Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist

Journal of Experimental Medicine

Volumn 201, Issue 8, 2005, Pages 1307-1318

  Broxmeyer, Hal E ^a,b   Orschell, Christie M ^a   Clapp, D Wade ^a   Hangoc, Giao ^a,b   Cooper, Scott ^a,b   Plett, P Artur ^a   Liles, W Conrad ^c   Li, Xiaxin ^a   Graham Evans, Barbara ^a,b   Campbell, Timothy B ^a,b   Calandra, Gary ^d   Bridger, Gary ^d   Dale, David C ^c   Srour, Edward F ^a  

^a INDIANA UNIVERSITY   (United States)

^b WALTHER CANCER INSTITUTE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d GENZYME CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,1' [1,4 PHENYLENEBIS(METHYLENE)]BIS(1,4,8,11 TETRAAZACYCLOTETRADECANE); CHEMOKINE RECEPTOR CXCR4; GRANULOCYTE COLONY STIMULATING FACTOR; STROMAL CELL DERIVED FACTOR 1;

ANIMAL CELL; ARTICLE; BONE MARROW; BONE PAIN; CD34 SELECTION; CELL MOTILITY; CELL POPULATION; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR BINDING;

ANIMALS; ANTIGENS, CD34; CHEMOKINES, CXC; COLONY-FORMING UNITS ASSAY; DRUG SYNERGISM; GRANULOCYTE COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM CELLS; HETEROCYCLIC COMPOUNDS; HUMANS; MICE; MICE, INBRED STRAINS; MICE, SCID; RECEPTORS, CXCR4;

EID: 20944440068     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20041385     Document Type: Article

References (54)

1. Kondo, M., A.J. Wagers, M.G. Manz, S.S. Prohaska, D.C. Scherer, G.F. Beilhack, J.A. Shizuru, and I.L. Weissman. 2003. Biology of hematopoietic stem cells and progenitors: implications for clinical application. Annu. Rev. Immunol. 21:759-806.
2. Manz, M.G., K. Akashi, and I.L. Weissman. 2004. Biology of hematopoietic stem and progenitor cells. In Thomas' Hematopoietic Cell Transplantation. 3rd ed. K.G. Blume, S.J. Forman, and F.R. Appelbaum, editors. Blackwell Publishing Ltd., Maiden, MA. 69-95.
3. Cooper, S., and H.E. Broxmeyer. 1996. Measurement of interleukin-3 and other hematopoietic growth factors, such as GM-CSF, G-CSF, M-CSF, erythropoietin and the potent co-stimulating cytokines steel factor and Flt-3 ligand. In Current Protocols in Immunology. J.E. Coligan, A.M. Kruisbeek, D.H. Margulies, E.M. Shevach, W. Strober, and R. Coico, editors. John Wiley & Sons, Inc., NY. Supp. 18, 6.4.1-6.4.12.
4. Wright, D.E., A.J. Wagers, A.P. Gulati, F.L. Johnson, and L.L. Weissman. 2001. Physiological migration of hematopoietic stem and progenitor cells. Science. 294:1933-1936.
5. Abkowitz, J.L., A.E. Robinson, S. Kale, M.W. Long, and J. Chen. 2003. The mobilization of hematopoietic stem cells during homeostasis and after cytokine exposure. Blood. 102:1249-1253.
6. Broxmeyer, H.E., and F.O. Smith. 2004. Cord blood hematopoietic cell transplantation. In Thomas' Hematopoietic Cell Transplantation. 3rd ed. K.G. Blume, S.J. Forman, and F.R. Appelbaum, editors. Blackwell Publishing Ltd., Malden, MA. 550-564.
7. Ng-Cashin, J., and T. Shen. 2004. Mobilization of autologous peripheral blood hematopoietic cells for support of high-dose cancer therapy. In Thomas' Hematopoietic Cell Transplantation. 3rd ed. K.G. Blume, S.J. Forman, and F.R. Appelbaum, editors. Blackwell Publishing, Ltd., Malden, MA. 576-587.
8. Schmitz, N. 2004. Peripheral blood hematopoietic cells for allogeneic transplantation. In Thomas' Hematopoietic Cell Transplantation. 3rd ed. K.G. Blume, S.J. Forman, and F.R. Appelbaum, editors. Blackwell Publishing, Ltd., Malden, MA. 588-598.
9. Papayannopoulou, T. 2004. Current mechanistic scenarios in hematopoietic stem/progenitor cell mobilization. Blood. 103:1580-1588.
10. Roberts, A.W., E. DeLuca, C.G. Begley, R. Basser, A.P. Grigg, and D. Metcalf. 1995. Broad inter-individual variations in circulating progenitor cell numbers induced by granulocyte colony-stimulating factor therapy. Stem Cells. 13:512-516.
11. Roberts, A.W., S. Foote, W.S. Alexander, C. Scott, L. Robb, and D. Metcalf. 1997. Genetic influences determining progenitor cell mobilization and leukocytosis induced by granulocyte colony-stimulating factor. Blood. 9:2736-2744.
12. De Haan, G., A. Ausema, M. Wilkens, G. Molineux, and B. Dontje. 2000. Efficient mobilization of haematopoietic progenitors after a single injection of pegylated recombinant human granulocyte colony-stimulating factor in mouse strains with distinct marrow-cell pool sizes. Br. J. Haematol. 110:638-646.
13. Croop, J.M., R. Cooper, C. Fernandez, V. Graves, S. Kreissman, H. Hanenberg, F.O. Smith, and D.A. Williams. 2001. Mobilization and collection of peripheral blood CD34+ cells from patients with Fanconi anemia. Blood. 98:2917-2921.
14. Hu, J., and C.E. Dunbar. 2002. Update on hematopoietic stem cell gene transfer using non-human primate models. Curr. Opin. Mol. Ther. 4:482-490.
15. + progenitors to peripheral blood. J. Exp. Med. 185:111-120.
16. Kim, C.H., and H.E. Broxmeyer. 1998. In vitro behavior of hematopoietic progenitor cells under the influence of chemoattractants: stromal cell-derived factor-1, steel factor and the bone marrow environment. Blood. 91:100-110.
17. Jo, D.-Y., S. Rafii, T. Hamada, and M.A.S. Moore. 2000. Chemotaxis of primitive hematopoietic cells in response to stromal cell-derived factor-1. J. Clin. Invest. 105:101-111.
18. Wright, D.E., E.P. Bowman, A.J. Wagers, E.C. Butcher, and L.L. Weissman. 2002. Hematopoietic stem cells are uniquely selective in their migratory response to chemokines. J. Exp. Med. 195:1145-1154.
19. Peled, A., I. Petit, O. Kollet, M. Magid, T. Ponomaryov, T. Byk, A. Nagler, H. Ben-Hur, A. Many, L. Shultz, O. Lider, R. Alon, D. Zipori, and T. Lapidot. 1999. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science. 283:845-848.
20. null mice. Leukemia. 16:1992-2203.
21. Christopherson, K.W., II, G. Hangoc, C. Mantel, and H.E. Broxmeyer. 2004. Modulation of hematopoietic stem cell homing and engraftment by CD26. Science. 305:1000-1003.
22. Broxmeyer, H.E., S. Cooper, L. Kohli, G. Hangoc, Y.H. Lee, C. Mantel, D.W. Clapp, and C.H. Kim. 2003. Transgenic expression of stromal cell derived factor-1/CXCL12 enhances myeloid progenitor cell survival/anti-apoptosis in vitro in response to growth factor withdrawal and enhances myelopoiesis in vivo. J. Immunol. 170:421-429.
23. Broxmeyer, H.E., L. Kohli, C.H. Kim, Y. Lee, C. Mantel, S. Cooper, G. Hangoc, M. Shaheen, X. Li, and D.W. Clapp. 2003. Stromal cell derived factor-1/CXCL12 enhances survival/anti-apoptosis of hematopoietic stem and myeloid progenitor cells: direct effects mediated through CXCR4 and Gαi proteins. J. Leuk. Biol. 73:630-638.
24. Shen, H., T. Cheng, I. Olszak, E. Garcia-Zepeda, Z. Lu, S. Hermann, R. Fallon, A.D. Luster, and D.T. Scadden. 2001. CXCR-4 desensitization is associated with tissue localization of hematopoietic progenitor cells. J. Immunol. 166:5027-5033.
25. Hattori, K., B. Heissig, K. Tashiro, T. Honjo, M. Tateno, J.H. Shieh, N.R. Hackett, M.S. Quitoriano, R.G. Crystal, S. Rafii, and M.A. Moore. 2001. Plasma elevation ot stromal cell-derived factor-1 induced mobilization of mature and immature hematopoietic progenitor and stem cells. Blood. 97:3354-3360.
26. Sweeny, E.A., H. Lortat-Jacob, G.V. Priestley, B. Nakamoto, and T. Papayannopoulou. 2002. Sulfated polysaccharides increase plasma levels of SDF-1 in monkeys and mice: involvement in mobilization of stem/progenitor cells. Blood. 99:44-51.
27. Petit, I., M. Szyper-Kravitz, A. Nagler, M. Lahav, A. Peled, L. Habler, T. Ponomaryov, R.S. Taichman, F. Arenzana-Seisdedos, N. Fujii, et al. 2002. G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat. Immunol. 3:687-694.
28. De Clercq, E. 2003. The bicyclam AMD3100 story. Nat. Rev. Drug Discov. 2:581-587.
29. Hatse, S., K. Princen, G. Bridger, E. De Clercq, and D. Schols. 2002. Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4. FEBS Lett. 527:255-262.
30. Joo, E.K., H.E. Broxmeyer, H.J. Kwon, H.B. Kang, J.S. Kim, J.S. Lim, Y.K. Choe, I.S. Choe, P.K. Myung, and Y. Lee. 2004. Enhancement of cell survival by stromal cell-derived factor-1/CXCL12 involves activation of CREB and induction of Mcl-1 and c-Fos in factor-dependent human cell line MO7e. Stem Cells Dev. 13:563-570.
31. Liles, W.C., H.E. Broxmeyer, E. Rodger, B. Wood, K. Hubel, S. Cooper, G. Hangoc, G. Bridger, G.W. Hensen, G. Calandra, and D.C. Daly. 2003. Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist. Blood. 102:2728-2730.
32. + hematopoietic progenitor cells by AMD3100, a CXCR4 antagonist. Supportive Cancer Therapy. 1:165-172.
33. Devine, S.M., N. Flomenberg, D.H. Vesole, J. Liesveld, D. Weisdorf, K. Badel, G. Calandra, and J.F. DiPersio. 2004. Rapid mobilization of CD34+ cells following administration of the CXCR4 antagonist AMD3100 to patients with multiple myeloma and non-Hodgkin's lymphoma. J. Clin. Oncol. 22:1095-1102.
34. Liles, W.C., E. Rodger, H.E. Broxmeyer, C. Dehner, K. Badel, G. Calandra, J. Christensen, B. Wood, T.H. Price, and D.C. Dale. 2004. Augmented mobilization and collection of CD34+ hematopoietic cells from normal human volunteers stimulated with G-CSF by single-dose administration of AMD3100, a CXCR4 antagonist. Transfusion. 45:295-300.
35. Broxmeyer, H.E., S. Cooper, G. Hangoc, J.-L. Gao, and P.M. Murphy. 1999. Dominant myelopoietic effector functions mediated by chemokine receptor CCR1. J. Exp. Med. 189:1987-1992.
36. Harrison, D. 1980. Competitive repopulation: a new assay for long term stem cell functional capacity. Blood. 55:77-81.
37. Haneline, L., H.E. Broxmeyer, S. Cooper, G. Hangoc, M. Carreau, M. Buchwald, and D.W. Clapp. 1998. Multiple inhibitory cytokines induce deregulated progenitor growth and apoptosis in hematopoietic cells from Fac -/- mice. Blood. 91:4092-4098.
38. Dick, J.E., M. Bhatia, O. Gan, U. Kapp, and J.C. Wang. 1997. Assay of human stem cells by repopulation of NOD/SCID mice. Stem Cells. 15:199-203.
39. Bodine, D. 2004. Animal models for the engraftment and differentiation of human hematopoietic stem and progenitor cells. In Cord Blood: Biology, Immunology, Banking, and Clinical Transplantation. H.E. Broxmeyer, editor. American Association of Blood Banking, Bethesda, MD. 47-64.
40. Orschell-Traycoff, C.M., K. Hiatt, R.N. Dagher, S. Rice, M.C. Yoder, and E.F. Srour. 2000. Homing and engraftment potential of Sca-1(+)lin(-) cells fractionated on the basis of adhesion molecule expression and position in cell cycle. Blood. 96:1380-1387.
41. Thomas, E.D. 2004. A history of bone marrow transplantation. In Thomas' Hematopoietic Cell Transplantation, 3rd ed. K.G. Blume, S.J. Forman, and F.R. Appelbaum, editors. Blackwell Publishing Ltd., Malden, MA. 3-8.
42. Grigg, A.P., A.W. Roberts, H. Raunow, S. Houghton, J.E. Layton, A.W. Boyd, K.M. McGrath, and D. Maher. 1995. Optimizing dose and scheduling of filgrastim (granulocyte colony-stimulating factor) for mobilization and collection of peripheral blood progenitor cells in normal volunteers. Blood. 86:4437-4445.
43. + cells in normal donors treated with filgrastim. Transfusion. 37:507-512.
44. Holm, M. 1998. Not all healthy donors mobilize hematopoietic progenitor cells sufficiently after G-CSF administration to allow for subsequent CD34 purification of the leukapheresis product. J. Hematol. 7:111-113.
45. de la Rubia, J., C. Arbona, F. de Arriba, C. del Canizo, S. Brunet, C. Zamora, M.A. Diaz, J. Bargay, J. Petit, J. de la Serna, et al. 2002. Analysis of factors associated with low peripheral blood progenitor cell collection in normal donors. Transfusion. 42:4-9.
46. Bhatia, M., J.C. Wang, U. Kapp, D. Bonnet, and J.E. Dick. 1997. Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice. Proc. Natl. Acad. Sci. USA. 94:5320-5325.
47. Chen, M., D.J. Tomkins, W. Auerbach, C. McKerlie, H. Youssoufian, L. Liu, O. Gan, M. Carreau, A. Auerbach, T. Groves, et al. 1996. Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconia anemia. Nat. Genet. 12:448-451.
48. Wilpshaar, J., J.H. Falkenburg, X. Tong, W.A. Noort, R. Breese, D. Heilman, H. Kanhai, C.M. Orschell-Traycoff, and E.F. Srour. 2000. Similar repopulating capacity of mitotically active and resting umbilical cord blood CD34+ cells in NOD/SCID mice. Blood. 96:2100-2107.
49. Taswell, C. 1981. Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. J. Immunol. 126:1614-1619.
50. Plett, P., S. Frankovitz, F. Wolber, R. Abonour, and C. Orschell-Traycoff. 2002. Treatment of circulating CD34+ cells with SDF-1α or anti-CXCR4 antibody enhances migration and NOD/SCID repopulating potential. Exp. Hematol. 30:1061-1069.
51. Plett, P.A., S.M. Frankovitz, and C.M. Orschell-Traycoff. 2002. In vivo trafficking, cell cycle activity, and engraftment potential of phenotypically defined primitive hematopoietic cells after transplantation into irradiated or nonirradiated recipients. Blood. 100:3545-3552.
52. Plett, P.A., S.M. Frankovitz, and C.M. Orschell. 2003. Distribution of marrow repopulating cells between bone marrow and spleen early after transplantation. Blood. 102:2285-2291.
53. Boggs, D. 1984. The total marrow mass of the mouse: a simplified method of measurement. Am. J. Hematol 16:277-286.
54. Jetmore, A., P.A. Plett, X. Tong, F.M. Wolber, R. Breese, R. Abonour, C.M. Orschell-Traycoff, and E.F. Srour. 2002. Homing efficiency, cell cycle kinetics and survival of quiescent and cycling human CD34+ cells transplanted into conditioned NOD/SCID mice. Blood. 99:1585-1593.