High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875.

Nature

Volumn 513, Issue 7516, 2014, Pages 124-127

  Srivastava, Ankita ^a   Yano, Jason ^a   Hirozane, Yoshihiko ^a   Kefala, Georgia ^a   Gruswitz, Franz ^a   Snell, Gyorgy ^a   Lane, Weston ^a   Ivetac, Anthony ^a   Aertgeerts, Kathleen ^a   Nguyen, Jasmine ^a   Jennings, Andy ^a   Okada, Kengo ^a  

^a Takeda San Diego Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOFURAN DERIVATIVE; FASIGLIFAM; FFAR1 PROTEIN, HUMAN; G PROTEIN COUPLED RECEPTOR; LIGAND; SULFONE; TAK-875;

ALLOSTERISM; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; DRUG POTENTIATION; HUMAN; LIPID BILAYER; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PARTIAL AGONISM; STRUCTURAL HOMOLOGY; SURFACE PROPERTY; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC REGULATION; BENZOFURANS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIABETES MELLITUS, TYPE 2; DRUG PARTIAL AGONISM; HUMANS; LIGANDS; LIPID BILAYERS; MODELS, MOLECULAR; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURAL HOMOLOGY, PROTEIN; SULFONES; SURFACE PROPERTIES;

EID: 84907221192     PISSN: None     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13494     Document Type: Article

References (0)