Molecular basis for the long duration of action and kinetic selectivity of tiotropium for the muscarinic M3 receptor

Journal of Medicinal Chemistry

Volumn 56, Issue 21, 2013, Pages 8746-8756

  Tautermann, Christofer S ^a   Kiechle, Tobias ^a   Seeliger, Daniel ^a   Diehl, Sonja ^a   Wex, Eva ^a   Banholzer, Rolf ^a   Gantner, Florian ^a   Pieper, Michael P ^a   Casarosa, Paola ^a  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; DRUG; HYDROXYL GROUP; LIGAND; MUSCARINIC M3 RECEPTOR; MUSCARINIC M3 RECEPTOR ANTAGONIST; TIOTROPIUM BROMIDE;

ARTICLE; BINDING KINETICS; BINDING SITE; CRYSTALLIZATION; DISSOCIATION; DRUG HALF LIFE; DRUG MECHANISM; DRUG STRUCTURE; HYDROGEN BOND; MOLECULAR DYNAMICS; STATIC ELECTRICITY; SYMPTOM;

BINDING SITES; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; MUTATION; RECEPTOR, MUSCARINIC M3; SCOPOLAMINE DERIVATIVES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84887874879     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401219y     Document Type: Article

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