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Volumn 113, Issue 3, 2004, Pages 340-345

Central role of the P2Y12 receptor in platelet activation

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; PURINE P2Y12 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; MEMBRANE PROTEIN; P2RY12 PROTEIN, HUMAN; PURINE P2 RECEPTOR;

EID: 85047693299     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI20986     Document Type: Review
Times cited : (506)

References (53)
  • 1
    • 0141721540 scopus 로고    scopus 로고
    • Signaling events underlying thrombus formation
    • Jackson, S.P., Nesbitt, W.S., and Kulkarni, S. 2003. Signaling events underlying thrombus formation. Thromb. Haemost. 1:1602-1612.
    • (2003) Thromb. Haemost. , vol.1 , pp. 1602-1612
    • Jackson, S.P.1    Nesbitt, W.S.2    Kulkarni, S.3
  • 2
    • 0141989954 scopus 로고    scopus 로고
    • ADP receptors: Targets for developing antithrombotic agents
    • Kunapuli, S.P., et al. 2003. ADP receptors: targets for developing antithrombotic agents. Curr. Pharm. Des. 9:2303-2316.
    • (2003) Curr. Pharm. Des. , vol.9 , pp. 2303-2316
    • Kunapuli, S.P.1
  • 3
    • 0037951524 scopus 로고    scopus 로고
    • Dynamic regulation of microtubule coils in ADP-induced platelet shape change by p160ROCK (Rho-kinase)
    • Paul, B.Z., et al. 2003. Dynamic regulation of microtubule coils in ADP-induced platelet shape change by p160ROCK (Rho-kinase). Platelets. 14:159-169.
    • (2003) Platelets , vol.14 , pp. 159-169
    • Paul, B.Z.1
  • 5
    • 0030877837 scopus 로고    scopus 로고
    • Signaling through G proteins in platelets: To the integrins and beyond
    • Brass, L.F., Manning, D.R., Cichowski, K., and Abrams, C.S. 1997. Signaling through G proteins in platelets: to the integrins and beyond. Tbromb. Haemost. 78:581-589.
    • (1997) Tbromb. Haemost. , vol.78 , pp. 581-589
    • Brass, L.F.1    Manning, D.R.2    Cichowski, K.3    Abrams, C.S.4
  • 6
    • 0032523064 scopus 로고    scopus 로고
    • Integrin signaling: The platelet paradigm
    • Shattil, S.J., Kashiwagi, H., and Pampori, N. 1998. Integrin signaling: the platelet paradigm. Blood. 91:2645-2657.
    • (1998) Blood , vol.91 , pp. 2645-2657
    • Shattil, S.J.1    Kashiwagi, H.2    Pampori, N.3
  • 8
    • 0030590746 scopus 로고    scopus 로고
    • A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)
    • CAPRIE Steering Committee
    • 1996. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee. Lancet. 348:1329-1339.
    • (1996) Lancet , vol.348 , pp. 1329-1339
  • 9
    • 0034746160 scopus 로고    scopus 로고
    • Potentiation of thromboxane A2-induced platelet secretion by Gi signaling through the phosphoinositide-3 kinase pathway
    • Dangelmaier, C., Jin, J., Smith, J.B., and Kunapuli, S.P. 2001. Potentiation of thromboxane A2-induced platelet secretion by Gi signaling through the phosphoinositide-3 kinase pathway. Tbromb. Haemost. 85:341-348.
    • (2001) Tbromb. Haemost. , vol.85 , pp. 341-348
    • Dangelmaier, C.1    Jin, J.2    Smith, J.B.3    Kunapuli, S.P.4
  • 10
    • 0032493295 scopus 로고    scopus 로고
    • Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation
    • Jin, J., and Kunapuli, S.P. 1998. Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation. Proc. Natl. Acad. Sci. U. S. A. 95:8070-8074.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 8070-8074
    • Jin, J.1    Kunapuli, S.P.2
  • 11
    • 0037032558 scopus 로고    scopus 로고
    • Coordinated signaling through both G12/13 and G(i) pathways is sufficient to activate GPIIb/IIIa in human platelets
    • Dorsam, R.T., Kim, S., Jin, J., and Kunapuli, S.P. 2002. Coordinated signaling through both G12/13 and G(i) pathways is sufficient to activate GPIIb/IIIa in human platelets. J. Biol. Chem. 277:47588-47595.
    • (2002) J. Biol. Chem. , vol.277 , pp. 47588-47595
    • Dorsam, R.T.1    Kim, S.2    Jin, J.3    Kunapuli, S.P.4
  • 12
    • 0036905073 scopus 로고    scopus 로고
    • Protein kinase C- and calcium-regulated pathways independently synergize with Gi pathways in agonist-induced fibrinogen receptor activation
    • Quinton, T.M., et al. 2002. Protein kinase C- and calcium-regulated pathways independently synergize with Gi pathways in agonist-induced fibrinogen receptor activation. Biochem. J. 368:535-543.
    • (2002) Biochem. J. , vol.368 , pp. 535-543
    • Quinton, T.M.1
  • 13
    • 0035860407 scopus 로고    scopus 로고
    • The P2Y(12) receptor induces platelet aggregation through weak activation of the alpha(IIb)beta(3) integrin: A phosphoinositide 3-kinase-dependent mechanism
    • Kauffenstein, G., et al. 2001. The P2Y(12) receptor induces platelet aggregation through weak activation of the alpha(IIb)beta(3) integrin: a phosphoinositide 3-kinase-dependent mechanism. FEBS Lett. 505:281-290.
    • (2001) FEBS Lett. , vol.505 , pp. 281-290
    • Kauffenstein, G.1
  • 14
    • 0037130959 scopus 로고    scopus 로고
    • Costimulation of Gi- and G12/G13-mediated signaling pathways reduces integrin alpha IIbbeta 3 activation in platelets
    • Nieswandt, B., Schulte, V., Zywietz, A., Gratacap, M.P., and Offermanns, S. 2002. Costimulation of Gi- and G12/G13-mediated signaling pathways reduces integrin alpha IIbbeta 3 activation in platelets. J.B Biol. Chem. 277:39493-39498.
    • (2002) J.B Biol. Chem. , vol.277 , pp. 39493-39498
    • Nieswandt, B.1    Schulte, V.2    Zywietz, A.3    Gratacap, M.P.4    Offermanns, S.5
  • 15
    • 0037341392 scopus 로고    scopus 로고
    • In vivo blockade of platelet ADP receptor P2Y12 reduces embolus and thrombus formation but not thrombus stability
    • van Gestel, M.A., et al. 2003. In vivo blockade of platelet ADP receptor P2Y12 reduces embolus and thrombus formation but not thrombus stability. Arterioscler. Thromb. Vasc. Biol. 23:518-523.
    • (2003) Arterioscler. Thromb. Vasc. Biol. , vol.23 , pp. 518-523
    • Van Gestel, M.A.1
  • 16
    • 85047694005 scopus 로고    scopus 로고
    • P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries
    • doi:10.1172/JCI200317864
    • Andre, P., et al. 2003. P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries. J. Clin. Invest. 112:398-406. doi:10.1172/JCI200317864.
    • (2003) J. Clin. Invest. , vol.112 , pp. 398-406
    • Andre, P.1
  • 18
    • 0034911702 scopus 로고    scopus 로고
    • ADP receptors of platelets and their inhibition
    • Gachet, C. 2001. ADP receptors of platelets and their inhibition. Thromb. Haemost. 86:222-232.
    • (2001) Thromb. Haemost. , vol.86 , pp. 222-232
    • Gachet, C.1
  • 19
    • 0035843178 scopus 로고    scopus 로고
    • Identification of the platelet ADP receptor targeted by antithrombotic drugs
    • Hollopeter, J., et al. 2001. Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature. 409:202-207.
    • (2001) Nature , vol.409 , pp. 202-207
    • Hollopeter, J.1
  • 20
    • 0035896562 scopus 로고    scopus 로고
    • ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999
    • Zhang, F.L., et al. 2001. ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999. J. Biol. Chem. 276:8608-8615.
    • (2001) J. Biol. Chem. , vol.276 , pp. 8608-8615
    • Zhang, F.L.1
  • 21
    • 0034665782 scopus 로고    scopus 로고
    • ADP induces partial platelet aggregation without shape change and potentiates collagen-induced aggregation in the absence of Galphaq
    • Ohlmann, P., et al. 2000. ADP induces partial platelet aggregation without shape change and potentiates collagen-induced aggregation in the absence of Galphaq. Blood. 96:2134-2139.
    • (2000) Blood , vol.96 , pp. 2134-2139
    • Ohlmann, P.1
  • 22
    • 0036095953 scopus 로고    scopus 로고
    • Adenosine diphosphate (ADP)-induced thromboxane A(2) generation in human platelets requires coordinated signaling through integrin alpha(IIb)beta(3) and ADP receptors
    • Jin, J., Quinton, T.M., Zhang, J., Rittenhouse, S.E., and Kunapuli, S.P. 2002. Adenosine diphosphate (ADP)-induced thromboxane A(2) generation in human platelets requires coordinated signaling through integrin alpha(IIb)beta(3) and ADP receptors. Blood. 99:193-198.
    • (2002) Blood , vol.99 , pp. 193-198
    • Jin, J.1    Quinton, T.M.2    Zhang, J.3    Rittenhouse, S.E.4    Kunapuli, S.P.5
  • 23
    • 0034781382 scopus 로고    scopus 로고
    • Effects of combining three different antiplatelet agents on platelets and leukocytes in whole blood in vitro
    • Zhao, L., Bath, P., and Heptinstall, S. 2001. Effects of combining three different antiplatelet agents on platelets and leukocytes in whole blood in vitro. Br. J. Pharmacol. 134:353-358.
    • (2001) Br. J. Pharmacol. , vol.134 , pp. 353-358
    • Zhao, L.1    Bath, P.2    Heptinstall, S.3
  • 24
    • 0036714323 scopus 로고    scopus 로고
    • Inhibition of ADP-induced P-selectin expression and platelet-leukocyte conjugate formation by clopidogrel and the P2Y12 receptor antagonist AR-C69931MX but not aspirin
    • Storey, R.F., Judge, H.M., Wilcox, R.G., and Heptinstall, S. 2002. Inhibition of ADP-induced P-selectin expression and platelet-leukocyte conjugate formation by clopidogrel and the P2Y12 receptor antagonist AR-C69931MX but not aspirin. Thromb. Haemost. 88:488-494.
    • (2002) Thromb. Haemost. , vol.88 , pp. 488-494
    • Storey, R.F.1    Judge, H.M.2    Wilcox, R.G.3    Heptinstall, S.4
  • 25
    • 0344200064 scopus 로고    scopus 로고
    • Role of intracellular signaling events in ADP-induced platelet aggregation
    • Daniel, J.L., Dangelmaier, C., Jin, J., Kim, Y.B., and Kunapuli, S.P. 1999. Role of intracellular signaling events in ADP-induced platelet aggregation. Thromb. Haemost. 82:1322-1326.
    • (1999) Thromb. Haemost. , vol.82 , pp. 1322-1326
    • Daniel, J.L.1    Dangelmaier, C.2    Jin, J.3    Kim, Y.B.4    Kunapuli, S.P.5
  • 26
    • 0034730185 scopus 로고    scopus 로고
    • Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs
    • Yang, J., et al. 2000. Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs. Proc. Natl. Acad. Sci. U. S. A. 97:9984-9989.
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 9984-9989
    • Yang, J.1
  • 27
    • 0035464192 scopus 로고    scopus 로고
    • Resistance to thromboembolism in PI3Kgamma-deficient mice
    • Hirsch, E., et al. 2001. Resistance to thromboembolism in PI3Kgamma-deficient mice. FASEB J. 15:2019-2021.
    • (2001) FASEB J. , vol.15 , pp. 2019-2021
    • Hirsch, E.1
  • 28
    • 2142645246 scopus 로고    scopus 로고
    • Rap1b regulates integrin IIb3 activity and platelet function: Lessons from a knockout
    • Abstr.
    • Chrzanowska-Wodnicka, M., Schoenwaelder, S., and White, G.C., II. 2003. Rap1b regulates integrin IIb3 activity and platelet function: lessons from a knockout. Blood. 102:773a. (Abstr.)
    • (2003) Blood , vol.102
    • Chrzanowska-Wodnicka, M.1    Schoenwaelder, S.2    White II, G.C.3
  • 29
    • 25544480484 scopus 로고    scopus 로고
    • Role of G-protein coupled inwardly rectifying potassium channels (GIRKs) in P2Y12 receptor-mediated platelet functional responses
    • Abstr.
    • Shankar, H., et al. 2003. Role of G-protein coupled inwardly rectifying potassium channels (GIRKs) in P2Y12 receptor-mediated platelet functional responses. Blood. 102:774a. (Abstr.)
    • (2003) Blood , vol.102
    • Shankar, H.1
  • 30
    • 2142810352 scopus 로고    scopus 로고
    • Mice lacking Akt2 have defects in platelet granule secretion and fibrinogen binding and reduced thrombus formation in vivo
    • Abstr.
    • Woulfe, D.S., et al. 2003. Mice lacking Akt2 have defects in platelet granule secretion and fibrinogen binding and reduced thrombus formation in vivo. Blood. 102:207a. (Abstr.)
    • (2003) Blood , vol.102
    • Woulfe, D.S.1
  • 31
    • 1042301420 scopus 로고    scopus 로고
    • Akt activation in platelets depends on Gi signaling pathways
    • In press
    • Kim, S., Jin, J., and Kunapuli, S.P. 2004. Akt activation in platelets depends on Gi signaling pathways. J. Biol. Chem. In press.
    • (2004) J. Biol. Chem.
    • Kim, S.1    Jin, J.2    Kunapuli, S.P.3
  • 32
    • 0028942659 scopus 로고
    • An inherited bleeding disorder linked to a defective interaction between ADP and its receptor on platelets. Its influence on glycoprotein IIb-IIIa complex function
    • Nurden, P., et al. 1995. An inherited bleeding disorder linked to a defective interaction between ADP and its receptor on platelets. Its influence on glycoprotein IIb-IIIa complex function. J. Clin. Invest. 95:1612-1622.
    • (1995) J. Clin. Invest. , vol.95 , pp. 1612-1622
    • Nurden, P.1
  • 33
    • 0026486964 scopus 로고
    • Identification of a new congenital defect of platelet function characterized by severe impairment of platelet responses to adenosine diphosphate
    • Cattaneo, M., Lecchi, A., Randi, A.M., McGregor, J.L., and Mannucci, P.M. 1992. Identification of a new congenital defect of platelet function characterized by severe impairment of platelet responses to adenosine diphosphate. Blood. 80:2787-2796.
    • (1992) Blood , vol.80 , pp. 2787-2796
    • Cattaneo, M.1    Lecchi, A.2    Randi, A.M.3    McGregor, J.L.4    Mannucci, P.M.5
  • 34
    • 0034323126 scopus 로고    scopus 로고
    • Platelets from a patient heterozygous for the defect of P2CYC receptors for ADP have a secretion defect despite normal thromboxane A2 production and normal granule stores: Further evidence that some cases of platelet 'primary secretion defect' are heterozygous for a defect of P2CYC receptors
    • Cattaneo, M., Lecchi, A., Lombardi, R., Gachet, C., and Zighetti, M.L. 2000. Platelets from a patient heterozygous for the defect of P2CYC receptors for ADP have a secretion defect despite normal thromboxane A2 production and normal granule stores: further evidence that some cases of platelet 'primary secretion defect' are heterozygous for a defect of P2CYC receptors. Arterioscler. Thromb. Vasc. Biol. 20:E101-E106.
    • (2000) Arterioscler. Thromb. Vasc. Biol. , vol.20
    • Cattaneo, M.1    Lecchi, A.2    Lombardi, R.3    Gachet, C.4    Zighetti, M.L.5
  • 35
    • 0037452681 scopus 로고    scopus 로고
    • Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding
    • Cattaneo, M., et al. 2003. Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding. Proc. Natl. Acad. Sci. U. S. A. 100:1978-1983.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 1978-1983
    • Cattaneo, M.1
  • 36
    • 0034978187 scopus 로고    scopus 로고
    • Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs
    • Foster, C.J., et al. 2001. Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs. J. Clin. Invest. 107:1591-1598.
    • (2001) J. Clin. Invest. , vol.107 , pp. 1591-1598
    • Foster, C.J.1
  • 37
    • 0030610096 scopus 로고    scopus 로고
    • Deficiency of (P-33)2MeS-ADP binding sites on platelets with secretion defect, normal granule stores and normal thromboxane A2 production. Evidence that Adp potentiates platelet secretion independently of the formation of large platelet aggregates and thromboxane A2 production
    • Cattaneo, M., et al. 1997. Deficiency of (P-33)2MeS-ADP binding sites on platelets with secretion defect, normal granule stores and normal thromboxane A2 production. Evidence that Adp potentiates platelet secretion independently of the formation of large platelet aggregates and thromboxane A2 production. Thromb. Haemost. 77:986-990.
    • (1997) Thromb. Haemost. , vol.77 , pp. 986-990
    • Cattaneo, M.1
  • 38
    • 0042703242 scopus 로고    scopus 로고
    • Scientific and therapeutic insights into the role of the platelet P2Y12 receptor in thrombosis
    • Conley, P.B., and Delaney, S.M. 2003. Scientific and therapeutic insights into the role of the platelet P2Y12 receptor in thrombosis. Curr. Opin. Hematol. 10:333-338.
    • (2003) Curr. Opin. Hematol. , vol.10 , pp. 333-338
    • Conley, P.B.1    Delaney, S.M.2
  • 39
    • 0035120357 scopus 로고    scopus 로고
    • Novel platelet inhibitors
    • Bennett, J.S. 2001. Novel platelet inhibitors. Annu. Rev. Med. 52:161-184.
    • (2001) Annu. Rev. Med. , vol.52 , pp. 161-184
    • Bennett, J.S.1
  • 40
    • 0034805389 scopus 로고    scopus 로고
    • P2y(12), a new platelet ADP receptor, target of clopidogrel
    • Savi, P., et al. 2001. P2y(12), a new platelet ADP receptor, target of clopidogrel. Biochem. Biophys. Res. Commun. 283:379-383.
    • (2001) Biochem. Biophys. Res. Commun. , vol.283 , pp. 379-383
    • Savi, P.1
  • 41
    • 0034858808 scopus 로고    scopus 로고
    • Molecular cloning of the platelet P2T(AC) ADP receptor: Pharmacological comparison with another ADP receptor, the P2Y(1) receptor
    • Takasaki, J., et al. 2001. Molecular cloning of the platelet P2T(AC) ADP receptor: pharmacological comparison with another ADP receptor, the P2Y(1) receptor. Mol. Pharmacol. 60:432-439.
    • (2001) Mol. Pharmacol. , vol.60 , pp. 432-439
    • Takasaki, J.1
  • 42
    • 0036121597 scopus 로고    scopus 로고
    • Role of ADP receptor P2Y(12) in platelet adhesion and thrombus formation in flowing blood
    • Remijn, J.A., et al. 2002. Role of ADP receptor P2Y(12) in platelet adhesion and thrombus formation in flowing blood. Arterioscler Thromb. Vasc. Biol. 22:686-691.
    • (2002) Arterioscler Thromb. Vasc. Biol. , vol.22 , pp. 686-691
    • Remijn, J.A.1
  • 43
    • 0035760304 scopus 로고    scopus 로고
    • Blockade of adenosine diphosphate receptors P2Y(12) and P2Y(1) is required to inhibit platelet aggregation in whole blood under flow
    • Turner, N.A., Moake, J.L., and McIntire, L.V. 2001. Blockade of adenosine diphosphate receptors P2Y(12) and P2Y(1) is required to inhibit platelet aggregation in whole blood under flow. Blood. 98:3340-3345.
    • (2001) Blood , vol.98 , pp. 3340-3345
    • Turner, N.A.1    Moake, J.L.2    McIntire, L.V.3
  • 44
    • 0037188563 scopus 로고    scopus 로고
    • Functional significance of adenosine 5′-diphosphate receptor (P2Y(12)) in platelet activation initiated by binding of von Willebrand factor to platelet GP 1balpha induced by conditions of high shear rate
    • Goto, S., Tamura, N., Eto, K., Ikeda, Y., and Handa, S. 2002. Functional significance of adenosine 5′-diphosphate receptor (P2Y(12)) in platelet activation initiated by binding of von Willebrand factor to platelet GP 1balpha induced by conditions of high shear rate. Circulation. 105:2531-2536.
    • (2002) Circulation , vol.105 , pp. 2531-2536
    • Goto, S.1    Tamura, N.2    Eto, K.3    Ikeda, Y.4    Handa, S.5
  • 45
    • 0035843684 scopus 로고    scopus 로고
    • Results of CURE trial for acute coronary syndrome
    • Mitka, M. 2001. Results of CURE trial for acute coronary syndrome. JAMA. 285:1828-1829.
    • (2001) JAMA , vol.285 , pp. 1828-1829
    • Mitka, M.1
  • 46
    • 0036153984 scopus 로고    scopus 로고
    • From CURE to MATCH: ADP receptor antagonists as the treatment of choice for high-risk atherothrombotic patients
    • Hacke, W. 2002. From CURE to MATCH: ADP receptor antagonists as the treatment of choice for high-risk atherothrombotic patients. Cerebrovasc. Dis. 13:22-26.
    • (2002) Cerebrovasc. Dis. , vol.13 , pp. 22-26
    • Hacke, W.1
  • 47
    • 0034660472 scopus 로고    scopus 로고
    • Thrombotic thrombocytopenic purpura associated with clopidogrel
    • Bennett, C.L., et al. 2000. Thrombotic thrombocytopenic purpura associated with clopidogrel. N. Engl. J. Med. 342:1773-1777.
    • (2000) N. Engl. J. Med. , vol.342 , pp. 1773-1777
    • Bennett, C.L.1
  • 48
    • 0038508970 scopus 로고    scopus 로고
    • The metabolism of clopidogrel is catalyzed by human cytochrome P450 3A and is inhibited by atorvastatin
    • Clarke, T.A., and Waskell, L.A. 2003. The metabolism of clopidogrel is catalyzed by human cytochrome P450 3A and is inhibited by atorvastatin. Drug Metab Dispos. 31:53-59.
    • (2003) Drug Metab Dispos. , vol.31 , pp. 53-59
    • Clarke, T.A.1    Waskell, L.A.2
  • 49
    • 0037422534 scopus 로고    scopus 로고
    • Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: A new drug-drug interaction
    • Lau, W.C., et al. 2003. Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: a new drug-drug interaction. Circulation. 107:32-37.
    • (2003) Circulation , vol.107 , pp. 32-37
    • Lau, W.C.1
  • 50
    • 0042780283 scopus 로고    scopus 로고
    • Lack of adverse clopidogrel-atorvastatin clinical interaction from secondary analysis of a randomized, placebo-controlled clopidogrel trial
    • Saw, J., et al. 2003. Lack of adverse clopidogrel-atorvastatin clinical interaction from secondary analysis of a randomized, placebo-controlled clopidogrel trial. Circulation. 108:921-924.
    • (2003) Circulation , vol.108 , pp. 921-924
    • Saw, J.1
  • 51
    • 0042848535 scopus 로고    scopus 로고
    • Comparison of clinical benefits of clopidogrel therapy in patients with acute coronary syndromes taking atorvastatin versus other statin therapies
    • Wienbergen, H., et al. 2003. Comparison of clinical benefits of clopidogrel therapy in patients with acute coronary syndromes taking atorvastatin versus other statin therapies. Am. J. Cardiol. 92:285-288.
    • (2003) Am. J. Cardiol. , vol.92 , pp. 285-288
    • Wienbergen, H.1
  • 52
    • 1542640443 scopus 로고    scopus 로고
    • Inhibition of localized thrombosis in P2Y1-deficient mice and todents treated with MRS2179, a P2Y1 receptor antagonist
    • Lenain, N., Freund, M., Leon, C., Cazenave, J.P., and Gachet, C. 2003. Inhibition of localized thrombosis in P2Y1-deficient mice and todents treated with MRS2179, a P2Y1 receptor antagonist. J. Thromb. Haemost. 1:1144-1149.
    • (2003) J. Thromb. Haemost. , vol.1 , pp. 1144-1149
    • Lenain, N.1    Freund, M.2    Leon, C.3    Cazenave, J.P.4    Gachet, C.5
  • 53
    • 0037289827 scopus 로고    scopus 로고
    • Blockade of the platelet P2Y12 receptor by AR-C69931MX sustains coronary artery recanalization and improves the myocardial tissue perfusion in a canine thrombosis model
    • Wang, K., et al. 2003. Blockade of the platelet P2Y12 receptor by AR-C69931MX sustains coronary artery recanalization and improves the myocardial tissue perfusion in a canine thrombosis model. Arterioscler. Thromb. Vasc. Biol. 23:357-362.
    • (2003) Arterioscler. Thromb. Vasc. Biol. , vol.23 , pp. 357-362
    • Wang, K.1


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