Identification of two distinct inactive conformations of the β 2-adrenergic receptor reconciles structural and biochemical observations

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 12, 2009, Pages 4689-4694

  Dror, Ron O ^a   Arlow, Daniel H ^a   Borhani, David W ^a   Jensen, Morten Ø ^a   Piana, Stefano ^a   Shaw, David E ^a,b  

^a D E SHAW RESEARCH   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

GPCR; Ionic lock; Molecular dynamics

Indexed keywords

BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; RHODOPSIN;

ARTICLE; CHEMICAL ANALYSIS; CONFORMATION; CRYSTAL STRUCTURE; MOLECULAR DYNAMICS; PRIORITY JOURNAL; WILD TYPE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; GENETICS; MUTATION; PROTEIN SECONDARY STRUCTURE; STRUCTURAL HOMOLOGY; X RAY CRYSTALLOGRAPHY;

COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; MUTATION; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, ADRENERGIC, BETA-2; RHODOPSIN; STRUCTURAL HOMOLOGY, PROTEIN;

EID: 63849294621     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0811065106     Document Type: Article

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