Chemokine receptors as HIV-1 coreceptors: Roles in viral entry, tropism, and disease

Annual Review of Immunology

Volumn 17, Issue , 1999, Pages 657-700

  Berger, Edward A ^a   Murphy, Philip M ^a   Farber, Joshua M ^b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

AIDS; G protein coupled receptors; Genetics; Pathogenesis; Therapeutics

Indexed keywords

CD4 ANTIGEN; CHEMOKINE; CHEMOKINE RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND; VIRUS FUSION PROTEIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; GENE MUTATION; GENETIC PREDISPOSITION; GENETIC VARIABILITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MEMBRANE FUSION; MOLECULAR DYNAMICS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; REVIEW; TARGET CELL; VIRUS INFECTIVITY; VIRUS TRANSMISSION;

ALLELES; HIV INFECTIONS; HIV-1; HUMANS; MEMBRANE FUSION; MODELS, BIOLOGICAL; POLYMORPHISM, GENETIC; RECEPTORS, CCR5; RECEPTORS, CHEMOKINE; RECEPTORS, CXCR4; RECEPTORS, HIV; VIRULENCE;

EID: 0033012398     PISSN: 07320582     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.immunol.17.1.657     Document Type: Review

References (230)

1. Unutmaz D, Kewalramani VN, Littman DR. 1998. G protein-coupled receptors in HIV and SIV entry: new perspectives on lentivirus-host interactions and on the utility of animal models. Semin. Immunol. 10:225-36
2. Marx PA, Chen ZW. 1998. The function of simian chemokine receptors in the replication of SIV. Semin. Immunol. 10:215-23
3. Wyatt R, Sodroski J. 1998. The HIV-1 envelope glycoproteins: fusogens, antigens, and immunogens. Science 280: 1884-88
4. Berger EA. 1997. HIV entry and tropism: the chemokine receptor connection. AIDS 11(Suppl. A):S3-S16
5. Miedema F, Meyaard L, Koot M, Klein MR, Roos MTL, Groenink M, Fouchier RAM, Van't Wout AB, Tersmette M, Schellenkens PTA, Schuitemaker H. 1994. Changing virus-host interactions in the course of HIV-1 infection. Immunol. Rev. 140:35-72
6. Feng Y, Broder CC, Kennedy PE, Berger EA. 1996. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272:872-77
7. Baggiolini M, Dewald B, Moser B. 1997. Human chemokines: an update. Annu. Rev. Immunol. 15:675-705
8. Murphy PM. 1996. Chemokine receptors: structure, function, and role in microbial pathogenesis. Cytokine Growth Fact. Rev. 7:47-64
9. Levy JA, Mackewicz CE, Barker E. 1996. Controlling HIV pathogenesis: the role of the noncytotoxic anti-HIV response of CD8(+) T cells. Immunol. Today 17:217-24
10. + T cells. Science 270:1811-15
11. Samson M, Labbe O, Mollereau C, Vassart G, Parmentier M. 1996. Molecular cloning and functional expression of a new human CC-chemokine receptor gene. Biochemistry 35:3362-67
12. Combadiere C, Ahuja SK, Tiffany HL, Murphy PM. 1996. Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1α, MIP-1β, and RANTES. J. Leukocyte Biol. 60:147-52
13. Raport CJ, Gosling J, Schweickart VL, Gray PW, Charo IF. 1996. Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1β, and MIP-1α. J. Biol. Chem. 271:17161-66
14. Deng HK, Liu R, Ellmeier W, Choe S, Unutmaz D, Burkhart M, Di Marzio P, Marmon S, Sutton RE, Hill CM, Davis CB, Peiper SC, Schall TJ, Littman DR, Landau NR. 1996. Identification of a major co-receptor for primary isolates of HIV-1. Nature 381:661-66
15. + cells is mediated by the chemokine receptor CC-CKR-5. Nature 381:667-73
16. Alkhatib G, Combadiere C, Broder CC, Feng Y, Kennedy PE, Murphy PM, Berger EA. 1996. CC CKR5: a RANTES, MIP-1α MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272:1955-58
17. Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, Wu L, Mackay CR, Larosa G, Newman W, Gerard N, Gerard C, Sodroski J. 1996. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 85:1135-48
18. Doranz BJ, Rucker J, Yi YJ, Smyth RJ, Samson M, Peiper SC, Parmentier M, Collman RG, Doms RW. 1996. A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 85:1149-58
19. Bleul CC, Farzan M, Choe H, Parolin C, Clark-Lewis I, Sodroski J, Springer TA. 1996. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 382:829-33
20. Oberlin E, Amara A, Bachelerie F, Bessia C, Virelizier JL, Arenzana-Seisdedos F, Schwartz O, Heard JM, Clark-Lewis I, Legler DF, Loetscher M, Baggiolini M, Moser B. 1996. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature 382:833-35
21. Zhang LQ, Huang YX, He T, Cao YZ, Ho DD. 1996. HIV-1 subtype and second-receptor use. Nature 383:768
22. Connor RI, Sheridan KE, Ceradini D, Choe S, Landau NR. 1997. Change in coreceptor use correlates with disease progression in HIV-1-infected individuals. J. Exp. Med. 185:621-28
23. Bjorndal A, Deng H, Jansson M, Fiore JR, Colognesi C, Karlsson A, Albert J, Scarlatti G, Littman DR, Fenyö EM. 1997. Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype. J. Virol. 71:7478-87
24. Scarlatti G, Tresoldi E, Bjorndal A, Fredriksson R, Colognesi C, Deng HK, Malnati MS, Plebani A, Siccardi AG, Littman DR, Fenyo EM, Lusso P. 1997. In vivo evolution of HIV-1 coreceptor usage and sensitivity to chemokine-mediated suppression. Nature Med. 3:1259-65
25. Bazan HA, Alkhatib G, Broder CC, Berger EA. 1998. Patterns of CCR5, CXCR4 and CCR3 usage by envelope glycoproteins from human immunodeficiency virus type 1 primary isolates. J. Virol. 72:4485-91
26. Trkola A, Paxton WA, Monard SP, Hoxie JA, Siani MA, Thompson DA, Wu L, Mackay CR, Horuk R, Moore JP. 1998. Genetic subtype-independent inhibition of human immunodeficiency virus type I replication by CC and CXC chemokines. J. Virol. 72:396-404
27. Tscherning C, Alaeus A, Fredriksson R, Bjorndal A, Deng HK, Littman DR, Fenyö EM, Albert J. 1998. Differences in chemokine coreceptor usage between genetic subtypes of HIV-1. Virology 241:181-88
28. Berger EA, Doms RW, Fenyö EM, Korber BTM, Littman DR, Moore JP, Sattentau QJ, Schuitemaker H, Sodroski J, Weiss RA. 1998. A new classification for HIV-1. Nature 391:240
29. Rucker J, Edinger AL, Sharron M, Samson M, Lee B, Berson JF, Yi Y, Margulies B, Collman RG, Doranz BJ, Parmentier M, Doms RW. 1997. Utilization of chemokine receptors, orphan receptors, and herpesvirus-encoded receptors by diverse human and simian immunodeficiency viruses. J. Virol. 71:8999-9007
30. Horuk R, Hesselgesser J, Zhou Y, Faulds D, Halks-Miller M, Harvey S, Taub D, Samson M, Parmentier M, Rucker J, Doranz BJ, Doms RW. 1998. The CC chemokine I-309 inhibits CCR8-dependent infection by diverse HIV-1 strains. J. Biol. Chem. 273:386-91
31. Jinno A, Shimizu N, Soda Y, Haraguchi Y, Kitamura T, Hoshino H. 1998. Identification of the chemokine receptor TER1/CCR8 expressed in brain-derived cells and T cells as a new coreceptor for HIV-1 infection. Biochem. Biophys. Res. Commun. 243:497-502
32. Choe H, Farzan M, Konkel M, Martin K, Sun Y, Marcon L, Cayabyab M, Berman M, Dorf ME, Gerard N, Gerard C, Sodroski J. 1998. The orphan seven-transmembrane receptor ApJ. supports the entry of primary T-cell-line-tropic and dualtropic human immunodeficiency virus type I. J. Virol. 72:6113-18
33. 3C chemokine fractalkine, and a fusion coreceptor for HIV-1. J. Biol. Chem. 273:23799-804
34. Liao F, Alkhatib G, Peden KWC, Sharma G, Berger EA, Farber JM. 1997. STRL33, a novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1. J. Exp. Med. 185:2015-23
35. Deng H, Unutmaz D, Kewalramani VN, Littman DR. 1997. Expression cloning of new receptors used by simian and human immunodeficiency viruses. Nature 388:296-300
36. Farzan M, Choe H, Martin K, Marcon L, Hofmann W, Karlsson G, Sun Y, Barrett P, Marchand N, Sullivan N, Gerard N, Gerard C, Sodroski J. 1997. Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection. J. Exp. Med. 186:405-11
37. Edinger AL, Hoffman TL, Sharron M, Lee BH, Yi YJ, Choe W, Kolson DL, Mitrovic B, Zhou YQ, Faulds D, Collman RG, Hesselgesser J, Horuk R, Doms RW. 1998. An orphan seven-transmembrane domain receptor expressed widely in the brain functions as a coreceptor for human immunodeficiency virus type I and simian immunodeficiency virus. J. Virol. 72: 7934-40
38. Pleskoff O, Treboute C, Brelot A, Heveker N, Seman M, Alizon M. 1997. Identification of a chemokine receptor encoded by human cytomegalovirus as a cofactor for HIV-1 entry. Science 276:1874-78
39. Kledal TN, Rosenkilde MM, Coulin F, Simmons G, Johnsen AH, Alouani S, Power CA, Luttichau HR, Gerstoft J, Clapham PR, Clark-Lewis I, Wells TNC, Schwartz TW. 1997. A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus. Science 277:1656-59
40. Boshoff C, Endo Y, Collins PD, Takeuchi Y, Reeves JD, Schweickart VL, Siani MA, Sasaki T, Williams TJ, Gray PW, Moore PS, Chang Y, Weiss RA. 1997. Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines. Science 278:290-94
41. Owman C, Garzino-Demo A, Cocchi F, Popovic M, Sabirsh A, Gallo RC. 1998. The leukotriene B-4 receptor functions as a novel type of coreceptor mediating entry of primary HIV-1 isolates into CD4-positive cells. Proc. Natl. Acad. Sci. USA 95:9530-34
42. Samson M, Edinger AL, Stordeur P, Rucker J, Verhasselt V, Sharron M, Govaerts C, Mollereau C, Vassart G, Doms RW, Parmentier M. 1998. ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains. Eur. J. Immunol. 28:1689-1700 4.3. Pal R, Garzino-Demo A, Markham PD, Burns J, Brown M, Gallo RC, DeVico AL. 1997. Inhibition of HIV-1 infection by the beta-chemokine MDC. Science 278:695-98
43. DeVico AL, Pal R, Markham PD, Garzino-Demo A, Gallo RC. 1998. β-chemokine MDC and HIV-1 infection. Science 281:487a
44. Struyf S, Proost P, Sozzani S, Mantovani A, Wuyts A, De Clercq E, Van Damme J. 1998. Enhanced anti-HIV-1 activity and altered chemotactic potency of NH2-terminally processed macrophage-derived chemokine (MDC) imply an additional MDC receptor. J. Immunol. 161:2672-75
45. Lee B, Rucker J, Doms RW, Tsang M, Hu X, Dietz M, Bailer R, Montaner LJ, Gerard C, Sullivan N, Sodroski J, Stantchev TS, Broder CC. 1998. β-chemokine MDC and HIV-1 infection. Science 281:487a
46. Arenzana-Seisdedos F, Amara A, Thomas D, Virelizier JL, Baleux F, Clark-Lewis I, Legler DF, Moser B, Baggiolini M. 1998. β-chemokine MDC and HIV-1 infection. Science 281: 487a
47. Imai T, Chantry D, Raport CJ, Wood CL, Nishimura M, Godiska R, Yoshie O, Gray PW. 1998. Macrophage-derived chemokine is a functional ligand for the CC chemokine rcceptor 4. J. Biol. Chem. 273:1764-1768
48. Tachibana K, Nakajima T, Sato A, Igarashi K, Shida H, Iizasa H, Yashida N, Yoshie O, Kishimoto T, Nagasawa T. 1997. CXCR4/fusin is not a species-specific barrier in murine cells for HIV-1 entry. J. Exp. Med. 185:1865-70
49. Bieniasz PD, Fridell RA, Anthony K, Cullen BR. 1997. Murine CXCR-4 is a functional coreceptor for T-cell-tropic and dual-tropic strains of human immunodeficiency virus type 1. J. Virol. 71:7097-7100
50. Parolin C, Barsetti A, Choe H, Farzan M, Kolchinsky P, Heesen M, Ma Q, Gerard C, Palu G, Dorf ME, Springer T, Sodroski J. 1998. Use of murine CXCR-4 as a second receptor by some T-cell-tropic human immunodeficiency viruses. J. Virol. 72:1652-56
51. Atchison RE, Gosling J, Monteclaro FS, Franci C, Digilio L, Charo IF, Goldsmith MA. 1996. Multiple extracellular elements of CCR5 and HIV-1 entry: dissociation from response to chemokines. Science 274:1924-26
52. Doranz BJ, Lu ZH, Rucker J, Zhang TY, Sharron M, Cen YH, Wang ZX, Guo HH, Du JG, Accavitti MA, Doms RW, Peiper SC. 1997. Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type I. J. Virol. 71:6305-14
53. Picard L, Simmons G, Power CA, Meyer A, Weiss RA, Clapham PR. 1997. Multiple extracellular domains of CCR-5 contribute to human immunodeficiency virus type I entry and fusion. J. Virol. 71:5003-11
54. Ross TM, Bieniasz PD, Cullen BR. 1998. Multiple residues contribute to the inability of murinc CCR-5 to function as a coreceptor for macrophage-tropic human immunodeficiency Virus type I isolates. J. Virol. 72:1918-24
55. + T lymphocytes from two multiply exposed, uninfected individuals resist infection with primary non-syncytium-inducing isolates of human immunodeficiency virus type I. J. Virol. 70:8758-64
56. Rana S, Besson G, Cook DG, Rucker J, Smyth RJ, Yi Y, Turner JD, Guo H-H, Du J-D, Peiper SC, Lavi E, Samson M, Libert F, Liesnard C, Vassart G, Doms RW, Parmenlier M, Collman RG. 1997. Role of CCR5 in infection of primary macrophages and lymphocytes by macrophage-tropic strains of human immunodeficiency virus: resistance to patient-derived and prototype isolates resulting from the delta CCR5 mutation. J. Virol. 71:3219-27
57. Wu L, Paxton WA, Kassam N, Ruffing N, Kottman JB, Sullivan N, Choe H, Sodroski J, Newman W, Koup RA, Mackay CR. 1997. CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro. J. Exp. Med. 185:1681-91
58. Simmons G, Wilkinson D, Reeves JD, Dittmar MT, Beddows S, Weber J, Carnegie G, Desselberger U, Gray PW, Weiss RA, Clapham PR. 1996. Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entry. J. Virol. 70:8355-60
59. Naif HM, Li S, Alali M, Sloane A, Wu L, Kelly M, Lynch G, Lloyd A, Cunningham AL. 1998. CCR5 expression correlates with susceptibility of maturing monocytes to human immunodeficiency virus type 1 infection. J. Virol. 72:830-36
60. Dittmar MT, McKnight A, Simmons G, Clapham PR, Weiss RA, Simmonds P. 1997. HIV-1 tropism and co-receptor use. Nature 385:495-96
61. Coffey MJ, Woffendin C, Phare SM, Streiter RM, Markovitz DM 1997. RANTES inhibits HIV-1 replication in human peripheral blood monocytes and alveolar macrophages. Am. J. Physiol. 272:L1025-29
62. Capobianchi MR, Abbate I, Antonelli G, Turriziani O, Dolci A, Dianzani F. 1998. Inhibition of HIV type 1 BaL replication by MIP-1 alpha, MIP-1 beta, and RANTES in macrophages. AIDS Res. Hum. Retrovir. 14:233-40
63. Schmidtmayerova H, Sherry B, Bukrinsky M. 1996. Chemokines and HIV replication. Nature 382:767
64. + T-cell-derived soluble factor(s), but not β-chemokines RANTES, MIP-1α, and MIP-1β, suppress HIV-1 replication in monocyte/macrophages. Proc. Natl. Acad. Sci. USA 93:15341-45
65. Oravecz T, Pall M, Wang J, Roderiquez G, Ditto M, Norcross MA. 1997. Regulation of anti-HIV-1 activity of RANTES by heparan sulfate proteoglycans. J. Immunol. 159:4587-92
66. Kelly MD, Naif HM, Adams SL, Cunningham AL, Lloyd AR,1998. Dichotomous effects of beta-chemokines on HIV replication in monocytes and monocyte-derived macrophages. J. Immunol. 160:3091-95
67. McKnight A, Wilkinson D, Simmons G, Talbot S, Picard L, Ahuja M, Marsh M, Hoxie JA, Clapham PR. 1997. Inhibition of human immunodeficiency virus fusion by a monoclonal antibody to a coreceptor (CXCR4) is both cell type and virus strain dependent. J. Virol. 71: 1692-96
68. Yi Y, Rana S, Turner JD, Gaddis N, Collman RG, 98. CXCR-4 is expressed by primary macrophages and supports CCR5-independent infection by dual-tropic but not T-tropic isolates of human immunodeficiency virus type 1. J. Virol. 72:772-77
69. Verani A, Pesenti E, Polo S, Tresoldi E, Scarlatti G, Lusso P, Siceardi AG, Vercelli D. 1998. CXCR4 is a functional coreceptor for infection of human macrophages by CXCR4-dependent primary HIV-1 isolates. J. Immunol. 161: 2084-88
70. Schmidtmayerova H, Aflano M, Nuovo G, Bukrinsky M. 1998. Human immunodeficiency virus type 1 T-lymphotropic strains enter macrophages via a CD4-and CXCR4-mediated pathway: Replication is restricted at a post-entry level. J. Virol. 72:4633-42
71. Kozak SL, Platt EJ, Madani N, Ferro FE Jr, Peden K, Kabat D. 1997. CD4, CXCR-4, and CCR-5 dependencies for infections by primary patient and laboratory-adapted isolates of human immunodeficiency virus type I. J. Virol. 71:873-82
72. He J, Chen Y, Farzan M, Choc H, Ehagen A, Gartner S, Busciglio J, Yang X, Hofmann W, Newman W, Mackay CR, Sodroski J, Gabuzda D. 1997. CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. Nature 385:645-49
73. Rubbert A, Combadiere C, Ostrowski M, Arthos J, Dybul M, Machado E, Cohn MA, Hoxie JA, Murphy PM, Fauci AS, Weissman D. 1998. Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry. J. Immunol. 160:3933-11
74. Lapham CK, Ouyang J, Chandrasekhar B, Nguyen NY, Dimitrov DS, Golding H. 1996. Evidence for cell-surface association between fusin and the CD4-gp120 complex in human cell lines. Science 274:602-5
75. Ugolini S, Moulard M, Mondor I, Barois N, Demandolx D, Hoxie J, Brelot A, Alizon M, Davoust J, Sattentau QJ. 1997. HIV-1 gp120 induces an association between CD4 and the chemokine receptor CXCR4. J. Immunol. 159:3000-8
76. + T cells: role of signal transduction. Proc. Natl. Acad. Sci. USA 95: 11880-85
77. Iyengar S, Hildreth JEK, Schwartz DH. 1998. Actin-dependent receptor colocalization required for human immunodeficiency virus entry into host cells. J. Virol. 72:5251-55
78. Wu L, Gerard NP, Wyatt R, Choc H, E Parolin C, Ruffing N, Borsetti A, Cardoso AA, Desjardin E, Newman W, Gerard C, Sodroski J. 1996. CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5. Nature 384:179-83
79. Trkola A, Dragic T, Arthos J, Binley JM, Olson WC, Allaway GP, Cheng-Mayer C, Robinson J, Maddon PJ, Moore JP. 1996. CD4-dependent antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5. Nature 384:184-87
80. Hill CM, Deng H, Unutmaz D, Kewalramani VN, Bastiani L, Gorny MK, Zolla-Pazner S, Littman DR. 1997. Envelope glycoproteins from human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus can use human CCR5as a coreceptor for viral entry and make direct CD4-dependent interactions with this chemokine receptor. J. Virol. 71:6296-304
81. Bandres JC, Wang QF, O'Leary J, Baleaux F, Amara A, Hoxie JA, Zolla-Pazner S, Gorny MK. 1998. Human immunodeficiency virus (HIV) envelope binds to CXCR4 independently of CD4, and binding can be enhanced by interaction with soluble CD4 or by HIV envelope deglycosylation. J. Virol. 72:2500-4
82. Sullivan N, Sun Y, Sattentau Q, Thali M, Wu D, Denisova G, Gershoni J, Robinson J, Moore J, Sodroski J. 1998. CD4-induced conformational changes in the human immunodeficiency virus type 1 gp120 glycoprotein: Consequences for virus entry and neutralization. J. Virol. 72:4694-4703
83. Kwong PD, Wyatt R, Robinson J, Sweet RW, Sodroski J, Hendrickson WA. 1998. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature 393:648-59
84. Rizzuto CD, Wyatt R, Hernandez-Ramos N, Sun Y, Kwong PD, Hendrickson WA, Sodroski J. 1998. A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding. Science 280:1949-53
85. Wyatt R, Kwong PD, Desjardins E, Sweet RW, Robinson J, Hendrickson WA, Sodroski JG. 1998. The antigenic structure of the HIV gp120 envelope glycoprotein. Nature 393:705-11
86. Farzan M, Choc H, MErtin KA, Sun Y, Sidelko M, Mackay CR, Gerard NP, Sodroski J, Gerard C. 1997. HIV-1 entry and macrophage inflammatory protein-1β-mediated signaling are independent functions of the chemokine receptor CCR5. J. Biol. Chem. 272:6854-57
87. Gosling J, Monteclaro FS, Atchison RE, Arai H, Tsou CL, Goldsmith MA, Charo IF. 1997. Molecular uncoupling of C-C chemokine receptor 5-induced chemotaxis and signal transduction from HIV-1 coreceptor activity. Proc. Natl. Acad. Sci. USA 94:5061-66
88. Alkhatib G, Locati M, Kennedy PE, Murphy PM, Berger EA. 1997. HIV-1 coreceptor activity of CCR5 and its inhibition by chemokines: independence from G protein signaling and importance of coreceptor downmodulation. Virology 234:340-48
89. Aramori I, Zhang J, Ferguson SS, Bieniasz PD, Cullen BR, Caron MG. 1997. Molecular mechanism of desensitization of the chemokine receptor CCR-5: receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor. EMBO. J. 16:4606-16
90. Hu H, Shioda T, Hori T, Moriya C, Kato A, Sakai Y, Natsushima K, Uchiyama T, Nagai Y. 1998. Dissociation of ligand-induced internalization of CXCR-4 from its co-receptor activity for HIV-1 Env-mediated membrane fusion. Arch. Virol. 143:851-61
91. Amara A, Gall S, Schwartz O, Salamero J, Montes M, Loetscher P, Baggiolini M, Virelizier J-L, Arenzana-Seisdedos F. 1997. HIV coreceptor downregulation as antiviral principle: SDF-1α-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication. J. Exp. Med. 186:139-46
92. Crump MP, Gong JH, Loetscher P, Rajarathnam K, Amara A, Arenzana-Seisdedos F, Virelizier JL, Baggiolini M, Sykes BD, Clark-Lewis I. 1997. Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1. EMBO J. 16:6996-7007
93. Signoret N, Oldridge J, Pelchen-Matthews A, Klasse PJ, Tran T, Brass LF, Rosenkilde MM, Schwartz TW, Holmes W, Dallas W, Luther MA, Wells TN, Hoxie JA, Marsh M. 1997. Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4. J. Cell. Biol. 139:651-664
94. Mack M, Luckaw B, Nelson PJ, Cihak J, Simmons G, Clapham PR, Signoret N, Marsh M, Stangassinger M, Borlat F, Wells TN, Schlondorff D, Proudfoot AE. 1998. Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity. J. Exp. Med. 187:1215-24
95. Tarasova NI, Stauber RH, Michejda CJ. 1998. Spontaneous and ligand-induced trafficking of CXC-chemokine receptor 4. J. Biol. Chem. 273:15883-86
96. Endres MJ, Clapham PR, Marsh M, Ahuja M, Turner JD, McKnight A, Thomas JF, Stoebenau-Haggarty B, Choe S, Vance PJ, Wells TNC, Power CA, Sutterwala SS, Doms RW, Landau NR, Hoxie JA. 1996. CD4-independent infection by HIV-2 is mediated by Fusin/CXCR4. Cell 87:745-56
97. Reeves JD, McKnight A, Potempa S, Simmons G, Gray PW, Power CA, Wells T, Weiss RA, Talbot SJ. 1997. CD4-independent infection by HIV-2 (ROD/B): use of the 7-transmembrane receptors CXCR-4, CCR-3, and V28 for entry. Virology 231:130-34
98. Potempa S, Picard L, Reeves JD, Wilkinson D, Weiss RA, Talbot SJ. 1997. CD4-independent infection by human immunodeficiency virus type 2 strain ROD/B: the role of the N-terminal domain of CXCR-4 in fusion and entry. J. Virol. 71:4419-24
99. Reeves JD, Schulz TF. 1997. The CD4-independent tropism of human immunodeficiency virus type 2 involves several regions of the envelope protein and correlated with a reduced activation threshold for envelope-mediated fusion. J. Virol. 71:1453-65
100. Martin KA, Wyatt R, Farzan M, Choe H, Marcon L, Desjardin E, Robinson J, Sodroski J, Gerard C, Gerard NP. 1997. CD4-independent binding of SIV gp120 to rhesus CCR5. Science 278:1470-73
101. Edinger AL, Markowski JL, Doranz BJ, Margulies BJ, Lee B, Rucker J, Sharron M, Hoffman TL, Berson JF, Zink MC, Hirsch VM, Clements JE, Doms RW. 1997. CD4-independent, CCR5-dependent infection of brain capillary endothelial cells by a neurovirulent simian immunodeficiency virus strain. Proc. Natl. Acad. Sci. USA 94:14742-47
102. Hesselgesser J, Halks-Miller M, Del-Vecchio V, Peiper SC, Hoxie J, Kolson DL, Taub D, Horuk R. 1997. CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons. Curr. Biol. 7:112-21
103. Dumonceaux J, Nisole S, Chanel C, Quivet L, Amara A, Baleux F, Briand F, Hazan U. 1998. Spontaneous mutations in the env gene of the human immunodeficiency virus type 1 NDK isolate are associated with a CD4-independent entry phenotype. J. Virol. 72:512-19
104. Cocchi F, DeVico AL, Garzino-Demo A, Cara A, Gallo RC, Lusso P. 1996. The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection. Nature Med. 2:1244-47
105. Bicniasz PD, Fridell RA, Aramori I, Ferguson SS, Caron MG, Cullen BR. 1997. HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor. EMBO J. 16:2599-2609
106. + cells expressing the rat homolog of CXCR-4 (fusin). J. Virol. 71: 3259-62
107. Speck RF, Wehrly K, Platt EJ, Atchison RE, Charo IF, Kabat D, Chesebro B, Goldsmith MA. 1997. Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope V3 loop. J. Virol. 71:7136-39
108. Cho MW, Lee MK, Carney MC, Berson JF, Doms RW, Martin MA. 1998. Identification of determinants on a dualtropic human immunodeficiency virus type 1 envelope glycoprotein that confer usage of CXCR4. J. Virol. 72:2509-15
109. Ross TM, Cullen BR. 1998. The ability of HIV type 1 to use CCR-3 as a coreceptor is controlled by envelope V1/V2 sequences acting in conjunction with a CCR-5 tropic V3 loop. Proc. Natl. Acad. Sci. USA 95:7682-86
110. Smythe RJ, Yi YJ, Singh A, Collman RG. 1998. Determinants of entry cofactor utilization and tropism in a dualtropic human immunodeficiency virus type 1 primary isolate. J. Virol. 72:4478-84
111. Wang WK, Dudek T, Zhao YJ, Brumblay HG, Essex M, Lee TH. 1998. CCR5 coreceptor utilization involves a highly conserved arginine residue of HIV type 1 gp120. Proc. Natl. Acad. Sci. USA 95: 5740-45
112. Xiao LZH, Owen SM, Goldman I, Lal AA, deJong JJ, Goudsmit J, Lal RB. 1998. CCR5 coreceptor usage of non-syncytium-inducing primary HIV-1 is independent of phylogenetically distinct global HIV-1 isolates: delineation of consensus motif in the V3 domain that predicts CCR5 usage. Virology 240:83-92
113. Hoffman TL, Stephens EB, Narayan O, Doms RW. 1998. HIV type I envelope determinants for use of the CCR2b, CCR3, STRL33, and APJ, coreceptors. Proc. Natl. Acad. Sci. USA 95:11360-65
114. Frade JMR, Llorente M, Mellado M, Alcami J, Gutierrez-Ramos JC, Zaballos A, Real G, Martinez-A C. 1997. The amino-terminal domain of the CCR2 chemokine receptor acts as coreceptor for HIV-1 infection. J. Clin Invest 100:497-502
115. Rucker J, Samson M, Doranz BJ, Libert F, Berson JF, Yi YJ, Smyth RJ, Collman RG, Broder CC, Vassart G, Doms RW, Parmentier M. 1996. Regions in beta-chemokine receptors CCR5 and CCR2b that determine HIV-1 cofactor specificity. Cell 87:437-46
116. Wu L, Larosa G, Kassam N, Gordon CJ, Heath H, Ruffing N, Chen H, Humblias J, Samson M, Parmentier M, Moore JP, Mackay CR. 1997. Interaction of chemokine receptor CCR5 with its ligands: multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding. J. Exp. Med. 186: 1373-81
117. Alkhatib G, Berger EA, Murphy PM, Pease JE. 1997. Determinants of HIV-1 coreceptor function on CC chemokine receptor 3: importance of both extracellular and transmembrane/cytoplasmic regions. J. Biol. Chem. 272:20420-26
118. Lu Z, Berson JF, Chen Y, Turner JD, Zhang T, Sharron M, Jenks MH, Wang Z, Kim J, Rucker J, Hoxie JA, Peiper SC, Doms RW. 1997. Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domains. Proc. Natl. Acad. Sci. USA 94: 6426-31
119. Edinger AL, Amedee A, Miller K, Doranz BJ, Endres M, Sharron M, Samson M, Lu ZH, Clements JE, Murphey-Corb M, Peiper SC, Parmentier M, Broder CC, Doms RW. 1997. Differential utilization of CCR5 by macrophage and T cell tropic simian immunodeficiency virus strains. Proc. Natl. Acad. Sci. USA 94:4005-10
120. Strizki JM, Turner JD, Collman RG, Hoxie J, Gonzalez-Scarano F. 1997. A monoclonal antibody (12G5) directed against CXCR-4 inhibits infection with the dual-tropic human immunodeficiency virus type 1 isolate HIV-1(89.6) but not the T-tropic isolate HIV-1(HxB). J. Virol. 71:5678-83
121. Alkhatib G, Ahuja SS, Light D, Mummidi S, Berger EA, Ahuja SK. 1997. CC chemokine receptor 5-mediated signaling and HIV-1 co-receptor activity share common structural determinants: critical residues in the third extracellular loop support HIV-1 fusion. J. Biol. Chem. 272:19771-76
122. Kuhmann SE, Platt EJ, Kozak SL, Kabat D. 1997. Polymorphisms in the CCR5 genes of African green monkeys and mice implicate specific amino acids in infections by simian and human immunodeficiency viruses. J. Virol. 71:8642-56
123. Willett BJ, Picard L, Hosie MJ, Turner JD, Adema K, Clapham PR. 1997. Shared usage of the chcmokinc receptor CXCR4 by the feline and human immunodeficiency viruses. J. Virol. 71:6407-15
124. Brelot A, Heveker N, Pleskoff O, Sol N, Alizon M. 1997. Role of the first and third extracellular domains of CXCR-4 in human immunodeficiency virus coreeeptor activity. J. Virol. 71:4744-51
125. Picard L, Wilkinson DA, McKnight A, Gray PW, Hoxie JA, Clapham PR, Weiss RA. 1997. Role of the amino-terminal extracellular domain of CXCR-4 in human immunodeficiency virus type 1 entry. Virology 231:105-11
126. Dragic T, Trkola A, Lin SW, Nagashima KA, Kajumo F, Zhao L, Olson WC, Wu LJ, Mackay CR, Allaway GP, Sakmar TP, Moore JP, Maddon PJ. 1998. Amino-terminal substitutions in the CCR5 coreceptor impair gp 120 binding and human immunodeficiency virus type 1 entry. J. Virol. 72:279-85
127. Rabul GEE, Konner JA, Kajumo F, Moore JP, Dragic T. 1998. Alanine substitutions of polar and nonpolar residues in the amino-terminal domain of CCR5 differently impair entry of macrophage-and dualtropic isolates of human immunodeficiency virus type 1. J. Virol. 72:3464-68
128. Wang ZX, Berson JF, Zhang TY, Cen YH, Sun Y, Sharron M, Lu ZH, Peiper SC. 1998. CXCR4 sequences involved in coreceptor determination of human immunodeficiency virus type-1 tropism. Unmasking of activity with M-tropic Env glycoproteins. J. Biol. Chem. 273:15007-15
129. Farzan M, Choe H, Vaca L, Martin K, Sun Y, Desjardins E, Ruffing N, Wu LJ, Wyatt R, Gerard N, Gerard C, Sodroski J. 1998. A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5. J. Virol. 72:1160-64
130. Reeves JD, Heveker N, Brelot A, Alizon M, Clapham HR, Picard L. 1998. The second extracellular loop of CXCR4 is involved in CD4-independent entry of human immunodeficiency virus type 2. J. Gen. Virol. 79:1793-99
131. Chan DC, Fass D, Berger JM, Kim PS. 1997. Core structure of gp41 from the HIV envelope glycoprotein. Cell 89: 263-73
132. Weissenhorn W, Dessen A, Harrison SC, Skehel JJ, Wiley DC. 1997. Atomic structure of the ectodomain from HIV-1 gp41. Nature 387:426-30
133. Caffrey M, Cai ML, Kaufman J, Stahl SJ, Wingfield PT, Covell DG, Gronenborn AM, Clore GM. 1998. Three-dimensional solution structure of the 44 kDa ectodomain of SIV gp41. EMBO J. 17:4572-84
134. Bleul CC, Wu L, Hoxie JA, Springer TA, Mackay CR. 1997. The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc. Natl. Acad. Sci. USA 94:1925-30
135. Rottman JB, Ganley KP, Williams K, Wu L, Mackay CR, Ringler DJ. 1997. Cellular localization of the chemokine receptor CCR5, Correlation to cellular targets of HIV-1 infection. Am. J. Pathol. 151:1341-51
136. Zhang LQ, He T, Talal A, Wang G, Frankel SS, Ho DD. 1998. In vivo distribution of the human immunodeficiency virus simian immunodeficiency virus coreceptors: CXCR4, CCR3, and CCR5. J. Virol. 72:5035-45
137. Granelli-Piperno A, Moser B, Pope M, Chen D, Wei Y, Isdell F, O'Doherty U, Paxton W, Koup R, Mojsov S, Bhardwa JN, Clark-Lewis I, Baggiolini M, Steinman RM. 1996. Efficient interaction of HIV-1 with purified dendritic cells via multiple chemokine coreceptors. J. Exp. Med. 184:2433-38
138. Ayehunie S, Garcia-Zepeda EA, Hoxie JA, Horuk R, Kupper TS, Luster AD, Ruprecht RM. 1997. Human immunodeficiency virus-1 entry into purified blood dendritic cells through CC and CXC chemokine coreceptors. Blood 90:1379-86
139. Dittmar MT, Simmons G, Hibbitts S, O'Hare M, Louisirirotchanakul S, Beddows S, Weber J, Clapham PR, Weiss RA. 1997. Langerhans cell tropism of human immunodeficiency virus type 1 subtype A through F isolates derived from different transmission groups. J. Virol. 71:8008-13
140. Zaitseva M, Blauvelt A, Lee S, Lapham CK, Klaus-Kovtun V, Mostowski H, Manischewitz J, Golding H, 197. Expression and function of CCR5 and CXCR4 on
141. Patterson BK, Landay A, Andersson J, Brown C, Behbahani H, Jiyamapa D, Burki Z, Stanlaslawski D, Czerniewski MA, Garcia P. 1998. Repertoire of chemokine receptor expression in the female genital tract: implications for human immunodeficiency virus transmission. Am. J. Pathol. 153:481-90
142. Liu R, Paxton WA, Choe S, Ceradini D, Martin SR, Horuk R, Macdonald ME, Stuhlmann H, Koup RA, Landau NR. 1996. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 86:367-77
143. Samson M, Libert F, Doranz BJ, Rucker J, Liesnard C, Farber CM, Saragosti S, Lapoumeroulie C, Cognaux J, Forceille C, Muyldermans G, Verhofstede C, Burtonboy G, Georges M, Imai T, Rana S, Yi YJ, Smyth RJ, Collman RG, Doms RW, Vassart G, Parmentier M. 1996. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 382:722-25
144. Dean M, Carrington M, Winkler C, Huttley GA, Smith MW, Allikmets R, Goedert JJ, Buchbinder SP, Vittinghoff E, Gomperts E, Dornfield S, Vlahov D, Kaslow R, Saah A, Rinaldo C, Detels R, Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study, O'Brien SJ. 1996. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science 273:1856-62
145. Zimmerman PA, Buckler-White A, Alkhatib G, Spalding T, Kubofcik J, Combadiere C, Weissman D, Cohen O, Rubbert A, Lam G, Vaccarezza M, Kennedy PE, Kumaraswami V, Giorgi JV, Detels R, Hunter J, Chopek M, Berger EA, Fauci AS, Nutman TB, Murphy PM. 1997. Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk. Mol. Med. 3:23-35
146. Benkirane M, Jin DY, Chun RF, Koup RA, Jeang KT. 1997. Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5delta32. J. Biol. Chem. 272:30603-6
147. Huang YX, Paxton WA, Wolinsky SM, Neumann AU, Zhang LQ, He T, Kang S, Ceradini D, Jin ZQ, Yazdanbakhsh K, Kunstman K, Erickson D, Dragon E, Landau NR, Phair J, Ho DD, Koup RA. 1996. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nature Med. 2:1240-43
148. O'Brien TR, Winkler C, Dean M, Nelson JR, Carrington M, Michael NL, White GC II. 1997. HIV-1 infection in a man homozygous for CCR5 delta 32. Lancet 349:1219
149. Paxton WA, Martin SR, Tse D, O'Brien TR, Skumick J, VanDevanter NL, Padian N, Braun JF, Kotler DP, Wolinsky SM, Koup RA. 1996. Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposures. Nature Med. 2:412-17
150. Edelstein RE, Arcuino LA, Hughes JP, Melvin AJ, Mohan KM, King PD, McLellan CL, Murante BL, Kassman BP, Frenkel LM. 1997. Risk of mother-to-infant transmission of HIV-1 is not reduced in CCR5/delta32ccr5 heterozygotes. J. Acquired Immune Defic. Syndr. Hum. Tetrovirol. 16:243-46
151. Rousseau CMS, Just JJ, Abrams EJ, Casabona J, Stein Z, King MC. 1997. CCR5del32 in perinatal HIV-1 infection. J. Acquired Immune Defic. Syndr. Hum. Retrovirol. 16:239-242
152. Michael NL, Chang G, Louie LG, Mascola JR, Dandero D, Birx DL, Sheppard HW. 1997. The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression. Nature Med. 3:338-40
153. Misrahi M, Teglas JP, N'Go N, Burgard M, Mayaux MJ, Rouzioux C, Delfraissy JF, Blanche S. 1998. CCR5 chemokine receptor variant in HIV-1 mother-to-child transmission and disease progression in children. J. Am. Med. Assoc. 279:317-18
154. Malo A, Rommel F, Bogner J, Gruber R, Schramm W, Goebel FD, Riethmuller G, Wank R. 1998. Lack of protection from HIV infection by the mutant HIV coreceptor CCR5 in intravenously HIV infected hemophilia patients. Immunobialogy 198:485-88
155. Mangano A, Prada F, Roldan A, Picchio G, Bologna R, Sen L. 1998. Distribution of CCR-5 delta32 allele in Argentinian children at risk of HIV-1 infection: its role in vertical transmission. AIDS 12:109-10
156. Shearer WT, Kalish LA, Zimmerman PA. 1998. CCR5 HIV-1 vertical transmission. J. Acquired Immune Defic. Syndr. 17:180-81
157. Mummidi S, Ahuja SS, Gonzalez E, Anderson SA, Santiago EN, Stephan KT, Craig FE, O'Connell P, Tryon V, Clark RA, Dolan MJ, Ahuja SK. 1998. Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression. Nature Med. 4:786-93
158. Hoffman TL, MacGregor RR, Burger H, Mick R, Doms RW, Collman RG. 1997. CCR5 genotypes in sexually active couples discordant for human immunodeficiency virus type 1 infection status. J. Infect. Dis. 176:1093-96
159. Mandl CW, Aberle SW, Henkel JH, Puchhammer-Stockl E, Heinz FX. 1998. Possible influence of the mutant CCR5 allele on vertical transmission of HIV-1. J. Med. Virol. 55:51-55
160. Quillent C, Oberlin E, Braun J, Rousset D, Gonzalez-Canali G, Metais P, Montagnier L, Virelizier J-L, Arenzana-Seisdedos F, Beretta A. 1998. HIV-1 resistance phenotype conferred by combination of two separate inherited mutations of CCR5 gene. Lancet 351:14-18
161. Biti R, Ffrench R, Young J, Bennetts B, Stewart G, Liang T. 1997. HIV-1 infection in an individual homozygous for the CCR5 deletion allele. Nature Med. 3:252-53
162. Theodorou I, Meyer L, Magierowska M, Katlama C, Rouzioux C, 199. HIV-1 infection in an individual homozygous for CCR5 delta 32. Lancet 349:1219-20
163. Michael NL, Nelson JAE, Kewalramani VN, Chang G, O'Brien SJ, Mascola JR, Volsky B, Louder M, White GC, Littman DR, Swanstrom R, O'Brien TR. 1998. Exclusive and persistent use of the entry coreceptor CXCR4 by human immunodeficieney virus type 1 from a subject homozygous for CCR5 Delta 32. J. Virol. 12:6040-47
164. Martinson JJ, Chapman NH, Rees DC, Liu YT, Clegg JB. 1997. Global distribution of the CCR5 gene 32-basepair deletion. Nature Genet 16:100-3
165. Stephens JC, Reich DE, Goldstein DB, Shin HD, Smith MW, Carrington M, Winkler C, Huttley GA, Allikmets R, Schriml L, Gerrard B, Malasky M, Ramos MD, Morlot S, Tzetis M, Oddoux C, di Giovine FS, Nasiolas G, Chandler D, Aseev M, Hanson M, Kalaydjieva L, Glavac D, Gasparini P, Kanavakis E, Claustres M, Kambouris M, Ostrer H, Duff G, Baranov V, Sibul H, Metspalu A, Goldman D, Martin N, Duffy D, Schmidtke J, Estivill X, O'Brien SJ, Dean M. 1998. Dating the origin of the CCR5-Delta 32 AIDS-resistance allele by the coalescence of haplotypes. Am. J. Hum. Genet. 62:1507-15
166. Libert F, Cochaux P, Beckman G, Samson M, Aksenova M, Cao A, Czeizel A, Claustres M, de la Rua C, Ferrari M, Ferree C, Glover G, Grinde B, Guran S, Kucinskas V, Lavinha J, Mercier B, Ogur G, Peltonen L, Rosatelli C, Schwartz M, Spitsyn V, Timar L, Beckman L, Parmentier M, Vassart G. 1998. The Delta ccr5 mutation conferring protection against HIV-1 in Caucasian populations has a single and recent origin in Northeastern Europe. Hum. Mol. Genet. 7:399-106
167. Simonsen JN, Fowke KR, MacDonald KS, Plummer FA. 1998. HIV pathogenesis: mechanisms of susceptibility and disease progression. Curr. Opin. Microbiol. 1:423-29
168. Zagury D, Lachgar A, Chains V, Fall LS, Bernard J, Zagury JF, Bizzini B, Gringeri A, Santagostino E, Rappaport J, Feldman M, O'Brien SJ, Burny A, Gallo RC. 1998. C-C chemokines, pivotal in protection against HIV type 1 infection. Proc. Natl. Acad. Sci. USA 95:3857-61
169. Paxton WA, Liu R, Kang S, Wu LJ, Gingeras TR, Landau NR, Mackay CR, Koup RA. 1998. Reduced HIV-1 infectabilily of CD4(+) lymphocytes from exposed-uninfected individuals: association with low expression of CCR5 and high production of beta-chemokines. Virology 244:66-73
170. Fauci AS. 1996. Host factors and the pathogenesis of HIV-induced disease. Nature 384:529-34
171. Eugen-Olsen J, Iversen AKN, Benfield TL, Koppelhus U, Garred P. 1998. Chemokine receptor CCR2b 641 polymorphism and its relation to CD4 T-cell counts and disease progression in a Danish cohort of HIV-infected individuals. J. Acquired Immune Defic. Syndr. 18:110-16
172. Meyer L, Magierowska M, Hubert JB, Rouzioux C, Deveau C, Sanson F, Debre P, Delfraissy JF, Theodorou I, the SEROCO Study Group. 1997. Early protective effect of CCR-5 delta 32 heterozygosity on HIV-1 disease progression: relationship with viral load. AIDS 11:F73-F78
173. McDermott DH, Zimmerman PA, Guig-nard F, Kleeberger CA, Leitman SF, Murphy PM. 1998. CCR5 promoter polymorphism and HIV-1 disease progression. Lancet 352:866-70
174. Smith MW, Dean M, Carrington M, Winkler C, Huttley GA, Lomb DA, Goedert JJ, O'Brien TR, Jacobson LP, Kaslow R, Buchbinder S, Vittinghof E, Vlahov D, Hoots K, Hilgartner MW, Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study, O'Brien SJ. 1997. Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Science 277:959 64
175. Kostrikis LG, Huang Y, Moore JP, Wolinsky SM, Zhang LQ, Guo Y, Deutsch L, Phair J, Neumann AU, Ho DD. 1998. A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation. Nature Med. 4:350-53
176. Winkler C, Modi W, Smith MW, Nelson GW, Wu X, Carrington M, Dean M, Honjo T, Tashiro K, Yabe D, Buchbinder S, Vittinghoff E, Goedert JJ, O'Brien TR, Jacobson LP, Detels R, Donfield S, Willoughby A, Gomperts E, Vlahov D, Phair J, ALIVE Study, Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), O'Brien SJ. 1998. Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. Science 279: 389-93
177. Cohen OJ, Paolucci S, Bende SM, Daucher M, Moriuchi H, Moriuchi M, Cicala C, Davey RT, Baird B, Fauci AS. 1998. CXCR4 and CCR5 genetic polymorphisms in long-term nonprogressive human immunodeficiency virus infection: lack of association with mutations other than CCR5-Delta 32. J. Virol. 72:6215-17
178. Samson M, Soularue P, Vassart G, Parmentier M. 1996. The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21. 3-p24 region of chromosome 3. Genomics 36:522-526
179. Cohen OJ, Vaccarezza M, Lam GK, Baird BF, Wildt K, Murphy PM, Zimmerman PA, Nutman TB, Fox CH, Hoover S, Adelsberger J, Baseler M, Arthos J, Davey RT Jr, Dewar RL, Metcalf J, Schwartzentruber DJ, Orenstein JM, Buchbinder S, Saah AJ, Detels R, Phair J, Rinaldo C, Margolick JB, Fauci AS. 1997. Heterozygosity for a defective gene for CC chemokine receptor 5 is not the sole determinant for the immunologic and virologic phenotype of HIV-infected long-term nonprogressors. J. Clin. Invest. 100:1581-89
180. Blaak H, Vantwout AB, Brouwer M, Cornelissen M, Kootstra NA, Albrechtvanlent N, Keet RPM, Goudsmit J, Coutinho RA, Schuitemaker H. 1998. Infectious cellular load in human immunodeficiency virus type I (HIV-1)-infected individuals and susceptibility of peripheral blood mononuclear cells from their exposed partners to non-syncytium-inducing HTV-1 as major determinants for HIV-1 transmission in homosexual couples. J. Virol. 72:218-24
181. Picchio GR, Gulizia RJ, Mosier DE. 1997. Chemokine receptor CCR5 genotype influences the kinetics of human immunodeficiency virus type 1 infection in human PBL-SCID mice. J. Virol. 71:7124-27
182. Garred P, Eugen-Olsen J, Iversen AK, Benfield TL, Svejgaard A, Hofmann B. 1997. Dual effect of CCR5 delta 32 gene deletion in HIV-1 -infected patients. Copenhagen AIDS Study Group. Lancet 349:1884
183. Rizzardi GP, Morawetz RA, Vicenzi E, Ghezzi S, Poli G, Lazzarin A, Pantaleo G. 1998. CCR2 polymorphism and HIV disease. Nature Med. 4:252-53
184. Michael NL, Louie LG, Rohrbaugh AL, Schultz KA, Dayhoff DE, Wang CE, Sheppard HW. 1997. The role of CCR5 and CCR2 polymorphisms in HIV-1 transmission and disease progression. Nature Med. 3:1160-62
185. Anzala AO, Ball TB, Rostron T, O'Brien SJ, Plummer FA, Rowland-Jones S, Univ. Nairobi Collab. HIV Res. 1998. CCR2-64I allele and genotype association with delayed AIDS progression in African women. Lancet 351:1632-33
186. Mellors JW, Rinaldo CR, Gupta P, White RM, Todd JA, Kingsley LA. 1996. Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science 272:1167-70
187. Lee B, Doranz BJ, Doms RW. 1998. Influence of the CCR2-V64I polymorphism on human immunodeficiency virus type 1 coreceptor activity and on hemokine receptor function of CCR2b, CCR3, CCR5 and CXCR4. J. Virol. 72: 2509-15
188. Mummidi S, Ahuja SS, McDaniel BL, Ahuja SK. 1997. The human CC chemokine receptor 5 (CCR5) gene: multiple transcripts with 5′-end heterogeneity, dual promoter usage, and evidence for polymorphisms within the regulatory regions and noncoding exons. J. Biol. Chem. 272:30662-71
189. Carrington M, Kissner T, Gerrard B, Ivanov S, O'Brien SJ, Dean M. 1997. Novel alleles of the chemokine-receptor gene CCR5. Am. J. Hum. Genet. 61: 1261-67
190. + T cells. Science 276:273-76
191. Valentin A, Lu WH, Rosati M, Schneider R, Albert J, Karlsson A, Pavlakis GN. 1998. Dual effect of interleukin 4 on HIV-1 expression: implications for viral phenotypic switch and disease progression. Proc. Natl. Acad. Sci. USA 95:8886-91
192. Tedla N, Palladinetti P, Kelly M, Kumar RK, DiGirolamo N, Chattophadhay U, Cooke B, Truskett P, Dwyer J, Wakefield D, Lloyd A. 1996. Chemokines and T lymphocyte recruitment to lymph nodes in HIV infection. Am. J. Pathol. 148:1367-73
193. Trumfheller C, Tenner-Racz K, Racz P, Fleischer B, Frosch S. 1998. Expression of macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta, and RANTES genes in lymph nodes from HIV+ individuals: correlation with a Th1-type cytokine response. Clin. Exp. Immunol. 112:92-99
194. Margolis LB, Glushakova S, Grivel J-C, Murphy PM. 1998. Blockade of CC chemokine receptor 5 (CCR5)-tropic human immunodeficiency virus-1 replication in human lymphoid tissue by CC chemokines. J. Clin. Invest. 101:1876-80
195. D'Aquila RT, Sutton L, Savara A, Hughes MD, Johnson VA. 1998. CCRS/Δ ccr5 heterozygosity: a selective pressure for the syncytium-inducing human immunodeficiency virus type 1 phenotype. J. Infect. Dis. 177:1549-53
196. Dolei A, Biolchini A, Serra C, Curreli S, Gomes E, Dianzani F. 1998. Increased replication of T-cell-tropic HIV strains and CXC-chemokine receptor-4 induction in T cells treated with macrophage inflammatory protiein (MTP)-1 alpha, MIP-1 beta and RANTES beta-chemokines. AIDS 12: 183-90
197. Ostrowski MA, Justement SJ, Catanzaro A, Hallahan CA, Ehler LA, Mizell SG, Kumar PN, Mican JA, Chun TW, Fauci AS. 1998. Expression of chemokine receptors CXCR4 and CCR5 in HIV-1-infected and uninfected individuals. J. Immunol. 161:3195-3201
198. Glushakova S, Baibakov B, Zimmerberg J. Margolis LB. 1997. Experimental HIV infection of human lymphoid tissue: correlation of CD4+ T cell depletion and virus syncytium-inducing/non-syncytium-inducing phenotype in histocultures inoculated with laboratory strains and patient isolates of HIV type 1. AIDS Res. Hum. Retroviruses 13:461-71
199. Picchio GR, Gulizia RJ, Wehrly K, Chesebro B, Mosier DE. 1998. The cell tropism of human immunodeficiency virus type 1 determines the kinetics of plasma viremia in SCID mite reconstituted with human peripheral blood leukocytes. J. Virol. 72:2002-9
200. Weissman D, Rabin RL, Arthos J, Rubbert A, Dybul M, Swofford R, Venkatesan S, Farber JM, Fauci AS. 1997. Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor. Nature 389:981-85
201. Davis CB, Dikie I, Unutmaz D, Hill CM, Arthos J, Siani MA, Thompson DA, Schlessinger J, Littman DR. 1997. Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5. J. Exp. Med. 186:1793-98
202. Hesselgesser J, Taub D, Baskar P, Greenberg M, Hoxie J, Kolson DL, Horuk R. 1998. Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1 alpha is medialed by the chemokine receptor CXCR4. Curr. Biol. 8:595-98
203. Herbein G, Mahlknecht U, Batliwalla F, Gregersen P, Pappas T, Butler J, O'Brien WA, Verdin E. 1998. Apoptosis of CD8(+) T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4. Nature 395:189-94
204. Madani N, Kozak SL, Kavanaugh MP, Kabat D. 1998. gp120 Envelope glycoproteins of human immunodeficiency viruses competitively antagonize signaling by corcccptors CXCR4 and CCR5. Proc. Natl. Acad. Sci. USA 95:8005-10
205. Ueda H, Howard OMZ, Grimm MC, Su SB, Gong WH, Evans G, Ruscetti FW, Oppenheim JJ, Wang JM. 1998. HIV-1 envelope gp41 is a potent inhibitor of chemoattractant receptor expression and function in monocytes. J. Clin. Invest. 102:804-12
206. Tiffany HL, Lautens LL, Gao J-L, Pease J, Locati M, Combadiere C, Modi W, Bonner TI, Murphy PM. 1997. Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309. J. Exp. Med. 186:165-70
207. Napolitano M, Zingoni A, Bernardini G, Spinetti G, Nista A, Storlazzi CT, Rocchi M, Samoni A. 1996. Molecular cloning of TER1, a chemokine receptor-like gene expressed by lymphoid tissues. J. Immunol. 157:2759-63
208. McCune JM. 1997. Thymic function in HIV-1 disease. Semin. Immunol. 9:397-404
209. Arenzana-Seisdedos F, Virelizier J-L, Roussel D, Clark-Lewis I, Loetscher P, Moser B, Baggiolini M. 1996. HIV blocked by chemokine antagonist. Nature 383:400
210. Simmons G, Clapham PR, Picard L, Offord RE, Rosenkilede NM, Schwartz TW, Buser R, Wells TNC, Proudfoot AE. 1997. Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist. Science 276:276-79
211. Struyf S, De Meester I, Scharpe S, Lanaerts JP, Menten P, Wang JM, Proost P, Van Damme J. 1998. Natural truncation of RANTES abolishes signaling through the CC chemokine receptors CCR1 and CCR3, impairs its chemotactic potency and generates a CC chemokine inhibitor. Eur. J. Immunol. 28:1262-71
212. Clemons MJ, Marshall E, Durig J, Watanabe K, Howell A, Miles D, Earl H, Kieman J, Griffiths A, Towlson K, DeTakats P, Testa NG, Dougal M, Hunter MG, Wood LM, Czaplewski LG, Millar A, Dexter TM, Lord BI. 1998. Randomized phase-II study of BB-10010 (macrophage inflammatory protein-1 alpha) in patients with advanced breast cancer receiving 5-fluorouracil, adriamycin, and cyclophosphamide chemotherapy. Blood 92:1532-40
213. Heveker N, Montes M, Germeroth L, Amara A, Trautman A, Alizon M, Schneider-Mergener J. 1998. Dissociation of the signalling and antiviral properties of SDF-1-derived small peptides. Curr. Biol. 8:369-76
214. Nishiyama Y, Murakami T, Kurita K, Yamamoto N. 1998. Synthesis of some peptides corresponding to the active region of RANTES for chemotaxis and evaluation of their anti-human immunodeficiency virus-1 activity. Chem. Pharmacolog. Bull. 45:2125-27
215. Doranz BJ, Grovit-Ferbas K, Sharron MP, Mao SH, Goetz MB, Daar ES, Doms RW, O'Brien WA. 1997. A small-molecule inhibitor directed against the chemokine receptor CXCR4 prevents its use as an HIV-1 coreceptor. J. Exp. Med. 186:1395-1400
216. Schols D, Struyf S, Van Damme J, Este JA, Henson G, De Clercq E. 1997. Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4. J. Exp. Med. 186:1383-88
217. Murakami T, Nakajima T, Koyanagi Y, Tachibana K, Fujii N, Tamamura H, Yoshida N, Waki M, Matsumoto A, Yoshie O, Kishimoto T, Yamamoto N, Nagasawa T. 1997. A small molecule CXCR4 inhibitor that blocks T cell line-tropic HIV-1 infection. J. Exp. Med. 186:1389-93
218. Howard OMZ, Openheim JJ, Hollingshead MG, Covey JM, Bigelow J, McCormack JJ, Buckheit RW, Clanton DJ, Turpin JA, Rice WG. 1998. Inhibition of in vitro and in vivo HIV replication by a distamycin analogue that interferes with chemokine receptor function: a candidate for chemotherapeutic and microbicidal application. J. Med. Chem. 41:2184-93
219. Datema R, Rabin L, Hincenbergs M, Moreno MB, Warren S, Linquist V, Rosenwirth B, Seifert J, McCune JM. 1996. Antiviral efficacy in vivo of the anti-human immunodeficiency virus bicyclam SDZ SID 791 (JM 3100), an inhibitor of infectious cell entry. Antimicrob. Agents Chemother. 40:750-54
220. Levine BL, Cotte J, Carroll RG, Riley JL, Small CS, Francomano TN, Weislow OS, St. Louis DC, Bernstein W, June CH. 1997. A phase 1 dose-escalation study of polyclonal CD4 T cell ex vivo expansion for immune system restoration of HIV infection. J. Aller. Clin. Immunol. 99, Part 2, Suppl.:1625
221. Goila R, Banerjea AC. 1998. Sequence specific cleavage of the HIV-1 coreceptor CCR5 gene by a hammer-head ribozyme and a DNA enzyme: inhibition of the coreceptor function by DNA-enzyme. FEBS Lett. 436:233-38
222. Chen JD, Bai X, Yang AG, Cong Y. Chen SY. 1997. Inactivation of HIV-1 chemokine co-receptor CXCR-4 by a novel intrakine strategy. Nature Med. 3:1110-16
223. Yang AG, Bai X, Huang XF, Yao C, Chen S. 1997. Phenotypic knockout of HIV type 1 chemokine coreceptor CCR5 by intrakines as potential therapeutic approach for HIV-1 infection. Proc. Natl. Acad. Sci. USA 94:11567-72
224. Mebatsion T, Finke S, Weiland F, Conzelmann KK. 1997. A CXCR4/CD4 pseudotype rhabdovirus that selectively infects HIV-1 envelope protein-expressing cells. Cell 90:841-47
225. Schnell MJ, Johnson JE, Buonocore L, Rose JK. 1997. Construction of a novel virus that targets HIV-1-infected cells and controls HIV-1 infection. Cell 90:849-57
226. Endres MJ, Jaffer S, Haggarty B, Turner JD, Doranz BJ, O'Brien PJ, Kolson DL, Hoxie JA. 1997. Targeting of HIV-and SIV-infected cells by CD4-chemokine receptor pseudotypes. Science 278:1462-64
227. Nagasawa T, Hirota S, Tachibana K, Takakura N, Nishikawa S, Kitamura Y, Yoshida N, Kikutnai H, Kishimoto T. 1996. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 382: 635-38
228. Tachibana K, Hirota S, Iizasa H, Yoshida H, Kawabata K, Kataoka Y, Kitamura Y, Matsushima K, Nishikawa S, Kishimoto T, Nagasawa T. 1998. The chemokine rccptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature 393:591-94
229. Zou YR, Kottmann AH, Kuroda M, Taniuchi I, Littman DR. 1998. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 393:595-99
230. Martin MP, Dean M, Smith MW, Winkler C, Gerrard B, Michael NL, Lee B, Doms RW, Margolick J, Buchbinder S, Goedert JJ, O'Brien TR, Hilgartner MW, Vlahov D, O'Brien SJ, Carrington M. 1998. Genetic acceleration of AIDS progression by a promoter variant of CCR5. Science 282:1907-11