2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

Neuropharmacology

Volumn 38, Issue 10, 1999, Pages 1493-1503

  Gasparini, Fabrizio ^a   Lingenhöhl, Kurt ^a   Stoehr, Natacha ^a   Flor, Peter J ^a   Heinrich, Micheline ^a   Vranesic, Ivo ^a   Biollaz, Michel ^a   Allgeier, Hans ^a   Heckendorn, Roland ^a   Urwyler, Stephan ^a   Varney, Mark A ^b   Johnson, Edwin C ^b   Hess, Stephen D ^b   Rao, Sara P ^b   Sacaan, Aida I ^b   Santori, Emily M ^b   Veliçelebi, Gönul ^b   Kuhn, Rainer ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antagonist; Metabotropic glutamate receptor; mGlu; MPEP; Non competitive

Indexed keywords

2 METHYL 6 (2 PHENYLVINYL)PYRIDINE; 2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 2 METHYL 6 STYRYL PYRIDINE; 6 METHYL 2 PHENYLAZO 3 PYRIDINOL; GLUTAMATE RECEPTOR ANTAGONIST; METABOTROPIC RECEPTOR; PYRIDINE DERIVATIVE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG INHIBITION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; HIPPOCAMPUS; NERVE CONDUCTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANIMALS, NEWBORN; BRAIN; CELL LINE; CYCLIC AMP; EXCITATORY AMINO ACID ANTAGONISTS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; LITHIUM CHLORIDE; MALE; METHOXYHYDROXYPHENYLGLYCOL; OOCYTES; PHOSPHATIDYLINOSITOLS; PYRIDINES; QUISQUALIC ACID; RADIOLIGAND ASSAY; RATS; RATS, INBRED STRAINS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; RECOMBINANT PROTEINS; SULFUR RADIOISOTOPES; TRANSFECTION; XENOPUS LAEVIS;

EID: 0032853255     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(99)00082-9     Document Type: Article

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