The TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activation

Journal of Biological Chemistry

Volumn 276, Issue 16, 2001, Pages 13217-13225

  Govaerts, Cédric ^a   Blanpain, Cédric ^a   Deupi, Xavier ^b   Ballet, Sébastien ^a   Ballesteros, Juan A ^c   Wodak, Shoshana J ^a   Vassart, Gilbert ^a   Pardo, Leonardo ^b   Parmentier, Marc ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c Novasite Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CHEMICAL ACTIVATION; COMPUTER SIMULATION; CONFORMATIONS; MOLECULAR DYNAMICS; MUTAGENESIS; VIRUSES;

CHEMOKINE RECEPTORS;

PROTEINS;

ALANINE; CHEMOKINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR5; CYSTEINE; G PROTEIN COUPLED RECEPTOR; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 2; RANTES; SERINE; VALINE; CCL8 CHEMOKINE; GUANINE NUCLEOTIDE BINDING PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN; RECOMBINANT PROTEIN; RHODOPSIN; VIRUS RECEPTOR;

ALPHA HELIX; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHO CELL; CONTROLLED STUDY; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MOTIF; PROTEIN STRUCTURE; RECEPTOR INTRINSIC ACTIVITY; SIMULATION; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS; TXP MOTIF; VIRUS STRAIN; AMINO ACID SUBSTITUTION; ANIMAL; BINDING SITE; CATTLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; GENETIC TRANSFECTION; HAMSTER; HUMAN; METABOLISM; MOLECULAR GENETICS; MOUSE; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CATTLE; CHEMOKINES; CHO CELLS; CRICETINAE; GTP-BINDING PROTEINS; HUMANS; MACROPHAGE INFLAMMATORY PROTEIN-1; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MONOCYTE CHEMOATTRACTANT PROTEINS; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, SECONDARY; RANTES; RECEPTORS, CCR5; RECEPTORS, CHEMOKINE; RECEPTORS, HIV; RECOMBINANT PROTEINS; RHODOPSIN; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; TRANSFECTION;

EID: 0035918313     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M011670200     Document Type: Article

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