Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists

Journal of Medicinal Chemistry

Volumn 48, Issue 6, 2005, Pages 2134-2153

  Mabire, Dominique ^a,c   Coupa, Sophie ^a   Adelinet, Christophe ^a   Poncelet, Alain ^a   Simonnet, Yvan ^a   Venet, Marc ^a,d   Wouters, Ria ^b   Lesage, Anne S J ^b   Van Beijsterveldt, Ludy ^b   Bischoff, François ^b  

^a Campus de Maigremont   (France)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^c PCAS   (France)

^d SERIPHARM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

3 ETHYL 2 METHOXYQUINOLIN 6 YL 4 METHOXYCYCLOHEXYL KETONE; 3,4 DIHYDRO 2H PYRANOQUINOLIN 7 YL 4 METHOXYCYCLOHEXYL KETONE; GLUTAMATE RECEPTOR ANTAGONIST; QUINOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LIVER MICROSOME; NONHUMAN; RAT; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; BIOLOGICAL AVAILABILITY; CALCIUM; CELL LINE, TUMOR; CHO CELLS; CRICETINAE; CRICETULUS; HALF-LIFE; HUMANS; INTRACELLULAR FLUID; MICROSOMES, LIVER; QUINOLINES; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; SIGNAL TRANSDUCTION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 20144369074     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049499o     Document Type: Article

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