-
1
-
-
40049099087
-
Microscale fluorescent thermal stability assay for membrane proteins
-
Alexandrov A.I., Mileni M., Chien E.Y.T., Hanson M.A., and Stevens R.C. Microscale fluorescent thermal stability assay for membrane proteins. Structure 16 (2008) 351-359
-
(2008)
Structure
, vol.16
, pp. 351-359
-
-
Alexandrov, A.I.1
Mileni, M.2
Chien, E.Y.T.3
Hanson, M.A.4
Stevens, R.C.5
-
2
-
-
0345735773
-
Agonist and inverse agonist actions of beta-blockers at the human beta 2-adrenoceptor provide evidence for agonist-directed signaling
-
Baker J.G., Hall I.P., and Hill S.J. Agonist and inverse agonist actions of beta-blockers at the human beta 2-adrenoceptor provide evidence for agonist-directed signaling. Mol. Pharmacol. 64 (2003) 1357-1369
-
(2003)
Mol. Pharmacol.
, vol.64
, pp. 1357-1369
-
-
Baker, J.G.1
Hall, I.P.2
Hill, S.J.3
-
3
-
-
77957055780
-
Integrated methods for the construction of three dimensional models and computational probing of structure-function relations in G-protein coupled receptors
-
Ballesteros J.A., and Weinstein H. Integrated methods for the construction of three dimensional models and computational probing of structure-function relations in G-protein coupled receptors. Methods Neurosci. 25 (1995) 366-428
-
(1995)
Methods Neurosci.
, vol.25
, pp. 366-428
-
-
Ballesteros, J.A.1
Weinstein, H.2
-
5
-
-
9944252602
-
A robotic system for crystallizing membrane and soluble proteins in lipidic mesophases
-
Cherezov V., Peddi A., Muthusubramaniam L., Zheng Y.F., and Caffrey M. A robotic system for crystallizing membrane and soluble proteins in lipidic mesophases. Acta Crystallogr. D Biol. Crystallogr. 60 (2004) 1795-1807
-
(2004)
Acta Crystallogr. D Biol. Crystallogr.
, vol.60
, pp. 1795-1807
-
-
Cherezov, V.1
Peddi, A.2
Muthusubramaniam, L.3
Zheng, Y.F.4
Caffrey, M.5
-
6
-
-
36448995359
-
High-resolution crystal structure of an engineered human β2-adrenergic G protein-coupled receptor
-
Cherezov V., Rosenbaum D.M., Hanson M.A., Rasmussen S.G., Thian F.S., Kobilka T.S., Choi H.J., Kuhn P., Weis W.I., Kobilka B.K., et al. High-resolution crystal structure of an engineered human β2-adrenergic G protein-coupled receptor. Science 318 (2007) 1258-1265
-
(2007)
Science
, vol.318
, pp. 1258-1265
-
-
Cherezov, V.1
Rosenbaum, D.M.2
Hanson, M.A.3
Rasmussen, S.G.4
Thian, F.S.5
Kobilka, T.S.6
Choi, H.J.7
Kuhn, P.8
Weis, W.I.9
Kobilka, B.K.10
-
7
-
-
0028350901
-
Inverse agonist activity of β-adrenergic antagonists
-
Chidiac P., Hebert T.E., Valiquette M., Dennis M., and Bouvier M. Inverse agonist activity of β-adrenergic antagonists. Mol. Pharmacol. 45 (1994) 490-499
-
(1994)
Mol. Pharmacol.
, vol.45
, pp. 490-499
-
-
Chidiac, P.1
Hebert, T.E.2
Valiquette, M.3
Dennis, M.4
Bouvier, M.5
-
8
-
-
0030596148
-
The crystal structure of a hyperthermophilic archaeal TATA-box binding protein
-
DeDecker B.S., O'Brien R., Fleming P.J., Geiger J.H., Jackson S.P., and Sigler P.B. The crystal structure of a hyperthermophilic archaeal TATA-box binding protein. J. Mol. Biol. 264 (1996) 1072-1084
-
(1996)
J. Mol. Biol.
, vol.264
, pp. 1072-1084
-
-
DeDecker, B.S.1
O'Brien, R.2
Fleming, P.J.3
Geiger, J.H.4
Jackson, S.P.5
Sigler, P.B.6
-
9
-
-
0034705142
-
Internal packing of helical membrane proteins
-
Eilers M., Shekar S.C., Shieh T., Smith S.O., and Fleming P.J. Internal packing of helical membrane proteins. Proc. Natl. Acad. Sci. USA 97 (2000) 5796-5801
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 5796-5801
-
-
Eilers, M.1
Shekar, S.C.2
Shieh, T.3
Smith, S.O.4
Fleming, P.J.5
-
10
-
-
0036226583
-
Comparison of helix interactions in membrane and soluble α-bundle proteins
-
Eilers M., Patel A.B., Liu W., and Smith S.O. Comparison of helix interactions in membrane and soluble α-bundle proteins. Biophys. J. 82 (2002) 2720-2736
-
(2002)
Biophys. J.
, vol.82
, pp. 2720-2736
-
-
Eilers, M.1
Patel, A.B.2
Liu, W.3
Smith, S.O.4
-
11
-
-
9644281567
-
Caveolin scaffolding region and cholesterol-rich domains in membranes
-
Epand R.M., Sayer B.G., and Epand R.F. Caveolin scaffolding region and cholesterol-rich domains in membranes. J. Mol. Biol. 345 (2005) 339-350
-
(2005)
J. Mol. Biol.
, vol.345
, pp. 339-350
-
-
Epand, R.M.1
Sayer, B.G.2
Epand, R.F.3
-
12
-
-
33646579178
-
Juxtamembrane protein segments that contribute to recruitment of cholesterol into domains
-
Epand R.F., Thomas A., Brasseur R., Vishwanathan S.A., Hunter E., and Epand R.M. Juxtamembrane protein segments that contribute to recruitment of cholesterol into domains. Biochemistry 45 (2006) 6105-6114
-
(2006)
Biochemistry
, vol.45
, pp. 6105-6114
-
-
Epand, R.F.1
Thomas, A.2
Brasseur, R.3
Vishwanathan, S.A.4
Hunter, E.5
Epand, R.M.6
-
13
-
-
0037206131
-
Cholesterol as stabilizer of the oxytocin receptor
-
Gimpl G., and Fahrenholz F. Cholesterol as stabilizer of the oxytocin receptor. Biochim. Biophys. Acta 1564 (2002) 384-392
-
(2002)
Biochim. Biophys. Acta
, vol.1564
, pp. 384-392
-
-
Gimpl, G.1
Fahrenholz, F.2
-
14
-
-
0030774729
-
Cholesterol as modulator of receptor function
-
Gimpl G., Burger K., and Fahrenholz F. Cholesterol as modulator of receptor function. Biochemistry 36 (1997) 10959-10974
-
(1997)
Biochemistry
, vol.36
, pp. 10959-10974
-
-
Gimpl, G.1
Burger, K.2
Fahrenholz, F.3
-
15
-
-
33645519597
-
A role for direct interactions in the modulation of rhodopsin by omega-3 polyunsaturated lipids
-
Grossfield A., Feller S.E., and Pitman M.C. A role for direct interactions in the modulation of rhodopsin by omega-3 polyunsaturated lipids. Proc. Natl. Acad. Sci. USA 103 (2006) 4888-4893
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 4888-4893
-
-
Grossfield, A.1
Feller, S.E.2
Pitman, M.C.3
-
16
-
-
0036893702
-
Mutation of Asn293 to Asp in transmembrane helix VI abolishes agonist-induced but not constitutive activity of the β(2)-adrenergic receptor
-
Hannawacker A., Krasel C., and Lohse M.J. Mutation of Asn293 to Asp in transmembrane helix VI abolishes agonist-induced but not constitutive activity of the β(2)-adrenergic receptor. Mol. Pharmacol. 62 (2002) 1431-1437
-
(2002)
Mol. Pharmacol.
, vol.62
, pp. 1431-1437
-
-
Hannawacker, A.1
Krasel, C.2
Lohse, M.J.3
-
17
-
-
20044376658
-
Characterization of the cholesterol recognition amino acid consensus sequence of the peripheral-type benzodiazepine receptor
-
Jamin N., Neumann J.M., Ostuni M.A., Vu T.K., Yao Z.X., Murail S., Robert J.C., Giatzakis C., Papadopoulos V., and Lacapere J.J. Characterization of the cholesterol recognition amino acid consensus sequence of the peripheral-type benzodiazepine receptor. Mol. Endocrinol. 19 (2005) 588-594
-
(2005)
Mol. Endocrinol.
, vol.19
, pp. 588-594
-
-
Jamin, N.1
Neumann, J.M.2
Ostuni, M.A.3
Vu, T.K.4
Yao, Z.X.5
Murail, S.6
Robert, J.C.7
Giatzakis, C.8
Papadopoulos, V.9
Lacapere, J.J.10
-
18
-
-
7044241302
-
How lipids affect the activities of integral membrane proteins
-
Lee A.G. How lipids affect the activities of integral membrane proteins. Biochim. Biophys. Acta 1666 (2004) 62-87
-
(2004)
Biochim. Biophys. Acta
, vol.1666
, pp. 62-87
-
-
Lee, A.G.1
-
19
-
-
0031755752
-
Peripheral-type benzodiazepine receptor function in cholesterol transport. Identification of a putative cholesterol recognition/interaction amino acid sequence and consensus pattern
-
Li H., and Papadopoulos V. Peripheral-type benzodiazepine receptor function in cholesterol transport. Identification of a putative cholesterol recognition/interaction amino acid sequence and consensus pattern. Endocrinology 139 (1998) 4991-4997
-
(1998)
Endocrinology
, vol.139
, pp. 4991-4997
-
-
Li, H.1
Papadopoulos, V.2
-
20
-
-
0344820768
-
Lipid composition of Spodoptera frugiperda (Sf9) and Trichoplusia ni (Tn) insect cells used for baculovirus infection
-
Marheineke K., Grunewald S., Christie W., and Reilander H. Lipid composition of Spodoptera frugiperda (Sf9) and Trichoplusia ni (Tn) insect cells used for baculovirus infection. FEBS Lett. 441 (1998) 49-52
-
(1998)
FEBS Lett.
, vol.441
, pp. 49-52
-
-
Marheineke, K.1
Grunewald, S.2
Christie, W.3
Reilander, H.4
-
22
-
-
0037036457
-
Manipulation of cholesterol levels in rod disk membranes by methyl-β-cyclodextrin: effects on receptor activation
-
Niu S.L., Mitchell D.C., and Litman B.J. Manipulation of cholesterol levels in rod disk membranes by methyl-β-cyclodextrin: effects on receptor activation. J. Biol. Chem. 277 (2002) 20139-20145
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 20139-20145
-
-
Niu, S.L.1
Mitchell, D.C.2
Litman, B.J.3
-
23
-
-
0035834749
-
Receptor number and caveolar co-localization determine receptor coupling efficiency to adenylyl cyclase
-
Ostrom R.S., Gregorian C., Drenan R.M., Xiang Y., Regan J.W., and Insel P.A. Receptor number and caveolar co-localization determine receptor coupling efficiency to adenylyl cyclase. J. Biol. Chem. 276 (2001) 42063-42069
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 42063-42069
-
-
Ostrom, R.S.1
Gregorian, C.2
Drenan, R.M.3
Xiang, Y.4
Regan, J.W.5
Insel, P.A.6
-
24
-
-
0033554397
-
Membrane cholesterol modulates galanin-GalR2 interaction
-
Pang L., Graziano M., and Wang S. Membrane cholesterol modulates galanin-GalR2 interaction. Biochemistry 38 (1999) 12003-12011
-
(1999)
Biochemistry
, vol.38
, pp. 12003-12011
-
-
Pang, L.1
Graziano, M.2
Wang, S.3
-
25
-
-
0029411262
-
Occluded molecular surface: analysis of protein packing
-
Pattabiraman N., Ward K.B., and Fleming P.J. Occluded molecular surface: analysis of protein packing. J. Mol. Recognit. 8 (1995) 334-344
-
(1995)
J. Mol. Recognit.
, vol.8
, pp. 334-344
-
-
Pattabiraman, N.1
Ward, K.B.2
Fleming, P.J.3
-
26
-
-
2442509293
-
Cholesterol modulates ligand binding and G-protein coupling to serotonin1A receptors from bovine hippocampus
-
Pucadyil T.J., and Chattopadhyay A. Cholesterol modulates ligand binding and G-protein coupling to serotonin1A receptors from bovine hippocampus. Biochim. Biophys. Acta 1663 (2004) 188-200
-
(2004)
Biochim. Biophys. Acta
, vol.1663
, pp. 188-200
-
-
Pucadyil, T.J.1
Chattopadhyay, A.2
-
27
-
-
33744543610
-
Role of cholesterol in the function and organization of G-protein coupled receptors
-
Pucadyil T.J., and Chattopadhyay A. Role of cholesterol in the function and organization of G-protein coupled receptors. Prog. Lipid Res. 45 (2006) 295-333
-
(2006)
Prog. Lipid Res.
, vol.45
, pp. 295-333
-
-
Pucadyil, T.J.1
Chattopadhyay, A.2
-
28
-
-
36248970132
-
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
-
Rasmussen S.G., Choi H.J., Rosenbaum D.M., Kobilka T.S., Thian F.S., Edwards P.C., Burghammer M., Ratnala V.R., Sanishvili R., Fischetti R.F., et al. Crystal structure of the human β2 adrenergic G-protein-coupled receptor. Nature 450 (2007) 383-387
-
(2007)
Nature
, vol.450
, pp. 383-387
-
-
Rasmussen, S.G.1
Choi, H.J.2
Rosenbaum, D.M.3
Kobilka, T.S.4
Thian, F.S.5
Edwards, P.C.6
Burghammer, M.7
Ratnala, V.R.8
Sanishvili, R.9
Fischetti, R.F.10
-
29
-
-
36448978229
-
GPCR engineering yields high-resolution structural insights into β2-adrenergic receptor function
-
Rosenbaum D.M., Cherezov V., Hanson M.A., Rasmussen S.G., Thian F.S., Kobilka T.S., Choi H.J., Yao X.J., Weis W.I., Stevens R.C., et al. GPCR engineering yields high-resolution structural insights into β2-adrenergic receptor function. Science 318 (2007) 1266-1273
-
(2007)
Science
, vol.318
, pp. 1266-1273
-
-
Rosenbaum, D.M.1
Cherezov, V.2
Hanson, M.A.3
Rasmussen, S.G.4
Thian, F.S.5
Kobilka, T.S.6
Choi, H.J.7
Yao, X.J.8
Weis, W.I.9
Stevens, R.C.10
-
30
-
-
39149100948
-
Stabilization of the human β2-adrenergic receptor TM4-TM3-TM5 helix interface by mutagenesis of Glu122(3.41), a critical residue in GPCR structure
-
Roth C.B., Hanson M.A., and Stevens R.C. Stabilization of the human β2-adrenergic receptor TM4-TM3-TM5 helix interface by mutagenesis of Glu122(3.41), a critical residue in GPCR structure. J. Mol. Biol. 376 (2008) 1305-1319
-
(2008)
J. Mol. Biol.
, vol.376
, pp. 1305-1319
-
-
Roth, C.B.1
Hanson, M.A.2
Stevens, R.C.3
-
31
-
-
0034731376
-
Differential targeting of β-adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae
-
Rybin V.O., Xu X., Lisanti M.P., and Steinberg S.F. Differential targeting of β-adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. J. Biol. Chem. 275 (2000) 41447-41457
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 41447-41457
-
-
Rybin, V.O.1
Xu, X.2
Lisanti, M.P.3
Steinberg, S.F.4
-
32
-
-
0034529050
-
How cells handle cholesterol
-
Simons K., and Ikonen E. How cells handle cholesterol. Science 290 (2000) 1721-1726
-
(2000)
Science
, vol.290
, pp. 1721-1726
-
-
Simons, K.1
Ikonen, E.2
-
33
-
-
3242741045
-
β2-Adrenergic receptor signaling complexes in cardiomyocyte caveolae/lipid rafts
-
Steinberg S.F. β2-Adrenergic receptor signaling complexes in cardiomyocyte caveolae/lipid rafts. J. Mol. Cell. Cardiol. 37 (2004) 407-415
-
(2004)
J. Mol. Cell. Cardiol.
, vol.37
, pp. 407-415
-
-
Steinberg, S.F.1
-
34
-
-
0037024360
-
Identification of G protein-coupled receptor genes from the human genome sequence
-
Takeda S., Kadowaki S., Haga T., Takaesu H., and Mitaku S. Identification of G protein-coupled receptor genes from the human genome sequence. FEBS Lett. 520 (2002) 97-101
-
(2002)
FEBS Lett.
, vol.520
, pp. 97-101
-
-
Takeda, S.1
Kadowaki, S.2
Haga, T.3
Takaesu, H.4
Mitaku, S.5
-
35
-
-
0029838206
-
Involvement of Asn-293 in stereospecific agonist recognition and in activation of the β2-adrenergic receptor
-
Wieland K., Zuurmond H.M., Krasel C., Ijzerman A.P., and Lohse M.J. Involvement of Asn-293 in stereospecific agonist recognition and in activation of the β2-adrenergic receptor. Proc. Natl. Acad. Sci. USA 93 (1996) 9276-9281
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 9276-9281
-
-
Wieland, K.1
Zuurmond, H.M.2
Krasel, C.3
Ijzerman, A.P.4
Lohse, M.J.5
-
36
-
-
0141591523
-
The PDZ-binding motif of the β2-adrenoceptor is essential for physiologic signaling and trafficking in cardiac myocytes
-
Xiang Y., and Kobilka B. The PDZ-binding motif of the β2-adrenoceptor is essential for physiologic signaling and trafficking in cardiac myocytes. Proc. Natl. Acad. Sci. USA 100 (2003) 10776-10781
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 10776-10781
-
-
Xiang, Y.1
Kobilka, B.2
-
37
-
-
23044445764
-
Using synthetic lipids to stabilize purified β2 adrenoceptor in detergent micelles
-
Yao Z., and Kobilka B. Using synthetic lipids to stabilize purified β2 adrenoceptor in detergent micelles. Anal. Biochem. 343 (2005) 344-346
-
(2005)
Anal. Biochem.
, vol.343
, pp. 344-346
-
-
Yao, Z.1
Kobilka, B.2
-
38
-
-
0017595572
-
Timolol. A β-adrenergic blocking agent for the treatment of glaucoma
-
Zimmerman T.J., and Kaufman H.E. Timolol. A β-adrenergic blocking agent for the treatment of glaucoma. Arch. Ophthalmol. 95 (1977) 601-604
-
(1977)
Arch. Ophthalmol.
, vol.95
, pp. 601-604
-
-
Zimmerman, T.J.1
Kaufman, H.E.2
|