Functionally selective dopamine D2, D3 receptor partial agonists

Journal of Medicinal Chemistry

Volumn 57, Issue 11, 2014, Pages 4861-4875

  Möller, Dorothee ^a   Kling, Ralf C ^a   Skultety, Marika ^a   Leuner, Kristina ^a   Hübner, Harald ^a   Gmeiner, Peter ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

5 [4 [4 (2,3 DICHLOROPHENYL)PIPERAZIN 1 YL]BUTOXY]PYRAZOLO[1,5 A]PYRIDINE 3 CARBALDEHYDE; 5 [4 [4 (2,3 DICHLOROPHENYL)PIPERAZIN 1 YL]BUTOXY]PYRAZOLO[1,5 A]PYRIDINE 3 CARBALDEHYDE OXIME; ALDOXIME; BETA ARRESTIN 2; DOPAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR STIMULATING AGENT; DOPAMINE 3 RECEPTOR; DOPAMINE 3 RECEPTOR STIMULATING AGENT; FUNCTIONAL GROUP; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); HALOPERIDOL; HETEROCYCLIC COMPOUND; PIPERAZINE DERIVATIVE; PYRAZOLE DERIVATIVE; PYRAZOLO[1,5 A]PYRIDINE DERIVATIVE; PYRIDINE DERIVATIVE; QUINPIROLE; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HEK293 CELL LINE; HUMAN; HUMAN CELL; LIGAND BINDING; MALE; MOLECULAR DOCKING; MOUSE; NEGATIVE SYNDROME; NERVE CELL PLASTICITY; NONHUMAN; PHYSICAL CHEMISTRY; PROTEIN EXPRESSION; SCHIZOPHRENIA; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; ANTIPSYCHOTIC AGENTS; ARRESTINS; CHO CELLS; CRICETULUS; DRUG PARTIAL AGONISM; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HEK293 CELLS; HETEROCYCLIC COMPOUNDS, 2-RING; HUMANS; MICE; MOLECULAR DOCKING SIMULATION; OXIMES; PIPERAZINES; PYRAZOLES; RADIOLIGAND ASSAY; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 84902440335     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm5004039     Document Type: Article

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