID; THREONINE; TRITIUM; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL STRAIN BHK; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; HUMAN; HUMAN CELL; KIDNEY CELL; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

ALANINE; AMINO ACID SEQUENCE; ANIMALS; CHO CELLS; CHROMONES; COS CELLS; CRICETINAE; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; THREONINE;

EID: 0033028258     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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