AFQ056, a new mGluR5 antagonist for treatment of fragile X syndrome

Neurobiology of Disease

Volumn 42, Issue 3, 2011, Pages 311-317

  Levenga, Josien ^a   Hayashi, Shigemi ^b   de Vrij, Femke M S ^a   Koekkoek, Sebastiaan K ^a   van der Linde, Herma C ^a   Nieuwenhuizen, Ingeborg ^a   Song, Cheng ^b   Buijsen, Ronald A M ^a   Pop, Andreea S ^a   GomezMancilla, Baltazar ^b   Nelson, David L ^c   Willemsen, Rob ^a   Gasparini, Fabrizio ^b   Oostra, Ben A ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b NOVARTIS PHARMA AG   (Switzerland)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

AFQ056; Fragile X syndrome; PPI; Spine morphology

Indexed keywords

AFQ 056; FRAGILE X MENTAL RETARDATION PROTEIN; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DENDRITIC SPINE; FRAGILE X SYNDROME; HIPPOCAMPUS; KNOCKOUT MOUSE; MOUSE; NERVE CELL CULTURE; NONHUMAN; PHENOTYPE; PREPULSE INHIBITION; PRIORITY JOURNAL; STARTLE REFLEX;

ANIMALS; CELLS, CULTURED; DENDRITIC SPINES; FRAGILE X MENTAL RETARDATION PROTEIN; HIPPOCAMPUS; MICE; MICE, KNOCKOUT; NEURONS; RECEPTORS, METABOTROPIC GLUTAMATE; SENSORY GATING; STARTLE REACTION;

EID: 79954629349     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2011.01.022     Document Type: Article

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