Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

Nature

Volumn 474, Issue 7352, 2011, Pages 521-526

  Lebon, Guillaume ^a   Warne, Tony ^a   Edwards, Patricia C ^a   Bennett, Kirstie ^b   Langmead, Christopher J ^b   Leslie, Andrew G W ^a   Tate, Christopher G ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b Heptares Therapeutics Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; ADENOSINE; ADENOSINE A2A RECEPTOR; BETA ADRENERGIC RECEPTOR; G PROTEIN COUPLED RECEPTOR;

CYTOPLASM; LIGAND; MEMBRANE; PROTEIN;

ARTICLE; BINDING SITE; COMPARATIVE STUDY; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; CYTOPLASM; HUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; THERMOSTABILITY;

ADENOSINE; ADENOSINE A2 RECEPTOR AGONISTS; ADENOSINE-5'-(N-ETHYLCARBOXAMIDE); ANIMALS; BINDING SITES; CHO CELLS; CRICETINAE; CRICETULUS; CRYSTALLOGRAPHY, X-RAY; DRUG INVERSE AGONISM; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; RECEPTOR, ADENOSINE A2A; TRIAZINES; TRIAZOLES;

EID: 79959564813     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature10136     Document Type: Article

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