Change in coreceptor use correlates with disease progression in HIV-1- infected individuals

Journal of Experimental Medicine

Volumn 185, Issue 4, 1997, Pages 621-628

  Connor, Ruth I ^a   Sheridan, Kristine E ^a   Ceradini, Daniel ^a   Choe, Sunny ^a   Landau, Nathaniel R ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN P24; GLYCOPROTEIN GP 120; GLYCOPROTEIN GP 41; VIRUS RECEPTOR; VIRUS ENVELOPE PROTEIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; HELPER CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; VIRUS ISOLATION; VIRUS REPLICATION; CD4 LYMPHOCYTE COUNT; CELL LINE; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM;

CD4 LYMPHOCYTE COUNT; CELL LINE; DISEASE PROGRESSION; GENE PRODUCTS, ENV; HIV INFECTIONS; HIV-1; HUMANS; RECEPTORS, VIRUS;

EID: 0031575431     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.185.4.621     Document Type: Article

References (40)

1. Cheng-Mayer, C., D. Seto, M. Tateno, and J.A. Levy. 1988. Biologic features of HIV-1 that correlate with virulence in the host. Science (Wash. DC). 240: 80-82.
2. Connor, R.I., and D.D. Ho. 1994. Human immunodeficiency virus type 1 variants with increased replicative capacity develop during the asymptomatic stage before disease progression. J. Virol. 68:4400-4408.
3. Fenyö, E., L. Morfeldt-Måson, F. Chiodi, B. Lind, A. Von Gegerfelt, J. Albert, and B. Åsjö. 1988. Distinctive replicative and cytopathic characteristics of human immunodeficiency virus isolates. J. Virol. 62:4414-4419.
4. Schuitemaker, H., M. Koot, N.A. Kootsra, M. Wouter-Dercksen, R.E.Y. de Goede, R.P. Van Steenwijk, J.M.A. Lange, J.K.M. Eeftink-Schattenkerk, F. Miedema, and M. Tersmette. 1992. Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell tropic virus populations. J. Virol. 66:1354-1360.
5. + T-lymphocyte decline and clinical progression in HIV-1 infected individuals. J. Virol. 67:1772-1778.
6. Roos, M.T.L., J.M.A. Lange, R.E.Y. de Goede, R.A. Coutinho, P.T.A. Schellekens, F. Miedema, and M. Tersmette. 1992. Viral phenotype and immune response in primary human immunodeficiency virus type 1 infection. J. Infect. Dis. 165:427-432.
7. Zhu, T., H. Mo, N. Wang, D.S. Nam, Y. Cao, R.A. Koup, and D.D. Ho. 1993. Genotypic and phenotypic characterization of HIV-1 in patients with primary infection. Science (Wash. DC). 261:1179-1181.
8. Tersmette, M., R.E.Y. de Goede, B.J.M. Al, I.N. Winkel, R.A. Gruters, H.T. Cuypers, H.G. Huisman, and F. Miedema. 1988. Differential syncytium-inducing capacity of human immunodeficiency virus isolates: frequent detection of syncytium-inducing isolates in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. J. Virol. 62:2026-2032.
9. Tersmette, M., J.M.A. Lange, R.E.Y. de Goede, F. de Wolf, J.K.M. Eeftink-Schattenkerk, P.T.A. Schellenkens, R.A. Coutinho, J.G. Huisman, J. Goudsmit, and F. Miedema. 1989. Association between biological properties of human immunodeficiency virus variants and risk tor AIDS mortality. Lancet. i:983-985.
10. Cheng-Mayer, C., M. Quiroga, J.W. Tung, D. Dina, and J.A. Levy. 1990. Viral determinants of human immunodeficiency virus type 1 T-cell or macrophage tropism, cytopathogenicity, and CD4 antigen modulation. J. Virol. 64:4390-4398.
11. De Jong, J.-J., J. Goudsmit, W. Keulen, B. Klaver, W. Krone, M. Tersmette, and A. de Ronde. 1992. Human immunodeficiency virus type 1 clones chimeric for the envelope V3 domain differ in syncytium formation and replication capacity. J. Virol. 66:757-765.
12. O'Brien, W.A., Y. Kovanagi, A. Namazie, J.Q. Zhao, A. Diagne, K. Idler, J.A. Zack, and I.S. Chen. 1990. HIV-1 tropism for mononuclear phagocytes can be determined by regions ot gp120 outside the CD4-binding domain. Nature (Lond.). 348:69-73.
13. Shioda, T., J.A. Levy, and C. Cheng-Mayer. 1991. Macrophage and T cell-line tropisms of HIV-1 are determined by specific regions of the envelope gp120 gene. Nature (Lond.). 349:167-169.
14. Westervelt, P., D.B. Trowbridge, L.G. Epstein, B.M. Blumberg, Y. Li, D.H. Hahn, G.M. Shaw, B.W. Price, and L. Ratner. 1992. Macrophage tropism determinants of human immunodeficiency virus type 1 in vivo. J. Virol. 66:2577-2582.
15. Moore, J.P., B.A. Jameson, R.A. Weiss, and Q.J. Sattentau. 1993. The HIV-cell fusion reaction. In Viral Fusion Mechanisms. J. Betz, editor. CRC Press, Inc., Boca Raton, FL. 233-289.
16. Ashorn, P., E. Berger, and J. Moss. 1990. Human immunodeficiency virus envelope glycoprotein/CD4-mediated fusion of nonprimate cells with human cells. J. Virol. 64:2149-2156.
17. Chesebro, B., R. Buller, J. Protis, and K. Wehrly. 1990. Failure of human immunodeficiency virus entry and infection in CD4-positive human brain and skin cells. J. Virol. 64:215-221.
18. Maddon, P.J., A.G. Dalgleish, J.S. McDougal, P.R. Clapham, R.A. Weiss, and R. Axel. 1986. The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell. 47:333-348.
19. Choe, H., M. Farazan, Y. Sun, N. Sullivan, B. Rollins, P.D. Ponath, L. Wu, C.R. Mackay, G. LaRosa, W. Newman, N. Gerard, C. Gerard, and J. Sodroski. 1996. The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell. 85:1135-1148.
20. Deng, H.K., S. Choe, W. Ellmeier, R. Liu, D. Unutmaz, M. Burkhart, P. DiMarzio, S. Marmon, R.E. Sutton, C.M. Hill et al. 1996. Identification of C-C chemokine receptor 5 as the major coreceptor for entry of macrophage-tropic human immunodeficiency virus type-1. Nature (Lond.). 381:661-666.
21. + cells via the C-C CKR5 co-receptor. Nature (Lond.). 381:667-673.
22. Doranz, B.J., J. Rucker, Y. Yi, R.J. Smyth, M. Samson, S. Peiper, M. Parmentier, R.G. Collman, and R.W. Doms. 1996. A dual-tropic, primary HIV-I isolate that uses fusin and the β-chemokine receptors CKR5, CKR3, and CKR-2b as fusion cofactors. Cell. 85:1149-1158.
23. Feng, Y., C.C. Broder, P.E. Kennedy, and E.A. Berger. 1996. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science (Wash. DC). 272:872-877.
24. Alkhatib, G., C. Combadiere, C.C. Broder, Y. Feng, P.E. Kennedy, P.M. Murphy, and E.A. Berger. 1996. CC CKR5: A RANTES, MIP-1α. MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science (Wash. DC). 272: 1955-1958.
25. Horuk, R. 1994. Molecular properties of the chemokine receptor family. Trends Pharmacol. Sci. 15:159-165.
26. Bleul, C.C., M. Farzan, H. Choe, G. Parolin, I. Clark-Lewis, J. Sodroski, and T.A. Springer. 1996. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature (Lond.). 382:829-833.
27. Oberlin, E., A. Amara, F. Bachelerie, C. Bessia, J.L. Virelizier, F. Arenzana-Seisdedos, O. Schwartz, J.M. Heard, I. Clark-Lewis, D.F. Legler, M. Loetscher, M. Baggiolini, and B. Moser. 1996. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell line adapted HIV-1. Nature (Lond.) 382:833-835.
28. Samson, M., O. Labbe, C. Mollereau, G. Vassert, and M. Parmentier. 1996. Molecular cloning and functional expression of a new human C-C-chemokine receptor gene. Biochemistry. 35:3362-3367.
29. Koot, M., A.H.V. Vos, R.P.M. Keet, R.E.Y. de Goede, M.W. Dercksen, F.G. Terpstra, R.A. Coutinho, F. Miedema, and M. Tersmette. 1992. HIV-1 biological phenotype in long-term infected individuals evaluated with an MT-2 cocultivation assay. AIDS (Phila). 6:49-54.
30. Connor, R.I., D.W. Notermans, H. Mohri, Y. Cao, and D.D. Ho. 1993. Biological cloning of functionally diverse quasispecies of HIV-1. AIDS Res. Hum. Retroviruses. 9:541-546.
31. Dulbecco, R. 1988. End-point method measurement of the infectious titer of a viral sample. In Virology. 2nd ed. J.P. Lippincott, Philadelphia, PA. 22-25.
32. Liu, R., W.A. Paxton, S. Choe, D. Ceradini, S.A. Martin, R. Horuk, M.E. Macdonald, H. Stuhlmann, R.A. Koup, and N.R. Landau. 1996. Homozygous defect in HIV-1 coreceptor accounts for resistance of some mutiply-exposed individuals to HIV-1 infection. Cell 87:367-377.
33. Connor, R.I., K.E. Sheridan, C. Lai, L. Zhang, and D.D. Ho. 1996. Characterization of the functional properties of env genes from long-term survivors of human immunodeficiency virus type-1 infection. J. Virol. 70:5306-5311.
34. Connor, R.I., B.K. Chen, S. Choe, and N.R. Landau. 1995. Vpr is required for efficient replication of human immunodeficiency virus type 1 in mononuclear phagocytes. Virology. 206:935-944.
35. De Jong, J.-J., A. de Ronde, W. Keulen, M. Tersmette, and J. Goudsmit. 1992. Minimal requirements for the human immunodeficiency virus type 1 V3 domain to support the syncytium-inducing phenotype: analysis by single amino acid substitution. J. Virol. 66:6777-6780.
36. Fouchier, R.A.M., M. Groenink, N.A. Kootstra, M. Tersmette, H.G. Huisman, F. Miedema, and H. Schuitemaker. 1992. Phenotype-associated sequence variation in the third variable domain of the human immunodeficiency virus type 1 gp120 molecule. J. Virol. 66:3183-3187.
37. + T-lymphocytes from two multiply exposed, uninfected individuals resist infection with primary NSI isolates of human immunodeficiency virus type-1. J. Virol. 70:8758-8764.
38. Paxton, W.A., S.R. Martin, D. Tse, T.R. O'Brien, J. Skurnick, N.L. VanDevanter, N. Padian, J.F. Braun, D.P. Kotler, S.M. Wolinsky, and R.A. Koup. 1996. Relative resistance of HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposures. Nat. Med. 2:412-417.
39. Ho, D.D., A.U. Neumann, A.S. Perelson, W. Chen, J.M. Leonard, and M. Markowitz. 1995. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature (Lond.). 373:123-126.
40. Wei, X., S.K. Ghosh, M.E. Taylor, V.A. Johnson, E.A. Emini, P. Duestch, J.D. Lifson, S. Bonhoeffer, M.A. Nowak, B.H. Hahn, and G.M. Shaw. 1995. Viral dynamics in human immunodeficiency virus type 1 infection. Nature (Lond.). 373: 117-122.