Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

Nature

Volumn 463, Issue 7277, 2010, Pages 108-112

  Bokoch, Michael P ^a   Zou, Yaozhong ^a   Rasmussen, Søren G F ^a   Liu, Corey W ^a   Nygaard, Rie ^a   Rosenbaum, Daniel M ^a   Fung, Juan José ^a   Choi, Hee Jung ^a   Thian, Foon Sun ^a   Kobilka, Tong Sun ^a   Puglisi, Joseph D ^a   Weis, William I ^a   Pardo, Leonardo ^b   Prosser, R Scott ^c   Mueller, Luciano ^d   Kobilka, Brian K ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c UNIVERSITY OF TORONTO   (Canada)

^d BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; G PROTEIN COUPLED RECEPTOR; LIGAND;

CRYSTAL STRUCTURE; HORMONE; LIGAND; NUCLEAR MAGNETIC RESONANCE; PROTEIN;

ARTICLE; BINDING SITE; CELL MEMBRANE; CELL SURFACE; CONFORMATIONAL TRANSITION; CROSS COUPLING REACTION; CRYSTAL STRUCTURE; EXTRACELLULAR SPACE; LIGAND BINDING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN CONFORMATION;

ALLOSTERIC REGULATION; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG INVERSE AGONISM; ETHANOLAMINES; HUMANS; LIGANDS; LYSINE; METHYLATION; MODELS, MOLECULAR; MUTANT PROTEINS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROPANOLAMINES; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ADRENERGIC, BETA-2; STATIC ELECTRICITY; SUBSTRATE SPECIFICITY;

EID: 73849149844     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature08650     Document Type: Article

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