Genetic dissection of mammalian Cdc7 kinase: Cell cycle and developmental roles

Cell Cycle

Volumn 3, Issue 3, 2004, Pages 300-304

  Jung, Min Kim ^a   Masai, Hisao ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

Cdc7 kinase; Initiation of DNA replication; MCM (minichromosome maintenance); Meiosis; p53 dependent apoptosis; S phase arrest; Spermatogenesis

Indexed keywords

CDC7 KINASE; PHOSPHOTRANSFERASE; PROTEIN P53; UNCLASSIFIED DRUG; CDC7 PROTEIN, HUMAN; CELL CYCLE PROTEIN; PROTEIN SERINE THREONINE KINASE;

APOPTOSIS; BODY SIZE; CELL CYCLE; CELL CYCLE S PHASE; CELL MATURATION; CELL METABOLISM; CELL PROLIFERATION; DNA REPLICATION; DNA SYNTHESIS; EMBRYONIC STEM CELL; ENZYME ACTIVITY; ENZYME INACTIVATION; FIBROBLAST; GENE EXPRESSION; GENE REPLICATION; GENETIC ANALYSIS; GENOME; GERM CELL; MAMMAL; MITOSIS; MUTATION; NONHUMAN; ORGANOGENESIS; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; TRANSGENE; YEAST; ANIMAL; ARTICLE; CELL DIFFERENTIATION; CYTOLOGY; GENETICS; METABOLISM;

MAMMALIA; SACCHAROMYCETALES;

ANIMALS; APOPTOSIS; BODY SIZE; CELL CYCLE; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CELL PROLIFERATION; DNA REPLICATION; GERM CELLS; METABOLISM; PROTEIN-SERINE-THREONINE KINASES;

EID: 16544391801     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: None     Document Type: Review

References (23)

1. Hartwell LH. Genetic control of the cell division cycle in yeast. II. Genes controlling DNA replication and its initiation. J Mol Biol 1971; 59:183-94.
2. Sclafani RA, Jackson AL. Cdc7 protein kinase for DNA metabolism comes of age. Mol Microbiol 1994; 11:805-10.
3. Johnston LH, Masai H, Sugino A. First the CDKs, now the DDKs. Trends Cell Biol 1999; 9:249-52.
4. Sclafani RA. Cdc7p-Dbf4p becomes famous in the cell cycle. J Cell Sci 2000; 113:2111-7.
5. Masai H, Arai K. Cdc7 kinase complex: A key regulator in the initiation of DNA replication. J Cell Physiol 2002; 190:287-96.
6. Kim JM, Nakao K, Nakamura K, Saito I, Katsuki M, Arai K, et al. Inactivation of Cdc7 kinase in mouse ES cells results in S-phase arrest and p53-dependent cell death. EMBO J 2002; 21:2168-79.
7. Sabapathy K, Klemm M, Jaenisch R, Wagner EF. Regulation of ES cell differentiation by functional and conformational modulation of p53. EMBO J 1997; 16:6217-29.
8. Gottifredi V, Shieh SY, Taya Y, Prives C. p53 accumulates but is functionally impaired when DNA synthesis is blocked. Proc Natl Acad Sci USA 2001; 98:1036-41.
9. Shimada K, Pasero P, Gasser SM. ORC and the intra-S-phase checkpoint: A threshold regulates Rad53p activation in S phase. Genes Dev 2002; 16:3236-52.
10. Donaldson AD, Fangman WL, Brewer BJ. Cdc7 is required throughout the yeast S phase to activate replication origins. Genes Dev 1998; 12:491-501.
11. Bousset K, Diffley JF. The Cdc7 protein kinase is required for origin firing during S phase. Genes Dev 1998; 12:480-90.
12. Nakamura H, Morita T, Sato C. Structural organizations of replicon domains during DNA synthetic phase in the mammalian nucleus. Exp Cell Res 1986; 165:291-7.
13. Kim JM, Takemoto N, Arai K, Masai H. Hypomorphic mutation in an essential cell cycle kinase causes growth retardation and impaired spermatigenesis. EMBO J 2003; 22:5260-72.
14. Schild D, Byers B. Meiotic effects of DNA-defective cell division cycle mutations of Saccharomyces cerevisiae. Chromosoma 1978; 70:109-30.
15. Matzuk MM, Lamb DJ. Genetic dissection of mammalian fertility pathways. Nat Cell Biol 2002; 4:s41-9.
16. Borde V, Goldman AS, Lichten M. Direct coupling between meiotic DNA replication and recombination initiation. Science 2000; 290:806-9.
17. Kilbey BJ. cdc7 alleles and the control of induced mutagenesis in yeast. Mutagenesis 1986; 1:29-31.
18. Ohmori H, Friedberg EC, Fuchs RP, Goodman MF, Hanaoka F, Hinkle D, et al. The Y-family of DNA polymerases. Mol Cell 2001; 8:7-8.
19. Takeda T, Ogino K, Matsui E, Iiyama H, Taniyama C, Arai K, et al. Regulation of initiation of S phase, replication checkpoint signaling, and maintenance of mitotic chromosome structures during S phase by Hsk1 kinase in the fission yeast. Mol Biol Cell 2001; 12:1257-74.
20. Snaith HA, Brown GW, Forsburg SL. Schizosaccharomyces pombe Hsk1p is a potential cds1p target required for genome integrity. Mol Cell Biol 2000; 20:7922-32.
21. Bailis JM, Bernard P, Antonelli R, Allshire RC, Forsburg SL. Hsk1-Dfp1 is required for heterochromatin-mediated cohesion at centromeres. Nat Cell Biol 2003; 5:1111-6.
22. Axelrod A, Rine J. A role for CDC7 in repression of transcription at the silent mating-type locus HMR in Saccharomyces cerevisiae. Mol Cell Biol 1991; 11:1080-91.
23. Pinto S, Quintana DG, Smith P, Mihalek RM, Hou ZH, Boynton S, et al. latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant. Neuron 1999; 23:45-54.