Functionally Different Agonists Induce Distinct Conformations in the G Protein Coupling Domain of the β2 Adrenergic Receptor

Journal of Biological Chemistry

Volumn 276, Issue 27, 2001, Pages 24433-24436

  Ghanouni, Pejman ^a   Gryczynski, Zygmunt ^b   Steenhuis, Jacqueline J ^a   Lee, Tae Weon ^a   Farrens, David L ^c   Lakowicz, Joseph R ^b   Kobilka, Brian K ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; DRUG PRODUCTS; FLUORESCENCE; PROTEINS;

AGONISTS; LIGANDS;

BIOCHEMISTRY;

BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; FLUORESCENT DYE; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND; 5 MALEIMIDOFLUORESCEIN; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; FLUORESCEIN 5-MALEIMIDE; FLUORESCEIN DERIVATIVE; ISOPRENALINE;

ARTICLE; CONFORMATIONAL TRANSITION; COVALENT BOND; FLUORESCENCE; G PROTEIN COUPLING DOMAIN; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; CHEMISTRY; METABOLISM; PROTEIN BINDING; SPECTROFLUOROMETRY; STRUCTURE ACTIVITY RELATION;

ADRENERGIC BETA-AGONISTS; FLUORESCEINS; GTP-BINDING PROTEINS; ISOPROTERENOL; LIGANDS; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, ADRENERGIC, BETA-2; SPECTROMETRY, FLUORESCENCE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035816704     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C100162200     Document Type: Article

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