Novel adenosine A2A receptor ligands: A synthetic, functional and computational investigation of selected literature adenosine A2A receptor antagonists for extending into extracellular space

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 11, 2013, Pages 3427-3433

  Jörg, Manuela ^a   Shonberg, Jeremy ^a   Mak, Frankie S ^b   Miller, Neil D ^b   Yuriev, Elizabeth ^a   Scammells, Peter J ^a   Capuano, Ben ^a  

^a MONASH UNIVERSITY   (Australia)

^b GLAXOSMITHKLINE   (Singapore)

Author keywords

Adenosine A2A antagonist; Congener; KW 6002; Parkinson's disease; ZM 241385

Indexed keywords

4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; ADENOSINE A2A RECEPTOR; ADENOSINE A2A RECEPTOR ANTAGONIST; ISTRADEFYLLINE; OXYGEN; PHENOL;

ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; EXTRACELLULAR SPACE; HUMAN; MOLECULAR DOCKING; PARKINSON DISEASE; STRUCTURE ACTIVITY RELATION;

ADENOSINE A2 RECEPTOR ANTAGONISTS; BINDING SITES; HUMANS; HYDROGEN BONDING; LIGANDS; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, ADENOSINE A2A; TRIAZINES; TRIAZOLES;

EID: 84877584576     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.03.070     Document Type: Article

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