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Volumn 407, Issue 6801, 2000, Pages 258-264

Thrombin signalling and protease-activated receptors

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 3; THROMBIN;

EID: 0034648757     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35025229     Document Type: Review
Times cited : (2233)

References (64)
  • 1
    • 0002613087 scopus 로고
    • eds Colman, R. W., Marder, V. J., Salzman, E. W. & Hirsh, J. Lippincott, Philadelphia
    • Colman, R. W., Marder, V. J., Salzman, E. W. & Hirsh, J. in Hemostasis and Thrombosis (eds Colman, R. W., Marder, V. J., Salzman, E. W. & Hirsh, J.) 3-18 (Lippincott, Philadelphia, 1994).
    • (1994) Hemostasis and Thrombosis , pp. 3-18
    • Colman, R.W.1    Marder, V.J.2    Salzman, E.W.3    Hirsh, J.4
  • 2
    • 0032879431 scopus 로고    scopus 로고
    • Inflammation, sepsis, and coagulation
    • Esmon, C. T. et al. Inflammation, sepsis, and coagulation. Haematologica 84, 254-2591 (1999).
    • (1999) Haematologica , vol.84 , pp. 254-2591
    • Esmon, C.T.1
  • 3
    • 0031756985 scopus 로고    scopus 로고
    • Tissue factor expression by monocytes: Regulation and pathophysiological roles
    • Osterud, B. Tissue factor expression by monocytes: regulation and pathophysiological roles. Blood Coag. Fibrin. 9(Suppl. 1), S9-S14 (1998).
    • (1998) Blood Coag. Fibrin. , vol.9 , Issue.1 SUPPL.
    • Osterud, B.1
  • 4
    • 13044304178 scopus 로고    scopus 로고
    • Blood-borne tissue factor: Another view of thrombosis
    • Giesen, P. L. et al. Blood-borne tissue factor: another view of thrombosis. Proc. Natl Acad. Sci. USA 96, 2311-2315 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 2311-2315
    • Giesen, P.L.1
  • 5
    • 0010460867 scopus 로고
    • Inducible endothelial functions in inflammation and coagulation
    • Bevilacqua, M. P. & Gimbrone, M. A. Jr Inducible endothelial functions in inflammation and coagulation. Semin. Thromb. Hemost. 13, 425-433 (1987).
    • (1987) Semin. Thromb. Hemost. , vol.13 , pp. 425-433
    • Bevilacqua, M.P.1    Gimbrone M.A., Jr.2
  • 6
    • 0031956683 scopus 로고    scopus 로고
    • Sol Sherry lecture in thrombosis: How thrombin 'talks' to cells: molecular mechanisms and roles in vivo
    • Coughlin, S. R. Sol Sherry lecture in thrombosis: how thrombin 'talks' to cells: molecular mechanisms and roles in vivo. Arterioscl. Thromb. Vasc. Biol. 18, 514-518 (1998).
    • (1998) Arterioscl. Thromb. Vasc. Biol. , vol.18 , pp. 514-518
    • Coughlin, S.R.1
  • 7
    • 0022221113 scopus 로고
    • A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation
    • Stenberg, P. E., McEver, R. P., Shuman, M. A., Jacques, Y. V. & Bainton, D. F. A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation. J. Cell Biol. 101, 880-886 (1985).
    • (1985) J. Cell Biol. , vol.101 , pp. 880-886
    • Stenberg, P.E.1    McEver, R.P.2    Shuman, M.A.3    Jacques, Y.V.4    Bainton, D.F.5
  • 8
    • 0032484987 scopus 로고    scopus 로고
    • CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cell
    • Henn, V. et al. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cell. Nature 391, 591-594 (1998).
    • (1998) Nature , vol.391 , pp. 591-594
    • Henn, V.1
  • 9
    • 0032168738 scopus 로고    scopus 로고
    • Integrin affinity modulation
    • Hughes, P. E. & Pfaff, M. Integrin affinity modulation. Trends Cell Biol. 8, 359-364 (1998).
    • (1998) Trends Cell Biol. , vol.8 , pp. 359-364
    • Hughes, P.E.1    Pfaff, M.2
  • 10
    • 0024325249 scopus 로고
    • Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane
    • Sims, P. J., Wiedmer, T., Esmon, C. T., Weiss, H. J. & Shattil, S. J. Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane. J. Biol. Chem. 264, 17049-17057 (1989).
    • (1989) J. Biol. Chem. , vol.264 , pp. 17049-17057
    • Sims, P.J.1    Wiedmer, T.2    Esmon, C.T.3    Weiss, H.J.4    Shattil, S.J.5
  • 11
    • 0024391784 scopus 로고
    • Stimulated secretion of endothelial vWF is accompanied by rapid redistribution to the cell surface of the intracellular granule membrane protein GMP-140
    • Hattori, R., Hamilton, K. K., Fugate, R. D., McEver, R. P. & Sims, P. J. Stimulated secretion of endothelial vWF is accompanied by rapid redistribution to the cell surface of the intracellular granule membrane protein GMP-140. J. Biol. Chem. 264, 7768-7771 (1989).
    • (1989) J. Biol. Chem. , vol.264 , pp. 7768-7771
    • Hattori, R.1    Hamilton, K.K.2    Fugate, R.D.3    McEver, R.P.4    Sims, P.J.5
  • 12
    • 0030049002 scopus 로고    scopus 로고
    • Defects in hemostosis in P-selection deficient mice
    • Subramaniam, M. et al. Defects in hemostosis in P-selection deficient mice. Blod 87, 1238-1242 (1996).
    • (1996) Blod , vol.87 , pp. 1238-1242
    • Subramaniam, M.1
  • 13
    • 0030030905 scopus 로고    scopus 로고
    • Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selections
    • Frenette, P. S., Mayadas, T. N., Rayburn, H., Hynes, R. O. & Wagner, D. D. Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selections Cell 84, 563-574 (1996).
    • (1996) Cell , vol.84 , pp. 563-574
    • Frenette, P.S.1    Mayadas, T.N.2    Rayburn, H.3    Hynes, R.O.4    Wagner, D.D.5
  • 14
    • 0028121374 scopus 로고
    • Regulation of vascular endothelial barries function
    • Lum, H. & Malik, A. B. Regulation of vascular endothelial barries function. Am. J. Physiol. 267, 1.223-1.241 (1994).
    • (1994) Am. J. Physiol. , vol.267 , pp. 1223-1241
    • Lum, H.1    Malik, A.B.2
  • 15
    • 0029862685 scopus 로고    scopus 로고
    • Thrombin functions as an inflammatory mediator through activation of its receptor
    • Cirino, G. et al. Thrombin functions as an inflammatory mediator through activation of its receptor. J. Exp. Med. 183, 821-827 (1996).
    • (1996) J. Exp. Med. , vol.183 , pp. 821-827
    • Cirino, G.1
  • 16
    • 0033613183 scopus 로고    scopus 로고
    • How the protease thrombin talks to cells
    • Coughlin, S. R. How the protease thrombin talks to cells. Proc. Natl Acad. Sci. USA 96, 11025-11027 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 11025-11027
    • Coughlin, S.R.1
  • 17
    • 0026035523 scopus 로고
    • Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
    • Vu, T.-K. H., Hung, D. T., Wheaton, V. I. & Coughlin, S. R. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64, 1057-1068 (1991).
    • (1991) Cell , vol.64 , pp. 1057-1068
    • Vu, T.-K.H.1    Hung, D.T.2    Wheaton, V.I.3    Coughlin, S.R.4
  • 18
    • 0025784847 scopus 로고
    • 2+ mobilization
    • 2+ mobilization. FEBS Lett. 288, 123-128 (1991).
    • (1991) FEBS Lett. , vol.288 , pp. 123-128
    • Rasmussen, U.B.1
  • 19
    • 0028364862 scopus 로고
    • Thrombin receptor activation: Confirmation of the intramolecular tethered liganding hypothesis and discovery of an alternative intermolecular liganding mode
    • Chen, J., Ishii, M., Wang, L., Ishii, K. & Coughlin, S. R. Thrombin receptor activation: confirmation of the intramolecular tethered liganding hypothesis and discovery of an alternative intermolecular liganding mode. J. Biol. Chem. 269, 16041-16045 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 16041-16045
    • Chen, J.1    Ishii, M.2    Wang, L.3    Ishii, K.4    Coughlin, S.R.5
  • 20
    • 0034608013 scopus 로고    scopus 로고
    • Thrombin responses in human endothelial cells. Contributions from receptors other than PARI include the transactivation of PAR2 by thrombin-cleaved PAR1
    • O'Brien, P. J. et al. Thrombin responses in human endothelial cells. Contributions from receptors other than PARI include the transactivation of PAR2 by thrombin-cleaved PAR1. J. Biol. Chem. 275, 13502-13509 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 13502-13509
    • O'Brien, P.J.1
  • 21
    • 0027309290 scopus 로고
    • Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling
    • Ishii, K., Hein, L., Kobilka, B. & Coughlin, S. R. Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling. J. Biol. Chem. 268, 9780-9786 (1993).
    • (1993) J. Biol. Chem. , vol.268 , pp. 9780-9786
    • Ishii, K.1    Hein, L.2    Kobilka, B.3    Coughlin, S.R.4
  • 22
    • 0029758276 scopus 로고    scopus 로고
    • Development of potent thrombin receptor antagonist peptides
    • Bernatowicz, M. S. et al. Development of potent thrombin receptor antagonist peptides. J. Med. Chem. 39, 4879-4887 (1996).
    • (1996) J. Med. Chem. , vol.39 , pp. 4879-4887
    • Bernatowicz, M.S.1
  • 23
    • 0030979972 scopus 로고    scopus 로고
    • Protease-activated receptor 3 is a second thrombin receptor in humans
    • Ishihara, H. et al. Protease-activated receptor 3 is a second thrombin receptor in humans. Nature 386, 502-506 (1997).
    • (1997) Nature , vol.386 , pp. 502-506
    • Ishihara, H.1
  • 24
    • 0032499696 scopus 로고    scopus 로고
    • Cloning and characterization of human protease-activated receptor 4
    • Xu, W. E. et al. Cloning and characterization of human protease-activated receptor 4. Proc. Natl Acad. Sci. USA 95, 6642-6646 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 6642-6646
    • Xu, W.E.1
  • 25
    • 0032514474 scopus 로고    scopus 로고
    • A dual thrombin receptor system for platelet activation
    • Kahn, M. L. et al. A dual thrombin receptor system for platelet activation. Nature 394, 690-694 (1998).
    • (1998) Nature , vol.394 , pp. 690-694
    • Kahn, M.L.1
  • 27
    • 15444346942 scopus 로고    scopus 로고
    • Interactions of mast cell tryptase with thrombin receptors and PAR-2
    • Molino, M. et al. Interactions of mast cell tryptase with thrombin receptors and PAR-2. J. Biol. Chem. 272, 4043-4049 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 4043-4049
    • Molino, M.1
  • 28
    • 0034624973 scopus 로고    scopus 로고
    • Tissue factor- and Factor X-dependent activation of PAR2 by Factor VIIa
    • Camerer, E., Huang, W. & Coughlin, S. R. Tissue factor- and Factor X-dependent activation of PAR2 by Factor VIIa. Proc. Natl Acad Sci. USA 97, 5253-5260 (2000).
    • (2000) Proc. Natl Acad Sci. USA , vol.97 , pp. 5253-5260
    • Camerer, E.1    Huang, W.2    Coughlin, S.R.3
  • 29
    • 0034611727 scopus 로고    scopus 로고
    • PAR3 is a cofactor for PAr4 activation by thrombin
    • Nakanishi-Matsui, M. et al. PAR3 is a cofactor for PAr4 activation by thrombin. Nature 404, 609-613 (2000).
    • (2000) Nature , vol.404 , pp. 609-613
    • Nakanishi-Matsui, M.1
  • 30
    • 0033559805 scopus 로고    scopus 로고
    • Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin
    • Kahn, M. L., Nakanishi-Matsui, M., Shapiro, M. J., Ishihara, H. & Coughlin, S. R. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J. Clin. Invest. 103, 879-887 (1999).
    • (1999) J. Clin. Invest. , vol.103 , pp. 879-887
    • Kahn, M.L.1    Nakanishi-Matsui, M.2    Shapiro, M.J.3    Ishihara, H.4    Coughlin, S.R.5
  • 31
    • 0026690665 scopus 로고
    • Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation
    • Hung, D. T., Vu, T. K., Wheaton, V. I., Ishii, K. & Coughlin, S. R. Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation. J. Clint. Invest. 89, 1350-1353 (1992).
    • (1992) J. Clint. Invest. , vol.89 , pp. 1350-1353
    • Hung, D.T.1    Vu, T.K.2    Wheaton, V.I.3    Ishii, K.4    Coughlin, S.R.5
  • 32
    • 0026631543 scopus 로고
    • Structure and function of the human platelet thrombin receptor. Studies using monoclonal antibodies directed against a defined domain within the receptor N terminus
    • Brass, L. F. et al. Structure and function of the human platelet thrombin receptor. Studies using monoclonal antibodies directed against a defined domain within the receptor N terminus. J. Biol. Chem. 267, 13795-13798 (1992).
    • (1992) J. Biol. Chem. , vol.267 , pp. 13795-13798
    • Brass, L.F.1
  • 33
    • 0023951925 scopus 로고
    • Cathepsin G is a strong platelet agonist released by neutrophils
    • Selak, M. A., Chignard, M. & Smith, J. B. Cathepsin G is a strong platelet agonist released by neutrophils. Biochem. J. 251, 293-299 (1988).
    • (1988) Biochem. J. , vol.251 , pp. 293-299
    • Selak, M.A.1    Chignard, M.2    Smith, J.B.3
  • 34
    • 0034629468 scopus 로고    scopus 로고
    • Cathepsin G activates protease-activated receptor-4 in human platelets
    • Sambrano, G. R. et al. Cathepsin G activates protease-activated receptor-4 in human platelets. J. Biol. Chem. 275, 6819-6823 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 6819-6823
    • Sambrano, G.R.1
  • 35
    • 0034682810 scopus 로고    scopus 로고
    • Protease-activated receptors 1 and 4 are shutoff with distinct tempos after activation by thrombin
    • in the press
    • Shapiro, M. J., Weiss, E. J., Faruqi, T. R. & Coughlin, S. R. Protease-activated receptors 1 and 4 are shutoff with distinct tempos after activation by thrombin. J. Biol. Chem. (in the press).
    • J. Biol. Chem.
    • Shapiro, M.J.1    Weiss, E.J.2    Faruqi, T.R.3    Coughlin, S.R.4
  • 36
    • 0018190052 scopus 로고
    • Platelet glycocalicin: Interaction with thrombin and role as thrombin receptor on the platelet surface
    • Okamura, T., Hasitz, M. & Jamieson, G. A. Platelet glycocalicin: interaction with thrombin and role as thrombin receptor on the platelet surface. J. Biol. Chem. 253, 3435-3443 (1978).
    • (1978) J. Biol. Chem. , vol.253 , pp. 3435-3443
    • Okamura, T.1    Hasitz, M.2    Jamieson, G.A.3
  • 37
    • 0032722464 scopus 로고
    • The glycoprotein Ib-IX-V complex in platelet adhesion and signaling
    • Andrews, R. K. et al. The glycoprotein Ib-IX-V complex in platelet adhesion and signaling. Thromb. Haemost. 82, 357-364 (1949).
    • (1949) Thromb. Haemost. , vol.82 , pp. 357-364
    • Andrews, R.K.1
  • 38
    • 0028040603 scopus 로고
    • Species variability in platelet and other cellular responsiveness to thrombin receptor-derived peptides
    • Connolly, T. M. et al. Species variability in platelet and other cellular responsiveness to thrombin receptor-derived peptides. Thromb. Haemost. 72, 627-633 (1994).
    • (1994) Thromb. Haemost. , vol.72 , pp. 627-633
    • Connolly, T.M.1
  • 39
    • 0029016907 scopus 로고
    • Species differences in platelet responses to thrombin and SFLLRN. Receptor-mediated calcium mobilization and aggregation and regulation by protein kinases
    • Derian, C. K., Santulli, R. J., Tomko, K. A., Haertlein, B. J. & Andrade-Gordon, P. Species differences in platelet responses to thrombin and SFLLRN. Receptor-mediated calcium mobilization and aggregation and regulation by protein kinases. Thromb. Res. 6, 505-519 (1995).
    • (1995) Thromb. Res. , vol.6 , pp. 505-519
    • Derian, C.K.1    Santulli, R.J.2    Tomko, K.A.3    Haertlein, B.J.4    Andrade-Gordon, P.5
  • 40
    • 0030008312 scopus 로고    scopus 로고
    • Role of the thrombin receptor in development and evidence for a second receptor
    • Connolly, A. J., Ishihara, H., Kahn, M. L., Farese, R. V. & Coughlin, S. R. Role of the thrombin receptor in development and evidence for a second receptor. Nature 381, 516-519 (1996).
    • (1996) Nature , vol.381 , pp. 516-519
    • Connolly, A.J.1    Ishihara, H.2    Kahn, M.L.3    Farese, R.V.4    Coughlin, S.R.5
  • 41
    • 0030890657 scopus 로고    scopus 로고
    • Platelet-activating factor (PAF): Signalling and adhesion in cell-cell interactions
    • Zimmerman, G. A. et al. Platelet-activating factor (PAF): signalling and adhesion in cell-cell interactions. Adv. Exp. Med. Biol. 416, 297-304 (1996).
    • (1996) Adv. Exp. Med. Biol. , vol.416 , pp. 297-304
    • Zimmerman, G.A.1
  • 42
    • 0032525041 scopus 로고    scopus 로고
    • Potential mechanisms for a promflammatory vascular cytokine response to coagulation activation
    • Johnson, K. et al. Potential mechanisms for a promflammatory vascular cytokine response to coagulation activation. J. Immunol. 160, 5130-5135 (1998).
    • (1998) J. Immunol. , vol.160 , pp. 5130-5135
    • Johnson, K.1
  • 43
    • 0034614895 scopus 로고    scopus 로고
    • Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritis
    • Cunningham, M. A. et al. Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritis. J. Exp. Med. 191, 455-462 (2000).
    • (2000) J. Exp. Med. , vol.191 , pp. 455-462
    • Cunningham, M.A.1
  • 44
    • 0029908545 scopus 로고    scopus 로고
    • Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation
    • Bugge, T. H., et al. Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation. Proc. Natl Acad. Sci. USA 93, 6258-6263 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 6258-6263
    • Bugge, T.H.1
  • 45
    • 0026782001 scopus 로고
    • The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate both phosphoinositide hydrolysis and inhibit adenylyl cyclase
    • Hung, D. T., Wong, Y. H., Vu, T.-K. H. & Coughlin, S. R. The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate both phosphoinositide hydrolysis and inhibit adenylyl cyclase. J. Biol. Chem. 353, 20831-20834 (1992).
    • (1992) J. Biol. Chem. , vol.353 , pp. 20831-20834
    • Hung, D.T.1    Wong, Y.H.2    Vu, T.-K.H.3    Coughlin, S.R.4
  • 46
    • 0028179510 scopus 로고
    • G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets
    • Offermanns, S., Laugwitz, K.-L., Spicher, K. & Schultz, G. G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets. Proc. Natl Acad. Sci. USA 91, 504-508 (1994).
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 504-508
    • Offermanns, S.1    Laugwitz, K.-L.2    Spicher, K.3    Schultz, G.4
  • 47
    • 0031029553 scopus 로고    scopus 로고
    • Reconstitution of receptors and GTP-binding regulatory proteins (G proteins) in Sf9 cells. A direct evaluation of selectivity in receptor-G protein coupling
    • Barr, A. J., Brass, I. F. & Manning, D. R. Reconstitution of receptors and GTP-binding regulatory proteins (G proteins) in Sf9 cells. A direct evaluation of selectivity in receptor-G protein coupling. J. Biol. Chem. 272, 2223-2229 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 2223-2229
    • Barr, A.J.1    Brass, I.F.2    Manning, D.R.3
  • 48
    • 0032569051 scopus 로고    scopus 로고
    • p115 RhoGEF, a GTPase-activating protein for Galpha12 and Galpha13
    • Kozasa, T. et al. p115 RhoGEF, a GTPase-activating protein for Galpha12 and Galpha13. Science 280, 2109-2111 (1998).
    • (1998) Science , vol.280 , pp. 2109-2111
    • Kozasa, T.1
  • 49
    • 0032568868 scopus 로고    scopus 로고
    • 13
    • 13 Science 280, 2112-2114 (1998).
    • (1998) Science , vol.280 , pp. 2112-2114
    • Hart, M.J.1
  • 50
    • 0033605294 scopus 로고    scopus 로고
    • A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho
    • Fukuhara, S., Murga, C., Zohar, M., Igishi, T. & Gutkind, J. S. A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho. J. Biol. Chem. 274, 5868-5879 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 5868-5879
    • Fukuhara, S.1    Murga, C.2    Zohar, M.3    Igishi, T.4    Gutkind, J.S.5
  • 51
    • 0033593667 scopus 로고    scopus 로고
    • Activation of G12/G13 results in shape change and rho/rho kinase-mediated myosin light chain phosphorylation in mouse platelets
    • Klages, B., Brandt, U., Simon, M. I., Schultz, G. & Offermanns, S. Activation of G12/G13 results in shape change and rho/rho kinase-mediated myosin light chain phosphorylation in mouse platelets. J. Cell. Biol. 144, 745-754 (1999).
    • (1999) J. Cell. Biol. , vol.144 , pp. 745-754
    • Klages, B.1    Brandt, U.2    Simon, M.I.3    Schultz, G.4    Offermanns, S.5
  • 52
    • 0031717365 scopus 로고    scopus 로고
    • Regulation of the actin cytoskeleton by thrombin in human endothelial cells: Role of Rho proteins in endothelial barrier function
    • Vouret-Craviari, V., Boquet, P., Pouysségur, J. & Van Obberghen-Schilling, E. Regulation of the actin cytoskeleton by thrombin in human endothelial cells: role of Rho proteins in endothelial barrier function. Mol. Biol. Cell 19, 2639-2653 (1998).
    • (1998) Mol. Biol. Cell , vol.19 , pp. 2639-2653
    • Vouret-Craviari, V.1    Boquet, P.2    Pouysségur, J.3    Van Obberghen-Schilling, E.4
  • 54
    • 0025860413 scopus 로고
    • Activation of the B1 isozyme of phospholipase C by a subunits of the Gq class of G proteins
    • Taylor, S., Chae, H. Z., Rhee, S.-G. & Exton, J. H. Activation of the B1 isozyme of phospholipase C by a subunits of the Gq class of G proteins. Nature 350, 516-518 (1991).
    • (1991) Nature , vol.350 , pp. 516-518
    • Taylor, S.1    Chae, H.Z.2    Rhee, S.-G.3    Exton, J.H.4
  • 56
    • 0029090212 scopus 로고
    • Cloning and characterization of a G protein-activated huiman phosphoinositide-3 kinase
    • Stoyanov, B. et al. Cloning and characterization of a G protein-activated huiman phosphoinositide-3 kinase. Science 269, 690-643 (1995).
    • (1995) Science , vol.269 , pp. 690-1643
    • Stoyanov, B.1
  • 58
    • 0032929762 scopus 로고    scopus 로고
    • Signalling through phosphuinositide3-kinases: The lipids take centre stage
    • Leevers, S. J., Vanhaesebroeck, B. & Waterfield, M. D. Signalling through phosphuinositide3-kinases: the lipids take centre stage. Curr. Opin. Cell Biol. 11, 219-225 (1999).
    • (1999) Curr. Opin. Cell Biol. , vol.11 , pp. 219-225
    • Leevers, S.J.1    Vanhaesebroeck, B.2    Waterfield, M.D.3
  • 59
    • 0033599039 scopus 로고    scopus 로고
    • EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
    • Prenzel, N. et al. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF, Nature 402, 884-888 (1999).
    • (1999) Nature , vol.402 , pp. 884-888
    • Prenzel, N.1
  • 60
    • 0034651718 scopus 로고    scopus 로고
    • Introduction: Are natural anticoagulants candidates for modulating the inflammatory response to endutoxin?
    • Esmon, C. T. Introduction: are natural anticoagulants candidates for modulating the inflammatory response to endutoxin? Blood 95, 1113-1116 (2000).
    • (2000) Blood , vol.95 , pp. 1113-1116
    • Esmon, C.T.1
  • 61
    • 0032845209 scopus 로고    scopus 로고
    • Regulation and functions of the protein C anticoagulant pathway
    • Esmon, C. T. et al. Regulation and functions of the protein C anticoagulant pathway. Haematologica 84, 363-368 (1999).
    • (1999) Haematologica , vol.84 , pp. 363-368
    • Esmon, C.T.1
  • 62
    • 0026495238 scopus 로고
    • Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets
    • Palabrica, T. et al. Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets. Nature 359, 848-851 (1992).
    • (1992) Nature , vol.359 , pp. 848-851
    • Palabrica, T.1
  • 63
    • 15844401726 scopus 로고    scopus 로고
    • The proteinase-activated receptor 2 is induced by ioflammatory mediators in human endothelial cells. Comparison with the thrombin receptor
    • Nystedt, S., Ramakrishnan, V. & Sundelin, J. The proteinase-activated receptor 2 is induced by ioflammatory mediators in human endothelial cells. Comparison with the thrombin receptor. J. Biol. Chem. 271, 14910-14915 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 14910-14915
    • Nystedt, S.1    Ramakrishnan, V.2    Sundelin, J.3
  • 64
    • 0030859367 scopus 로고    scopus 로고
    • Purpura fulminans induced by disseminated intravascular coagulation following infection in 2 unrelated children with double heterozygosity for factor V Leiden and protein S deficiency
    • Inbal, A. et al. Purpura fulminans induced by disseminated intravascular coagulation following infection in 2 unrelated children with double heterozygosity for factor V Leiden and protein S deficiency. Thromb. Haemost. 77, 1086-1089 (1997).
    • (1997) Thromb. Haemost. , vol.77 , pp. 1086-1089
    • Inbal, A.1


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