Targeting of smoothened for therapeutic gain

Trends in Pharmacological Sciences

Volumn 35, Issue 5, 2014, Pages 237-246

  Ruat, Martial ^a   Hoch, Lucile ^a   Faure, Hélène ^a   Rognan, Didier ^b  

^a CNRS   (France)

^b Faculté de Pharmacie   (France)

Author keywords

bias agonism; cancer; Hedgehog; neurodegenerative disease; stem cell

Indexed keywords

GSA 10; QUINOLONE; SARIDEGIB; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; SONIDEGIB; UNCLASSIFIED DRUG; VISMODEGIB;

ANTINEOPLASTIC ACTIVITY; BASAL CELL CARCINOMA; BRAIN INJURY; CANCER THERAPY; DEMYELINATING DISEASE; DRUG MECHANISM; HUMAN; LIGAND BINDING; MOLECULARLY TARGETED THERAPY; NERVE REGENERATION; NEURAL STEM CELL; NONHUMAN; OLIGOMERIZATION; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN TARGETING; REVIEW; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; SYSTEMIC SCLEROSIS;

BIAS AGONISM; CANCER; HEDGEHOG; NEURODEGENERATIVE DISEASE; STEM CELL;

ANIMALS; HEDGEHOG PROTEINS; HUMANS; LIGANDS; MOLECULAR TARGETED THERAPY; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 84899654206     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2014.03.002     Document Type: Review

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