-
1
-
-
0016793098
-
Genetic control of cell size at cell division in yeast
-
Nurse, P. Genetic control of cell size at cell division in yeast. Nature, 1975, 256, 547-551.
-
(1975)
Nature
, vol.256
, pp. 547-551
-
-
Nurse, P.1
-
2
-
-
0035235736
-
Mitotic kinases as regulators of cell division and its checkpoints
-
Nigg, E. A. Mitotic kinases as regulators of cell division and its checkpoints. Nat Rev Mol Cell Biol, 2001, 2, 21-32.
-
(2001)
Nat Rev Mol Cell Biol
, vol.2
, pp. 21-32
-
-
Nigg, E. A.1
-
3
-
-
33745674468
-
Drug discovery in the ubiquitin-proteasome system
-
Nalepa, G.; Rolfe, M.; Harper, J. W. Drug discovery in the ubiquitin-proteasome system. Nat Rev Drug Discov, 2006, 5, 596-613.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 596-613
-
-
Nalepa, G.1
Rolfe, M.2
Harper, J. W.3
-
4
-
-
33745156511
-
Ubiquitin and SUMO systems in the regulation of mitotic checkpoints
-
Gutierrez, G. J.; Ronai, Z. Ubiquitin and SUMO systems in the regulation of mitotic checkpoints. Trends Biochem Sci, 2006, 31, 324-332.
-
(2006)
Trends Biochem Sci
, vol.31
, pp. 324-332
-
-
Gutierrez, G. J.1
Ronai, Z.2
-
5
-
-
33646345376
-
Ubiquitin ligases: cell-cycle control and cancer
-
Nakayama, K. I.; Nakayama, K. Ubiquitin ligases: cell-cycle control and cancer. Nat Rev Cancer, 2006, 6, 369-381.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 369-381
-
-
Nakayama, K. I.1
Nakayama, K.2
-
6
-
-
33645279534
-
Epigenetics and cancer: altered chromatin remodeling via Snf5 loss leads to aberrant cell cycle regulation
-
Sansam, C. G.; Roberts, C. W. Epigenetics and cancer: altered chromatin remodeling via Snf5 loss leads to aberrant cell cycle regulation. Cell Cycle, 2006, 5, 621-624.
-
(2006)
Cell Cycle
, vol.5
, pp. 621-624
-
-
Sansam, C. G.1
Roberts, C. W.2
-
7
-
-
0035754080
-
To cycle or not to cycle: a critical decision in cancer
-
Malumbres, M.; Barbacid, M. To cycle or not to cycle: a critical decision in cancer. Nat Rev Cancer, 2001, 1, 222-231.
-
(2001)
Nat Rev Cancer
, vol.1
, pp. 222-231
-
-
Malumbres, M.1
Barbacid, M.2
-
8
-
-
9244239811
-
G1 cell-cycle control and cancer
-
Massague, J. G1 cell-cycle control and cancer. Nature, 2004, 432, 298-306.
-
(2004)
Nature
, vol.432
, pp. 298-306
-
-
Massague, J.1
-
9
-
-
0034660892
-
The Pezcoller lecture: cancer cell cycles revisited
-
Sherr, C. J. The Pezcoller lecture: cancer cell cycles revisited. Cancer Res, 2000, 60, 3689-3695.
-
(2000)
Cancer Res
, vol.60
, pp. 3689-3695
-
-
Sherr, C. J.1
-
10
-
-
0037075887
-
Cyclin D-dependent kinases, INK4 inhibitors and cancer
-
Ortega, S.; Malumbres, M.; Barbacid, M. Cyclin D-dependent kinases, INK4 inhibitors and cancer. Biochim Biophys Acta, 2002, 1602, 73-87.
-
(2002)
Biochim Biophys Acta
, vol.1602
, pp. 73-87
-
-
Ortega, S.1
Malumbres, M.2
Barbacid, M.3
-
12
-
-
27544470656
-
Mammalian cyclin-dependent kinases
-
Malumbres, M.; Barbacid, M. Mammalian cyclin-dependent kinases. Trends Biochem Sci, 2005, 30, 630-641.
-
(2005)
Trends Biochem Sci
, vol.30
, pp. 630-641
-
-
Malumbres, M.1
Barbacid, M.2
-
13
-
-
0020961333
-
Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division
-
Evans, Tom; Rosenthal, Eric T.; Youngblom, Jim; Distel, Dan; Hunt, Tim. Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division. Cell, 1983, 33, 389-396.
-
(1983)
Cell
, vol.33
, pp. 389-396
-
-
Evans, Tom1
Rosenthal, Eric T.2
Youngblom, Jim3
Distel, Dan4
Hunt, Tim5
-
14
-
-
33646087914
-
Cellular responses to DNA damage: current state of the field and review of the 52nd Benzon Symposium
-
Lukas, J.; Bohr, V. A.; Halazonetis, T. D. Cellular responses to DNA damage: current state of the field and review of the 52nd Benzon Symposium. DNA Repair (Amst), 2006, 5, 591-601.
-
(2006)
DNA Repair (Amst)
, vol.5
, pp. 591-601
-
-
Lukas, J.1
Bohr, V. A.2
Halazonetis, T. D.3
-
15
-
-
5044220936
-
Checking on DNA damage in S phase
-
Bartek, J.; Lukas, C.; Lukas, J. Checking on DNA damage in S phase. Nat Rev Mol Cell Biol, 2004, 5, 792-804.
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 792-804
-
-
Bartek, J.1
Lukas, C.2
Lukas, J.3
-
16
-
-
9244251125
-
Cell-cycle checkpoints and cancer
-
Kastan, M. B.; Bartek, J. Cell-cycle checkpoints and cancer. Nature, 2004, 432, 316-323.
-
(2004)
Nature
, vol.432
, pp. 316-323
-
-
Kastan, M. B.1
Bartek, J.2
-
17
-
-
25844475838
-
On the road to cancer: Aneuploidy abd the mitotic checkpoint
-
Kops, Geert J. P. L.; Weaver, Beth A. A.; Cleveland, Don W. On the road to cancer: Aneuploidy abd the mitotic checkpoint. Nature Reviews Cancer, 2005, 5, 773-785.
-
(2005)
Nature Reviews Cancer
, vol.5
, pp. 773-785
-
-
Kops, Geert J. P. L.1
Weaver, Beth A. A.2
Cleveland, Don W.3
-
18
-
-
4544221279
-
Regulation of early events in chromosome replication
-
Diffley, J. F. Regulation of early events in chromosome replication. Curr Biol, 2004, 14, R778-786.
-
(2004)
Curr Biol
, vol.14
, pp. R778-R786
-
-
Diffley, J. F.1
-
19
-
-
0033564697
-
CDK inhibitors: positive and negative regulators of G1-phase progression
-
Sherr, C. J.; Roberts, J. M. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev, 1999, 13, 1501-1512.
-
(1999)
Genes Dev
, vol.13
, pp. 1501-1512
-
-
Sherr, C. J.1
Roberts, J. M.2
-
20
-
-
16544391801
-
Genetic dissection of mammalian Cdc7 kinase: cell cycle and developmental roles
-
Kim, J. M.; Masai, H. Genetic dissection of mammalian Cdc7 kinase: cell cycle and developmental roles. Cell Cycle, 2004, 3, 300-304.
-
(2004)
Cell Cycle
, vol.3
, pp. 300-304
-
-
Kim, J. M.1
Masai, H.2
-
21
-
-
16844364661
-
A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases
-
Yoshizawa-Sugata, N.; Ishii, A.; Taniyama, C.; Matsui, E.; Arai, K.; Masai, H. A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases. J Biol Chem, 2005, 280, 13062-13070.
-
(2005)
J Biol Chem
, vol.280
, pp. 13062-13070
-
-
Yoshizawa-Sugata, N.1
Ishii, A.2
Taniyama, C.3
Matsui, E.4
Arai, K.5
Masai, H.6
-
22
-
-
0642378446
-
Cell cycle deregulation: a common motif in cancer
-
Malumbres, M.; Carnero, A. Cell cycle deregulation: a common motif in cancer. Prog Cell Cycle Res, 2003, 5, 5-18.
-
(2003)
Prog Cell Cycle Res
, vol.5
, pp. 5-18
-
-
Malumbres, M.1
Carnero, A.2
-
23
-
-
0035803395
-
Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors
-
Sotillo, R.; Dubus, P.; Martin, J.; De La Cueva, E.; Ortega, S.; Malumbres, M.; Barbacid, M. Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors. Embo J, 2001, 20, 6637-6647.
-
(2001)
Embo J
, vol.20
, pp. 6637-6647
-
-
Sotillo, R.1
Dubus, P.2
Martin, J.3
De La Cueva, E.4
Ortega, S.5
Malumbres, M.6
Barbacid, M.7
-
24
-
-
0035818589
-
Invasive melanoma in Cdk4-targeted mice
-
Sotillo, R.; Garcia, J. F.; Ortega, S.; Martin, J.; Dubus, P.; Barbacid, M.; Malumbres, M. Invasive melanoma in Cdk4-targeted mice. Proc Natl Acad Sci U S A, 2001, 98, 13312-13317.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 13312-13317
-
-
Sotillo, R.1
Garcia, J. F.2
Ortega, S.3
Martin, J.4
Dubus, P.5
Barbacid, M.6
Malumbres, M.7
-
25
-
-
18144424779
-
Cooperation between Cdk4 and p27kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity
-
Sotillo, R.; Renner, O.; Dubus, P.; Ruiz-Cabello, J.; Martin-Caballero, J.; Barbacid, M.; Carnero, A.; Malumbres, M. Cooperation between Cdk4 and p27kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity. Cancer Res, 2005, 65, 3846-3852.
-
(2005)
Cancer Res
, vol.65
, pp. 3846-3852
-
-
Sotillo, R.1
Renner, O.2
Dubus, P.3
Ruiz-Cabello, J.4
Martin-Caballero, J.5
Barbacid, M.6
Carnero, A.7
Malumbres, M.8
-
26
-
-
4444247138
-
Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6
-
Malumbres, M.; Sotillo, R.; Santamaria, D.; Galan, J.; Cerezo, A.; Ortega, S.; Dubus, P.; Barbacid, M. Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell, 2004, 118, 493-504.
-
(2004)
Cell
, vol.118
, pp. 493-504
-
-
Malumbres, M.1
Sotillo, R.2
Santamaria, D.3
Galan, J.4
Cerezo, A.5
Ortega, S.6
Dubus, P.7
Barbacid, M.8
-
27
-
-
30344478587
-
Is Cyclin D1-CDK4 kinase a bona fide cancer target?
-
Malumbres, Marcos; Barbacid, Mariano. Is Cyclin D1-CDK4 kinase a bona fide cancer target? Cancer Cell, 2006, 9, 2-4.
-
(2006)
Cancer Cell
, vol.9
, pp. 2-4
-
-
Malumbres, Marcos1
Barbacid, Mariano2
-
28
-
-
25444483052
-
Revisiting the "Cdk-centric" view of the mammalian cell cycle
-
Malumbres, M. Revisiting the "Cdk-centric" view of the mammalian cell cycle. Cell Cycle, 2005, 4, 206-210.
-
(2005)
Cell Cycle
, vol.4
, pp. 206-210
-
-
Malumbres, M.1
-
29
-
-
0034162636
-
Preclinical and Clinical Development of Cyclin-Dependent Kinase Modulators
-
Senderowicz, Adrian M.; Sausville, Edward A. Preclinical and Clinical Development of Cyclin-Dependent Kinase Modulators. J Natl Cancer Inst, 2000, 92, 376-387.
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 376-387
-
-
Senderowicz, Adrian M.1
Sausville, Edward A.2
-
30
-
-
0036220822
-
Complexities in the development of cyclin-dependent kinase inhibitor drugs
-
Sausville, Edward A. Complexities in the development of cyclin-dependent kinase inhibitor drugs. Trends in Molecular Medicine, 2002, 8, S32-S37.
-
(2002)
Trends in Molecular Medicine
, vol.8
, pp. S32-S37
-
-
Sausville, Edward A.1
-
31
-
-
0242708738
-
Small-molecule cyclin-dependent kinase modulators
-
Senderowicz, A. M. Small-molecule cyclin-dependent kinase modulators. Oncogene, 2003, 22, 6609-6620.
-
(2003)
Oncogene
, vol.22
, pp. 6609-6620
-
-
Senderowicz, A. M.1
-
32
-
-
33645802169
-
Cyclin-dependent kinase pathways as targets for cancer treatment
-
Shapiro, G. I. Cyclin-dependent kinase pathways as targets for cancer treatment. J Clin Oncol, 2006, 24, 1770-1783.
-
(2006)
J Clin Oncol
, vol.24
, pp. 1770-1783
-
-
Shapiro, G. I.1
-
33
-
-
0038440704
-
Cyclin-dependent kinase inhibitors
-
Fischer, P. M.; Endicott, J.; Meijer, L. Cyclin-dependent kinase inhibitors. Prog Cell Cycle Res, 2003, 5, 235-248.
-
(2003)
Prog Cell Cycle Res
, vol.5
, pp. 235-248
-
-
Fischer, P. M.1
Endicott, J.2
Meijer, L.3
-
34
-
-
27844608451
-
Cell cycle regulatory kinase modulators: interim progress and issues
-
Sausville, E. A. Cell cycle regulatory kinase modulators: interim progress and issues. Curr Top Med Chem, 2005, 5, 1109-1117.
-
(2005)
Curr Top Med Chem
, vol.5
, pp. 1109-1117
-
-
Sausville, E. A.1
-
35
-
-
16844366148
-
Review of UCN-01 development: a lesson in the importance of clinical pharmacology
-
Fuse, E.; Kuwabara, T.; Sparreboom, A.; Sausville, E. A.; Figg, W. D. Review of UCN-01 development: a lesson in the importance of clinical pharmacology. J Clin Pharmacol, 2005, 45, 394-403.
-
(2005)
J Clin Pharmacol
, vol.45
, pp. 394-403
-
-
Fuse, E.1
Kuwabara, T.2
Sparreboom, A.3
Sausville, E. A.4
Figg, W. D.5
-
36
-
-
0036710767
-
Pharmacological inhibitors of cyclin-dependent kinases
-
Knockaert, M.; Greengard, P.; Meijer, L. Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci, 2002, 23, 417-425.
-
(2002)
Trends Pharmacol Sci
, vol.23
, pp. 417-425
-
-
Knockaert, M.1
Greengard, P.2
Meijer, L.3
-
37
-
-
9444228344
-
Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts
-
Fry, David W.; Harvey, Patricia J.; Keller, Paul R.; Elliott, William L.; Meade, Maryanne; Trachet, Erin; Albassam, Mudher; Zheng, Xianxian; Leopold, Wilbur R.; Pryer, Nancy K.; Toogood, Peter L. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther, 2004, 3, 1427-1438.
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 1427-1438
-
-
Fry, David W.1
Harvey, Patricia J.2
Keller, Paul R.3
Elliott, William L.4
Meade, Maryanne5
Trachet, Erin6
Albassam, Mudher7
Zheng, Xianxian8
Leopold, Wilbur R.9
Pryer, Nancy K.10
Toogood, Peter L.11
-
38
-
-
12444262227
-
Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 1: identification and optimisation of substituted 4,6-Bis anilino pyrimidines
-
Beattie, John F.; Breault, Gloria A.; Ellston, Rebecca P. A.; Green, Stephen; Jewsbury, Philip J.; Midgley, Catherine J.; Naven, Russell T.; Minshull, Claire A.; Pauptit, Richard A.; Tucker, Julie A.; Pease, J. Elizabeth. Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 1: identification and optimisation of substituted 4,6-Bis anilino pyrimidines. Bioorganic & Medicinal Chemistry Letters, 2003, 13, 2955-2960.
-
(2003)
Bioorganic & Medicinal Chemistry Letters
, vol.13
, pp. 2955-2960
-
-
Beattie, John F.1
Breault, Gloria A.2
Ellston, Rebecca P. A.3
Green, Stephen4
Jewsbury, Philip J.5
Midgley, Catherine J.6
Naven, Russell T.7
Minshull, Claire A.8
Pauptit, Richard A.9
Tucker, Julie A.10
Pease, J. Elizabeth11
-
39
-
-
0035925574
-
Selective In Vivo and In Vitro Effects of a Small Molecule Inhibitor of Cyclin-Dependent Kinase 4
-
Soni, Rajeev; O'reilly, Terence; Furet, Pascal; Muller, Lionel; Stephan, Christine; Zumstein-Mecker, Sabine; Fretz, Heinz; Fabbro, Doriano; Chaudhuri, Bhabatosh. Selective In Vivo and In Vitro Effects of a Small Molecule Inhibitor of Cyclin-Dependent Kinase 4. J Natl Cancer Inst, 2001, 93, 436-446.
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 436-446
-
-
Soni, Rajeev1
O'reilly, Terence2
Furet, Pascal3
Muller, Lionel4
Stephan, Christine5
Zumstein-Mecker, Sabine6
Fretz, Heinz7
Fabbro, Doriano8
Chaudhuri, Bhabatosh9
-
40
-
-
17944375799
-
Identification of selective inhibitors of cyclin dependent kinase 4
-
Carini, David J.; Kaltenbach, Robert F.; Liu, Jie; Benfield, Pamela A.; Boylan, John; Boisclair, Michael; Brizuela, Leonardo; Burton, Catherine R.; Cox, Sarah. Identification of selective inhibitors of cyclin dependent kinase 4. Bioorganic & Medicinal Chemistry Letters, 2001, 11, 2209-2211.
-
(2001)
Bioorganic & Medicinal Chemistry Letters
, vol.11
, pp. 2209-2211
-
-
Carini, David J.1
Kaltenbach, Robert F.2
Liu, Jie3
Benfield, Pamela A.4
Boylan, John5
Boisclair, Michael6
Brizuela, Leonardo7
Burton, Catherine R.8
Cox, Sarah9
-
41
-
-
0035924235
-
Structure-Based Generation of a New Class of Potent Cdk4 Inhibitors: New de Novo Design Strategy and Library Design
-
Honma, T.; Hayashi, K.; Aoyama, T.; Hashimoto, N.; Machida, T.; Fukasawa, K.; Iwama, T.; Ikeura, C.; Ikuta, M.; Suzuki-Takahashi, I.; Iwasawa, Y.; Hayama, T.; Nishimura, S.; Morishima, H. Structure-Based Generation of a New Class of Potent Cdk4 Inhibitors: New de Novo Design Strategy and Library Design. J. Med. Chem., 2001, 44, 4615-4627.
-
(2001)
J. Med. Chem
, vol.44
, pp. 4615-4627
-
-
Honma, T.1
Hayashi, K.2
Aoyama, T.3
Hashimoto, N.4
Machida, T.5
Fukasawa, K.6
Iwama, T.7
Ikeura, C.8
Ikuta, M.9
Suzuki-Takahashi, I.10
Iwasawa, Y.11
Hayama, T.12
Nishimura, S.13
Morishima, H.14
-
42
-
-
0037573393
-
Synthesis, Structure-Activity Relationship, and Biological Studies of Indolocarbazoles as Potent Cyclin D1-CDK4 Inhibitors
-
Zhu, G.; Conner, S. E.; Zhou, X.; Shih, C.; Li, T.; Anderson, B. D.; Brooks, H. B.; Campbell, R. M.; Considine, E.; Dempsey, J. A.; Faul, M. M.; Ogg, C.; Patel, B.; Schultz, R. M.; Spencer, C. D.; Teicher, B.; Watkins, S. A. Synthesis, Structure-Activity Relationship, and Biological Studies of Indolocarbazoles as Potent Cyclin D1-CDK4 Inhibitors. J. Med. Chem., 2003, 46, 2027-2030.
-
(2003)
J. Med. Chem
, vol.46
, pp. 2027-2030
-
-
Zhu, G.1
Conner, S. E.2
Zhou, X.3
Shih, C.4
Li, T.5
Anderson, B. D.6
Brooks, H. B.7
Campbell, R. M.8
Considine, E.9
Dempsey, J. A.10
Faul, M. M.11
Ogg, C.12
Patel, B.13
Schultz, R. M.14
Spencer, C. D.15
Teicher, B.16
Watkins, S. A.17
-
43
-
-
0035907260
-
Cell Cycle and Biochemical Effects of PD 0183812. A Potent Inhibitor of the Cyclin D-dependent Kinases CDK4 and CDK6
-
Fry, David W.; Bedford, David C.; Harvey, Patricia H.; Fritsch, Alexandra; Keller, Paul R.; Wu, Zhipei; Dobrusin, Ellen; Leopold, Wilbur R.; Fattaey, Ali; Garrett, Michelle D. Cell Cycle and Biochemical Effects of PD 0183812. A Potent Inhibitor of the Cyclin D-dependent Kinases CDK4 and CDK6. J. Biol. Chem., 2001, 276, 16617-16623.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 16617-16623
-
-
Fry, David W.1
Bedford, David C.2
Harvey, Patricia H.3
Fritsch, Alexandra4
Keller, Paul R.5
Wu, Zhipei6
Dobrusin, Ellen7
Leopold, Wilbur R.8
Fattaey, Ali9
Garrett, Michelle D.10
-
44
-
-
20244365948
-
Discovery of a Potent and Selective Inhibitor of Cyclin-Dependent Kinase 4/6
-
Toogood, P. L.; Harvey, P. J.; Repine, J. T.; Sheehan, D. J.; Vanderwel, S. N.; Zhou, H.; Keller, P. R.; Mcnamara, D. J.; Sherry, D.; Zhu, T.; Brodfuehrer, J.; Choi, C.; Barvian, M. R.; Fry, D. W. Discovery of a Potent and Selective Inhibitor of Cyclin-Dependent Kinase 4/6. J. Med. Chem., 2005, 48, 2388-2406.
-
(2005)
J. Med. Chem
, vol.48
, pp. 2388-2406
-
-
Toogood, P. L.1
Harvey, P. J.2
Repine, J. T.3
Sheehan, D. J.4
Vanderwel, S. N.5
Zhou, H.6
Keller, P. R.7
Mcnamara, D. J.8
Sherry, D.9
Zhu, T.10
Brodfuehrer, J.11
Choi, C.12
Barvian, M. R.13
Fry, D. W.14
-
45
-
-
7444229923
-
A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry
-
Matsumoto, Y.; Maller, J. L. A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry. Science, 2004, 306, 885-888.
-
(2004)
Science
, vol.306
, pp. 885-888
-
-
Matsumoto, Y.1
Maller, J. L.2
-
46
-
-
0037048277
-
Two for two: Cdk2 and its role in centrosome doubling
-
Hinchcliffe, E. H.; Sluder, G. Two for two: Cdk2 and its role in centrosome doubling. Oncogene, 2002, 21, 6154-6160.
-
(2002)
Oncogene
, vol.21
, pp. 6154-6160
-
-
Hinchcliffe, E. H.1
Sluder, G.2
-
47
-
-
33646710394
-
Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication
-
Duensing, A.; Liu, Y.; Tseng, M.; Malumbres, M.; Barbacid, M.; Duensing, S. Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication. Oncogene, 2006, 25, 2943-2949.
-
(2006)
Oncogene
, vol.25
, pp. 2943-2949
-
-
Duensing, A.1
Liu, Y.2
Tseng, M.3
Malumbres, M.4
Barbacid, M.5
Duensing, S.6
-
48
-
-
0034565159
-
The role of the centrosome in the development of malignant tumors
-
Lingle, W. L.; Salisbury, J. L. The role of the centrosome in the development of malignant tumors. Curr Top Dev Biol, 2000, 49, 313-329.
-
(2000)
Curr Top Dev Biol
, vol.49
, pp. 313-329
-
-
Lingle, W. L.1
Salisbury, J. L.2
-
49
-
-
0035188129
-
Managing the centrosome numbers game: from chaos to stability in cancer cell division
-
Brinkley, Bill R. Managing the centrosome numbers game: from chaos to stability in cancer cell division. Trends in Cell Biology, 2001, 11, 18-21.
-
(2001)
Trends in Cell Biology
, vol.11
, pp. 18-21
-
-
Brinkley, Bill R.1
-
50
-
-
23844531942
-
An analysis of the binding modes of ATP-competitive CDK2 inhibitors as revealed by X-ray structures of protein-inhibitor complexes
-
Vulpetti, A.; Pevarello, P. An analysis of the binding modes of ATP-competitive CDK2 inhibitors as revealed by X-ray structures of protein-inhibitor complexes. Curr Med Chem Anticancer Agents, 2005, 5, 561-573.
-
(2005)
Curr Med Chem Anticancer Agents
, vol.5
, pp. 561-573
-
-
Vulpetti, A.1
Pevarello, P.2
-
51
-
-
0037058678
-
In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine)
-
Steven J. Mcclue, David Blake, Rosemary Clarke, Angela Cowan, Lorna Cummings, Peter M. Fischer, Mairi Mackenzie, Jean Melville, Kevin Stewart, Shudong Wang, Nikolai Zhelev, Daniella Zheleva, David P. Lane. In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine). International Journal of Cancer, 2002, 102, 463-468.
-
(2002)
International Journal of Cancer
, vol.102
, pp. 463-468
-
-
Mcclue, Steven J.1
Blake, David2
Clarke, Rosemary3
Cowan, Angela4
Cummings, Lorna5
Fischer, Peter M.6
Mackenzie, Mairi7
Melville, Jean8
Stewart, Kevin9
Wang, Shudong10
Zhelev, Nikolai11
Zheleva, Daniella12
Lane, David P.13
-
52
-
-
12144285797
-
N-(Cycloalkylamino)acyl-2-aminothiazole Inhibitors of Cyclin-Dependent Kinase 2. N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide (BMS-387032), a Highly Efficacious and Selective Antitumor Agent
-
Misra, R. N.; Xiao, H. Y; Kim, K. S.; Lu, S.; Han, W. C.; Barbosa, S. A.; Hunt, J. T.; Rawlins, D. B.; Shan, W.; Ahmed, S. Z.; Qian, L.; Chen, B. C.; Zhao, R.; Bednarz, M. S.; Kellar, K. A.; Mulheron, J. G.; Batorsky, R.; Roongta, U.; Kamath, A.; Marathe, P.; Ranadive, S. A.; Sack, J. S.; Tokarski, J. S.; Pavletich, N. P.; Lee, F. Y. F.; Webster, K. R.; Kimball, S. D. N-(Cycloalkylamino)acyl-2-aminothiazole Inhibitors of Cyclin-Dependent Kinase 2. N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide (BMS-387032), a Highly Efficacious and Selective Antitumor Agent. J. Med. Chem., 2004, 47, 1719-1728.
-
(2004)
J. Med. Chem
, vol.47
, pp. 1719-1728
-
-
Misra, R. N.1
Xiao, H. Y2
Kim, K. S.3
Lu, S.4
Han, W. C.5
Barbosa, S. A.6
Hunt, J. T.7
Rawlins, D. B.8
Shan, W.9
Ahmed, S. Z.10
Qian, L.11
Chen, B. C.12
Zhao, R.13
Bednarz, M. S.14
Kellar, K. A.15
Mulheron, J. G.16
Batorsky, R.17
Roongta, U.18
Kamath, A.19
Marathe, P.20
Ranadive, S. A.21
Sack, J. S.22
Tokarski, J. S.23
Pavletich, N. P.24
Lee, F. Y. F.25
Webster, K. R.26
Kimball, S. D.27
more..
-
53
-
-
85144101709
-
-
Abst 829
-
Siemeister, G.; Briem, H.; Brumby, T.; Haberey, M.; Hess-Stumpp, H.; Jautelat, R.; Kruger, M.; Lucking, U.; Reichel, A.; Schafer, M.; Bosslet, K. In Proc. Am. Assoc. Cancer Res, 2004; Vol. 45, Abst 829..
-
(2004)
Proc. Am. Assoc. Cancer Res
, vol.45
-
-
Siemeister, G.1
Briem, H.2
Brumby, T.3
Haberey, M.4
Hess-Stumpp, H.5
Jautelat, R.6
Kruger, M.7
Lucking, U.8
Reichel, A.9
Schafer, M.10
Bosslet, K.11
-
54
-
-
24744437350
-
Roscovitine targets, protein kinases and pyridoxal kinase
-
Bach, S.; Knockaert, M.; Reinhardt, J.; Lozach, O.; Schmitt, S.; Baratte, B.; Koken, M.; Coburn, S. P.; Tang, L.; Jiang, T.; Liang, D. C.; Galons, H.; Dierick, J. F.; Pinna, L. A.; Meggio, F.; Totzke, F.; Schachtele, C.; Lerman, A. S.; Carnero, A.; Wan, Y.; Gray, N.; Meijer, L. Roscovitine targets, protein kinases and pyridoxal kinase. J Biol Chem, 2005, 280, 31208-31219.
-
(2005)
J Biol Chem
, vol.280
, pp. 31208-31219
-
-
Bach, S.1
Knockaert, M.2
Reinhardt, J.3
Lozach, O.4
Schmitt, S.5
Baratte, B.6
Koken, M.7
Coburn, S. P.8
Tang, L.9
Jiang, T.10
Liang, D. C.11
Galons, H.12
Dierick, J. F.13
Pinna, L. A.14
Meggio, F.15
Totzke, F.16
Schachtele, C.17
Lerman, A. S.18
Carnero, A.19
Wan, Y.20
Gray, N.21
Meijer, L.22
more..
-
55
-
-
22244440750
-
Synthesis and Identification of [1,3,5]Triazine-pyridine Biheteroaryl as a Novel Series of Potent Cyclin-Dependent Kinase Inhibitors
-
Kuo, G. H.; Deangelis, A.; Emanuel, S.; Wang, A.; Zhang, Y.; Connolly, P. J.; Chen, X.; Gruninger, R. H.; Rugg, C.; Fuentes-Pesquera, A.; Middleton, S. A.; Jolliffe, L.; Murray, W. V. Synthesis and Identification of [1,3,5]Triazine-pyridine Biheteroaryl as a Novel Series of Potent Cyclin-Dependent Kinase Inhibitors. J. Med. Chem., 2005, 48, 4535-4546.
-
(2005)
J. Med. Chem
, vol.48
, pp. 4535-4546
-
-
Kuo, G. H.1
Deangelis, A.2
Emanuel, S.3
Wang, A.4
Zhang, Y.5
Connolly, P. J.6
Chen, X.7
Gruninger, R. H.8
Rugg, C.9
Fuentes-Pesquera, A.10
Middleton, S. A.11
Jolliffe, L.12
Murray, W. V.13
-
56
-
-
0041854279
-
Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice
-
Ortega, S.; Prieto, I.; Odajima, J.; Martin, A.; Dubus, P.; Sotillo, R.; Barbero, J. L.; Malumbres, M.; Barbacid, M. Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Nat Genet, 2003, 35, 25-31.
-
(2003)
Nat Genet
, vol.35
, pp. 25-31
-
-
Ortega, S.1
Prieto, I.2
Odajima, J.3
Martin, A.4
Dubus, P.5
Sotillo, R.6
Barbero, J. L.7
Malumbres, M.8
Barbacid, M.9
-
57
-
-
0142116249
-
Cdk2 knockout mice are viable
-
Berthet, C.; Aleem, E.; Coppola, V.; Tessarollo, L.; Kaldis, P. Cdk2 knockout mice are viable. Curr Biol, 2003, 13, 1775-1785.
-
(2003)
Curr Biol
, vol.13
, pp. 1775-1785
-
-
Berthet, C.1
Aleem, E.2
Coppola, V.3
Tessarollo, L.4
Kaldis, P.5
-
58
-
-
0041327168
-
Proliferation of cancer cells despite CDK2 inhibition
-
Tetsu, O.; Mccormick, F. Proliferation of cancer cells despite CDK2 inhibition. Cancer Cell, 2003, 3, 233-245.
-
(2003)
Cancer Cell
, vol.3
, pp. 233-245
-
-
Tetsu, O.1
Mccormick, F.2
-
59
-
-
20444410393
-
Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27(Kip1) and p21(Cip1)
-
Martin, A.; Odajima, J.; Hunt, S. L.; Dubus, P.; Ortega, S.; Malumbres, M.; Barbacid, M. Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27(Kip1) and p21(Cip1). Cancer Cell, 2005, 7, 591-598.
-
(2005)
Cancer Cell
, vol.7
, pp. 591-598
-
-
Martin, A.1
Odajima, J.2
Hunt, S. L.3
Dubus, P.4
Ortega, S.5
Malumbres, M.6
Barbacid, M.7
-
60
-
-
23144451917
-
Cdc2-cyclin E complexes regulate the G1/S phase transition
-
Aleem, E.; Kiyokawa, H.; Kaldis, P. Cdc2-cyclin E complexes regulate the G1/S phase transition. Nat Cell Biol, 2005, 7, 831-836.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 831-836
-
-
Aleem, E.1
Kiyokawa, H.2
Kaldis, P.3
-
61
-
-
1942421702
-
Cyclin C/Cdk3 Promotes Rb-Dependent G0 Exit
-
Ren, Shengjun; Rollins, Barrett J. Cyclin C/Cdk3 Promotes Rb-Dependent G0 Exit. Cell, 2004, 117, 239-251.
-
(2004)
Cell
, vol.117
, pp. 239-251
-
-
Ren, Shengjun1
Rollins, Barrett J.2
-
62
-
-
0029926060
-
Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit
-
Hofmann, F.; Livingston, D. M. Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit. Genes Dev, 1996, 10, 851-861.
-
(1996)
Genes Dev
, vol.10
, pp. 851-861
-
-
Hofmann, F.1
Livingston, D. M.2
-
63
-
-
0035852699
-
A premature-termination mutation in the Mus musculus cyclin-dependent kinase 3 gene
-
Ye, Xin; Zhu, Cihui; Harper, J. Wade. A premature-termination mutation in the Mus musculus cyclin-dependent kinase 3 gene. PNAS, 2001, 98, 1682-1686.
-
(2001)
PNAS
, vol.98
, pp. 1682-1686
-
-
Ye, Xin1
Zhu, Cihui2
Harper, J. Wade3
-
64
-
-
0029893446
-
Expression of CDK7/CAK in normal and tumor cells of diverse histogenesis, cell-cycle position and differentiation
-
Bartkova, J.; Zemanova, M.; Bartek, J. Expression of CDK7/CAK in normal and tumor cells of diverse histogenesis, cell-cycle position and differentiation. Int J Cancer, 1996, 66, 732-737.
-
(1996)
Int J Cancer
, vol.66
, pp. 732-737
-
-
Bartkova, J.1
Zemanova, M.2
Bartek, J.3
-
65
-
-
21644474090
-
Role of CDK/cyclin complexes in transcription and RNA splicing
-
Loyer, P.; Trembley, J. H.; Katona, R.; Kidd, V. J.; Lahti, J. M. Role of CDK/cyclin complexes in transcription and RNA splicing. Cell Signal, 2005, 17, 1033-1051.
-
(2005)
Cell Signal
, vol.17
, pp. 1033-1051
-
-
Loyer, P.1
Trembley, J. H.2
Katona, R.3
Kidd, V. J.4
Lahti, J. M.5
-
66
-
-
33645525342
-
The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation
-
Petretti, C.; Savoian, M.; Montembault, E.; Glover, D. M.; Prigent, C.; Giet, R. The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation. EMBO Rep, 2006, 7, 418-424.
-
(2006)
EMBO Rep
, vol.7
, pp. 418-424
-
-
Petretti, C.1
Savoian, M.2
Montembault, E.3
Glover, D. M.4
Prigent, C.5
Giet, R.6
-
67
-
-
33749496131
-
Essential Role of Phosphorylation of MCM2 by Cdc7/Dbf4 in the Initiation of DNA Replication in Mammalian Cells
-
Tsuji, T.; Ficarro, S. B.; Jiang, W. Essential Role of Phosphorylation of MCM2 by Cdc7/Dbf4 in the Initiation of DNA Replication in Mammalian Cells. Mol Biol Cell, 2006, 17.
-
(2006)
Mol Biol Cell
, vol.17
-
-
Tsuji, T.1
Ficarro, S. B.2
Jiang, W.3
-
68
-
-
0036154983
-
Cdc7 kinase complex: a key regulator in the initiation of DNA replication
-
Masai, H.; Arai, K. Cdc7 kinase complex: a key regulator in the initiation of DNA replication. J Cell Physiol, 2002, 190, 287-296.
-
(2002)
J Cell Physiol
, vol.190
, pp. 287-296
-
-
Masai, H.1
Arai, K.2
-
69
-
-
0036566328
-
Inactivation of Cdc7 kinase in mouse ES cells results in S-phase arrest and p53-dependent cell death
-
Kim, J. M.; Nakao, K.; Nakamura, K.; Saito, I.; Katsuki, M.; Arai, K.; Masai, H. Inactivation of Cdc7 kinase in mouse ES cells results in S-phase arrest and p53-dependent cell death. Embo J, 2002, 21, 2168-2179.
-
(2002)
Embo J
, vol.21
, pp. 2168-2179
-
-
Kim, J. M.1
Nakao, K.2
Nakamura, K.3
Saito, I.4
Katsuki, M.5
Arai, K.6
Masai, H.7
-
70
-
-
33645474441
-
Gene expression in poorly differentiated papillary thyroid carcinomas
-
Fluge, O.; Bruland, O.; Akslen, L. A.; Lillehaug, J. R.; Varhaug, J. E. Gene expression in poorly differentiated papillary thyroid carcinomas. Thyroid, 2006, 16, 161-175.
-
(2006)
Thyroid
, vol.16
, pp. 161-175
-
-
Fluge, O.1
Bruland, O.2
Akslen, L. A.3
Lillehaug, J. R.4
Varhaug, J. E.5
-
71
-
-
4944256913
-
Cdc7 Inhibition Reveals a p53-Dependent Replication Checkpoint That Is Defective in Cancer Cells
-
Montagnoli, Alessia; Tenca, Pierluigi; Sola, Francesco; Carpani, Daniela; Brotherton, Deborah; Albanese, Clara; Santocanale, Corrado. Cdc7 Inhibition Reveals a p53-Dependent Replication Checkpoint That Is Defective in Cancer Cells. Cancer Res, 2004, 64, 7110-7116.
-
(2004)
Cancer Res
, vol.64
, pp. 7110-7116
-
-
Montagnoli, Alessia1
Tenca, Pierluigi2
Sola, Francesco3
Carpani, Daniela4
Brotherton, Deborah5
Albanese, Clara6
Santocanale, Corrado7
-
72
-
-
0141641137
-
Hypomorphic mutation in an essential cell-cycle kinase causes growth retardation and impaired spermatogenesis
-
Kim, J. M.; Takemoto, N.; Arai, K.; Masai, H. Hypomorphic mutation in an essential cell-cycle kinase causes growth retardation and impaired spermatogenesis. Embo J, 2003, 22, 5260-5272.
-
(2003)
Embo J
, vol.22
, pp. 5260-5272
-
-
Kim, J. M.1
Takemoto, N.2
Arai, K.3
Masai, H.4
-
73
-
-
7744243520
-
The DNA damage response: sensing and signaling
-
Mcgowan, C. H.; Russell, P. The DNA damage response: sensing and signaling. Curr Opin Cell Biol, 2004, 16, 629-633.
-
(2004)
Curr Opin Cell Biol
, vol.16
, pp. 629-633
-
-
Mcgowan, C. H.1
Russell, P.2
-
74
-
-
2642528031
-
DNA damage-induced activation of ATM and ATM-dependent signaling pathways
-
Kurz, E. U.; Lees-Miller, S. P. DNA damage-induced activation of ATM and ATM-dependent signaling pathways. DNA Repair (Amst), 2004, 3, 889-900.
-
(2004)
DNA Repair (Amst)
, vol.3
, pp. 889-900
-
-
Kurz, E. U.1
Lees-Miller, S. P.2
-
75
-
-
4444344407
-
G2 checkpoint abrogators as anticancer drugs
-
Kawabe, T. G2 checkpoint abrogators as anticancer drugs. Mol Cancer Ther, 2004, 3, 513-519.
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 513-519
-
-
Kawabe, T.1
-
76
-
-
0035449355
-
Cell cycle checkpoint signaling through the ATM and ATR kinases
-
Abraham, R. T. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev, 2001, 15, 2177-2196.
-
(2001)
Genes Dev
, vol.15
, pp. 2177-2196
-
-
Abraham, R. T.1
-
77
-
-
0037365789
-
ATM and related protein kinases: safeguarding genome integrity
-
Shiloh, Y. ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer, 2003, 3, 155-168.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 155-168
-
-
Shiloh, Y.1
-
78
-
-
1542751745
-
Targeting DNA checkpoint kinases in cancer therapy
-
Zhou, B. B.; Anderson, H. J.; Roberge, M. Targeting DNA checkpoint kinases in cancer therapy. Cancer Biol Ther, 2003, 2, S16-22.
-
(2003)
Cancer Biol Ther
, vol.2
, pp. S16-S22
-
-
Zhou, B. B.1
Anderson, H. J.2
Roberge, M.3
-
79
-
-
0035503171
-
Somatic Mutations in the DNA Damage-Response Genes ATR and CHK1 in Sporadic Stomach Tumors with Microsatellite Instability
-
Menoyo, Anna; Alazzouzi, Hafid; Espin, Eloi; Armengol, Manel; Yamamoto, Hiroyuki; Schwartz, Simo, Jr. Somatic Mutations in the DNA Damage-Response Genes ATR and CHK1 in Sporadic Stomach Tumors with Microsatellite Instability. Cancer Res, 2001, 61, 7727-7730.
-
(2001)
Cancer Res
, vol.61
, pp. 7727-7730
-
-
Menoyo, Anna1
Alazzouzi, Hafid2
Espin, Eloi3
Armengol, Manel4
Yamamoto, Hiroyuki5
Schwartz, Simo6
-
80
-
-
0006493706
-
Duplication of ATR inhibits MyoD, induces aneuploidy and eliminates radiation-induced G1 arrest
-
Smith, L.; Liu, S. J.; Goodrich, L.; Jacobson, D.; Degnin, C.; Bentley, N.; Carr, A.; Flaggs, G.; Keegan, K.; Hoekstra, M.; Thayer, M. J. Duplication of ATR inhibits MyoD, induces aneuploidy and eliminates radiation-induced G1 arrest. Nat Genet, 1998, 19, 39-46.
-
(1998)
Nat Genet
, vol.19
, pp. 39-46
-
-
Smith, L.1
Liu, S. J.2
Goodrich, L.3
Jacobson, D.4
Degnin, C.5
Bentley, N.6
Carr, A.7
Flaggs, G.8
Keegan, K.9
Hoekstra, M.10
Thayer, M. J.11
-
81
-
-
0034102337
-
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
-
Brown, E. J.; Baltimore, D. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev, 2000, 14, 397-402.
-
(2000)
Genes Dev
, vol.14
, pp. 397-402
-
-
Brown, E. J.1
Baltimore, D.2
-
82
-
-
0035941021
-
ATR and ATRIP: partners in checkpoint signaling
-
Cortez, D.; Guntuku, S.; Qin, J.; Elledge, S. J. ATR and ATRIP: partners in checkpoint signaling. Science, 2001, 294, 1713-1716.
-
(2001)
Science
, vol.294
, pp. 1713-1716
-
-
Cortez, D.1
Guntuku, S.2
Qin, J.3
Elledge, S. J.4
-
83
-
-
0032472330
-
Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints
-
Cliby, W. A.; Roberts, C. J.; Cimprich, K. A.; Stringer, C. M.; Lamb, J. R.; Schreiber, S. L.; Friend, S. H. Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. Embo J, 1998, 17, 159-169.
-
(1998)
Embo J
, vol.17
, pp. 159-169
-
-
Cliby, W. A.1
Roberts, C. J.2
Cimprich, K. A.3
Stringer, C. M.4
Lamb, J. R.5
Schreiber, S. L.6
Friend, S. H.7
-
84
-
-
0034678730
-
Phosphatidylinositol 3-kinase inhibitors, Wortmannin or LY294002, inhibited accumulation of p21 protein after [gamma]-irradiation by stabilization of the protein
-
Fukuchi, Kunihiko; Watanabe, Hiroyuki; Tomoyasu, Shigeru; Ichimura, Sachiko; Tatsumi, Kouichi; Gomi, Kunihide. Phosphatidylinositol 3-kinase inhibitors, Wortmannin or LY294002, inhibited accumulation of p21 protein after [gamma]-irradiation by stabilization of the protein. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 2000, 1496, 207-220.
-
(2000)
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
, vol.1496
, pp. 207-220
-
-
Fukuchi, Kunihiko1
Watanabe, Hiroyuki2
Tomoyasu, Shigeru3
Ichimura, Sachiko4
Tatsumi, Kouichi5
Gomi, Kunihide6
-
85
-
-
0242299702
-
Inhibition of DNA repair by Pentoxifylline and related methylxanthine derivatives
-
Bohm, Lothar; Roos, Wynand Paul; Serafin, Antonio Mendes. Inhibition of DNA repair by Pentoxifylline and related methylxanthine derivatives. Toxicology, 2003, 193, 153-160.
-
(2003)
Toxicology
, vol.193
, pp. 153-160
-
-
Bohm, Lothar1
Roos, Wynand Paul2
Serafin, Antonio Mendes3
-
86
-
-
0033199892
-
Inhibition of ATM and ATR Kinase Activities by the Radiosensitizing Agent, Caffeine
-
Sarkaria, Jann N.; Busby, Ericka C.; Tibbetts, Randal S.; Roos, Pia; Taya, Yoichi; Karnitz, Larry M.; Abraham, Robert T. Inhibition of ATM and ATR Kinase Activities by the Radiosensitizing Agent, Caffeine. Cancer Res, 1999, 59, 4375-4382.
-
(1999)
Cancer Res
, vol.59
, pp. 4375-4382
-
-
Sarkaria, Jann N.1
Busby, Ericka C.2
Tibbetts, Randal S.3
Roos, Pia4
Taya, Yoichi5
Karnitz, Larry M.6
Abraham, Robert T.7
-
87
-
-
9744271049
-
Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM
-
Hickson, I.; Zhao, Y.; Richardson, C. J.; Green, S. J.; Martin, N. M.; Orr, A. I.; Reaper, P. M.; Jackson, S. P.; Curtin, N. J.; Smith, G. C. Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res, 2004, 64, 9152-9159.
-
(2004)
Cancer Res
, vol.64
, pp. 9152-9159
-
-
Hickson, I.1
Zhao, Y.2
Richardson, C. J.3
Green, S. J.4
Martin, N. M.5
Orr, A. I.6
Reaper, P. M.7
Jackson, S. P.8
Curtin, N. J.9
Smith, G. C.10
-
88
-
-
73949141159
-
The ATM inhibitor KU-55933 suppresses cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt
-
Li, Y.; Yang, D. Q. The ATM inhibitor KU-55933 suppresses cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt. Mol Cancer Ther, 2010, 9, 113-125.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 113-125
-
-
Li, Y.1
Yang, D. Q.2
-
89
-
-
54749148734
-
Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation
-
Rainey, M. D.; Charlton, M. E.; Stanton, R. V.; Kastan, M. B. Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. Cancer Res, 2008, 68, 7466-7474.
-
(2008)
Cancer Res
, vol.68
, pp. 7466-7474
-
-
Rainey, M. D.1
Charlton, M. E.2
Stanton, R. V.3
Kastan, M. B.4
-
90
-
-
0038418869
-
Chk1 and Chk2 kinases in checkpoint control and cancer
-
Bartek, Jiri; Lukas, Jiri. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell, 2003, 3, 421-429.
-
(2003)
Cancer Cell
, vol.3
, pp. 421-429
-
-
Bartek, Jiri1
Lukas, Jiri2
-
91
-
-
0034659341
-
Aberrant cell cycle checkpoint function and early embryonic death in Chk1-/-mice
-
Takai, Hiroyuki; Tominaga, Kaoru; Motoyama, Noboru; Minamishima, Yohji A.; Nagahama, Hiroyasu; Tsukiyama, Tadasuke; Ikeda, Kyoji; Nakayama, Keiko; Nakanishi, Makoto; Nakayama, Kei-Ichi. Aberrant cell cycle checkpoint function and early embryonic death in Chk1-/-mice. Genes Dev., 2000, 14, 1439-1447.
-
(2000)
Genes Dev
, vol.14
, pp. 1439-1447
-
-
Takai, Hiroyuki1
Tominaga, Kaoru2
Motoyama, Noboru3
Minamishima, Yohji A.4
Nagahama, Hiroyasu5
Tsukiyama, Tadasuke6
Ikeda, Kyoji7
Nakayama, Keiko8
Nakanishi, Makoto9
Nakayama, Kei-Ichi10
-
92
-
-
17644432403
-
Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint
-
Liu, Qinghua; Guntuku, Saritha; Cui, Xian-Shu; Matsuoka, Shuhei; Cortez, David; Tamai, Katsuyuki; Luo, Guangbin; Carattini-Rivera, Sandra; Demayo, Francisco; Bradley, Allan; Donehower, Larry A.; Elledge, Stephen J. Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint. Genes Dev., 2000, 14, 1448-1459.
-
(2000)
Genes Dev
, vol.14
, pp. 1448-1459
-
-
Liu, Qinghua1
Guntuku, Saritha2
Cui, Xian-Shu3
Matsuoka, Shuhei4
Cortez, David5
Tamai, Katsuyuki6
Luo, Guangbin7
Carattini-Rivera, Sandra8
Demayo, Francisco9
Bradley, Allan10
Donehower, Larry A.11
Elledge, Stephen J.12
-
93
-
-
1542754615
-
Human Chk1 Expression Is Dispensable for Somatic Cell Death and Critical for Sustaining G2 DNA Damage Checkpoint
-
Chen, Zehan; Xiao, Zhan; Chen, Jun; Ng, Shi-Chung; Sowin, Thomas; Sham, Hing; Rosenberg, Saul; Fesik, Steve; Zhang, Haiying. Human Chk1 Expression Is Dispensable for Somatic Cell Death and Critical for Sustaining G2 DNA Damage Checkpoint. Mol Cancer Ther, 2003, 2, 543-548.
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 543-548
-
-
Chen, Zehan1
Xiao, Zhan2
Chen, Jun3
Ng, Shi-Chung4
Sowin, Thomas5
Sham, Hing6
Rosenberg, Saul7
Fesik, Steve8
Zhang, Haiying9
-
94
-
-
0037099597
-
Genes Involved in DNA Repair Are Mutational Targets in Endometrial Cancers with Microsatellite Instability
-
Vassileva, Vessela; Millar, Anna; Briollais, Laurent; Chapman, William; Bapat, Bharati. Genes Involved in DNA Repair Are Mutational Targets in Endometrial Cancers with Microsatellite Instability. Cancer Res, 2002, 62, 4095-4099.
-
(2002)
Cancer Res
, vol.62
, pp. 4095-4099
-
-
Vassileva, Vessela1
Millar, Anna2
Briollais, Laurent3
Chapman, William4
Bapat, Bharati5
-
95
-
-
3242884449
-
The Chk2 protein kinase
-
Ahn, J.; Urist, M.; Prives, C. The Chk2 protein kinase. DNA Repair (Amst), 2004, 3, 1039-1047.
-
(2004)
DNA Repair (Amst)
, vol.3
, pp. 1039-1047
-
-
Ahn, J.1
Urist, M.2
Prives, C.3
-
96
-
-
0033601346
-
Heterozygous Germ Line hCHK2 Mutations in Li-Fraumeni Syndrome
-
Bell, Daphne W.; Varley, Jennifer M.; Szydlo, Tara E.; Kang, Deborah H.; Wahrer, Doke C.; Nbsp; R; Shannon, Kristen E.; Lubratovich, Marcie; Verselis, Sigitas J.; Isselbacher, Kurt J.; Fraumeni, Joseph F.; Birch, Jillian M.; Li, Frederick P.; Garber, Judy E.; Haber, Daniel A. Heterozygous Germ Line hCHK2 Mutations in Li-Fraumeni Syndrome. Science, 1999, 286, 2528-2531.
-
(1999)
Science
, vol.286
, pp. 2528-2531
-
-
Bell, Daphne W.1
Varley, Jennifer M.2
Szydlo, Tara E.3
Kang, Deborah H.4
Wahrer, Doke C.5
Nbsp6
R7
Shannon, Kristen E.8
Lubratovich, Marcie9
Verselis, Sigitas J.10
Isselbacher, Kurt J.11
Fraumeni, Joseph F.12
Birch, Jillian M.13
Li, Frederick P.14
Garber, Judy E.15
Haber, Daniel A.16
-
97
-
-
0037011665
-
CHEK2 variants in susceptibility to breast cancer and evidence of retention of the wild type allele in tumours
-
Sodha, N.; Bullock, S.; Taylor, R.; Mitchell, G.; Guertl-Lackner, B.; Williams, R. D.; Bevan, S.; Bishop, K.; Mcguire, S.; Houlston, R.S; Eeles, R.A. CHEK2 variants in susceptibility to breast cancer and evidence of retention of the wild type allele in tumours. British Journal Of Cancer, 2002, 87, 1445-1448.
-
(2002)
British Journal Of Cancer
, vol.87
, pp. 1445-1448
-
-
Sodha, N.1
Bullock, S.2
Taylor, R.3
Mitchell, G.4
Guertl-Lackner, B.5
Williams, R. D.6
Bevan, S.7
Bishop, K.8
Mcguire, S.9
Houlston, R.S10
Eeles, R.A.11
-
98
-
-
0345669750
-
Variants in CHEK2 other than 1100delC do not make a major contribution to breast cancer susceptibility
-
Schutte, M.; Seal, S.; Barfoot, R.; Meijers-Heijboer, H.; Wasielewski, M.; Evans, D.G.; Eccles, D.; Meijers, C.; Lohman, F.; Klijn, J.; Van Den Ouweland, A.; Futreal, P.A.; Nathanson, K.L.; Weber, B.L.; Easton, D.F.; Stratton, M.R.; Rahman, N. Variants in CHEK2 other than 1100delC do not make a major contribution to breast cancer susceptibility. American Journal Of Human Genetics, 2003, 72, 1023-1028.
-
(2003)
American Journal Of Human Genetics
, vol.72
, pp. 1023-1028
-
-
Schutte, M.1
Seal, S.2
Barfoot, R.3
Meijers-Heijboer, H.4
Wasielewski, M.5
Evans, D.G.6
Eccles, D.7
Meijers, C.8
Lohman, F.9
Klijn, J.10
Van Den Ouweland, A.11
Futreal, P.A.12
Nathanson, K.L.13
Weber, B.L.14
Easton, D.F.15
Stratton, M.R.16
Rahman, N.17
-
99
-
-
0037320555
-
Mutations in CHEK2 associated with prostate cancer risk
-
Dong, Xiangyang; Wang, Liang; Taniguchi, Ken; Wang, Xianshu; Cunningham, Julie M.; Mcdonnell, Shannon K.; Qian, Chiping; Marks, Angela F.; Slager, Susan L.; Peterson, Brett J.; Smith, David I.; Cheville, John C.; Blute, Michael L.; Jacobsen, Steve J.; Schaid, Daniel J.; Tindall, Donald J.; Thibodeau, Stephen N.; Liu, Wanguo.. Mutations in CHEK2 associated with prostate cancer risk. American Journal Of Human Genetics, 2003, 72, 270-280.
-
(2003)
American Journal Of Human Genetics
, vol.72
, pp. 270-280
-
-
Dong, Xiangyang1
Wang, Liang2
Taniguchi, Ken3
Wang, Xianshu4
Cunningham, Julie M.5
Mcdonnell, Shannon K.6
Qian, Chiping7
Marks, Angela F.8
Slager, Susan L.9
Peterson, Brett J.10
Smith, David I.11
Cheville, John C.12
Blute, Michael L.13
Jacobsen, Steve J.14
Schaid, Daniel J.15
Tindall, Donald J.16
Thibodeau, Stephen N.17
Liu, Wanguo18
-
100
-
-
0037162506
-
Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response
-
Jack, Melissa T.; Woo, Richard A.; Hirao, Atsushi; Cheung, Alison; Mak, Tak W.; Lee, Patrick W. K. Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response. PNAS, 2002, 99, 9825-9829.
-
(2002)
PNAS
, vol.99
, pp. 9825-9829
-
-
Jack, Melissa T.1
Woo, Richard A.2
Hirao, Atsushi3
Cheung, Alison4
Mak, Tak W.5
Lee, Patrick W. K.6
-
101
-
-
0034642532
-
Cyclin-dependent kinase inhibitors: useful targets in cell cycle regulation
-
Sielecki, T. M.; Boylan, J. F.; Benfield, P. A.; Trainor, G. L. Cyclin-dependent kinase inhibitors: useful targets in cell cycle regulation. J Med Chem, 2000, 43, 1-18.
-
(2000)
J Med Chem
, vol.43
, pp. 1-18
-
-
Sielecki, T. M.1
Boylan, J. F.2
Benfield, P. A.3
Trainor, G. L.4
-
102
-
-
0037228519
-
The Protein Kinase C Inhibitor Go6976 Is a Potent Inhibitor of DNA Damage-induced S and G2 Cell Cycle Checkpoints
-
Kohn, Ethan A.; Yoo, Carolyn J.; Eastman, Alan. The Protein Kinase C Inhibitor Go6976 Is a Potent Inhibitor of DNA Damage-induced S and G2 Cell Cycle Checkpoints. Cancer Res, 2003, 63, 31-35.
-
(2003)
Cancer Res
, vol.63
, pp. 31-35
-
-
Kohn, Ethan A.1
Yoo, Carolyn J.2
Eastman, Alan3
-
103
-
-
0033975054
-
An Indolocarbazole Inhibitor of Human Checkpoint Kinase (Chk1) Abrogates Cell Cycle Arrest Caused by DNA Damage
-
Jackson, Jeffrey R.; Gilmartin, Aidan; Imburgia, Christina; Winkler, James D.; Marshall, Lisa A.; Roshak, Amy. An Indolocarbazole Inhibitor of Human Checkpoint Kinase (Chk1) Abrogates Cell Cycle Arrest Caused by DNA Damage. Cancer Res, 2000, 60, 566-572.
-
(2000)
Cancer Res
, vol.60
, pp. 566-572
-
-
Jackson, Jeffrey R.1
Gilmartin, Aidan2
Imburgia, Christina3
Winkler, James D.4
Marshall, Lisa A.5
Roshak, Amy6
-
104
-
-
0012365397
-
A Novel Indolocarbazole, ICP-1, Abrogates DNA Damage-induced Cell Cycle Arrest and Enhances Cytotoxicity: Similarities and Differences to the Cell Cycle Checkpoint Abrogator UCN-01
-
Eastman, Alan; Kohn, Ethan A.; Brown, Mary Kay; Rathman, Joerg; Livingstone, Mark; Blank, David H.; Gribble, Gordon W. A Novel Indolocarbazole, ICP-1, Abrogates DNA Damage-induced Cell Cycle Arrest and Enhances Cytotoxicity: Similarities and Differences to the Cell Cycle Checkpoint Abrogator UCN-01. Mol Cancer Ther, 2002, 1, 1067-1078.
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 1067-1078
-
-
Eastman, Alan1
Kohn, Ethan A.2
Brown, Mary Kay3
Rathman, Joerg4
Livingstone, Mark5
Blank, David H.6
Gribble, Gordon W.7
-
105
-
-
0033406451
-
Sensitization of Cancer Cells to DNA Damage-induced Cell Death by Specific Cell Cycle G2 Checkpoint Abrogation
-
Suganuma, Masashi; Kawabe, Takumi; Hori, Haruna; Funabiki, Takahiko; Okamoto, Takashi. Sensitization of Cancer Cells to DNA Damage-induced Cell Death by Specific Cell Cycle G2 Checkpoint Abrogation. Cancer Res, 1999, 59, 5887-5891.
-
(1999)
Cancer Res
, vol.59
, pp. 5887-5891
-
-
Suganuma, Masashi1
Kawabe, Takumi2
Hori, Haruna3
Funabiki, Takahiko4
Okamoto, Takashi5
-
106
-
-
3142761620
-
Potent inhibition of checkpoint kinase activity by a hymenialdisine-derived indoloazepine
-
Sharma, Vasudha; Tepe, Jetze J. Potent inhibition of checkpoint kinase activity by a hymenialdisine-derived indoloazepine. Bioorganic & Medicinal Chemistry Letters, 2004, 14, 4319-4321.
-
(2004)
Bioorganic & Medicinal Chemistry Letters
, vol.14
, pp. 4319-4321
-
-
Sharma, Vasudha1
Tepe, Jetze J.2
-
107
-
-
48249092713
-
DNA damage detection and repair pathways--recent advances with inhibitors of checkpoint kinases in cancer therapy
-
Ashwell, S.; Zabludoff, S. DNA damage detection and repair pathways--recent advances with inhibitors of checkpoint kinases in cancer therapy. Clin Cancer Res, 2008, 14, 4032-4037.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4032-4037
-
-
Ashwell, S.1
Zabludoff, S.2
-
108
-
-
35848942839
-
Structure-based design and synthesis of (5-arylamino-2H-pyrazol-3-yl)-biphenyl-2',4'-diols as novel and potent human CHK1 inhibitors
-
Teng, M.; Zhu, J.; Johnson, M. D.; Chen, P.; Kornmann, J.; Chen, E.; Blasina, A.; Register, J.; Anderes, K.; Rogers, C.; Deng, Y.; Ninkovic, S.; Grant, S.; Hu, Q.; Lundgren, K.; Peng, Z.; Kania, R. S. Structure-based design and synthesis of (5-arylamino-2H-pyrazol-3-yl)-biphenyl-2',4'-diols as novel and potent human CHK1 inhibitors. J Med Chem, 2007, 50, 5253-5256.
-
(2007)
J Med Chem
, vol.50
, pp. 5253-5256
-
-
Teng, M.1
Zhu, J.2
Johnson, M. D.3
Chen, P.4
Kornmann, J.5
Chen, E.6
Blasina, A.7
Register, J.8
Anderes, K.9
Rogers, C.10
Deng, Y.11
Ninkovic, S.12
Grant, S.13
Hu, Q.14
Lundgren, K.15
Peng, Z.16
Kania, R. S.17
-
109
-
-
0012966157
-
Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A
-
Sorensen, Claus Storgaard; Syljuasen, Randi G.; Falck, Jacob; Schroeder, Tine; Ronnstrand, Lars; Khanna, Kum Kum; Zhou, Bin-Bing; Bartek, Jiri; Lukas, Jiri. Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell, 2003, 3, 247-258.
-
(2003)
Cancer Cell
, vol.3
, pp. 247-258
-
-
Sorensen, Claus Storgaard1
Syljuasen, Randi G.2
Falck, Jacob3
Schroeder, Tine4
Ronnstrand, Lars5
Khanna, Kum Kum6
Zhou, Bin-Bing7
Bartek, Jiri8
Lukas, Jiri9
-
110
-
-
34748854847
-
Identification of a Bis-guanylhydrazone [4,4'-Diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase
-
Jobson, A. G.; Cardellina, J. H., 2nd; Scudiero, D.; Kondapaka, S.; Zhang, H.; Kim, H.; Shoemaker, R.; Pommier, Y. Identification of a Bis-guanylhydrazone [4,4'-Diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase. Mol Pharmacol, 2007, 72, 876-884.
-
(2007)
Mol Pharmacol
, vol.72
, pp. 876-884
-
-
Jobson, A. G.1
Cardellina, J. H.2
Scudiero, D.3
Kondapaka, S.4
Zhang, H.5
Kim, H.6
Shoemaker, R.7
Pommier, Y.8
-
112
-
-
0029825066
-
Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells
-
Jin, P.; Gu, Y.; Morgan, D. O. Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells. J. Cell Biol., 1996, 134, 963-970.
-
(1996)
J. Cell Biol
, vol.134
, pp. 963-970
-
-
Jin, P.1
Gu, Y.2
Morgan, D. O.3
-
113
-
-
0027244234
-
Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated cdc2 kinase
-
Heald, Rebecca; Mcloughlin, Michael; Mckeon, Frank. Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated cdc2 kinase. Cell, 1993, 74, 463-474.
-
(1993)
Cell
, vol.74
, pp. 463-474
-
-
Heald, Rebecca1
Mcloughlin, Michael2
Mckeon, Frank3
-
114
-
-
0033961880
-
Constitutive Activation of Cyclin B1-associated cdc2 Kinase Overrides p53-mediated G2-M Arrest
-
Park, Misoon; Chae, Hee-Don; Yun, Jeanho; Jung, Moonsu; Kim, Yeon-Soo; Kim, Sung-Ho; Han, Moon Hi; Shin, Deug Y. Constitutive Activation of Cyclin B1-associated cdc2 Kinase Overrides p53-mediated G2-M Arrest. Cancer Res, 2000, 60, 542-545.
-
(2000)
Cancer Res
, vol.60
, pp. 542-545
-
-
Park, Misoon1
Chae, Hee-Don2
Yun, Jeanho3
Jung, Moonsu4
Kim, Yeon-Soo5
Kim, Sung-Ho6
Han, Moon Hi7
Shin, Deug Y.8
-
115
-
-
0032145479
-
Negative regulation of Wee1 expression and Cdc2 phosphorylation during p53-mediated growth arrest and apoptosis
-
Leach, S. D.; Scatena, C. D.; Keefer, C. J.; Goodman, H. A.; Song, S. Y.; Yang, L.; Pietenpol, J. A. Negative regulation of Wee1 expression and Cdc2 phosphorylation during p53-mediated growth arrest and apoptosis. Cancer Res, 1998, 58, 3231-3236.
-
(1998)
Cancer Res
, vol.58
, pp. 3231-3236
-
-
Leach, S. D.1
Scatena, C. D.2
Keefer, C. J.3
Goodman, H. A.4
Song, S. Y.5
Yang, L.6
Pietenpol, J. A.7
-
116
-
-
0029001804
-
Rescue from granzyme B-induced apoptosis by Wee1 kinase
-
Chen, G.; Shi, L.; Litchfield, D. W.; Greenberg, A. H. Rescue from granzyme B-induced apoptosis by Wee1 kinase. J. Exp. Med., 1995, 181, 2295-2300.
-
(1995)
J. Exp. Med
, vol.181
, pp. 2295-2300
-
-
Chen, G.1
Shi, L.2
Litchfield, D. W.3
Greenberg, A. H.4
-
117
-
-
0035890610
-
Radiosensitization of p53 Mutant Cells by PD0166285, a Novel G2 Checkpoint Abrogator
-
Wang, Yuli; Li, Jun; Booher, Robert N.; Kraker, Alan; Lawrence, Theodore; Leopold, Wilbur R.; Sun, Yi. Radiosensitization of p53 Mutant Cells by PD0166285, a Novel G2 Checkpoint Abrogator. Cancer Res, 2001, 61, 8211-8217.
-
(2001)
Cancer Res
, vol.61
, pp. 8211-8217
-
-
Wang, Yuli1
Li, Jun2
Booher, Robert N.3
Kraker, Alan4
Lawrence, Theodore5
Leopold, Wilbur R.6
Sun, Yi7
-
118
-
-
70949083026
-
Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents
-
Hirai, H.; Iwasawa, Y.; Okada, M.; Arai, T.; Nishibata, T.; Kobayashi, M.; Kimura, T.; Kaneko, N.; Ohtani, J.; Yamanaka, K.; Itadani, H.; Takahashi-Suzuki, I.; Fukasawa, K.; Oki, H.; Nambu, T.; Jiang, J.; Sakai, T.; Arakawa, H.; Sakamoto, T.; Sagara, T.; Yoshizumi, T.; Mizuarai, S.; Kotani, H. Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents. Mol Cancer Ther, 2009, 8, 2992-3000.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 2992-3000
-
-
Hirai, H.1
Iwasawa, Y.2
Okada, M.3
Arai, T.4
Nishibata, T.5
Kobayashi, M.6
Kimura, T.7
Kaneko, N.8
Ohtani, J.9
Yamanaka, K.10
Itadani, H.11
Takahashi-Suzuki, I.12
Fukasawa, K.13
Oki, H.14
Nambu, T.15
Jiang, J.16
Sakai, T.17
Arakawa, H.18
Sakamoto, T.19
Sagara, T.20
Yoshizumi, T.21
Mizuarai, S.22
Kotani, H.23
more..
-
119
-
-
18744398382
-
The radiation hypersensitivity of cells at mitosis
-
Stobbe, C. C.; Park, S. J.; Chapman, J. D. The radiation hypersensitivity of cells at mitosis. Int J Radiat Biol, 2002, 78, 1149-1157.
-
(2002)
Int J Radiat Biol
, vol.78
, pp. 1149-1157
-
-
Stobbe, C. C.1
Park, S. J.2
Chapman, J. D.3
-
120
-
-
0015187833
-
Heat-induced lethality and chromosomal damage in synchronized Chinese hamster cells treated with 5-bromodeoxyuridine
-
Dewey, W. C.; Westra, A.; Miller, H. H.; Nagasawa, H. Heat-induced lethality and chromosomal damage in synchronized Chinese hamster cells treated with 5-bromodeoxyuridine. Int J Radiat Biol Relat Stud Phys Chem Med, 1971, 20, 505-520.
-
(1971)
Int J Radiat Biol Relat Stud Phys Chem Med
, vol.20
, pp. 505-520
-
-
Dewey, W. C.1
Westra, A.2
Miller, H. H.3
Nagasawa, H.4
-
121
-
-
0015000275
-
Variation in sensitivity to heat shock during the cell-cycle of Chinese hamster cells in vitro
-
Westra, A.; Dewey, W. C. Variation in sensitivity to heat shock during the cell-cycle of Chinese hamster cells in vitro. Int J Radiat Biol Relat Stud Phys Chem Med, 1971, 19, 467-477.
-
(1971)
Int J Radiat Biol Relat Stud Phys Chem Med
, vol.19
, pp. 467-477
-
-
Westra, A.1
Dewey, W. C.2
-
122
-
-
0035433029
-
Past and future of the mitotic spindle as an oncology target
-
Wood, Kenneth W.; Cornwell, William D.; Jackson, Jeffrey R. Past and future of the mitotic spindle as an oncology target. Current Opinion in Pharmacology, 2001, 1, 370-377.
-
(2001)
Current Opinion in Pharmacology
, vol.1
, pp. 370-377
-
-
Wood, Kenneth W.1
Cornwell, William D.2
Jackson, Jeffrey R.3
-
124
-
-
0037373258
-
G1 tetraploidy checkpoint and the suppression of tumorigenesis
-
Margolis, R. L.; Lohez, O. D.; Andreassen, P. R. G1 tetraploidy checkpoint and the suppression of tumorigenesis. J Cell Biochem, 2003, 88, 673-683.
-
(2003)
J Cell Biochem
, vol.88
, pp. 673-683
-
-
Margolis, R. L.1
Lohez, O. D.2
Andreassen, P. R.3
-
125
-
-
7744233719
-
Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint
-
Rieder, C. L.; Maiato, H. Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint. Dev Cell, 2004, 7, 637-651.
-
(2004)
Dev Cell
, vol.7
, pp. 637-651
-
-
Rieder, C. L.1
Maiato, H.2
-
126
-
-
0035524309
-
Chromosome segregation and cancer: cutting through the mystery
-
Jallepalli, P. V.; Lengauer, C. Chromosome segregation and cancer: cutting through the mystery. Nature Reviews. Cancer, 2001, 1, 109-117.
-
(2001)
Nature Reviews. Cancer
, vol.1
, pp. 109-117
-
-
Jallepalli, P. V.1
Lengauer, C.2
-
128
-
-
33749057529
-
Therapeutic opportunities to control tumor cell cycles
-
Malumbres, M. Therapeutic opportunities to control tumor cell cycles. Clin Transl Oncol, 2006, 8, 399-408.
-
(2006)
Clin Transl Oncol
, vol.8
, pp. 399-408
-
-
Malumbres, M.1
-
129
-
-
1942474378
-
Dependence of paclitaxel sensitivity on a functional spindle assembly checkpoint
-
Sudo, Tamotsu; Nitta, Masayuki; Saya, Hideyuki; Ueno, Naoto T. Dependence of paclitaxel sensitivity on a functional spindle assembly checkpoint. Cancer Research, 2004, 64, 2502-2508.
-
(2004)
Cancer Research
, vol.64
, pp. 2502-2508
-
-
Sudo, Tamotsu1
Nitta, Masayuki2
Saya, Hideyuki3
Ueno, Naoto T.4
-
130
-
-
34447094967
-
A census of mitotic cancer genes: new insights into tumor cell biology and cancer therapy
-
Perez De Castro, I.; De Carcer, G.; Malumbres, M. A census of mitotic cancer genes: new insights into tumor cell biology and cancer therapy. Carcinogenesis, 2007, 28, 899-912.
-
(2007)
Carcinogenesis
, vol.28
, pp. 899-912
-
-
Perez De Castro, I.1
De Carcer, G.2
Malumbres, M.3
-
131
-
-
0030611850
-
cdc2 and cyclin D1 protein expression in prostate adenocarcinoma
-
cdc2 and cyclin D1 protein expression in prostate adenocarcinoma. Cancer, 1997, 80, 753-763.
-
(1997)
Cancer
, vol.80
, pp. 753-763
-
-
Kallakury, Bhaskar V. S.1
Sheehan, Christine E.2
Ambros, Robert A.3
Fisher, Hugh A.G.4
Kaufman, Ronald P.5
Ross, Jeffrey S.6
-
132
-
-
0033870724
-
Overexpression of Cyclin B1 in Early-Stage Non-Small Cell Lung Cancer and Its Clinical Implication
-
Soria, Jean-Charles; Jang, Se Jin; Khuri, Fadlo R.; Hassan, Khaled; Liu, Diane; Hong, Waun Ki; Mao, Li. Overexpression of Cyclin B1 in Early-Stage Non-Small Cell Lung Cancer and Its Clinical Implication. Cancer Res, 2000, 60, 4000-4004.
-
(2000)
Cancer Res
, vol.60
, pp. 4000-4004
-
-
Soria, Jean-Charles1
Jang, Se Jin2
Khuri, Fadlo R.3
Hassan, Khaled4
Liu, Diane5
Hong, Waun Ki6
Mao, Li7
-
133
-
-
0036604222
-
Prognostic value of cyclin B1 in patients with esophageal squamous cell carcinoma
-
Shinsuke Takeno, Tsuyoshi Noguchi, Ryuichi Kikuchi, Yuzo Uchida, Shigeo Yokoyama, Wolfram Müller. Prognostic value of cyclin B1 in patients with esophageal squamous cell carcinoma. Cancer, 2002, 94, 2874-2881.
-
(2002)
Cancer
, vol.94
, pp. 2874-2881
-
-
Takeno, Shinsuke1
Noguchi, Tsuyoshi2
Kikuchi, Ryuichi3
Uchida, Yuzo4
Yokoyama, Shigeo5
Müller, Wolfram6
-
134
-
-
0038100182
-
3 integrin expression up-regulates cdc2, which modulates cell migration
-
3 integrin expression up-regulates cdc2, which modulates cell migration. J. Cell Biol., 2003, 161, 817-826.
-
(2003)
J. Cell Biol
, vol.161
, pp. 817-826
-
-
Manes, Thomas1
Zheng, Duo-Qi2
Tognin, Simona3
Woodard, Amy S.4
Marchisio, Pier Carlo5
Languino, Lucia R.6
-
135
-
-
33646239607
-
Discovery and Evaluation of Dual CDK1 and CDK2 Inhibitors
-
Payton, Marc; Chung, Grace; Yakowec, Peter; Wong, Andrew; Powers, Dave; Xiong, Ling; Zhang, Nancy; Leal, Juan; Bush, Tammy L.; Santora, Vincent; Askew, Ben; Tasker, Andrew; Radinsky, Robert; Kendall, Richard; Coats, Steve. Discovery and Evaluation of Dual CDK1 and CDK2 Inhibitors. Cancer Res, 2006, 66, 4299-4308.
-
(2006)
Cancer Res
, vol.66
, pp. 4299-4308
-
-
Payton, Marc1
Chung, Grace2
Yakowec, Peter3
Wong, Andrew4
Powers, Dave5
Xiong, Ling6
Zhang, Nancy7
Leal, Juan8
Bush, Tammy L.9
Santora, Vincent10
Askew, Ben11
Tasker, Andrew12
Radinsky, Robert13
Kendall, Richard14
Coats, Steve15
-
136
-
-
0037468466
-
Evaluation of the first cytostatically active 1-aza-9-oxafluorenes as novel selective CDK1 inhibitors with P-glycoprotein modulating properties
-
Brachwitz, K.; Voigt, B.; Meijer, L.; Lozach, O.; Schachtele, C.; Molnar, J.; Hilgeroth, A. Evaluation of the first cytostatically active 1-aza-9-oxafluorenes as novel selective CDK1 inhibitors with P-glycoprotein modulating properties. J Med Chem, 2003, 46, 876-879.
-
(2003)
J Med Chem
, vol.46
, pp. 876-879
-
-
Brachwitz, K.1
Voigt, B.2
Meijer, L.3
Lozach, O.4
Schachtele, C.5
Molnar, J.6
Hilgeroth, A.7
-
137
-
-
33746094659
-
Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1
-
Vassilev, Lyubomir T.; Tovar, Christian; Chen, Shaoqing; Knezevic, Dejan; Zhao, Xiaolan; Sun, Hongmao; Heimbrook, David C.; Chen, Li. Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. PNAS, 2006, 103, 10660-10665.
-
(2006)
PNAS
, vol.103
, pp. 10660-10665
-
-
Vassilev, Lyubomir T.1
Tovar, Christian2
Chen, Shaoqing3
Knezevic, Dejan4
Zhao, Xiaolan5
Sun, Hongmao6
Heimbrook, David C.7
Chen, Li8
-
138
-
-
37549036250
-
CDK inhibitors in cancer therapy: what is next?
-
Malumbres, M.; Pevarello, P.; Barbacid, M.; Bischoff, J. R. CDK inhibitors in cancer therapy: what is next? Trends Pharmacol Sci, 2008, 29, 16-21.
-
(2008)
Trends Pharmacol Sci
, vol.29
, pp. 16-21
-
-
Malumbres, M.1
Pevarello, P.2
Barbacid, M.3
Bischoff, J. R.4
-
139
-
-
77955557891
-
Discovery of novel CDK1 inhibitors by combining pharmacophore modeling, QSAR analysis and in silico screening followed by in vitro bioassay
-
Al-Sha'er, M. A.; Taha, M. O. Discovery of novel CDK1 inhibitors by combining pharmacophore modeling, QSAR analysis and in silico screening followed by in vitro bioassay. Eur J Med Chem, 2010, 45, 4316-4330.
-
(2010)
Eur J Med Chem
, vol.45
, pp. 4316-4330
-
-
Al-Sha'er, M. A.1
Taha, M. O.2
-
140
-
-
34447137342
-
Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC
-
Goga, A.; Yang, D.; Tward, A. D.; Morgan, D. O.; Bishop, J. M. Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC. Nat Med, 2007, 13, 820-827.
-
(2007)
Nat Med
, vol.13
, pp. 820-827
-
-
Goga, A.1
Yang, D.2
Tward, A. D.3
Morgan, D. O.4
Bishop, J. M.5
-
142
-
-
0842281498
-
Aurora kinases link chromosome segregation and cell division to cancer susceptibility
-
Meraldi, P.; Honda, R.; Nigg, E. A. Aurora kinases link chromosome segregation and cell division to cancer susceptibility. Curr Opin Genet Dev, 2004, 14, 29-36.
-
(2004)
Curr Opin Genet Dev
, vol.14
, pp. 29-36
-
-
Meraldi, P.1
Honda, R.2
Nigg, E. A.3
-
143
-
-
10344236486
-
Aurora-kinase inhibitors as anticancer agents
-
Keen, N.; Taylor, S. Aurora-kinase inhibitors as anticancer agents. Nat Rev Cancer, 2004, 4, 927-936.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 927-936
-
-
Keen, N.1
Taylor, S.2
-
144
-
-
0037586498
-
AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol
-
Anand, S.; Penrhyn-Lowe, S.; Venkitaraman, A. R. AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol. Cancer Cell, 2003, 3, 51-62.
-
(2003)
Cancer Cell
, vol.3
, pp. 51-62
-
-
Anand, S.1
Penrhyn-Lowe, S.2
Venkitaraman, A. R.3
-
145
-
-
0032100685
-
A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers
-
Bischoff, J. R.; Anderson, L.; Zhu, Y.; Mossie, K.; Ng, L.; Souza, B.; Schryver, B.; Flanagan, P.; Clairvoyant, F.; Ginther, C.; Chan, C. S.; Novotny, M.; Slamon, D. J.; Plowman, G. D. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. Embo J, 1998, 17, 3052-3065.
-
(1998)
Embo J
, vol.17
, pp. 3052-3065
-
-
Bischoff, J. R.1
Anderson, L.2
Zhu, Y.3
Mossie, K.4
Ng, L.5
Souza, B.6
Schryver, B.7
Flanagan, P.8
Clairvoyant, F.9
Ginther, C.10
Chan, C. S.11
Novotny, M.12
Slamon, D. J.13
Plowman, G. D.14
-
146
-
-
0037084163
-
Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/-cells
-
Meraldi, P.; Honda, R.; Nigg, E. A. Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/-cells. Embo J, 2002, 21, 483-492.
-
(2002)
Embo J
, vol.21
, pp. 483-492
-
-
Meraldi, P.1
Honda, R.2
Nigg, E. A.3
-
147
-
-
2442584567
-
BRCA1 Phosphorylation by Aurora-A in the Regulation of G2 to M Transition
-
Ouchi, Mutsuko; Fujiuchi, Nobuko; Sasai, Kaori; Katayama, Hiroshi; Minamishima, Yohji A.; Ongusaha, Pat P.; Deng, Chuxia; Sen, Subrata; Lee, Sam W.; Ouchi, Toru. BRCA1 Phosphorylation by Aurora-A in the Regulation of G2 to M Transition. J. Biol. Chem., 2004, 279, 19643-19648.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 19643-19648
-
-
Ouchi, Mutsuko1
Fujiuchi, Nobuko2
Sasai, Kaori3
Katayama, Hiroshi4
Minamishima, Yohji A.5
Ongusaha, Pat P.6
Deng, Chuxia7
Sen, Subrata8
Lee, Sam W.9
Ouchi, Toru10
-
148
-
-
2942687404
-
The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase
-
Toji, S.; Yabuta, N.; Hosomi, T.; Nishihara, S.; Kobayashi, T.; Suzuki, S.; Tamai, K.; Nojima, H. The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. Genes Cells, 2004, 9, 383-397.
-
(2004)
Genes Cells
, vol.9
, pp. 383-397
-
-
Toji, S.1
Yabuta, N.2
Hosomi, T.3
Nishihara, S.4
Kobayashi, T.5
Suzuki, S.6
Tamai, K.7
Nojima, H.8
-
149
-
-
33746508429
-
Mitotic kinases: The key to duplication, segregation, and cytokinesis errors, chromosomal instability, and oncogenesis
-
Li, Jonathan J.; Li, Sara Antonia. Mitotic kinases: The key to duplication, segregation, and cytokinesis errors, chromosomal instability, and oncogenesis. Pharmacology & Therapeutics, 2006, 111, 974-984.
-
(2006)
Pharmacology & Therapeutics
, vol.111
, pp. 974-984
-
-
Li, Jonathan J.1
Li, Sara Antonia2
-
150
-
-
0037233327
-
Survivin and apoptosis control
-
Altieri, D. C. Survivin and apoptosis control. Adv Cancer Res, 2003, 88, 31-52.
-
(2003)
Adv Cancer Res
, vol.88
, pp. 31-52
-
-
Altieri, D. C.1
-
151
-
-
8744313990
-
Direct Association with Inner Centromere Protein (INCENP) Activates the Novel Chromosomal Passenger Protein, Aurora-C
-
Li, Xiangyu; Sakashita, Gyosuke; Matsuzaki, Hideki; Sugimoto, Kenji; Kimura, Keiji; Hanaoka, Fumio; Taniguchi, Hisaaki; Furukawa, Koichi; Urano, Takeshi. Direct Association with Inner Centromere Protein (INCENP) Activates the Novel Chromosomal Passenger Protein, Aurora-C. J. Biol. Chem., 2004, 279, 47201-47211.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 47201-47211
-
-
Li, Xiangyu1
Sakashita, Gyosuke2
Matsuzaki, Hideki3
Sugimoto, Kenji4
Kimura, Keiji5
Hanaoka, Fumio6
Taniguchi, Hisaaki7
Furukawa, Koichi8
Urano, Takeshi9
-
152
-
-
19944394833
-
Subrata Sen Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells
-
Kaori Sasai, Hiroshi Katayama, David L. Stenoien, Satoshi Fujii, Reiko Honda, Masashi Kimura, Yukio Okano, Masaaki Tatsuka, Fumio Suzuki, Erich A. Nigg, William C. Earnshaw, William R. Brinkley, Subrata Sen Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. Cell Motility and the Cytoskeleton, 2004, 59, 249-263.
-
(2004)
Cell Motility and the Cytoskeleton
, vol.59
, pp. 249-263
-
-
Sasai, Kaori1
Katayama, Hiroshi2
Stenoien, David L.3
Fujii, Satoshi4
Honda, Reiko5
Kimura, Masashi6
Okano, Yukio7
Tatsuka, Masaaki8
Suzuki, Fumio9
Nigg, Erich A.10
Earnshaw, William C.11
Brinkley, William R.12
-
153
-
-
4544277193
-
Dawn of Aurora kinase inhibitors as anticancer drugs
-
Doggrell, S. A. Dawn of Aurora kinase inhibitors as anticancer drugs. Expert Opin Investig Drugs, 2004, 13, 1199-1201.
-
(2004)
Expert Opin Investig Drugs
, vol.13
, pp. 1199-1201
-
-
Doggrell, S. A.1
-
154
-
-
0038746733
-
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint
-
Hauf, Silke; Cole, Richard W.; Laterra, Sabrina; Zimmer, Christine; Schnapp, Gisela; Walter, Rainer; Heckel, Armin; Van Meel, Jacques; Rieder, Conly L.; Peters, Jan-Michael. The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J. Cell Biol., 2003, 161, 281-294.
-
(2003)
J. Cell Biol
, vol.161
, pp. 281-294
-
-
Hauf, Silke1
Cole, Richard W.2
Laterra, Sabrina3
Zimmer, Christine4
Schnapp, Gisela5
Walter, Rainer6
Heckel, Armin7
Van Meel, Jacques8
Rieder, Conly L.9
Peters, Jan-Michael10
-
155
-
-
14844330690
-
Aurora Kinase Inhibitor ZM447439 Blocks Chromosome-induced Spindle Assembly, the Completion of Chromosome Condensation, and the Establishment of the Spindle Integrity Checkpoint in Xenopus Egg Extracts
-
Gadea, Bedrick B.; Ruderman, Joan V. Aurora Kinase Inhibitor ZM447439 Blocks Chromosome-induced Spindle Assembly, the Completion of Chromosome Condensation, and the Establishment of the Spindle Integrity Checkpoint in Xenopus Egg Extracts. Mol. Biol. Cell, 2005, 16, 1305-1318.
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 1305-1318
-
-
Gadea, Bedrick B.1
Ruderman, Joan V.2
-
156
-
-
2342639645
-
VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo
-
Harrington, Elizabeth A.; Bebbington, David; Moore, Jeff; Rasmussen, Richele K.; Ajose-Adeogun, Abi O.; Nakayama, Tomoko; Graham, Joanne A.; Demur, Cecile; Hercend, Thierry; Diu-Hercend, Anita; Su, Michael; Golec, Julian M. C.; Miller, Karen M. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat Med, 2004, 10, 262-267.
-
(2004)
Nat Med
, vol.10
, pp. 262-267
-
-
Harrington, Elizabeth A.1
Bebbington, David2
Moore, Jeff3
Rasmussen, Richele K.4
Ajose-Adeogun, Abi O.5
Nakayama, Tomoko6
Graham, Joanne A.7
Demur, Cecile8
Hercend, Thierry9
Diu-Hercend, Anita10
Su, Michael11
Golec, Julian M. C.12
Miller, Karen M.13
-
157
-
-
33746080016
-
PHA-680632, a Novel Aurora Kinase Inhibitor with Potent Antitumoral Activity
-
Soncini, Chiara; Carpinelli, Patrizia; Gianellini, Laura; Fancelli, Daniele; Vianello, Paola; Rusconi, Luisa; Storici, Paola; Zugnoni, Paola; Pesenti, Enrico; Croci, Valter; Ceruti, Roberta; Giorgini, Maria Laura; Cappella, Paolo; Ballinari, Dario; Sola, Francesco; Varasi, Mario; Bravo, Rodrigo; Moll, Jurgen. PHA-680632, a Novel Aurora Kinase Inhibitor with Potent Antitumoral Activity. Clin Cancer Res, 2006, 12, 4080-4089.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 4080-4089
-
-
Soncini, Chiara1
Carpinelli, Patrizia2
Gianellini, Laura3
Fancelli, Daniele4
Vianello, Paola5
Rusconi, Luisa6
Storici, Paola7
Zugnoni, Paola8
Pesenti, Enrico9
Croci, Valter10
Ceruti, Roberta11
Giorgini, Maria Laura12
Cappella, Paolo13
Ballinari, Dario14
Sola, Francesco15
Varasi, Mario16
Bravo, Rodrigo17
Moll, Jurgen18
-
158
-
-
25444456359
-
The In vitro and In vivo Effects of JNJ-7706621: A Dual Inhibitor of Cyclin-Dependent Kinases and Aurora Kinases
-
Emanuel, Stuart; Rugg, Catherine A.; Gruninger, Robert H.; Lin, Ronghui; Fuentes-Pesquera, Angel; Connolly, Peter J.; Wetter, Steven K.; Hollister, Beth; Kruger, Walter W.; Napier, Cheryl; Jolliffe, Linda; Middleton, Steven A. The In vitro and In vivo Effects of JNJ-7706621: A Dual Inhibitor of Cyclin-Dependent Kinases and Aurora Kinases. Cancer Res, 2005, 65, 9038-9046.
-
(2005)
Cancer Res
, vol.65
, pp. 9038-9046
-
-
Emanuel, Stuart1
Rugg, Catherine A.2
Gruninger, Robert H.3
Lin, Ronghui4
Fuentes-Pesquera, Angel5
Connolly, Peter J.6
Wetter, Steven K.7
Hollister, Beth8
Kruger, Walter W.9
Napier, Cheryl10
Jolliffe, Linda11
Middleton, Steven A.12
-
159
-
-
78649476052
-
Shared and separate functions of polo-like kinases and aurora kinases in cancer
-
Lens, S. M.; Voest, E. E.; Medema, R. H. Shared and separate functions of polo-like kinases and aurora kinases in cancer. Nat Rev Cancer, 2010, 10, 825-841.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 825-841
-
-
Lens, S. M.1
Voest, E. E.2
Medema, R. H.3
-
160
-
-
78649864566
-
Aurora kinase inhibitors as anticancer molecules
-
Katayama, H.; Sen, S. Aurora kinase inhibitors as anticancer molecules. Biochim Biophys Acta, 2010, 1799, 829-839.
-
(2010)
Biochim Biophys Acta
, vol.1799
, pp. 829-839
-
-
Katayama, H.1
Sen, S.2
-
161
-
-
47949108203
-
Aurora kinases and their inhibitors: more than one target and one drug
-
Carpinelli, P.; Moll, J. Aurora kinases and their inhibitors: more than one target and one drug. Adv Exp Med Biol, 2008, 610, 54-73.
-
(2008)
Adv Exp Med Biol
, vol.610
, pp. 54-73
-
-
Carpinelli, P.1
Moll, J.2
-
162
-
-
13244269808
-
Polo-like kinases and oncogenesis
-
Eckerdt, Frank; Yuan, Juping; Strebhardt, Klaus. Polo-like kinases and oncogenesis. Oncogene, 2005, 24, 267-276.
-
(2005)
Oncogene
, vol.24
, pp. 267-276
-
-
Eckerdt, Frank1
Yuan, Juping2
Strebhardt, Klaus3
-
163
-
-
13244271313
-
Polo-like kinases (Plks) and cancer
-
Takai, Noriyuki; Hamanaka, Ryoji; Yoshimatsu, Jun; Miyakawa, Isao. Polo-like kinases (Plks) and cancer. Oncogene, 2005, 24, 287-291.
-
(2005)
Oncogene
, vol.24
, pp. 287-291
-
-
Takai, Noriyuki1
Hamanaka, Ryoji2
Yoshimatsu, Jun3
Miyakawa, Isao4
-
164
-
-
77955167321
-
Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy
-
Strebhardt, K. Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy. Nat Rev Drug Discov, 9, 643-660.
-
Nat Rev Drug Discov
, vol.9
, pp. 643-660
-
-
Strebhardt, K.1
-
165
-
-
79960446938
-
From Plk1 to Plk5: functional evolution of polo-like kinases
-
De Carcer, G.; Manning, G.; Malumbres, M. From Plk1 to Plk5: functional evolution of polo-like kinases. Cell Cycle, 10, 2255-2262.
-
Cell Cycle
, vol.10
, pp. 2255-2262
-
-
De Carcer, G.1
Manning, G.2
Malumbres, M.3
-
166
-
-
2942615282
-
Polo-like kinases and the orchestration of cell division
-
Barr, F. A.; Sillje, H. H.; Nigg, E. A. Polo-like kinases and the orchestration of cell division. Nat Rev Mol Cell Biol, 2004, 5, 429-440.
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 429-440
-
-
Barr, F. A.1
Sillje, H. H.2
Nigg, E. A.3
-
167
-
-
33645316142
-
Targeting polo-like kinase 1 for cancer therapy
-
Strebhardt, Klaus; Ullrich, Axel. Targeting polo-like kinase 1 for cancer therapy. Nat Rev Cancer, 2006, 6, 321-330.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 321-330
-
-
Strebhardt, Klaus1
Ullrich, Axel2
-
168
-
-
0036185931
-
Scytonemin--a marine natural product inhibitor of kinases key in hyperproliferative inflammatory diseases
-
Stevenson, C. S.; Capper, E. A.; Roshak, A. K.; Marquez, B.; Grace, K.; Gerwick, W. H.; Jacobs, R. S.; Marshall, L. A. Scytonemin--a marine natural product inhibitor of kinases key in hyperproliferative inflammatory diseases. Inflamm Res, 2002, 51, 112-114.
-
(2002)
Inflamm Res
, vol.51
, pp. 112-114
-
-
Stevenson, C. S.1
Capper, E. A.2
Roshak, A. K.3
Marquez, B.4
Grace, K.5
Gerwick, W. H.6
Jacobs, R. S.7
Marshall, L. A.8
-
169
-
-
12344256951
-
Wortmannin, a Widely Used Phosphoinositide 3-Kinase Inhibitor, also Potently Inhibits Mammalian Polo-like Kinase
-
Liu, Yongsheng; Shreder, Kevin R.; Gai, Wenzhi; Corral, Sergio; Ferris, Douglas K.; Rosenblum, Jonathan S. Wortmannin, a Widely Used Phosphoinositide 3-Kinase Inhibitor, also Potently Inhibits Mammalian Polo-like Kinase. Chemistry & Biology, 2005, 12, 99-107.
-
(2005)
Chemistry & Biology
, vol.12
, pp. 99-107
-
-
Liu, Yongsheng1
Shreder, Kevin R.2
Gai, Wenzhi3
Corral, Sergio4
Ferris, Douglas K.5
Rosenblum, Jonathan S.6
-
170
-
-
34948818671
-
Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis
-
Santamaria, A.; Neef, R.; Eberspacher, U.; Eis, K.; Husemann, M.; Mumberg, D.; Prechtl, S.; Schulze, V.; Siemeister, G.; Wortmann, L.; Barr, F. A.; Nigg, E. A. Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis. Mol Biol Cell, 2007, 18, 4024-4036.
-
(2007)
Mol Biol Cell
, vol.18
, pp. 4024-4036
-
-
Santamaria, A.1
Neef, R.2
Eberspacher, U.3
Eis, K.4
Husemann, M.5
Mumberg, D.6
Prechtl, S.7
Schulze, V.8
Siemeister, G.9
Wortmann, L.10
Barr, F. A.11
Nigg, E. A.12
-
171
-
-
85144152377
-
-
Vol (June 20 Supplement)
-
G. Munzert, S. Steinbild, A. Frost, S. Hedborn, J. Rentschler, R. Kaiser, D. Trommeshauser, M. Hoffmann, M. Steegmaier, K. Mross. In ASCO Annual Meeting Proceedings Journal of Clinical Oncology, 2006; Vol. Vol 24, No. 18S (June 20 Supplement).
-
(2006)
ASCO Annual Meeting Proceedings Journal of Clinical Oncology
, vol.24
, Issue.18S
-
-
Munzert, G.1
Steinbild, S.2
Frost, A.3
Hedborn, S.4
Rentschler, J.5
Kaiser, R.6
Trommeshauser, D.7
Hoffmann, M.8
Steegmaier, M.9
Mross, K.10
-
172
-
-
33750299898
-
A phase I repeated dose escalation study of the Polo-like kinase 1 inhibitor BI 2536 in patients with advanced solid tumours
-
Hofheinz, R.; Hochhaus, A.; Al-Batran, S.; Nanci, A.; Reichardt, V.; Trommeshauser, D.; Hoffmann, M.; Steegmaier, M.; Munzert, G.; Jager, E. A phase I repeated dose escalation study of the Polo-like kinase 1 inhibitor BI 2536 in patients with advanced solid tumours. J Clin Oncol (Meeting Abstracts), 2006, 24, 2038-.
-
(2006)
J Clin Oncol (Meeting Abstracts)
, vol.24
, pp. 2038
-
-
Hofheinz, R.1
Hochhaus, A.2
Al-Batran, S.3
Nanci, A.4
Reichardt, V.5
Trommeshauser, D.6
Hoffmann, M.7
Steegmaier, M.8
Munzert, G.9
Jager, E.10
-
173
-
-
65649105075
-
BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity
-
Rudolph, D.; Steegmaier, M.; Hoffmann, M.; Grauert, M.; Baum, A.; Quant, J.; Haslinger, C.; Garin-Chesa, P.; Adolf, G. R. BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity. Clin Cancer Res, 2009, 15, 3094-3102.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3094-3102
-
-
Rudolph, D.1
Steegmaier, M.2
Hoffmann, M.3
Grauert, M.4
Baum, A.5
Quant, J.6
Haslinger, C.7
Garin-Chesa, P.8
Adolf, G. R.9
-
174
-
-
0036827627
-
The Identification and Characterization of the Marine Natural Product Scytonemin as a Novel Antiproliferative Pharmacophore
-
Stevenson, Christopher S.; Capper, Elizabeth A.; Roshak, Amy K.; Marquez, Brian; Eichman, Chris; Jackson, Jeffrey R.; Mattern, Michael; Gerwick, William H.; Jacobs, Robert S.; Marshall, Lisa A. The Identification and Characterization of the Marine Natural Product Scytonemin as a Novel Antiproliferative Pharmacophore. J Pharmacol Exp Ther, 2002, 303, 858-866.
-
(2002)
J Pharmacol Exp Ther
, vol.303
, pp. 858-866
-
-
Stevenson, Christopher S.1
Capper, Elizabeth A.2
Roshak, Amy K.3
Marquez, Brian4
Eichman, Chris5
Jackson, Jeffrey R.6
Mattern, Michael7
Gerwick, William H.8
Jacobs, Robert S.9
Marshall, Lisa A.10
-
175
-
-
51449108571
-
Emerging cancer therapeutic opportunities by inhibiting mitotic kinases
-
Perez De Castro, I.; De Carcer, G.; Montoya, G.; Malumbres, M. Emerging cancer therapeutic opportunities by inhibiting mitotic kinases. Curr Opin Pharmacol, 2008, 8, 375-383.
-
(2008)
Curr Opin Pharmacol
, vol.8
, pp. 375-383
-
-
Perez De Castro, I.1
De Carcer, G.2
Montoya, G.3
Malumbres, M.4
-
176
-
-
77956624673
-
Exploring Potential Binding Modes of Small Drug-like Molecules to the Polo-Box Domain of Human Polo-like Kinase 1
-
Liao, C.; Park, J. E.; Bang, J. K.; Nicklaus, M. C.; Lee, K. S. Exploring Potential Binding Modes of Small Drug-like Molecules to the Polo-Box Domain of Human Polo-like Kinase 1. ACS Med Chem Lett, 2010, 1, 110-114.
-
(2010)
ACS Med Chem Lett
, vol.1
, pp. 110-114
-
-
Liao, C.1
Park, J. E.2
Bang, J. K.3
Nicklaus, M. C.4
Lee, K. S.5
-
177
-
-
43149088028
-
Pinning down the polo-box domain
-
Lee, K. S.; Idle, J. R. Pinning down the polo-box domain. Chem Biol, 2008, 15, 415-416.
-
(2008)
Chem Biol
, vol.15
, pp. 415-416
-
-
Lee, K. S.1
Idle, J. R.2
-
178
-
-
70350678893
-
The natural product Aristolactam AIIIa as a new ligand targeting the polo-box domain of polo-like kinase 1 potently inhibits cancer cell proliferation
-
Li, L.; Wang, X.; Chen, J.; Ding, H.; Zhang, Y.; Hu, T. C.; Hu, L. H.; Jiang, H. L.; Shen, X. The natural product Aristolactam AIIIa as a new ligand targeting the polo-box domain of polo-like kinase 1 potently inhibits cancer cell proliferation. Acta Pharmacol Sin, 2009, 30, 1443-1453.
-
(2009)
Acta Pharmacol Sin
, vol.30
, pp. 1443-1453
-
-
Li, L.1
Wang, X.2
Chen, J.3
Ding, H.4
Zhang, Y.5
Hu, T. C.6
Hu, L. H.7
Jiang, H. L.8
Shen, X.9
-
179
-
-
43149093993
-
Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions
-
Reindl, W.; Yuan, J.; Kramer, A.; Strebhardt, K.; Berg, T. Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions. Chem Biol, 2008, 15, 459-466.
-
(2008)
Chem Biol
, vol.15
, pp. 459-466
-
-
Reindl, W.1
Yuan, J.2
Kramer, A.3
Strebhardt, K.4
Berg, T.5
-
180
-
-
67650472492
-
A pan-specific inhibitor of the polo-box domains of polo-like kinases arrests cancer cells in mitosis
-
Reindl, W.; Yuan, J.; Kramer, A.; Strebhardt, K.; Berg, T. A pan-specific inhibitor of the polo-box domains of polo-like kinases arrests cancer cells in mitosis. Chembiochem, 2009, 10, 1145-1148.
-
(2009)
Chembiochem
, vol.10
, pp. 1145-1148
-
-
Reindl, W.1
Yuan, J.2
Kramer, A.3
Strebhardt, K.4
Berg, T.5
-
181
-
-
17644368237
-
ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent
-
Gumireddy, Kiranmai; Reddy, M. V. Ramana; Cosenza, Stephen C.; Nathan, R. Boomi; Baker, Stacey J.; Papathi, Nabisa; Jiang, Jiandong; Holland, James; Reddy, E. Premkumar. ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent. Cancer Cell, 2005, 7, 275-286.
-
(2005)
Cancer Cell
, vol.7
, pp. 275-286
-
-
Gumireddy, Kiranmai1
Reddy, M. V. Ramana2
Cosenza, Stephen C.3
Nathan, R. Boomi4
Baker, Stacey J.5
Papathi, Nabisa6
Jiang, Jiandong7
Holland, James8
Reddy, E. Premkumar9
-
182
-
-
31144463968
-
The Polo kinase Plk4 functions in centriole duplication
-
Habedanck, R.; Stierhof, Y. D.; Wilkinson, C. J.; Nigg, E. A. The Polo kinase Plk4 functions in centriole duplication. Nat Cell Biol, 2005, 7, 1140-1146.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 1140-1146
-
-
Habedanck, R.1
Stierhof, Y. D.2
Wilkinson, C. J.3
Nigg, E. A.4
-
183
-
-
13244255264
-
Sak//Plk4 and mitotic fidelity
-
Swallow, Carol J.; Ko, Michael A.; Siddiqui, Najeeb U.; Hudson, John W.; Dennis, James W. Sak//Plk4 and mitotic fidelity. Oncogene, 2005, 24, 306-312.
-
(2005)
Oncogene
, vol.24
, pp. 306-312
-
-
Swallow, Carol J.1
Ko, Michael A.2
Siddiqui, Najeeb U.3
Hudson, John W.4
Dennis, James W.5
-
184
-
-
23044488055
-
Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis
-
Ko, Michael A.; Rosario, Carla O.; Hudson, John W.; Kulkarni, Sarang; Pollett, Aaron; Dennis, James W.; Swallow, Carol J. Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis. Nat Genet, 2005, 37, 883-888.
-
(2005)
Nat Genet
, vol.37
, pp. 883-888
-
-
Ko, Michael A.1
Rosario, Carla O.2
Hudson, John W.3
Kulkarni, Sarang4
Pollett, Aaron5
Dennis, James W.6
Swallow, Carol J.7
-
185
-
-
79952263859
-
Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression
-
De Carcer, G.; Escobar, B.; Higuero, A. M.; Garcia, L.; Anson, A.; Perez, G.; Mollejo, M.; Manning, G.; Melendez, B.; Abad-Rodriguez, J.; Malumbres, M. Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression. Mol Cell Biol, 2011, 31, 1225-1239.
-
(2011)
Mol Cell Biol
, vol.31
, pp. 1225-1239
-
-
De Carcer, G.1
Escobar, B.2
Higuero, A. M.3
Garcia, L.4
Anson, A.5
Perez, G.6
Mollejo, M.7
Manning, G.8
Melendez, B.9
Abad-Rodriguez, J.10
Malumbres, M.11
-
186
-
-
0038739131
-
Never say never. The NIMA-related protein kinases in mitotic control
-
O'connell, Matthew J.; Krien, Michael J. E.; Hunter, Tony. Never say never. The NIMA-related protein kinases in mitotic control. Trends in Cell Biology, 2003, 13, 221-228.
-
(2003)
Trends in Cell Biology
, vol.13
, pp. 221-228
-
-
O'connell, Matthew J.1
Krien, Michael J. E.2
Hunter, Tony3
-
187
-
-
29244456404
-
Caught Nek-ing: cilia and centrioles
-
Quarmby, L. M.; Mahjoub, M. R. Caught Nek-ing: cilia and centrioles. J Cell Sci, 2005, 118, 5161-5169.
-
(2005)
J Cell Sci
, vol.118
, pp. 5161-5169
-
-
Quarmby, L. M.1
Mahjoub, M. R.2
-
188
-
-
33646839443
-
Nek2 kinase in chromosome instability and cancer
-
Hayward, Daniel G.; Fry, Andrew M. Nek2 kinase in chromosome instability and cancer. Cancer Letters, 2006, 237, 155-166.
-
(2006)
Cancer Letters
, vol.237
, pp. 155-166
-
-
Hayward, Daniel G.1
Fry, Andrew M.2
-
189
-
-
0037048312
-
The Nek2 protein kinase: a novel regulator of centrosome structure
-
Fry, A. M. The Nek2 protein kinase: a novel regulator of centrosome structure. Oncogene, 2002, 21, 6184-6194.
-
(2002)
Oncogene
, vol.21
, pp. 6184-6194
-
-
Fry, A. M.1
-
190
-
-
0036290778
-
Nek2 Localizes to Multiple Sites in Mitotic Cells, Suggesting Its Involvement in Multiple Cellular Functions during the Cell Cycle
-
Ha Kim, Yong; Yeol Choi, Jun; Jeong, Yeontae; Wolgemuth, Debra J.; Rhee, Kunsoo. Nek2 Localizes to Multiple Sites in Mitotic Cells, Suggesting Its Involvement in Multiple Cellular Functions during the Cell Cycle. Biochemical and Biophysical Research Communications, 2002, 290, 730-736.
-
(2002)
Biochemical and Biophysical Research Communications
, vol.290
, pp. 730-736
-
-
Ha Kim, Yong1
Choi, Jun2
Jeong, Yeontae3
Wolgemuth, Debra J.4
Rhee, Kunsoo5
-
191
-
-
2442504702
-
NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling
-
Lou, Yang; Yao, Jianhui; Zereshki, Arzhang; Dou, Zhen; Ahmed, Kashif; Wang, Hongmei; Hu, Junbin; Wang, Yuzhen; Yao, Xuebiao. NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling. The Journal Of Biological Chemistry, 2004, 279, 20049-20057.
-
(2004)
The Journal Of Biological Chemistry
, vol.279
, pp. 20049-20057
-
-
Lou, Yang1
Yao, Jianhui2
Zereshki, Arzhang3
Dou, Zhen4
Ahmed, Kashif5
Wang, Hongmei6
Hu, Junbin7
Wang, Yuzhen8
Yao, Xuebiao9
-
192
-
-
0347579850
-
Phosphorylation of the Mitotic Regulator Protein Hec1 by Nek2 Kinase Is Essential for Faithful Chromosome Segregation
-
Chen, Yumay; Riley, Daniel J.; Zheng, Lei; Chen, Phang-Lang; Lee, Wen-Hwa. Phosphorylation of the Mitotic Regulator Protein Hec1 by Nek2 Kinase Is Essential for Faithful Chromosome Segregation. J. Biol. Chem., 2002, 277, 49408-49416.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 49408-49416
-
-
Chen, Yumay1
Riley, Daniel J.2
Zheng, Lei3
Chen, Phang-Lang4
Lee, Wen-Hwa5
-
193
-
-
32344439117
-
Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients
-
Chen, Jian; Li, Li; Zhang, Yuanyuan; Yang, Huirong; Wei, Youheng; Zhang, Lin; Liu, Xianghua; Yu, Long. Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients. Biochemical and Biophysical Research Communications, 2006, 341, 1059-1065.
-
(2006)
Biochemical and Biophysical Research Communications
, vol.341
, pp. 1059-1065
-
-
Chen, Jian1
Li, Li2
Zhang, Yuanyuan3
Yang, Huirong4
Wei, Youheng5
Zhang, Lin6
Liu, Xianghua7
Yu, Long8
-
194
-
-
0036931712
-
A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish
-
Liu, Shanming; Lu, Weining; Obara, Tomoko; Kuida, Shiei; Lehoczky, Jennifer; Dewar, Ken; Drummond, Iain A.; Beier, David R. A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish. Development (Cambridge, England), 2002, 129, 5839-5846.
-
(2002)
Development (Cambridge, England)
, vol.129
, pp. 5839-5846
-
-
Liu, Shanming1
Lu, Weining2
Obara, Tomoko3
Kuida, Shiei4
Lehoczky, Jennifer5
Dewar, Ken6
Drummond, Iain A.7
Beier, David R.8
-
195
-
-
1542395668
-
Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors
-
Bowers, Alex J.; Boylan, John F. Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors. Gene, 2004, 328, 135-142.
-
(2004)
Gene
, vol.328
, pp. 135-142
-
-
Bowers, Alex J.1
Boylan, John F.2
-
196
-
-
78149250139
-
Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization
-
Whelligan, D. K.; Solanki, S.; Taylor, D.; Thomson, D. W.; Cheung, K. M.; Boxall, K.; Mas-Droux, C.; Barillari, C.; Burns, S.; Grummitt, C. G.; Collins, I.; Van Montfort, R. L.; Aherne, G. W.; Bayliss, R.; Hoelder, S. Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization. J Med Chem, 2010, 53, 7682-7698.
-
(2010)
J Med Chem
, vol.53
, pp. 7682-7698
-
-
Whelligan, D. K.1
Solanki, S.2
Taylor, D.3
Thomson, D. W.4
Cheung, K. M.5
Boxall, K.6
Mas-Droux, C.7
Barillari, C.8
Burns, S.9
Grummitt, C. G.10
Collins, I.11
Van Montfort, R. L.12
Aherne, G. W.13
Bayliss, R.14
Hoelder, S.15
-
197
-
-
0642306010
-
Targeting the kinetochore for mitosis-specific inhibitors
-
Jablonski, S. A.; Liu, S. T.; Yen, T. J. Targeting the kinetochore for mitosis-specific inhibitors. Cancer Biol Ther, 2003, 2, 236-241.
-
(2003)
Cancer Biol Ther
, vol.2
, pp. 236-241
-
-
Jablonski, S. A.1
Liu, S. T.2
Yen, T. J.3
-
198
-
-
0032546360
-
Mutations of mitotic checkpoint genes in human cancers
-
Cahill, Daniel P.; Lengauer, Christoph; Yu, Jian; Riggins, Gregory J.; Willson, James K. V.; Markowitz, Sanford D.; Kinzler, Kenneth W.; Vogelstein, Bert. Mutations of mitotic checkpoint genes in human cancers. Nature, 1998, 392, 300-303.
-
(1998)
Nature
, vol.392
, pp. 300-303
-
-
Cahill, Daniel P.1
Lengauer, Christoph2
Yu, Jian3
Riggins, Gregory J.4
Willson, James K. V.5
Markowitz, Sanford D.6
Kinzler, Kenneth W.7
Vogelstein, Bert8
-
199
-
-
0037063174
-
hBUB1 defects in leukemia and lymphoma cells
-
Ru, H. Y.; Chen, R. L.; Lu, W. C.; Chen, J. H. hBUB1 defects in leukemia and lymphoma cells. Oncogene, 2002, 21, 4673-4679.
-
(2002)
Oncogene
, vol.21
, pp. 4673-4679
-
-
Ru, H. Y.1
Chen, R. L.2
Lu, W. C.3
Chen, J. H.4
-
200
-
-
0033800018
-
Somatic mutation of the hBUB1 mitotic checkpoint gene in primary lung cancer
-
Akihiko Gemma, Masahiro Seike, Yoko Seike, Kazutsugu Uematsu, Suguru Hibino, Futosi Kurimoto, Akinobu Yoshimura, Masahiko Shibuya, Curtis C. Harris, Shoji Kudoh. Somatic mutation of the hBUB1 mitotic checkpoint gene in primary lung cancer. Genes, Chromosomes and Cancer, 2000, 29, 213-218.
-
(2000)
Genes, Chromosomes and Cancer
, vol.29
, pp. 213-218
-
-
Gemma, Akihiko1
Seike, Masahiro2
Seike, Yoko3
Uematsu, Kazutsugu4
Hibino, Suguru5
Kurimoto, Futosi6
Yoshimura, Akinobu7
Shibuya, Masahiko8
Harris, Curtis C.9
Kudoh, Shoji10
-
201
-
-
0037389466
-
A double missense variation of the BUB1 gene and a defective mitotic spindle checkpoint in the pancreatic cancer cell line Hs766T
-
Hempen, P. M.; Kurpad, H.; Calhoun, E. S.; Abraham, S.; Kern, S. E. A double missense variation of the BUB1 gene and a defective mitotic spindle checkpoint in the pancreatic cancer cell line Hs766T. Hum Mutat, 2003, 21, 445.
-
(2003)
Hum Mutat
, vol.21
, pp. 445
-
-
Hempen, P. M.1
Kurpad, H.2
Calhoun, E. S.3
Abraham, S.4
Kern, S. E.5
-
202
-
-
10644258336
-
Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B
-
Hanks, Sandra; Coleman, Kim; Reid, Sarah; Plaja, Alberto; Firth, Helen; Fitzpatrick, David; Kidd, Alexa; Mehes, Karoly; Nash, Richard; Robin, Nathanial; Shannon, Nora; Tolmie, John; Swansbury, John; Irrthum, Alexandre; Douglas, Jenny; Rahman, Nazneen. Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B. Nat Genet, 2004, 36, 1159-1161.
-
(2004)
Nat Genet
, vol.36
, pp. 1159-1161
-
-
Hanks, Sandra1
Coleman, Kim2
Reid, Sarah3
Plaja, Alberto4
Firth, Helen5
Fitzpatrick, David6
Kidd, Alexa7
Mehes, Karoly8
Nash, Richard9
Robin, Nathanial10
Shannon, Nora11
Tolmie, John12
Swansbury, John13
Irrthum, Alexandre14
Douglas, Jenny15
Rahman, Nazneen16
-
203
-
-
32444444090
-
Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome
-
Matsuura, S.; Matsumoto, Y.; Morishima, K.; Izumi, H.; Matsumoto, H.; Ito, E.; Tsutsui, K.; Kobayashi, J.; Tauchi, H.; Kajiwara, Y.; Hama, S.; Kurisu, K.; Tahara, H.; Oshimura, M.; Komatsu, K.; Ikeuchi, T.; Kajii, T. Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome. Am J Med Genet A, 2006, 140, 358-367.
-
(2006)
Am J Med Genet A
, vol.140
, pp. 358-367
-
-
Matsuura, S.1
Matsumoto, Y.2
Morishima, K.3
Izumi, H.4
Matsumoto, H.5
Ito, E.6
Tsutsui, K.7
Kobayashi, J.8
Tauchi, H.9
Kajiwara, Y.10
Hama, S.11
Kurisu, K.12
Tahara, H.13
Oshimura, M.14
Komatsu, K.15
Ikeuchi, T.16
Kajii, T.17
-
204
-
-
0034665634
-
Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis
-
Kalitsis, P.; Earle, E.; Fowler, K. J.; Choo, K. H. Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis. Genes Dev, 2000, 14, 2277-2282.
-
(2000)
Genes Dev
, vol.14
, pp. 2277-2282
-
-
Kalitsis, P.1
Earle, E.2
Fowler, K. J.3
Choo, K. H.4
-
205
-
-
3042761646
-
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
-
Baker, D. J.; Jeganathan, K. B.; Cameron, J. D.; Thompson, M.; Juneja, S.; Kopecka, A.; Kumar, R.; Jenkins, R. B.; De Groen, P. C.; Roche, P.; Van Deursen, J. M. BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat Genet, 2004, 36, 744-749.
-
(2004)
Nat Genet
, vol.36
, pp. 744-749
-
-
Baker, D. J.1
Jeganathan, K. B.2
Cameron, J. D.3
Thompson, M.4
Juneja, S.5
Kopecka, A.6
Kumar, R.7
Jenkins, R. B.8
De Groen, P. C.9
Roche, P.10
Van Deursen, J. M.11
-
206
-
-
23044434841
-
Increased chromosome instability but not cancer predisposition in haploinsufficient Bub3 mice
-
Kalitsis, P.; Fowler, K. J.; Griffiths, B.; Earle, E.; Chow, C. W.; Jamsen, K.; Choo, K. H. Increased chromosome instability but not cancer predisposition in haploinsufficient Bub3 mice. Genes Chromosomes Cancer, 2005, 44, 29-36.
-
(2005)
Genes Chromosomes Cancer
, vol.44
, pp. 29-36
-
-
Kalitsis, P.1
Fowler, K. J.2
Griffiths, B.3
Earle, E.4
Chow, C. W.5
Jamsen, K.6
Choo, K. H.7
-
207
-
-
32644435114
-
Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice
-
Baker, D. J.; Jeganathan, K. B.; Malureanu, L.; Perez-Terzic, C.; Terzic, A.; Van Deursen, J. M. Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice. J Cell Biol, 2006, 172, 529-540.
-
(2006)
J Cell Biol
, vol.172
, pp. 529-540
-
-
Baker, D. J.1
Jeganathan, K. B.2
Malureanu, L.3
Perez-Terzic, C.4
Terzic, A.5
Van Deursen, J. M.6
-
208
-
-
2942567685
-
Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint
-
Kops, G. J.; Foltz, D. R.; Cleveland, D. W. Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint. Proc Natl Acad Sci U S A, 2004, 101, 8699-8704.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 8699-8704
-
-
Kops, G. J.1
Foltz, D. R.2
Cleveland, D. W.3
-
209
-
-
4544254677
-
A field guide to the Mps1 family of protein kinases
-
Fisk, H. A.; Mattison, C. P.; Winey, M. A field guide to the Mps1 family of protein kinases. Cell Cycle, 2004, 3, 439-442.
-
(2004)
Cell Cycle
, vol.3
, pp. 439-442
-
-
Fisk, H. A.1
Mattison, C. P.2
Winey, M.3
-
210
-
-
0037007206
-
Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication
-
Stucke, V. M.; Sillje, H. H. W.; Arnaud, L.; Nigg, E. A. Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication. Embo Journal, 2002, 21, 1723-1732.
-
(2002)
Embo Journal
, vol.21
, pp. 1723-1732
-
-
Stucke, V. M.1
Sillje, H. H. W.2
Arnaud, L.3
Nigg, E. A.4
-
211
-
-
33746887033
-
Anaphase inactivation of the spindle checkpoint
-
Palframan, W. J.; Meehl, J. B.; Jaspersen, S. L.; Winey, M.; Murray, A. W. Anaphase inactivation of the spindle checkpoint. Science, 2006, 313, 680-684.
-
(2006)
Science
, vol.313
, pp. 680-684
-
-
Palframan, W. J.1
Meehl, J. B.2
Jaspersen, S. L.3
Winey, M.4
Murray, A. W.5
-
212
-
-
4544232810
-
Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1
-
Stucke, V. M.; Baumann, C.; Nigg, E. A. Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1. Chromosoma, 2004, 113, 1-15.
-
(2004)
Chromosoma
, vol.113
, pp. 1-15
-
-
Stucke, V. M.1
Baumann, C.2
Nigg, E. A.3
-
213
-
-
14844333117
-
TTK/hMps1 Participates in the Regulation of DNA Damage Checkpoint Response by Phosphorylating CHK2 on Threonine 68
-
Wei, Jen-Hsuan; Chou, Yi-Fan; Ou, Yi-Hung; Yeh, Yen-Hsiu; Tyan, Shiaw-Wei; Sun, Te-Ping; Shen, Chen-Yang; Shieh, Sheau-Yann. TTK/hMps1 Participates in the Regulation of DNA Damage Checkpoint Response by Phosphorylating CHK2 on Threonine 68. J. Biol. Chem., 2005, 280, 7748-7757.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 7748-7757
-
-
Wei, Jen-Hsuan1
Chou, Yi-Fan2
Ou, Yi-Hung3
Yeh, Yen-Hsiu4
Tyan, Shiaw-Wei5
Sun, Te-Ping6
Shen, Chen-Yang7
Shieh, Sheau-Yann8
-
214
-
-
3042702374
-
Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1
-
Poss, K. D.; Nechiporuk, A.; Stringer, K. F.; Lee, C.; Keating, M. T. Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1. Genes Dev, 2004, 18, 1527-1532.
-
(2004)
Genes Dev
, vol.18
, pp. 1527-1532
-
-
Poss, K. D.1
Nechiporuk, A.2
Stringer, K. F.3
Lee, C.4
Keating, M. T.5
-
215
-
-
20144381969
-
A Small-Molecule Inhibitor of Mps1 Blocks the Spindle-Checkpoint Response to a Lack of Tension on Mitotic Chromosomes
-
Dorer, Russell K.; Zhong, Sheng; Tallarico, John A.; Wong, Wing Hung; Mitchison, Timothy J.; Murray, Andrew W. A Small-Molecule Inhibitor of Mps1 Blocks the Spindle-Checkpoint Response to a Lack of Tension on Mitotic Chromosomes. Current Biology, 2005, 15, 1070-1076.
-
(2005)
Current Biology
, vol.15
, pp. 1070-1076
-
-
Dorer, Russell K.1
Zhong, Sheng2
Tallarico, John A.3
Wong, Wing Hung4
Mitchison, Timothy J.5
Murray, Andrew W.6
-
216
-
-
30944452440
-
Ablation of the spindle assembly checkpoint by a compound targeting Mps1
-
Schmidt, M.; Budirahardja, Y.; Klompmaker, R.; Medema, R. H. Ablation of the spindle assembly checkpoint by a compound targeting Mps1. EMBO Rep, 2005, 6, 866-872.
-
(2005)
EMBO Rep
, vol.6
, pp. 866-872
-
-
Schmidt, M.1
Budirahardja, Y.2
Klompmaker, R.3
Medema, R. H.4
-
217
-
-
77951299152
-
Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function
-
Kwiatkowski, N.; Jelluma, N.; Filippakopoulos, P.; Soundararajan, M.; Manak, M. S.; Kwon, M.; Choi, H. G.; Sim, T.; Deveraux, Q. L.; Rottmann, S.; Pellman, D.; Shah, J. V.; Kops, G. J.; Knapp, S.; Gray, N. S. Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat Chem Biol, 2010, 6, 359-368.
-
(2010)
Nat Chem Biol
, vol.6
, pp. 359-368
-
-
Kwiatkowski, N.1
Jelluma, N.2
Filippakopoulos, P.3
Soundararajan, M.4
Manak, M. S.5
Kwon, M.6
Choi, H. G.7
Sim, T.8
Deveraux, Q. L.9
Rottmann, S.10
Pellman, D.11
Shah, J. V.12
Kops, G. J.13
Knapp, S.14
Gray, N. S.15
-
218
-
-
77954698217
-
Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine
-
Santaguida, S.; Tighe, A.; D'alise, A. M.; Taylor, S. S.; Musacchio, A. Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine. J Cell Biol, 2010, 190, 73-87.
-
(2010)
J Cell Biol
, vol.190
, pp. 73-87
-
-
Santaguida, S.1
Tighe, A.2
D'alise, A. M.3
Taylor, S. S.4
Musacchio, A.5
-
219
-
-
78650322902
-
Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase
-
Colombo, R.; Caldarelli, M.; Mennecozzi, M.; Giorgini, M. L.; Sola, F.; Cappella, P.; Perrera, C.; Depaolini, S. R.; Rusconi, L.; Cucchi, U.; Avanzi, N.; Bertrand, J. A.; Bossi, R. T.; Pesenti, E.; Galvani, A.; Isacchi, A.; Colotta, F.; Donati, D.; Moll, J. Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase. Cancer Res, 2010, 70, 10255-10264.
-
(2010)
Cancer Res
, vol.70
, pp. 10255-10264
-
-
Colombo, R.1
Caldarelli, M.2
Mennecozzi, M.3
Giorgini, M. L.4
Sola, F.5
Cappella, P.6
Perrera, C.7
Depaolini, S. R.8
Rusconi, L.9
Cucchi, U.10
Avanzi, N.11
Bertrand, J. A.12
Bossi, R. T.13
Pesenti, E.14
Galvani, A.15
Isacchi, A.16
Colotta, F.17
Donati, D.18
Moll, J.19
-
220
-
-
33644830944
-
Targeting the cell cycle: a new approach to cancer therapy
-
Schwartz, G. K.; Shah, M. A. Targeting the cell cycle: a new approach to cancer therapy. J Clin Oncol, 2005, 23, 9408-9421.
-
(2005)
J Clin Oncol
, vol.23
, pp. 9408-9421
-
-
Schwartz, G. K.1
Shah, M. A.2
-
221
-
-
13844252061
-
The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment
-
Dai, Jun; Sultan, Sammy; Taylor, Stephen S.; Higgins, Jonathan M. G. The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. Genes Dev., 2005, 19, 472-488.
-
(2005)
Genes Dev
, vol.19
, pp. 472-488
-
-
Dai, Jun1
Sultan, Sammy2
Taylor, Stephen S.3
Higgins, Jonathan M. G.4
-
222
-
-
0038381428
-
Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue
-
Walter, S. A.; Cutler, R. E., Jr.; Martinez, R.; Gishizky, M.; Hill, R. J. Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue. J Biol Chem, 2003, 278, 18221-18228.
-
(2003)
J Biol Chem
, vol.278
, pp. 18221-18228
-
-
Walter, S. A.1
Cutler, R. E.2
Martinez, R.3
Gishizky, M.4
Hill, R. J.5
-
223
-
-
0033948542
-
Ste20-like kinase (SLK), a regulatory kinase for polo-like kinase (Plk) during the G2/M transition in somatic cells
-
Ellinger-Ziegelbauer, H.; Karasuyama, H.; Yamada, E.; Tsujikawa, K.; Todokoro, K.; Nishida, E. Ste20-like kinase (SLK), a regulatory kinase for polo-like kinase (Plk) during the G2/M transition in somatic cells. Genes Cells, 2000, 5, 491-498.
-
(2000)
Genes Cells
, vol.5
, pp. 491-498
-
-
Ellinger-Ziegelbauer, H.1
Karasuyama, H.2
Yamada, E.3
Tsujikawa, K.4
Todokoro, K.5
Nishida, E.6
-
224
-
-
10944228764
-
Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF
-
Du, J.; Widlund, H. R.; Horstmann, M. A.; Ramaswamy, S.; Ross, K.; Huber, W. E.; Nishimura, E. K.; Golub, T. R.; Fisher, D. E. Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF. Cancer Cell, 2004, 6, 565-576.
-
(2004)
Cancer Cell
, vol.6
, pp. 565-576
-
-
Du, J.1
Widlund, H. R.2
Horstmann, M. A.3
Ramaswamy, S.4
Ross, K.5
Huber, W. E.6
Nishimura, E. K.7
Golub, T. R.8
Fisher, D. E.9
-
225
-
-
1642377561
-
ONCOMINE: a cancer microarray database and integrated data-mining platform
-
Rhodes, D. R.; Yu, J.; Shanker, K.; Deshpande, N.; Varambally, R.; Ghosh, D.; Barrette, T.; Pandey, A.; Chinnaiyan, A. M. ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia, 2004, 6, 1-6.
-
(2004)
Neoplasia
, vol.6
, pp. 1-6
-
-
Rhodes, D. R.1
Yu, J.2
Shanker, K.3
Deshpande, N.4
Varambally, R.5
Ghosh, D.6
Barrette, T.7
Pandey, A.8
Chinnaiyan, A. M.9
-
226
-
-
0028978274
-
A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma
-
Wolfel, T.; Hauer, M.; Schneider, J.; Serrano, M.; Wolfel, C.; Klehmann-Hieb, E.; De Plaen, E.; Hankeln, T.; Meyer Zum Buschenfelde, K. H.; Beach, D. A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science, 1995, 269, 1281-1284.
-
(1995)
Science
, vol.269
, pp. 1281-1284
-
-
Wolfel, T.1
Hauer, M.2
Schneider, J.3
Serrano, M.4
Wolfel, C.5
Klehmann-Hieb, E.6
De Plaen, E.7
Hankeln, T.8
Meyer Zum Buschenfelde, K. H.9
Beach, D.10
-
227
-
-
0029664339
-
Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma
-
Zuo, L.; Weger, J.; Yang, Q.; Goldstein, A. M.; Tucker, M. A.; Walker, G. J.; Hayward, N.; Dracopoli, N. C. Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma. Nature Genetics, 1996, 12, 97-99.
-
(1996)
Nature Genetics
, vol.12
, pp. 97-99
-
-
Zuo, L.1
Weger, J.2
Yang, Q.3
Goldstein, A. M.4
Tucker, M. A.5
Walker, G. J.6
Hayward, N.7
Dracopoli, N. C.8
-
228
-
-
33745676300
-
Toward Understanding the Structural Basis of Cyclin-Dependent Kinase 6 Specific Inhibition
-
Lu, H.; Schulze-Gahmen, U. Toward Understanding the Structural Basis of Cyclin-Dependent Kinase 6 Specific Inhibition. J. Med. Chem., 2006, 49, 3826-3831.
-
(2006)
J. Med. Chem
, vol.49
, pp. 3826-3831
-
-
Lu, H.1
Schulze-Gahmen, U.2
-
229
-
-
4344716728
-
Cell cycle checkpoint control mechanisms that can be disrupted in cancer
-
Dash, B. C.; El-Deiry, W. S. Cell cycle checkpoint control mechanisms that can be disrupted in cancer. Methods Mol Biol, 2004, 280, 99-161.
-
(2004)
Methods Mol Biol
, vol.280
, pp. 99-161
-
-
Dash, B. C.1
El-Deiry, W. S.2
-
230
-
-
33746943715
-
Characterization of CHEK2 mutations in prostate cancer
-
Xianglin Wu, Xiangyang Dong Wanguo Liu Junjie Chen. Characterization of CHEK2 mutations in prostate cancer. Human Mutation, 2006, 27, 742-747.
-
(2006)
Human Mutation
, vol.27
, pp. 742-747
-
-
Wu, Xianglin1
Dong, Xiangyang2
Liu, Wanguo3
Chen, Junjie4
-
231
-
-
18544389716
-
Low-penetrance susceptibility to breast cancer due to CHEK2*1100delC in noncarriers of BRCA1 or BRCA2 mutations
-
Meijers-Heijboer H, Van Den Ouweland a, Klijn J, Wasielewski M, De Snoo a, Oldenburg R, Hollestelle a, Houben M, Crepin E, Van Veghel-Plandsoen M, Elstrodt F, Van Duijn C, Bartels C, Meijers C, Schutte M, Mcguffog L, Thompson D, Easton D, Sodha N, Seal S, Barfoot R, Mangion J, Chang-Claude J, Eccles D, Eeles R, Evans Dg, Houlston R, Murday V, Narod S, Peretz T, Peto J, Phelan C, Zhang Hx, Szabo C, Devilee P, Goldgar D, Futreal Pa, Nathanson Kl, Weber B, Rahman N, Stratton Mr,. Low-penetrance susceptibility to breast cancer due to CHEK2*1100delC in noncarriers of BRCA1 or BRCA2 mutations. Nat Genet, 2002, 31, 55-59.
-
(2002)
Nat Genet
, vol.31
, pp. 55-59
-
-
Meijers-Heijboer, H1
Van Den Ouweland, a2
Klijn, J3
Wasielewski, M4
De Snoo, a5
Oldenburg, R6
Hollestelle, a7
Houben, M8
Crepin, E9
Van Veghel-Plandsoen, M10
Elstrodt, F11
Van Duijn, C12
Bartels, C13
Meijers, C14
Schutte, M15
Mcguffog, L16
Thompson, D17
Easton, D18
Sodha, N19
Seal, S20
Barfoot, R21
Mangion, J22
Chang-Claude, J23
Eccles, D24
Eeles, R25
Dg, Evans26
Houlston, R27
Murday, V28
Narod, S29
Peretz, T30
Peto, J31
Phelan, C32
Hx, Zhang33
Szabo, C34
Devilee, P35
Goldgar, D36
Pa, Futreal37
Kl, Nathanson38
Weber, B39
Rahman, N40
Mr, Stratton41
more..
-
232
-
-
8844283535
-
A Novel Founder CHEK2 Mutation is Associated with Increased Prostate Cancer Risk
-
Cybulski, Cezary; Huzarski, Tomasz; Gorski, Bohdan; Masojc, Bartlomiej; Mierzejewski, Marek; Debniak, Tadeusz; Gliniewicz, Bartlomiej; Matyjasik, Joanna; Zlowocka, Elzbieta; Kurzawski, Grzegorz; Sikorski, Andrzej; Posmyk, Michal; Szwiec, Marek; Czajka, Ryszard; Narod, Steven A.; Lubinski, Jan. A Novel Founder CHEK2 Mutation is Associated with Increased Prostate Cancer Risk. Cancer Res, 2004, 64, 2677-2679.
-
(2004)
Cancer Res
, vol.64
, pp. 2677-2679
-
-
Cybulski, Cezary1
Huzarski, Tomasz2
Gorski, Bohdan3
Masojc, Bartlomiej4
Mierzejewski, Marek5
Debniak, Tadeusz6
Gliniewicz, Bartlomiej7
Matyjasik, Joanna8
Zlowocka, Elzbieta9
Kurzawski, Grzegorz10
Sikorski, Andrzej11
Posmyk, Michal12
Szwiec, Marek13
Czajka, Ryszard14
Narod, Steven A.15
Lubinski, Jan16
-
233
-
-
0033778278
-
Mutations in the Plk gene lead to instability of Plk protein in human tumour cell lines
-
Simizu, Siro; Osada, Hiroyuki. Mutations in the Plk gene lead to instability of Plk protein in human tumour cell lines. Nat Cell Biol, 2000, 2, 852-854.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 852-854
-
-
Simizu, Siro1
Osada, Hiroyuki2
-
234
-
-
32444444090
-
Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome
-
Shinya Matsuura, Yoshiyuki Matsumoto, Ken-Ichi Morishima, Hideki Izumi, Hiroshi Matsumoto, Emi Ito, Keisuke Tsutsui, Junya Kobayashi, Hiroshi Tauchi, Yoshinori Kajiwara, Seiji Hama, Kaoru Kurisu, Hidetoshi Tahara, Mitsuo Oshimura, Kenshi Komatsu, Tatsuro Ikeuchi, Tadashi Kajii. Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome. American Journal of Medical Genetics Part A, 2006, 140A, 358-367.
-
(2006)
American Journal of Medical Genetics Part A
, vol.140A
, pp. 358-367
-
-
Matsuura, Shinya1
Matsumoto, Yoshiyuki2
Morishima, Ken-Ichi3
Izumi, Hideki4
Matsumoto, Hiroshi5
Ito, Emi6
Tsutsui, Keisuke7
Kobayashi, Junya8
Tauchi, Hiroshi9
Kajiwara, Yoshinori10
Hama, Seiji11
Kurisu, Kaoru12
Tahara, Hidetoshi13
Oshimura, Mitsuo14
Komatsu, Kenshi15
Ikeuchi, Tatsuro16
Kajii, Tadashi17
-
235
-
-
0034843846
-
Mechanisms of action of the novel sulfonamide anticancer agent E7070 on cell cycle progression in human non-small cell lung cancer cells
-
Fukuoka, K.; Usuda, J.; Iwamoto, Y.; Fukumoto, H.; Nakamura, T.; Yoneda, T.; Narita, N.; Saijo, N.; Nishio, K. Mechanisms of action of the novel sulfonamide anticancer agent E7070 on cell cycle progression in human non-small cell lung cancer cells. Invest New Drugs, 2001, 19, 219-227.
-
(2001)
Invest New Drugs
, vol.19
, pp. 219-227
-
-
Fukuoka, K.1
Usuda, J.2
Iwamoto, Y.3
Fukumoto, H.4
Nakamura, T.5
Yoneda, T.6
Narita, N.7
Saijo, N.8
Nishio, K.9
-
236
-
-
20944448138
-
3-Aminopyrazole Inhibitors of CDK2/Cyclin A as Antitumor Agents. 2. Lead Optimization
-
Pevarello, P.; Brasca, M. G.; Orsini, P.; Traquandi, G.; Longo, A.; Nesi, M.; Orzi, F.; Piutti, C.; Sansonna, P.; Varasi, M.; Cameron, A.; Vulpetti, A.; Roletto, F.; Alzani, R.; Ciomei, M.; Albanese, C.; Pastori, W.; Marsiglio, A.; Pesenti, E.; Fiorentini, F.; Bischoff, J. R.; Mercurio, C. 3-Aminopyrazole Inhibitors of CDK2/Cyclin A as Antitumor Agents. 2. Lead Optimization. J. Med. Chem., 2005, 48, 2944-2956.
-
(2005)
J. Med. Chem
, vol.48
, pp. 2944-2956
-
-
Pevarello, P.1
Brasca, M. G.2
Orsini, P.3
Traquandi, G.4
Longo, A.5
Nesi, M.6
Orzi, F.7
Piutti, C.8
Sansonna, P.9
Varasi, M.10
Cameron, A.11
Vulpetti, A.12
Roletto, F.13
Alzani, R.14
Ciomei, M.15
Albanese, C.16
Pastori, W.17
Marsiglio, A.18
Pesenti, E.19
Fiorentini, F.20
Bischoff, J. R.21
Mercurio, C.22
more..
-
237
-
-
0034010742
-
Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent
-
Meijer, L.; Thunnissen, A. M.; White, A. W.; Garnier, M.; Nikolic, M.; Tsai, L. H.; Walter, J.; Cleverley, K. E.; Salinas, P. C.; Wu, Y. Z.; Biernat, J.; Mandelkow, E. M.; Kim, S. H.; Pettit, G. R. Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent. Chem Biol, 2000, 7, 51-63.
-
(2000)
Chem Biol
, vol.7
, pp. 51-63
-
-
Meijer, L.1
Thunnissen, A. M.2
White, A. W.3
Garnier, M.4
Nikolic, M.5
Tsai, L. H.6
Walter, J.7
Cleverley, K. E.8
Salinas, P. C.9
Wu, Y. Z.10
Biernat, J.11
Mandelkow, E. M.12
Kim, S. H.13
Pettit, G. R.14
-
238
-
-
0034721195
-
Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles
-
Arris, C. E.; Boyle, F. T.; Calvert, A. H.; Curtin, N. J.; Endicott, J. A.; Garman, E. F.; Gibson, A. E.; Golding, B. T.; Grant, S.; Griffin, R. J.; Jewsbury, P.; Johnson, L. N.; Lawrie, A. M.; Newell, D. R.; Noble, M. E. M.; Sausville, E. A.; Schultz, R.; Yu, W. Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles. J. Med. Chem., 2000, 43, 2797-2804.
-
(2000)
J. Med. Chem
, vol.43
, pp. 2797-2804
-
-
Arris, C. E.1
Boyle, F. T.2
Calvert, A. H.3
Curtin, N. J.4
Endicott, J. A.5
Garman, E. F.6
Gibson, A. E.7
Golding, B. T.8
Grant, S.9
Griffin, R. J.10
Jewsbury, P.11
Johnson, L. N.12
Lawrie, A. M.13
Newell, D. R.14
Noble, M. E. M.15
Sausville, E. A.16
Schultz, R.17
Yu, W.18
-
239
-
-
18744404784
-
4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2
-
Mesguiche, Veronique; Parsons, Rachel J.; Arris, Christine E.; Bentley, Johanne; Boyle, F. Thomas; Curtin, Nicola J.; Davies, Thomas G.; Endicott, Jane A.; Gibson, Ashleigh E.; Golding, Bernard T. 4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2. Bioorganic & Medicinal Chemistry Letters, 2003, 13, 217-222.
-
(2003)
Bioorganic & Medicinal Chemistry Letters
, vol.13
, pp. 217-222
-
-
Mesguiche, Veronique1
Parsons, Rachel J.2
Arris, Christine E.3
Bentley, Johanne4
Boyle, F. Thomas5
Curtin, Nicola J.6
Davies, Thomas G.7
Endicott, Jane A.8
Gibson, Ashleigh E.9
Golding, Bernard T.10
-
240
-
-
33645471100
-
The cellular phenotype of AZ703, a novel selective imidazo[1,2-a]pyridine cyclin-dependent kinase inhibitor
-
Byth, Kate F.; Geh, Catherine; Forder, Cheryl L.; Oakes, Sandra E.; Thomas, Andrew P. The cellular phenotype of AZ703, a novel selective imidazo[1,2-a]pyridine cyclin-dependent kinase inhibitor. Mol Cancer Ther, 2006, 5, 655-664.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 655-664
-
-
Byth, Kate F.1
Geh, Catherine2
Forder, Cheryl L.3
Oakes, Sandra E.4
Thomas, Andrew P.5
-
241
-
-
31544459273
-
AZ703, an Imidazo[1,2-a]Pyridine Inhibitor of Cyclin-Dependent Kinases 1 and 2, Induces E2F-1-Dependent Apoptosis Enhanced by Depletion of Cyclin-Dependent Kinase 9
-
Cai, Dongpo; Byth, Kate F.; Shapiro, Geoffrey I. AZ703, an Imidazo[1,2-a]Pyridine Inhibitor of Cyclin-Dependent Kinases 1 and 2, Induces E2F-1-Dependent Apoptosis Enhanced by Depletion of Cyclin-Dependent Kinase 9. Cancer Res, 2006, 66, 435-444.
-
(2006)
Cancer Res
, vol.66
, pp. 435-444
-
-
Cai, Dongpo1
Byth, Kate F.2
Shapiro, Geoffrey I.3
-
242
-
-
0037665145
-
Roscovitine and Other Purines as Kinase Inhibitors. From Starfish Oocytes to Clinical Trials
-
Meijer, L.; Raymond, E. Roscovitine and Other Purines as Kinase Inhibitors. From Starfish Oocytes to Clinical Trials. Acc. Chem. Res., 2003, 36, 417-425.
-
(2003)
Acc. Chem. Res
, vol.36
, pp. 417-425
-
-
Meijer, L.1
Raymond, E.2
-
243
-
-
33644676352
-
Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation
-
Pennati, Marzia; Campbell, Allyson J.; Curto, Maria; Binda, Mara; Cheng, Yuzhu; Wang, Lan-Zeng; Curtin, Nicola; Golding, Bernard T.; Griffin, Roger J.; Hardcastle, Ian R.; Henderson, Andrew; Zaffaroni, Nadia; Newell, David R. Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol Cancer Ther, 2005, 4, 1328-1337.
-
(2005)
Mol Cancer Ther
, vol.4
, pp. 1328-1337
-
-
Pennati, Marzia1
Campbell, Allyson J.2
Curto, Maria3
Binda, Mara4
Cheng, Yuzhu5
Wang, Lan-Zeng6
Curtin, Nicola7
Golding, Bernard T.8
Griffin, Roger J.9
Hardcastle, Ian R.10
Henderson, Andrew11
Zaffaroni, Nadia12
Newell, David R.13
-
244
-
-
15444355744
-
CVT-313, a Specific and Potent Inhibitor of CDK2 That Prevents Neointimal Proliferation
-
Brooks, Eric E.; Gray, Nathanael S.; Joly, Alison; Kerwar, Suresh S.; Lum, Robert; Mackman, Richard L.; Norman, Thea C.; Rosete, Jose; Rowe, Michael; Schow, Steven R.; Schultz, Peter G.; Wang, Xingbo; Wick, Michael M.; Shiffman, Dov. CVT-313, a Specific and Potent Inhibitor of CDK2 That Prevents Neointimal Proliferation. J. Biol. Chem., 1997, 272, 29207-29211.
-
(1997)
J. Biol. Chem
, vol.272
, pp. 29207-29211
-
-
Brooks, Eric E.1
Gray, Nathanael S.2
Joly, Alison3
Kerwar, Suresh S.4
Lum, Robert5
Mackman, Richard L.6
Norman, Thea C.7
Rosete, Jose8
Rowe, Michael9
Schow, Steven R.10
Schultz, Peter G.11
Wang, Xingbo12
Wick, Michael M.13
Shiffman, Dov14
-
245
-
-
0035881591
-
A Novel cdk2-selective Inhibitor, SU9516, Induces Apoptosis in Colon Carcinoma Cells
-
Lane, Maureen E.; Yu, Bo; Rice, Audie; Lipson, Kenneth E.; Liang, Chris; Sun, Li; Tang, Cho; Mcmahon, Gerald; Pestell, Richard G.; Wadler, Scott. A Novel cdk2-selective Inhibitor, SU9516, Induces Apoptosis in Colon Carcinoma Cells. Cancer Res, 2001, 61, 6170-6177.
-
(2001)
Cancer Res
, vol.61
, pp. 6170-6177
-
-
Lane, Maureen E.1
Yu, Bo2
Rice, Audie3
Lipson, Kenneth E.4
Liang, Chris5
Sun, Li6
Tang, Cho7
Mcmahon, Gerald8
Pestell, Richard G.9
Wadler, Scott10
-
246
-
-
0344809977
-
ATP-site directed inhibitors of cyclin-dependent kinases
-
Gray, N.; Detivaud, L.; Doerig, C.; Meijer, L. ATP-site directed inhibitors of cyclin-dependent kinases. Curr Med Chem, 1999, 6, 859-875.
-
(1999)
Curr Med Chem
, vol.6
, pp. 859-875
-
-
Gray, N.1
Detivaud, L.2
Doerig, C.3
Meijer, L.4
-
247
-
-
26844501695
-
Anticancer therapeutics: "Addictive" targets, multi-targeted drugs, new drug combinations
-
Broxterman, Henk J.; Georgopapadakou, Nafsika H. Anticancer therapeutics: "Addictive" targets, multi-targeted drugs, new drug combinations. Drug Resistance Updates, 2005, 8, 183-197.
-
(2005)
Drug Resistance Updates
, vol.8
, pp. 183-197
-
-
Broxterman, Henk J.1
Georgopapadakou, Nafsika H.2
-
248
-
-
0034618674
-
Inhibition of Cyclin-Dependent Kinase 4 (Cdk4) by Fascaplysin, a Marine Natural Product
-
Soni, Rajeev; Muller, Lionel; Furet, Pascal; Schoepfer, Joseph; Stephan, Christine; Zumstein-Mecker, Sabine; Fretz, Heinz; Chaudhuri, Bhabatosh. Inhibition of Cyclin-Dependent Kinase 4 (Cdk4) by Fascaplysin, a Marine Natural Product. Biochemical and Biophysical Research Communications, 2000, 275, 877-884.
-
(2000)
Biochemical and Biophysical Research Communications
, vol.275
, pp. 877-884
-
-
Soni, Rajeev1
Muller, Lionel2
Furet, Pascal3
Schoepfer, Joseph4
Stephan, Christine5
Zumstein-Mecker, Sabine6
Fretz, Heinz7
Chaudhuri, Bhabatosh8
-
249
-
-
33745727153
-
CA224, a non-planar analogue of fascaplysin, inhibits Cdk4 but not Cdk2 and arrests cells at G0/G1 inhibiting pRB phosphorylation
-
Mahale, Sachin; Aubry, Carine; James Wilson, A.; Jenkins, Paul R.; Marechal, Jean-Didier; Sutcliffe, Michael J.; Chaudhuri, Bhabatosh. CA224, a non-planar analogue of fascaplysin, inhibits Cdk4 but not Cdk2 and arrests cells at G0/G1 inhibiting pRB phosphorylation. Bioorganic & Medicinal Chemistry Letters, 2006, 16, 4272-4278.
-
(2006)
Bioorganic & Medicinal Chemistry Letters
, vol.16
, pp. 4272-4278
-
-
Mahale, Sachin1
Aubry, Carine2
James Wilson, A.3
Jenkins, Paul R.4
Marechal, Jean-Didier5
Sutcliffe, Michael J.6
Chaudhuri, Bhabatosh7
-
250
-
-
0029895439
-
UCN-01: a Potent Abrogator of G2 Checkpoint Function in Cancer Cells With Disrupted p53
-
Wang, Qizhi; Fan, Saijun; Eastman, Alan; Worland, Peter J.; Sausville, Edward A.; O'connor, Patrick M. UCN-01: a Potent Abrogator of G2 Checkpoint Function in Cancer Cells With Disrupted p53. J Natl Cancer Inst, 1996, 88, 956-965.
-
(1996)
J Natl Cancer Inst
, vol.88
, pp. 956-965
-
-
Wang, Qizhi1
Fan, Saijun2
Eastman, Alan3
Worland, Peter J.4
Sausville, Edward A.5
O'connor, Patrick M.6
-
251
-
-
52949145309
-
Keeping checkpoint kinases in line: new selective inhibitors in clinical trials
-
Ashwell, S.; Janetka, J. W.; Zabludoff, S. Keeping checkpoint kinases in line: new selective inhibitors in clinical trials. Expert Opin Investig Drugs, 2008, 17, 1331-1340.
-
(2008)
Expert Opin Investig Drugs
, vol.17
, pp. 1331-1340
-
-
Ashwell, S.1
Janetka, J. W.2
Zabludoff, S.3
-
252
-
-
79955623625
-
A novel Chk inhibitor, XL-844, increases human cancer cell radiosensitivity through promotion of mitotic catastrophe
-
Riesterer, O.; Matsumoto, F.; Wang, L.; Pickett, J.; Molkentine, D.; Giri, U.; Milas, L.; Raju, U. A novel Chk inhibitor, XL-844, increases human cancer cell radiosensitivity through promotion of mitotic catastrophe. Invest New Drugs, 29, 514-522.
-
Invest New Drugs
, vol.29
, pp. 514-522
-
-
Riesterer, O.1
Matsumoto, F.2
Wang, L.3
Pickett, J.4
Molkentine, D.5
Giri, U.6
Milas, L.7
Raju, U.8
-
253
-
-
33846856967
-
CHIR-124, a novel potent inhibitor of Chk1, potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo
-
Tse, A. N.; Rendahl, K. G.; Sheikh, T.; Cheema, H.; Aardalen, K.; Embry, M.; Ma, S.; Moler, E. J.; Ni, Z. J.; Lopes De Menezes, D. E.; Hibner, B.; Gesner, T. G.; Schwartz, G. K. CHIR-124, a novel potent inhibitor of Chk1, potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo. Clin Cancer Res, 2007, 13, 591-602.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 591-602
-
-
Tse, A. N.1
Rendahl, K. G.2
Sheikh, T.3
Cheema, H.4
Aardalen, K.5
Embry, M.6
Ma, S.7
Moler, E. J.8
Ni, Z. J.9
Lopes De Menezes, D. E.10
Hibner, B.11
Gesner, T. G.12
Schwartz, G. K.13
-
254
-
-
68049085247
-
A Phase I and pharmacokinetic study of HMN-214, a novel oral polo-like kinase inhibitor, in patients with advanced solid tumors
-
Von Hoff, D. D.; Taylor, C.; Rubin, S.; Cohen, J.; Garland, L. A Phase I and pharmacokinetic study of HMN-214, a novel oral polo-like kinase inhibitor, in patients with advanced solid tumors. J Clin Oncol (Meeting Abstracts), 2004, 22, 3034-.
-
(2004)
J Clin Oncol (Meeting Abstracts)
, vol.22
, pp. 3034
-
-
Von Hoff, D. D.1
Taylor, C.2
Rubin, S.3
Cohen, J.4
Garland, L.5
-
255
-
-
33750227695
-
Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance
-
Mcinnes, C.; Mazumdar, A.; Mezna, M.; Meades, C.; Midgley, C.; Scaerou, F.; Carpenter, L.; Mackenzie, M.; Taylor, P.; Walkinshaw, M.; Fischer, P. M.; Glover, D. Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance. Nat Chem Biol, 2006, 2, 608-617.
-
(2006)
Nat Chem Biol
, vol.2
, pp. 608-617
-
-
Mcinnes, C.1
Mazumdar, A.2
Mezna, M.3
Meades, C.4
Midgley, C.5
Scaerou, F.6
Carpenter, L.7
Mackenzie, M.8
Taylor, P.9
Walkinshaw, M.10
Fischer, P. M.11
Glover, D.12
-
256
-
-
79955560817
-
NMS-P937, a 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivative as potent and selective Polo-like kinase 1 inhibitor
-
Beria, I.; Bossi, R. T.; Brasca, M. G.; Caruso, M.; Ceccarelli, W.; Fachin, G.; Fasolini, M.; Forte, B.; Fiorentini, F.; Pesenti, E.; Pezzetta, D.; Posteri, H.; Scolaro, A.; Re Depaolini, S.; Valsasina, B. NMS-P937, a 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivative as potent and selective Polo-like kinase 1 inhibitor. Bioorg Med Chem Lett, 2011, 21, 2969-2974.
-
(2011)
Bioorg Med Chem Lett
, vol.21
, pp. 2969-2974
-
-
Beria, I.1
Bossi, R. T.2
Brasca, M. G.3
Caruso, M.4
Ceccarelli, W.5
Fachin, G.6
Fasolini, M.7
Forte, B.8
Fiorentini, F.9
Pesenti, E.10
Pezzetta, D.11
Posteri, H.12
Scolaro, A.13
Re Depaolini, S.14
Valsasina, B.15
-
257
-
-
33847403132
-
In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1
-
Lansing, T. J.; Mcconnell, R. T.; Duckett, D. R.; Spehar, G. M.; Knick, V. B.; Hassler, D. F.; Noro, N.; Furuta, M.; Emmitte, K. A.; Gilmer, T. M.; Mook, R. A., Jr.; Cheung, M. In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1. Mol Cancer Ther, 2007, 6, 450-459.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 450-459
-
-
Lansing, T. J.1
Mcconnell, R. T.2
Duckett, D. R.3
Spehar, G. M.4
Knick, V. B.5
Hassler, D. F.6
Noro, N.7
Furuta, M.8
Emmitte, K. A.9
Gilmer, T. M.10
Mook, R. A.11
Cheung, M.12
-
258
-
-
79954498856
-
Polo-like kinase 1 (Plk1) is expressed by cutaneous T-cell lymphomas (CTCLs), and its downregulation promotes cell cycle arrest and apoptosis
-
Nihal, M.; Stutz, N.; Schmit, T.; Ahmad, N.; Wood, G. S. Polo-like kinase 1 (Plk1) is expressed by cutaneous T-cell lymphomas (CTCLs), and its downregulation promotes cell cycle arrest and apoptosis. Cell Cycle, 2011, 10, 1303-1311.
-
(2011)
Cell Cycle
, vol.10
, pp. 1303-1311
-
-
Nihal, M.1
Stutz, N.2
Schmit, T.3
Ahmad, N.4
Wood, G. S.5
-
259
-
-
67651094078
-
Imidazopyridine derivatives as potent and selective Polo-like kinase (PLK) inhibitors
-
Sato, Y.; Onozaki, Y.; Sugimoto, T.; Kurihara, H.; Kamijo, K.; Kadowaki, C.; Tsujino, T.; Watanabe, A.; Otsuki, S.; Mitsuya, M.; Iida, M.; Haze, K.; Machida, T.; Nakatsuru, Y.; Komatani, H.; Kotani, H.; Iwasawa, Y. Imidazopyridine derivatives as potent and selective Polo-like kinase (PLK) inhibitors. Bioorg Med Chem Lett, 2009, 19, 4673-4678.
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 4673-4678
-
-
Sato, Y.1
Onozaki, Y.2
Sugimoto, T.3
Kurihara, H.4
Kamijo, K.5
Kadowaki, C.6
Tsujino, T.7
Watanabe, A.8
Otsuki, S.9
Mitsuya, M.10
Iida, M.11
Haze, K.12
Machida, T.13
Nakatsuru, Y.14
Komatani, H.15
Kotani, H.16
Iwasawa, Y.17
-
260
-
-
70149099357
-
Distinct concentration-dependent effects of the polo-like kinase 1-specific inhibitor GSK461364A, including differential effect on apoptosis
-
Gilmartin, A. G.; Bleam, M. R.; Richter, M. C.; Erskine, S. G.; Kruger, R. G.; Madden, L.; Hassler, D. F.; Smith, G. K.; Gontarek, R. R.; Courtney, M. P.; Sutton, D.; Diamond, M. A.; Jackson, J. R.; Laquerre, S. G. Distinct concentration-dependent effects of the polo-like kinase 1-specific inhibitor GSK461364A, including differential effect on apoptosis. Cancer Res, 2009, 69, 6969-6977.
-
(2009)
Cancer Res
, vol.69
, pp. 6969-6977
-
-
Gilmartin, A. G.1
Bleam, M. R.2
Richter, M. C.3
Erskine, S. G.4
Kruger, R. G.5
Madden, L.6
Hassler, D. F.7
Smith, G. K.8
Gontarek, R. R.9
Courtney, M. P.10
Sutton, D.11
Diamond, M. A.12
Jackson, J. R.13
Laquerre, S. G.14
-
261
-
-
21444446863
-
Divide and conquer: new generation of drugs targets mitosis
-
Garber, K. Divide and conquer: new generation of drugs targets mitosis. J Natl Cancer Inst, 2005, 97, 874-876.
-
(2005)
J Natl Cancer Inst
, vol.97
, pp. 874-876
-
-
Garber, K.1
-
262
-
-
33748299545
-
Identification of a lead small-molecule inhibitor of the Aurora kinases using a structure-assisted, fragment-based approach
-
Warner, Steven L.; Bashyam, Sridevi; Vankayalapati, Hariprasad; Bearss, David J.; Han, Haiyong; Von Hoff, Daniel D.; Hurley, Laurence H. Identification of a lead small-molecule inhibitor of the Aurora kinases using a structure-assisted, fragment-based approach. Mol Cancer Ther, 2006, 5, 1764-1773.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 1764-1773
-
-
Warner, Steven L.1
Bashyam, Sridevi2
Vankayalapati, Hariprasad3
Bearss, David J.4
Han, Haiyong5
Hoff, Von6
Daniel, D.7
Hurley, Laurence H.8
-
263
-
-
85144096510
-
-
Ed.; Humana Press
-
Shakalya, Kishore; Mahadevan, Daruka; Dai, Wei. Teicher, B.A., Ed.; Humana Press, 2008, pp 243-269.
-
(2008)
, pp. 243-269
-
-
Shakalya, Kishore1
Mahadevan, Daruka2
Dai, Wei3
Teicher, B.A.4
-
264
-
-
37549071104
-
PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer
-
Carpinelli, P.; Ceruti, R.; Giorgini, M. L.; Cappella, P.; Gianellini, L.; Croci, V.; Degrassi, A.; Texido, G.; Rocchetti, M.; Vianello, P.; Rusconi, L.; Storici, P.; Zugnoni, P.; Arrigoni, C.; Soncini, C.; Alli, C.; Patton, V.; Marsiglio, A.; Ballinari, D.; Pesenti, E.; Fancelli, D.; Moll, J. PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer. Mol Cancer Ther, 2007, 6, 3158-3168.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 3158-3168
-
-
Carpinelli, P.1
Ceruti, R.2
Giorgini, M. L.3
Cappella, P.4
Gianellini, L.5
Croci, V.6
Degrassi, A.7
Texido, G.8
Rocchetti, M.9
Vianello, P.10
Rusconi, L.11
Storici, P.12
Zugnoni, P.13
Arrigoni, C.14
Soncini, C.15
Alli, C.16
Patton, V.17
Marsiglio, A.18
Ballinari, D.19
Pesenti, E.20
Fancelli, D.21
Moll, J.22
more..
-
265
-
-
43249111278
-
Simultaneous targeting of Aurora kinases and Bcr-Abl kinase by the small molecule inhibitor PHA-739358 is effective against imatinib-resistant BCR-ABL mutations including T315I
-
Gontarewicz, A.; Balabanov, S.; Keller, G.; Colombo, R.; Graziano, A.; Pesenti, E.; Benten, D.; Bokemeyer, C.; Fiedler, W.; Moll, J.; Brummendorf, T. H. Simultaneous targeting of Aurora kinases and Bcr-Abl kinase by the small molecule inhibitor PHA-739358 is effective against imatinib-resistant BCR-ABL mutations including T315I. Blood, 2008, 111, 4355-4364.
-
(2008)
Blood
, vol.111
, pp. 4355-4364
-
-
Gontarewicz, A.1
Balabanov, S.2
Keller, G.3
Colombo, R.4
Graziano, A.5
Pesenti, E.6
Benten, D.7
Bokemeyer, C.8
Fiedler, W.9
Moll, J.10
Brummendorf, T. H.11
-
266
-
-
71449112904
-
Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen
-
Mclaughlin, J.; Markovtsov, V.; Li, H.; Wong, S.; Gelman, M.; Zhu, Y.; Franci, C.; Lang, D. W.; Pali, E.; Lasaga, J.; Low, C.; Zhao, F.; Chang, B.; Gururaja, T. L.; Xu, W.; Baluom, M.; Sweeny, D.; Carroll, D.; Sran, A.; Thota, S.; Parmer, M.; Romane, A.; Clemens, G.; Grossbard, E.; Qu, K.; Jenkins, Y.; Kinoshita, T.; Taylor, V.; Holland, S. J.; Argade, A.; Singh, R.; Pine, P.; Payan, D. G.; Hitoshi, Y. Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen. J Cancer Res Clin Oncol, 2010, 136, 99-113.
-
(2010)
J Cancer Res Clin Oncol
, vol.136
, pp. 99-113
-
-
Mclaughlin, J.1
Markovtsov, V.2
Li, H.3
Wong, S.4
Gelman, M.5
Zhu, Y.6
Franci, C.7
Lang, D. W.8
Pali, E.9
Lasaga, J.10
Low, C.11
Zhao, F.12
Chang, B.13
Gururaja, T. L.14
Xu, W.15
Baluom, M.16
Sweeny, D.17
Carroll, D.18
Sran, A.19
Thota, S.20
Parmer, M.21
Romane, A.22
Clemens, G.23
Grossbard, E.24
Qu, K.25
Jenkins, Y.26
Kinoshita, T.27
Taylor, V.28
Holland, S. J.29
Argade, A.30
Singh, R.31
Pine, P.32
Payan, D. G.33
Hitoshi, Y.34
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