메뉴 건너뛰기
Angewandte Chemie - International Edition
Volumn 52, Issue 25, 2013, Pages 6366-6378
A brief history of G-protein coupled receptors (Nobel Lecture)
Author keywords

2 adrenergic receptor; G protein coupled receptors; Nobel lecture; protein structures; signaling
Indexed keywords

ADRENERGIC RECEPTORS; G PROTEIN COUPLED RECEPTORS; MEMBRANE RECEPTORS; NOBEL LECTURE; NOBEL PRIZES; PROTEIN STRUCTURES;
EID: 84878952621     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201301924     Document Type: Review
Times cited : (226)
References (65)
  • 2
    • 28244486354 scopus 로고
    • On the reaction of cells and of nerve-endings to certain poisons, chiefly as regards the reaction of striated muscle to nicotine and to curare
    • "On the reaction of cells and of nerve-endings to certain poisons, chiefly as regards the reaction of striated muscle to nicotine and to curare":, J. N. Langley, J. Physiol. 1905, 33, 374-413.
    • (1905) J. Physiol. , vol.33 , pp. 374-413
    • Langley, J.N.1
  • 3
    • 37049174908 scopus 로고
    • Modes of Drug Action. General Introductory Address
    • "Modes of Drug Action. General Introductory Address":, H. H. Dale, Trans. Faraday Soc. 1943, 39, 319-322.
    • (1943) Trans. Faraday Soc. , vol.39 , pp. 319-322
    • Dale, H.H.1
  • 4
    • 84951653316 scopus 로고
    • A study of the adrenotropic receptors
    • "A study of the adrenotropic receptors":, R. P. Ahlquist, Am. J. Physiol. 1948, 153, 586-600.
    • (1948) Am. J. Physiol. , vol.153 , pp. 586-600
    • Ahlquist, R.P.1
  • 5
    • 0015857085 scopus 로고
    • Adrenergic receptors: A personal and practical view
    • "Adrenergic receptors: a personal and practical view":, R. P. Ahlquist, Perspect. Biol. Med. 1973, 17, 119-122.
    • (1973) Perspect. Biol. Med. , vol.17 , pp. 119-122
    • Ahlquist, R.P.1
  • 6
    • 0016769472 scopus 로고
    • Identification of β-adrenergic receptors in frog erythrocyte membranes with (-)-[3H]alprenolol
    • "Identification of β-adrenergic receptors in frog erythrocyte membranes with (-)-[3H]alprenolol":, C. Mukherjee, M. G. Caron, M. Coverstone, R. J. Lefkowitz, J. Biol. Chem. 1975, 250, 4869-4875.
    • (1975) J. Biol. Chem. , vol.250 , pp. 4869-4875
    • Mukherjee, C.1    Caron, M.G.2    Coverstone, M.3    Lefkowitz, R.J.4
  • 7
    • 0017119170 scopus 로고
    • Identification of α-adrenergic receptors by [H3]dihydroergocryptine binding
    • "Identification of α-adrenergic receptors by [H3]dihydroergocryptine binding":, L. T. Williams, R. J. Lefkowitz, Science 1976, 192, 791-793.
    • (1976) Science , vol.192 , pp. 791-793
    • Williams, L.T.1    Lefkowitz, R.J.2
  • 8
    • 0021327070 scopus 로고
    • The β-adrenergic receptor: Biochemical mechanisms of physiological regulation
    • "The β-adrenergic receptor: Biochemical mechanisms of physiological regulation":, G. L. Stiles, M. G. Caron, R. J. Lefkowitz, Physiol. Rev. 1984, 64, 661-743.
    • (1984) Physiol. Rev. , vol.64 , pp. 661-743
    • Stiles, G.L.1    Caron, M.G.2    Lefkowitz, R.J.3
  • 9
    • 0025204495 scopus 로고
    • Expression of three α-2 adrenergic receptor subtypes in rat tissues: Implications for α-2 receptor classification
    • "Expression of three α-2 adrenergic receptor subtypes in rat tissues: Implications for α-2 receptor classification":, W. Lorenz, J. W. Lomasney, S. Collins, J. W. Regan, M. G. Caron, R. J. Lefkowitz, Mol. Pharmacol. 1990, 38, 599-603.
    • (1990) Mol. Pharmacol. , vol.38 , pp. 599-603
    • Lorenz, W.1    Lomasney, J.W.2    Collins, S.3    Regan, J.W.4    Caron, M.G.5    Lefkowitz, R.J.6
  • 10
    • 0017303494 scopus 로고
    • Regulation of β-adrenergic receptors by 5′- guanylylimidodiphosphate and other purine nucleotides
    • "Regulation of β-adrenergic receptors by 5′- guanylylimidodiphosphate and other purine nucleotides":, R. J. Lefkowitz, D. Mullikin, M. G. Caron, J. Biol. Chem. 1976, 251, 4688-4692.
    • (1976) J. Biol. Chem. , vol.251 , pp. 4688-4692
    • Lefkowitz, R.J.1    Mullikin, D.2    Caron, M.G.3
  • 11
    • 0018862848 scopus 로고
    • A quantitative analysis of β-adrenergic receptor interactions: Resolution of high and low affinity states of the receptor by computer modelling of ligand binding data
    • "A quantitative analysis of β-adrenergic receptor interactions: Resolution of high and low affinity states of the receptor by computer modelling of ligand binding data":, R. S. Kent, A. De Lean, R. J. Lefkowitz, Mol. Pharmacol. 1980, 17, 14-23.
    • (1980) Mol. Pharmacol. , vol.17 , pp. 14-23
    • Kent, R.S.1    De Lean, A.2    Lefkowitz, R.J.3
  • 12
    • 0019137579 scopus 로고
    • A ternary complex model explains the agonist-specific binding properties of the adenylate-cyclase coupled β-adrenergic receptor
    • "A ternary complex model explains the agonist-specific binding properties of the adenylate-cyclase coupled β-adrenergic receptor":, A. De Lean, J. M. Stadel, R. J. Lefkowitz, J. Biol. Chem. 1980, 255, 7108-7117.
    • (1980) J. Biol. Chem. , vol.255 , pp. 7108-7117
    • De Lean, A.1    Stadel, J.M.2    Lefkowitz, R.J.3
  • 16
    • 0025812324 scopus 로고
    • Model systems for the study of seven-transmembrane-segment receptors
    • "Model systems for the study of seven-transmembrane-segment receptors":, H. G. Dohlman, J. Thorner, M. G. Caron, R. J. Lefkowitz, Annu. Rev. Biochem. 1991, 60, 653-688.
    • (1991) Annu. Rev. Biochem. , vol.60 , pp. 653-688
    • Dohlman, H.G.1    Thorner, J.2    Caron, M.G.3    Lefkowitz, R.J.4
  • 17
    • 0021083170 scopus 로고
    • The pure β-adrenergic receptor: A single polypeptide confers catecholamine responsiveness to an adenylate cyclase system
    • "The pure β-adrenergic receptor: A single polypeptide confers catecholamine responsiveness to an adenylate cyclase system":, R. A. Cerione, B. Strulovici, J. L. Benovic, R. J. Lefkowitz, M. G. Caron, Nature 1983, 306, 562-566.
    • (1983) Nature , vol.306 , pp. 562-566
    • Cerione, R.A.1    Strulovici, B.2    Benovic, J.L.3    Lefkowitz, R.J.4    Caron, M.G.5
  • 18
    • 0021212048 scopus 로고
    • Reconstitution of a hormone-sensitive adenylate cyclase system: The pure β-adrenergic receptor and guanine nucleotide regulatory protein confer hormone responsiveness on the resolved catalytic unit
    • "Reconstitution of a hormone-sensitive adenylate cyclase system: The pure β-adrenergic receptor and guanine nucleotide regulatory protein confer hormone responsiveness on the resolved catalytic unit":, R. A. Cerione, D. R. Sibley, J. Codina, J. L. Benovic, J. Winslow, E. J. Neer, L. Birnbaumer, M. G. Caron, R. J. Lefkowitz, J. Biol. Chem. 1984, 259, 9979-9982.
    • (1984) J. Biol. Chem. , vol.259 , pp. 9979-9982
    • Cerione, R.A.1    Sibley, D.R.2    Codina, J.3    Benovic, J.L.4    Winslow, J.5    Neer, E.J.6    Birnbaumer, L.7    Caron, M.G.8    Lefkowitz, R.J.9
  • 21
    • 0020373509 scopus 로고
    • Rhodopsin and bacteriorhodopsin: Structure-function relationships
    • "Rhodopsin and bacteriorhodopsin: structure-function relationships":, Y. A. Ovchinnikov, FEBS Lett. 1982, 148, 179-191.
    • (1982) FEBS Lett. , vol.148 , pp. 179-191
    • Ovchinnikov, Y.A.1
  • 24
    • 0025106721 scopus 로고
    • The Adrenergic Receptors. Advances in Second Messenger and Phosphoprotein Research
    • (Eds.: Y. Nishizuka et al.), Raven, New York
    • "The Adrenergic Receptors. Advances in Second Messenger and Phosphoprotein Research":, R. J. Lefkowitz, M. G. Caron, in The Biology and Medicine of Signal Transduction, Vol. 24 (Eds.:, Y. Nishizuka et al.,), Raven, New York, 1990, pp. 1-8.
    • (1990) The Biology and Medicine of Signal Transduction, Vol. 24 , pp. 1-8
    • Lefkowitz, R.J.1    Caron, M.G.2
  • 27
    • 0023244963 scopus 로고
    • A family of receptors coupled to guanine nucleotide regulatory proteins
    • "A family of receptors coupled to guanine nucleotide regulatory proteins":, H. G. Dohlman, M. G. Caron, R. J. Lefkowitz, Biochemistry 1987, 26, 2657-2664.
    • (1987) Biochemistry , vol.26 , pp. 2657-2664
    • Dohlman, H.G.1    Caron, M.G.2    Lefkowitz, R.J.3
  • 28
    • 0023815680 scopus 로고    scopus 로고
    • Site directed mutagenesis of the cytoplasmic domains of the human β2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling
    • "Site directed mutagenesis of the cytoplasmic domains of the human β2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling":, B. F. O'Dowd, M. Hnatowich, J. W. Regan, W. M. Leader, M. G. Caron, R. J. Lefkowitz, J. Biol. Chem. 1998, 263, 15985-15992.
    • (1998) J. Biol. Chem. , vol.263 , pp. 15985-15992
    • O'Dowd, B.F.1    Hnatowich, M.2    Regan, J.W.3    Leader, W.M.4    Caron, M.G.5    Lefkowitz, R.J.6
  • 29
    • 0023889603 scopus 로고
    • Chimeric α2-,β2-adrenergic receptors: Delineation of domains involved in effector coupling and ligand binding specificity
    • "Chimeric α2-,β2-adrenergic receptors: Delineation of domains involved in effector coupling and ligand binding specificity":, B. K. Kobilka, T. S. Kobilka, K. Daniel, J. W. Regan, M. G. Caron, R. J. Lefkowitz, Science 1988, 240, 1310-1316.
    • (1988) Science , vol.240 , pp. 1310-1316
    • Kobilka, B.K.1    Kobilka, T.S.2    Daniel, K.3    Regan, J.W.4    Caron, M.G.5    Lefkowitz, R.J.6
  • 31
    • 0025896246 scopus 로고
    • Genetic Analysis of the β-adrenergic receptor
    • "Genetic Analysis of the β-adrenergic receptor":, C. D. Strader, R. A. Dixon, Adv. Exp. Med. Biol. 1991, 287, 209-220.
    • (1991) Adv. Exp. Med. Biol. , vol.287 , pp. 209-220
    • Strader, C.D.1    Dixon, R.A.2
  • 32
    • 0025212680 scopus 로고
    • Regions of the α1-adrenergic receptor implicated in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function
    • "Regions of the α1-adrenergic receptor implicated in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function":, S. Cotecchia, S. Exum, M. G. Caron, R. J. Lefkowitz, Proc. Natl. Acad. Sci. USA 1990, 87, 2896-2900.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 2896-2900
    • Cotecchia, S.1    Exum, S.2    Caron, M.G.3    Lefkowitz, R.J.4
  • 33
    • 0026592357 scopus 로고
    • Constitutive activation of the α1B-adrenergic receptor by all amino acid substitutions at a single site
    • "Constitutive activation of the α1B-adrenergic receptor by all amino acid substitutions at a single site":, M. A. Kjelsberg, S. Cotecchia, J. Ostrowski, M. G. Caron, R. J. Lefkowitz, J. Biol. Chem. 1992, 267, 1430-1433.
    • (1992) J. Biol. Chem. , vol.267 , pp. 1430-1433
    • Kjelsberg, M.A.1    Cotecchia, S.2    Ostrowski, J.3    Caron, M.G.4    Lefkowitz, R.J.5
  • 34
    • 0027513982 scopus 로고
    • A mutation-induced activated state of the β2-adrenergic receptor-extending the ternary complex model
    • "A mutation-induced activated state of the β2-adrenergic receptor-extending the ternary complex model":, P. Samama, S. Cotecchia, T. Costa, R. J. Lefkowitz, J. Biol. Chem. 1993, 268, 4625-4636.
    • (1993) J. Biol. Chem. , vol.268 , pp. 4625-4636
    • Samama, P.1    Cotecchia, S.2    Costa, T.3    Lefkowitz, R.J.4
  • 36
    • 41449088987 scopus 로고    scopus 로고
    • 2-Adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real-time cAMP dynamics
    • "β2-Adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real-time cAMP dynamics":, J. D. Violin, L. M. DiPilato, N. Yildirim, T. C. Elston, J. Zhang, R. J. Lefkowitz, J. Biol. Chem. 2008, 283, 2949-2961.
    • (2008) J. Biol. Chem. , vol.283 , pp. 2949-2961
    • Violin, J.D.1    Dipilato, L.M.2    Yildirim, N.3    Elston, T.C.4    Zhang, J.5    Lefkowitz, R.J.6
  • 38
    • 0020405929 scopus 로고
    • Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase. Structural alterations in the β-adrenergic receptor revealed by photoaffinity labeling
    • "Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase. Structural alterations in the β-adrenergic receptor revealed by photoaffinity labeling":, J. M. Stadel, P. Nambi, T. N. Lavin, S. L. Heald, M. G. Caron, R. J. Lefkowitz, J. Biol. Chem. 1982, 257, 7242-9245.
    • (1982) J. Biol. Chem. , vol.257 , pp. 7242-9245
    • Stadel, J.M.1    Nambi, P.2    Lavin, T.N.3    Heald, S.L.4    Caron, M.G.5    Lefkowitz, R.J.6
  • 39
    • 0344812247 scopus 로고
    • Adrenergic receptor kinase: Identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor
    • "β-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor":, J. L. Benovic, R. H. Strasser, M. G. Caron, R. J. Lefkowitz, Proc. Natl. Acad. Sci. USA 1986, 83, 2797-2801.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 2797-2801
    • Benovic, J.L.1    Strasser, R.H.2    Caron, M.G.3    Lefkowitz, R.J.4
  • 41
    • 0024412926 scopus 로고
    • Adrenergic receptor kinase: Primary structure delineates a multigene family
    • "β-adrenergic receptor kinase: primary structure delineates a multigene family":, J. L. Benovic, A. DeBlasi, W. C. Stone, M. G. Caron, R. J. Lefkowitz, Science 1989, 246, 235-240.
    • (1989) Science , vol.246 , pp. 235-240
    • Benovic, J.L.1    Deblasi, A.2    Stone, W.C.3    Caron, M.G.4    Lefkowitz, R.J.5
  • 42
    • 0025987010 scopus 로고
    • The receptor kinase family: Primary structure of rhodopsin kinase reveals similarities to the β-adrenergic receptor kinase
    • "The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the β-adrenergic receptor kinase":, W. Lorenz, J. Inglese, K. Palczewski, J. J. Onorato, M. G. Caron, R. J. Lefkowitz, Proc. Natl. Acad. Sci. USA 1991, 88, 8715-8719.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 8715-8719
    • Lorenz, W.1    Inglese, J.2    Palczewski, K.3    Onorato, J.J.4    Caron, M.G.5    Lefkowitz, R.J.6
  • 44
    • 0037799206 scopus 로고    scopus 로고
    • Keeping G Proteins at Bay: A Complex between G Protein-Coupled Receptor Kinase 2 and Gβγ
    • "Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gβγ":, D. T. Lodowski, J. A. Pitcher, W. D. Capel, R. J. Lefkowitz, J. J. G. Tesmer, Science 2003, 300, 1256-1262.
    • (2003) Science , vol.300 , pp. 1256-1262
    • Lodowski, D.T.1    Pitcher, J.A.2    Capel, W.D.3    Lefkowitz, R.J.4    Tesmer, J.J.G.5
  • 45
    • 0023515309 scopus 로고
    • Functional desensitization of the isolated β-adrenergic receptor by the β-adrenergic receptor kinase: Potential role of an analog of the retinal protein arrestin (48K protein)
    • "Functional desensitization of the isolated β-adrenergic receptor by the β-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48K protein)":, J. L. Benovic, H. Kuhn, I. Weyand, J. Codina, M. G. Caron, R. J. Lefkowitz, Proc. Natl. Acad. Sci. USA 1987, 84, 8879-8882.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 8879-8882
    • Benovic, J.L.1    Kuhn, H.2    Weyand, I.3    Codina, J.4    Caron, M.G.5    Lefkowitz, R.J.6
  • 46
    • 0023217357 scopus 로고
    • Deactivation of photoactivated rhodopsin by rhodopsin-kinase and arrestin
    • "Deactivation of photoactivated rhodopsin by rhodopsin-kinase and arrestin":, H. Kuhn, U. Wilden, J. Recept. Res. 1987, 7, 283-298.
    • (1987) J. Recept. Res. , vol.7 , pp. 283-298
    • Kuhn, H.1    Wilden, U.2
  • 48
    • 0025352299 scopus 로고
    • Arrestin: A protein that regulates β-adrenergic receptor function
    • "β-arrestin: a protein that regulates β-adrenergic receptor function":, M. J. Lohse, J. L. Benovic, J. Codina, M. G. Caron, R. J. Lefkowitz, Science 1990, 248, 1547-1550.
    • (1990) Science , vol.248 , pp. 1547-1550
    • Lohse, M.J.1    Benovic, J.L.2    Codina, J.3    Caron, M.G.4    Lefkowitz, R.J.5
  • 50
    • 0034802172 scopus 로고    scopus 로고
    • Crystal structure of β-arrestin at 1.9 A: Possible mechanism of receptor binding and membrane translocation
    • "Crystal structure of β-arrestin at 1.9 A: possible mechanism of receptor binding and membrane translocation":, M. Han, V. V. Gurevich, S. A. Vishnivetskiy, P. B. Sigler, C. Schubert, Structure 2001, 9, 869-880.
    • (2001) Structure , vol.9 , pp. 869-880
    • Han, M.1    Gurevich, V.V.2    Vishnivetskiy, S.A.3    Sigler, P.B.4    Schubert, C.5
  • 51
    • 0025223081 scopus 로고
    • Turning off the signal: Desensitization of β-adrenergic receptor function
    • "Turning off the signal: Desensitization of β-adrenergic receptor function":, W. P. Hausdorff, M. G. Caron, R. J. Lefkowitz, FASEB J. 1990, 4, 2881-2889.
    • (1990) FASEB J. , vol.4 , pp. 2881-2889
    • Hausdorff, W.P.1    Caron, M.G.2    Lefkowitz, R.J.3
  • 52
    • 0023181803 scopus 로고
    • Regulation of adrenergic receptor function by phosphorylation: Effects of agonist occupancy on phosphorylation of α1- and β2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase
    • "Regulation of adrenergic receptor function by phosphorylation: Effects of agonist occupancy on phosphorylation of α1- and β2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase":, M. Bouvier, L. M. Leeb-Lundberg, J. L. Benovic, M. G. Caron, R. J. Lefkowitz, J. Biol. Chem. 1987, 262, 3106-3113.
    • (1987) J. Biol. Chem. , vol.262 , pp. 3106-3113
    • Bouvier, M.1    Leeb-Lundberg, L.M.2    Benovic, J.L.3    Caron, M.G.4    Lefkowitz, R.J.5
  • 54
    • 80052359992 scopus 로고    scopus 로고
    • Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling
    • "Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling":, A. K. Shukla, K. Xiao, R. J. Lefkowitz, Trends Biochem. Sci. 2011, 36, 457-469.
    • (2011) Trends Biochem. Sci. , vol.36 , pp. 457-469
    • Shukla, A.K.1    Xiao, K.2    Lefkowitz, R.J.3
  • 55
    • 80052038573 scopus 로고    scopus 로고
    • Arrestin-mediated receptor trafficking and signal transduction
    • "β-Arrestin-mediated receptor trafficking and signal transduction":, S. K. Shenoy, R. J. Lefkowitz, Trends Pharmacol. Sci. 2011, 32, 521-533.
    • (2011) Trends Pharmacol. Sci. , vol.32 , pp. 521-533
    • Shenoy, S.K.1    Lefkowitz, R.J.2
  • 56
    • 34447649922 scopus 로고    scopus 로고
    • Arrestin-biased ligands at seven-transmembrane receptors
    • "β-arrestin-biased ligands at seven-transmembrane receptors":, J. D. Violin, R. J. Lefkowitz, Trends Pharmacol. Sci. 2007, 28, 416-422.
    • (2007) Trends Pharmacol. Sci. , vol.28 , pp. 416-422
    • Violin, J.D.1    Lefkowitz, R.J.2
  • 57
    • 77951844975 scopus 로고    scopus 로고
    • Teaching old receptors new tricks: Biasing seven-transmembrane receptors
    • "Teaching old receptors new tricks: biasing seven-transmembrane receptors":, S. Rajagopal, K. Rajagopal, R. J. Lefkowitz, Nat. Rev. Drug Discovery 2010, 9, 1-12.
    • (2010) Nat. Rev. Drug Discovery , vol.9 , pp. 1-12
    • Rajagopal, S.1    Rajagopal, K.2    Lefkowitz, R.J.3
  • 60
    • 67649797371 scopus 로고    scopus 로고
    • Arrestin-2 Mediates Anti-Apoptotic Signaling Through Regulation of BAD Phosphorylation
    • "β-Arrestin-2 Mediates Anti-Apoptotic Signaling Through Regulation of BAD Phosphorylation":, S. Ahn, J. Kim, M. R. Hara, X.-R. Ren, R. J. Lefkowitz, J. Biol. Chem. 2009, 284, 8855-8865.
    • (2009) J. Biol. Chem. , vol.284 , pp. 8855-8865
    • Ahn, S.1    Kim, J.2    Hara, M.R.3    Ren, X.-R.4    Lefkowitz, R.J.5
  • 61
    • 84856343982 scopus 로고    scopus 로고
    • Cardiorenal actions of TRV120027, a novel β-arrestin-biased ligand at the angiotensin II type i receptor, in healthy and heart failure canines: A novel therapeutic strategy for acute heart failure
    • "Cardiorenal actions of TRV120027, a novel β-arrestin-biased ligand at the angiotensin II type I receptor, in healthy and heart failure canines: a novel therapeutic strategy for acute heart failure":, G. Boerrigter, M. W. Lark, E. J. Whalen, D. G. Soergel, J. D. Violin, J. C. Burnett, Jr., Circ. Heart Failure 2011, 4, 770-778.
    • (2011) Circ. Heart Failure , vol.4 , pp. 770-778
    • Boerrigter, G.1    Lark, M.W.2    Whalen, E.J.3    Soergel, D.G.4    Violin, J.D.5    Burnett, Jr.J.C.6
  • 63
    • 23944485741 scopus 로고    scopus 로고
    • Morphine side effects in β-arrestin 2 knockout mice
    • "Morphine side effects in β-arrestin 2 knockout mice":, K. M. Raehal, J. K. Walker, L. M. Bohn, J. Pharmacol. Exp. Ther. 2005, 314, 1195-1201.
    • (2005) J. Pharmacol. Exp. Ther. , vol.314 , pp. 1195-1201
    • Raehal, K.M.1    Walker, J.K.2    Bohn, L.M.3
  • 64
    • 0034619796 scopus 로고    scopus 로고
    • Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence
    • "μ-opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence":, L. M. Bohn, R. R. Gainetdinov, F. T. Lin, R. J. Lefkowitz, M. G. Caron, Nature 2000, 408, 720-723.
    • (2000) Nature , vol.408 , pp. 720-723
    • Bohn, L.M.1    Gainetdinov, R.R.2    Lin, F.T.3    Lefkowitz, R.J.4    Caron, M.G.5
  • 65
    • 33947420477 scopus 로고    scopus 로고
    • Seven Transmembrane Receptors. A Brief Personal Retrospective
    • "Seven Transmembrane Receptors. A Brief Personal Retrospective":, R. J. Lefkowitz, Biochem. Biophys. Acta Biomembr. 2007, 1768, 748-755.
    • (2007) Biochem. Biophys. Acta Biomembr , vol.1768 , pp. 748-755
    • Lefkowitz, R.J.1

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.