Structure of the human smoothened receptor bound to an antitumour agent

Nature

Volumn 497, Issue 7449, 2013, Pages 338-343

  Wang, Chong ^a   Wu, Huixian ^a   Katritch, Vsevolod ^a   Han, Gye Won ^a   Huang, Xi Ping ^b   Liu, Wei ^a   Siu, Fai Yiu ^a   Roth, Bryan L ^b   Cherezov, Vadim ^a   Stevens, Raymond C ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; G PROTEIN COUPLED RECEPTOR; LY 2940680; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

BIOLOGICAL DEVELOPMENT; CARCINOGEN; CHEMICAL BONDING; CRYSTAL STRUCTURE; DISEASE RESISTANCE; EMBRYO; LIGAND; MEMBRANE; PROTEIN; SIGNALING; TUMOR;

ARTICLE; BINDING SITE; CELL DIFFERENTIATION; CELL POLARITY; CELL PROLIFERATION; CRYSTAL STRUCTURE; DRUG RECEPTOR BINDING; HUMAN; LIGAND BINDING; PHYLOGENY; PRIORITY JOURNAL; PROTEIN STRUCTURE; REGULATORY MECHANISM; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANTINEOPLASTIC AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DISULFIDES; FRIZZLED RECEPTORS; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHTHALAZINES; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURAL HOMOLOGY, PROTEIN;

ERINACEIDAE;

EID: 84878112106     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12167     Document Type: Article

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