-
1
-
-
0037365789
-
ATM and related protein kinases: Safeguarding genome integrity
-
Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nat. Rev. Cancer. 3:2003;155-168
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 155-168
-
-
Shiloh, Y.1
-
2
-
-
2142691766
-
ATM: Ready, set, go
-
Shiloh Y. ATM: ready, set, go. Cell Cycle. 2:2003;116-117
-
(2003)
Cell Cycle
, vol.2
, pp. 116-117
-
-
Shiloh, Y.1
-
3
-
-
0030933152
-
The genetic defect in ataxia-telangiectasia
-
Lavin M.F., Shiloh Y. The genetic defect in ataxia-telangiectasia. Annu. Rev. Immunol. 15:1997;177-202
-
(1997)
Annu. Rev. Immunol.
, vol.15
, pp. 177-202
-
-
Lavin, M.F.1
Shiloh, Y.2
-
4
-
-
0028827312
-
The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species
-
Savitsky K., Sfez S., Tagle D.A., Ziv Y., Sartiel A., Collins F.S., Shiloh Y., Rotman G. The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species. Hum. Mol. Genet. 4:1995;2025-2032
-
(1995)
Hum. Mol. Genet.
, vol.4
, pp. 2025-2032
-
-
Savitsky, K.1
Sfez, S.2
Tagle, D.A.3
Ziv, Y.4
Sartiel, A.5
Collins, F.S.6
Shiloh, Y.7
Rotman, G.8
-
5
-
-
0029057336
-
A single ataxia telangiectasia gene with a product similar to PI-3 kinase
-
Savitsky K., Bar-Shira A., Gilad S., Rotman G., Ziv Y., Vanagaite L., Tagle D.A., Smith S., Uziel T., Sfez S. A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science. 268:1995;1749-1753
-
(1995)
Science
, vol.268
, pp. 1749-1753
-
-
Savitsky, K.1
Bar-Shira, A.2
Gilad, S.3
Rotman, G.4
Ziv, Y.5
Vanagaite, L.6
Tagle, D.A.7
Smith, S.8
Uziel, T.9
Sfez, S.10
-
6
-
-
0035155661
-
ATM, a central controller of cellular responses to DNA damage
-
Khanna K., Lavin M., Jackson S., Mulhern T. ATM, a central controller of cellular responses to DNA damage. Cell Death Differ. 8:2001;1052-1065
-
(2001)
Cell Death Differ.
, vol.8
, pp. 1052-1065
-
-
Khanna, K.1
Lavin, M.2
Jackson, S.3
Mulhern, T.4
-
8
-
-
0037032835
-
The protein kinase complement of the human genome
-
Manning G., Whyte D.B., Martinez R., Hunter T., Sudarsanam S. The protein kinase complement of the human genome. Science. 298:2002;1912-1934
-
(2002)
Science
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
9
-
-
0033621392
-
Substrate specificities and identification of putative substrates of ATM kinase family members
-
Kim S.T., Lim D.S., Canman C.E., Kastan M.B. Substrate specificities and identification of putative substrates of ATM kinase family members. J. Biol. Chem. 274:1999;37538-37543
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 37538-37543
-
-
Kim, S.T.1
Lim, D.S.2
Canman, C.E.3
Kastan, M.B.4
-
10
-
-
0034725592
-
Utilization of oriented peptide libraries to identify substrate motifs selected by ATM
-
O'Neill T., Dwyer A.J., Ziv Y., Chan D.W., Lees-Miller S.P., Abraham R.H., Lai J.H., Hill D., Shiloh Y., Cantley L.C., Rathbun G.A. Utilization of oriented peptide libraries to identify substrate motifs selected by ATM. J. Biol. Chem. 275:2000;22719-22727
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 22719-22727
-
-
O'Neill, T.1
Dwyer, A.J.2
Ziv, Y.3
Chan, D.W.4
Lees-Miller, S.P.5
Abraham, R.H.6
Lai, J.H.7
Hill, D.8
Shiloh, Y.9
Cantley, L.C.10
Rathbun, G.A.11
-
12
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
Bakkenist C.J., Kastan M.B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature. 421:2003;499-506
-
(2003)
Nature
, vol.421
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
13
-
-
0037462453
-
The ATRs, ATMs, and TORs are giant HEAT repeat proteins
-
Perry J., Kleckner N. The ATRs, ATMs, and TORs are giant HEAT repeat proteins. Cell. 112:2003;151-155
-
(2003)
Cell
, vol.112
, pp. 151-155
-
-
Perry, J.1
Kleckner, N.2
-
14
-
-
0038339042
-
Electron microscopy and 3D reconstructions reveal that human ATM kinase uses an arm-like domain to clamp around double-stranded DNA
-
Llorca O., Rivera-Calzada A., Grantham J., Willison K.R. Electron microscopy and 3D reconstructions reveal that human ATM kinase uses an arm-like domain to clamp around double-stranded DNA. Oncogene. 22:2003;3867-3874
-
(2003)
Oncogene
, vol.22
, pp. 3867-3874
-
-
Llorca, O.1
Rivera-Calzada, A.2
Grantham, J.3
Willison, K.R.4
-
15
-
-
0033104498
-
Structure of DNA-dependent protein kinase: Implications for its regulation by DNA
-
Leuther K.K., Hammarsten O., Kornberg R.D., Chu G. Structure of DNA-dependent protein kinase: implications for its regulation by DNA. EMBO J. 18:1999;1114-1123
-
(1999)
EMBO J.
, vol.18
, pp. 1114-1123
-
-
Leuther, K.K.1
Hammarsten, O.2
Kornberg, R.D.3
Chu, G.4
-
16
-
-
0030903145
-
DNA looping by Ku and the DNA-dependent protein kinase
-
Cary R.B., Peterson S.R., Wang J., Bear D.G., Bradbury E.M., Chen D.J. DNA looping by Ku and the DNA-dependent protein kinase. Proc. Natl. Acad. Sci. U.S.A. 94:1997;4267-4272
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 4267-4272
-
-
Cary, R.B.1
Peterson, S.R.2
Wang, J.3
Bear, D.G.4
Bradbury, E.M.5
Chen, D.J.6
-
17
-
-
0033613099
-
Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM
-
Smith G.C., Cary R.B., Lakin N.D., Hann B.C., Teo S.H., Chen D.J., Jackson S.P. Purification and DNA binding properties of the ataxia- telangiectasia gene product ATM. Proc. Natl. Acad. Sci. U.S.A. 96:1999;11134-11139
-
(1999)
Proc. Natl. Acad. Sci. U.S.A.
, vol.96
, pp. 11134-11139
-
-
Smith, G.C.1
Cary, R.B.2
Lakin, N.D.3
Hann, B.C.4
Teo, S.H.5
Chen, D.J.6
Jackson, S.P.7
-
18
-
-
0037159220
-
The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation
-
Merkle D., Douglas P., Moorhead G.B., Leonenko Z., Yu Y., Cramb D., Bazett-Jones D.P., Lees-Miller S.P. The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation. Biochemistry. 41:2002;12706-12714
-
(2002)
Biochemistry
, vol.41
, pp. 12706-12714
-
-
Merkle, D.1
Douglas, P.2
Moorhead, G.B.3
Leonenko, Z.4
Yu, Y.5
Cramb, D.6
Bazett-Jones, D.P.7
Lees-Miller, S.P.8
-
19
-
-
0030746109
-
Interaction of DNA-dependent protein kinase with DNA and with Ku: Biochemical and atomic-force microscopy studies
-
Yaneva M., Kowalewski T., Lieber M.R. Interaction of DNA-dependent protein kinase with DNA and with Ku: biochemical and atomic-force microscopy studies. EMBO J. 16:1997;5098-5112
-
(1997)
EMBO J.
, vol.16
, pp. 5098-5112
-
-
Yaneva, M.1
Kowalewski, T.2
Lieber, M.R.3
-
20
-
-
0032508504
-
Enhanced phosphorylation of p53 by ATM in response to DNA damage
-
Banin S., Moyal L., Shieh S., Taya Y., Anderson C.W., Chessa L., Smorodinsky N.I., Prives C., Reiss Y., Shiloh Y., Ziv Y. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science. 281:1998;1674-1677
-
(1998)
Science
, vol.281
, pp. 1674-1677
-
-
Banin, S.1
Moyal, L.2
Shieh, S.3
Taya, Y.4
Anderson, C.W.5
Chessa, L.6
Smorodinsky, N.I.7
Prives, C.8
Reiss, Y.9
Shiloh, Y.10
Ziv, Y.11
-
21
-
-
0030472725
-
Analysis of the ATM protein in wild-type and ataxia telangiectasia cells
-
Lakin N.D., Weber P., Stankovic T., Rottinghaus S.T., Taylor A.M., Jackson S.P. Analysis of the ATM protein in wild-type and ataxia telangiectasia cells. Oncogene. 13:1996;2707-2716
-
(1996)
Oncogene
, vol.13
, pp. 2707-2716
-
-
Lakin, N.D.1
Weber, P.2
Stankovic, T.3
Rottinghaus, S.T.4
Taylor, A.M.5
Jackson, S.P.6
-
22
-
-
0032508608
-
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
-
Canman C.E., Lim D.S., Cimprich K.A., Taya Y., Tamai K., Sakaguchi K., Appella E., Kastan M.B., Siliciano J.D. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science. 281:1998;1677-1679
-
(1998)
Science
, vol.281
, pp. 1677-1679
-
-
Canman, C.E.1
Lim, D.S.2
Cimprich, K.A.3
Taya, Y.4
Tamai, K.5
Sakaguchi, K.6
Appella, E.7
Kastan, M.B.8
Siliciano, J.D.9
-
23
-
-
0031825714
-
Lack of correlation between ATM protein expression and tumour cell radiosensitivity
-
Chan D.W., Gately D.P., Urban S., Galloway A.M., Lees-Miller S.P., Yen T., Allalunis-Turner J. Lack of correlation between ATM protein expression and tumour cell radiosensitivity. Int. J. Radiat. Biol. 74:1998;217-224
-
(1998)
Int. J. Radiat. Biol.
, vol.74
, pp. 217-224
-
-
Chan, D.W.1
Gately, D.P.2
Urban, S.3
Galloway, A.M.4
Lees-Miller, S.P.5
Yen, T.6
Allalunis-Turner, J.7
-
24
-
-
0038660596
-
ATP activates ATM in vitro: Importance of autophosphorylation
-
Kozlov S., Gueven N., Keating K., Ramsay J., Lavin M.F. ATP activates ATM in vitro: importance of autophosphorylation. J. Biol. Chem. 278:2003;9309-9317
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 9309-9317
-
-
Kozlov, S.1
Gueven, N.2
Keating, K.3
Ramsay, J.4
Lavin, M.F.5
-
25
-
-
0034677786
-
Purification and characterization of ATM from human placenta. a manganese-dependent, wortmannin-sensitive serine/threonine protein kinase
-
Chan D.W., Son S.C., Block W., Ye R., Khanna K.K., Wold M.S., Douglas P., Goodarzi A.A., Pelley J., Taya Y., Lavin M.F., Lees-Miller S.P. Purification and characterization of ATM from human placenta. A manganese-dependent, wortmannin-sensitive serine/threonine protein kinase. J. Biol. Chem. 275:2000;7803-7810
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 7803-7810
-
-
Chan, D.W.1
Son, S.C.2
Block, W.3
Ye, R.4
Khanna, K.K.5
Wold, M.S.6
Douglas, P.7
Goodarzi, A.A.8
Pelley, J.9
Taya, Y.10
Lavin, M.F.11
Lees-Miller, S.P.12
-
26
-
-
0033520432
-
Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation
-
Suzuki K., Kodama S., Watanabe M. Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation. J. Biol. Chem. 274:1999;25571-25575
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 25571-25575
-
-
Suzuki, K.1
Kodama, S.2
Watanabe, M.3
-
27
-
-
0035851090
-
Nuclear retention of ATM at sites of DNA double strand breaks
-
Andegeko Y., Moyal L., Mittelman L., Tsarfaty I., Shiloh Y., Rotman G. Nuclear retention of ATM at sites of DNA double strand breaks. J. Biol. Chem. 276:2001;38224-38230
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38224-38230
-
-
Andegeko, Y.1
Moyal, L.2
Mittelman, L.3
Tsarfaty, I.4
Shiloh, Y.5
Rotman, G.6
-
28
-
-
0142011461
-
The cellular response to DNA double-strand breaks: Defining the sensors and mediators
-
Petrini J.H., Stracker T.H. The cellular response to DNA double-strand breaks: defining the sensors and mediators. Trends Cell Biol. 13:2003;458-462
-
(2003)
Trends Cell Biol.
, vol.13
, pp. 458-462
-
-
Petrini, J.H.1
Stracker, T.H.2
-
29
-
-
0142186242
-
The MRN complex: Coordinating and mediating the response to broken chromosomes
-
van den Bosch M., Bree R.T., Lowndes N.F. The MRN complex: coordinating and mediating the response to broken chromosomes. EMBO Rep. 4:2003;844-849
-
(2003)
EMBO Rep.
, vol.4
, pp. 844-849
-
-
Van Den Bosch, M.1
Bree, R.T.2
Lowndes, N.F.3
-
30
-
-
0033544724
-
The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder
-
Stewart G.S., Maser R.S., Stankovic T., Bressan D.A., Kaplan M.I., Jaspers N.G., Raams A., Byrd P.J., Petrini J.H., Taylor A.M. The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder. Cell. 99:1999;577-587
-
(1999)
Cell
, vol.99
, pp. 577-587
-
-
Stewart, G.S.1
Maser, R.S.2
Stankovic, T.3
Bressan, D.A.4
Kaplan, M.I.5
Jaspers, N.G.6
Raams, A.7
Byrd, P.J.8
Petrini, J.H.9
Taylor, A.M.10
-
31
-
-
0142136826
-
Requirement of the MRN complex for ATM activation by DNA damage
-
Uziel T., Lerenthal Y., Moyal L., Andegeko Y., Mittelman L., Shiloh Y. Requirement of the MRN complex for ATM activation by DNA damage. EMBO J. 22:2003;5612-5621
-
(2003)
EMBO J.
, vol.22
, pp. 5612-5621
-
-
Uziel, T.1
Lerenthal, Y.2
Moyal, L.3
Andegeko, Y.4
Mittelman, L.5
Shiloh, Y.6
-
32
-
-
0345732687
-
The Mre11 complex is required for ATM activation and the G(2)/M checkpoint
-
Carson C.T., Schwartz R.A., Stracker T.H., Lilley C.E., Lee D.V., Weitzman M.D. The Mre11 complex is required for ATM activation and the G(2)/M checkpoint. EMBO J. 22:2003;6610-6620
-
(2003)
EMBO J.
, vol.22
, pp. 6610-6620
-
-
Carson, C.T.1
Schwartz, R.A.2
Stracker, T.H.3
Lilley, C.E.4
Lee, D.V.5
Weitzman, M.D.6
-
33
-
-
0037341599
-
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage
-
Lukas C., Falck J., Bartkova J., Bartek J., Lukas J. Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage. Nat. Cell Biol. 5:2003;255-260
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 255-260
-
-
Lukas, C.1
Falck, J.2
Bartkova, J.3
Bartek, J.4
Lukas, J.5
-
34
-
-
0032861343
-
Megabase chromatin domains involved in DNA double-strand breaks in vivo
-
Rogakou E.P., Boon C., Redon C., Bonner W.M. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J. Cell Biol. 146:1999;905-916
-
(1999)
J. Cell Biol.
, vol.146
, pp. 905-916
-
-
Rogakou, E.P.1
Boon, C.2
Redon, C.3
Bonner, W.M.4
-
35
-
-
0037468169
-
MDC1 is required for the intra-S-phase DNA damage checkpoint
-
Goldberg M., Stucki M., Falck J., D'Amours D., Rahman D., Pappin D., Bartek J., Jackson S.P. MDC1 is required for the intra-S-phase DNA damage checkpoint. Nature. 421:2003;952-956
-
(2003)
Nature
, vol.421
, pp. 952-956
-
-
Goldberg, M.1
Stucki, M.2
Falck, J.3
D'Amours, D.4
Rahman, D.5
Pappin, D.6
Bartek, J.7
Jackson, S.P.8
-
36
-
-
0346059615
-
53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage
-
Mochan T.A., Venere M., DiTullio R.A. Jr., Halazonetis T.D. 53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage. Cancer Res. 63:2003;8586-8591
-
(2003)
Cancer Res.
, vol.63
, pp. 8586-8591
-
-
Mochan, T.A.1
Venere, M.2
Ditullio Jr., R.A.3
Halazonetis, T.D.4
-
37
-
-
0038182453
-
A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein
-
Foray N., Marot D., Gabriel A., Randrianarison V., Carr A.M., Perricaudet M., Ashworth A., Jeggo P. A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein. EMBO J. 22:2003;2860-2871
-
(2003)
EMBO J.
, vol.22
, pp. 2860-2871
-
-
Foray, N.1
Marot, D.2
Gabriel, A.3
Randrianarison, V.4
Carr, A.M.5
Perricaudet, M.6
Ashworth, A.7
Jeggo, P.8
-
38
-
-
0036500555
-
Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage
-
Kim S.T., Xu B., Kastan M.B. Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. Genes Dev. 16:2002;560-570
-
(2002)
Genes Dev.
, vol.16
, pp. 560-570
-
-
Kim, S.T.1
Xu, B.2
Kastan, M.B.3
-
39
-
-
0036510163
-
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
-
Yarden R.I., Pardo-Reoyo S., Sgagias M., Cowan K.H., Brody L.C. BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. Nat. Genet. 30:2002;285-289
-
(2002)
Nat. Genet.
, vol.30
, pp. 285-289
-
-
Yarden, R.I.1
Pardo-Reoyo, S.2
Sgagias, M.3
Cowan, K.H.4
Brody, L.C.5
-
40
-
-
0035907395
-
Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. in vivo assessment using phospho-specific antibodies
-
Gatei M., Zhou B.B., Hobson K., Scott S., Young D., Khanna K.K. Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies. J. Biol. Chem. 276:2001;17276-17280
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 17276-17280
-
-
Gatei, M.1
Zhou, B.B.2
Hobson, K.3
Scott, S.4
Young, D.5
Khanna, K.K.6
-
41
-
-
0034655991
-
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
-
Wang Y., Cortez D., Yazdi P., Neff N., Elledge S.J., Qin J. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev. 14:2000;927-939
-
(2000)
Genes Dev.
, vol.14
, pp. 927-939
-
-
Wang, Y.1
Cortez, D.2
Yazdi, P.3
Neff, N.4
Elledge, S.J.5
Qin, J.6
-
42
-
-
0142147272
-
The BRCT domain is a phospho-protein binding domain
-
Yu X., Chini C.C., He M., Mer G., Chen J. The BRCT domain is a phospho-protein binding domain. Science. 302:2003;639-642
-
(2003)
Science
, vol.302
, pp. 639-642
-
-
Yu, X.1
Chini, C.C.2
He, M.3
Mer, G.4
Chen, J.5
-
43
-
-
0142240342
-
BRCT repeats as phosphopeptide-binding modules involved in protein targeting
-
Manke I.A., Lowery D.M., Nguyen A., Yaffe M.B. BRCT repeats as phosphopeptide-binding modules involved in protein targeting. Science. 302:2003;636-639
-
(2003)
Science
, vol.302
, pp. 636-639
-
-
Manke, I.A.1
Lowery, D.M.2
Nguyen, A.3
Yaffe, M.B.4
-
44
-
-
0346101743
-
Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains
-
Rodriguez M., Yu X., Chen J., Songyang Z. Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains. J. Biol. Chem. 278:2003;52914-52918
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 52914-52918
-
-
Rodriguez, M.1
Yu, X.2
Chen, J.3
Songyang, Z.4
-
45
-
-
0037112506
-
Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha
-
Liu Y., Virshup D.M., White R.L., Hsu L.C. Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha. Cancer Res. 62:2002;6357-6361
-
(2002)
Cancer Res.
, vol.62
, pp. 6357-6361
-
-
Liu, Y.1
Virshup, D.M.2
White, R.L.3
Hsu, L.C.4
-
46
-
-
0035937809
-
ATM is required for IkappaB kinase (IKKk) activation in response to DNA double strand breaks
-
Li N., Banin S., Ouyang H., Li G.C., Courtois G., Shiloh Y., Karin M., Rotman G. ATM is required for IkappaB kinase (IKKk) activation in response to DNA double strand breaks. J. Biol. Chem. 276:2001;8898-8903
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 8898-8903
-
-
Li, N.1
Banin, S.2
Ouyang, H.3
Li, G.C.4
Courtois, G.5
Shiloh, Y.6
Karin, M.7
Rotman, G.8
-
47
-
-
0036901639
-
Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366
-
Sapkota G.P., Deak M., Kieloch A., Morrice N., Goodarzi A.A., Smythe C., Shiloh Y., Lees-Miller S.P., Alessi D.R. Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. Biochem. J. 368:2002;507-516
-
(2002)
Biochem. J.
, vol.368
, pp. 507-516
-
-
Sapkota, G.P.1
Deak, M.2
Kieloch, A.3
Morrice, N.4
Goodarzi, A.A.5
Smythe, C.6
Shiloh, Y.7
Lees-Miller, S.P.8
Alessi, D.R.9
-
48
-
-
0030925565
-
Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation
-
Baskaran R., Wood L.D., Whitaker L.L., Canman C.E., Morgan S.E., Xu Y., Barlow C., Baltimore D., Wynshaw-Boris A., Kastan M.B., Wang J.Y. Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. Nature. 387:1997;516-519
-
(1997)
Nature
, vol.387
, pp. 516-519
-
-
Baskaran, R.1
Wood, L.D.2
Whitaker, L.L.3
Canman, C.E.4
Morgan, S.E.5
Xu, Y.6
Barlow, C.7
Baltimore, D.8
Wynshaw-Boris, A.9
Kastan, M.B.10
Wang, J.Y.11
-
49
-
-
0038013782
-
Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation
-
Gatei M., Sloper K., Sorensen C., Syljuasen R., Falck J., Hobson K., Savage K., Lukas J., Zhou B.B., Bartek J., Khanna K.K. Ataxia-telangiectasia- mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. J. Biol. Chem. 278:2003;14806-14811
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 14806-14811
-
-
Gatei, M.1
Sloper, K.2
Sorensen, C.3
Syljuasen, R.4
Falck, J.5
Hobson, K.6
Savage, K.7
Lukas, J.8
Zhou, B.B.9
Bartek, J.10
Khanna, K.K.11
-
50
-
-
0346095320
-
Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair
-
Zhang J., Willers H., Feng Z., Ghosh J.C., Kim S., Weaver D.T., Chung J.H., Powell S.N., Xia F. Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair. Mol. Cell Biol. 24:2004;708-718
-
(2004)
Mol. Cell Biol.
, vol.24
, pp. 708-718
-
-
Zhang, J.1
Willers, H.2
Feng, Z.3
Ghosh, J.C.4
Kim, S.5
Weaver, D.T.6
Chung, J.H.7
Powell, S.N.8
Xia, F.9
-
51
-
-
0034624718
-
HCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
-
Lee J.S., Collins K.M., Brown A.L., Lee C.H., Chung J.H. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature. 404:2000;201-204
-
(2000)
Nature
, vol.404
, pp. 201-204
-
-
Lee, J.S.1
Collins, K.M.2
Brown, A.L.3
Lee, C.H.4
Chung, J.H.5
-
52
-
-
0030992749
-
Interaction between ATM protein and c-Abl in response to DNA damage
-
Shafman T., Khanna K.K., Kedar P., Spring K., Kozlov S., Yen T., Hobson K., Gatei M., Zhang N., Watters D., Egerton M., Shiloh Y., Kharbanda S., Kufe D., Lavin M.F. Interaction between ATM protein and c-Abl in response to DNA damage. Nature. 387:1997;520-523
-
(1997)
Nature
, vol.387
, pp. 520-523
-
-
Shafman, T.1
Khanna, K.K.2
Kedar, P.3
Spring, K.4
Kozlov, S.5
Yen, T.6
Hobson, K.7
Gatei, M.8
Zhang, N.9
Watters, D.10
Egerton, M.11
Shiloh, Y.12
Kharbanda, S.13
Kufe, D.14
Lavin, M.F.15
-
53
-
-
0033617368
-
Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl
-
Chen G., Yuan S.S., Liu W., Xu Y., Trujillo K., Song B., Cong F., Goff S.P., Wu Y., Arlinghaus R., Baltimore D., Gasser P.J., Park M.S., Sung P., Lee E.Y. Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl. J. Biol. Chem. 274:1999;12748-12752
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 12748-12752
-
-
Chen, G.1
Yuan, S.S.2
Liu, W.3
Xu, Y.4
Trujillo, K.5
Song, B.6
Cong, F.7
Goff, S.P.8
Wu, Y.9
Arlinghaus, R.10
Baltimore, D.11
Gasser, P.J.12
Park, M.S.13
Sung, P.14
Lee, E.Y.15
-
54
-
-
0036258350
-
Constitutive association of BRCA1 and c-Abl and its ATM-dependent disruption after irradiation
-
Foray N., Marot D., Randrianarison V., Venezia N.D., Picard D., Perricaudet M., Favaudon V., Jeggo P. Constitutive association of BRCA1 and c-Abl and its ATM-dependent disruption after irradiation. Mol. Cell Biol. 22:2002;4020-4032
-
(2002)
Mol. Cell Biol.
, vol.22
, pp. 4020-4032
-
-
Foray, N.1
Marot, D.2
Randrianarison, V.3
Venezia, N.D.4
Picard, D.5
Perricaudet, M.6
Favaudon, V.7
Jeggo, P.8
-
55
-
-
0141534462
-
Roles of BRCA1 and BRCA2 in homologous recombination
-
Powell S.N., Kachnic L.A. Roles of BRCA1 and BRCA2 in homologous recombination. Oncogene. 22:2003;5784-5791
-
(2003)
Oncogene
, vol.22
, pp. 5784-5791
-
-
Powell, S.N.1
Kachnic, L.A.2
-
56
-
-
0141618358
-
Differential involvement of the hMRE11/hRAD50/NBS1 complex, BRCA1 and MLH1 in NF-kappaB activation by camptothecin and X-ray
-
Habraken Y., Jolois O., Piette J. Differential involvement of the hMRE11/hRAD50/NBS1 complex, BRCA1 and MLH1 in NF-kappaB activation by camptothecin and X-ray. Oncogene. 22:2003;6090-6099
-
(2003)
Oncogene
, vol.22
, pp. 6090-6099
-
-
Habraken, Y.1
Jolois, O.2
Piette, J.3
-
57
-
-
0141785046
-
Functional genomics as a window on radiation stress signaling
-
Amundson S.A., Bittner M., Fornace A.J. Jr. Functional genomics as a window on radiation stress signaling. Oncogene. 22:2003;5828-5833
-
(2003)
Oncogene
, vol.22
, pp. 5828-5833
-
-
Amundson, S.A.1
Bittner, M.2
Fornace Jr., A.J.3
-
58
-
-
0043009733
-
ATM-dependent and -independent gene expression changes in response to oxidative stress, gamma irradiation, and UV irradiation
-
Heinloth A.N., Shackelford R.E., Innes C.L., Bennett L., Li L., Amin R.P., Sieber S.O., Flores K.G., Bushel P.R., Paules R.S. ATM-dependent and -independent gene expression changes in response to oxidative stress, gamma irradiation, and UV irradiation. Radiat. Res. 160:2003;273-290
-
(2003)
Radiat. Res.
, vol.160
, pp. 273-290
-
-
Heinloth, A.N.1
Shackelford, R.E.2
Innes, C.L.3
Bennett, L.4
Li, L.5
Amin, R.P.6
Sieber, S.O.7
Flores, K.G.8
Bushel, P.R.9
Paules, R.S.10
-
59
-
-
0242410719
-
P53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa
-
Villunger A., Michalak E.M., Coultas L., Mullauer F., Bock G., Ausserlechner M.J., Adams J.M., Strasser A. p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science. 302:2003;1036-1038
-
(2003)
Science
, vol.302
, pp. 1036-1038
-
-
Villunger, A.1
Michalak, E.M.2
Coultas, L.3
Mullauer, F.4
Bock, G.5
Ausserlechner, M.J.6
Adams, J.M.7
Strasser, A.8
-
60
-
-
0031435944
-
DNA damage induces phosphorylation of the amino terminus of p53
-
Siliciano J.D., Canman C.E., Taya Y., Sakaguchi K., Appella E., Kastan M.B. DNA damage induces phosphorylation of the amino terminus of p53. Genes Dev. 11:1997;3471-3481
-
(1997)
Genes Dev.
, vol.11
, pp. 3471-3481
-
-
Siliciano, J.D.1
Canman, C.E.2
Taya, Y.3
Sakaguchi, K.4
Appella, E.5
Kastan, M.B.6
-
61
-
-
0037066695
-
ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation
-
Saito S., Goodarzi A.A., Higashimoto Y., Noda Y., Lees-Miller S.P., Appella E., Anderson C.W. ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation. J. Biol. Chem. 277:2002;12491-12494
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 12491-12494
-
-
Saito, S.1
Goodarzi, A.A.2
Higashimoto, Y.3
Noda, Y.4
Lees-Miller, S.P.5
Appella, E.6
Anderson, C.W.7
-
62
-
-
0030591651
-
DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: Bleomycin
-
Povirk L.F. DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: bleomycin. Mutat. Res. 355:1996;71-89
-
(1996)
Mutat. Res.
, vol.355
, pp. 71-89
-
-
Povirk, L.F.1
-
63
-
-
0037080679
-
Sensing of intermediates in V(D)J recombination by ATM
-
Perkins E.J., Nair A., Cowley D.O., Van Dyke T., Chang Y., Ramsden D.A. Sensing of intermediates in V(D)J recombination by ATM. Genes Dev. 16:2002;159-164
-
(2002)
Genes Dev.
, vol.16
, pp. 159-164
-
-
Perkins, E.J.1
Nair, A.2
Cowley, D.O.3
Van Dyke, T.4
Chang, Y.5
Ramsden, D.A.6
-
64
-
-
0035895895
-
The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner
-
Ye R., Bodero A., Zhou B.B., Khanna K.K., Lavin M.F., Lees-Miller S.P. The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner. J. Biol. Chem. 276:2001;4828-4833
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 4828-4833
-
-
Ye, R.1
Bodero, A.2
Zhou, B.B.3
Khanna, K.K.4
Lavin, M.F.5
Lees-Miller, S.P.6
-
65
-
-
0842303315
-
The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM
-
Ye R., Goodarzi A.A., Kurz E.U., Saito S., Higashimoto Y., Lavin M.F., Appella E., Anderson C.W., Lees-Miller S.P. The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM. DNA Repair (Amst.). 3:2004;235-244
-
(2004)
DNA Repair (Amst.)
, vol.3
, pp. 235-244
-
-
Ye, R.1
Goodarzi, A.A.2
Kurz, E.U.3
Saito, S.4
Higashimoto, Y.5
Lavin, M.F.6
Appella, E.7
Anderson, C.W.8
Lees-Miller, S.P.9
-
66
-
-
0036938075
-
Evaluation of the clastogenic, DNA intercalative, and topoisomerase II - Interactive properties of bioflavonoids in Chinese hamster V79 cells
-
Snyder R.D., Gillies P.J. Evaluation of the clastogenic, DNA intercalative, and topoisomerase II - interactive properties of bioflavonoids in Chinese hamster V79 cells. Environ. Mol. Mutagen. 40:2002;266-276
-
(2002)
Environ. Mol. Mutagen.
, vol.40
, pp. 266-276
-
-
Snyder, R.D.1
Gillies, P.J.2
-
67
-
-
0242576442
-
Effects of dietary flavonoids on major signal transduction pathways in human epithelial cells
-
O'Prey J., Brown J., Fleming J., Harrison P.R. Effects of dietary flavonoids on major signal transduction pathways in human epithelial cells. Biochem. Pharmacol. 66:2003;2075-2088
-
(2003)
Biochem. Pharmacol.
, vol.66
, pp. 2075-2088
-
-
O'Prey, J.1
Brown, J.2
Fleming, J.3
Harrison, P.R.4
-
68
-
-
0037034210
-
Activation of ATM and phosphorylation of p53 by heat shock
-
Miyakoda M., Suzuki K., Kodama S., Watanabe M. Activation of ATM and phosphorylation of p53 by heat shock. Oncogene. 21:2002;1090-1096
-
(2002)
Oncogene
, vol.21
, pp. 1090-1096
-
-
Miyakoda, M.1
Suzuki, K.2
Kodama, S.3
Watanabe, M.4
-
69
-
-
0037414761
-
Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein
-
Suzuki A., Kusakai G., Kishimoto A., Lu J., Ogura T., Lavin M.F., Esumi H. Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein. J. Biol. Chem. 278:2003;48-53
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 48-53
-
-
Suzuki, A.1
Kusakai, G.2
Kishimoto, A.3
Lu, J.4
Ogura, T.5
Lavin, M.F.6
Esumi, H.7
-
70
-
-
0033662156
-
Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1
-
Yang D.Q., Kastan M.B. Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1. Nat. Cell Biol. 2:2000;893-898
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 893-898
-
-
Yang, D.Q.1
Kastan, M.B.2
-
71
-
-
0036012789
-
ATM deficiency and oxidative stress: A new dimension of defective response to DNA damage
-
Barzilai A., Rotman G., Shiloh Y. ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage. DNA Repair (Amst.). 1:2002;3-25
-
(2002)
DNA Repair (Amst.)
, vol.1
, pp. 3-25
-
-
Barzilai, A.1
Rotman, G.2
Shiloh, Y.3
-
72
-
-
0041732381
-
Characteristics of gamma-H2AX foci at DNA double-strand breaks sites
-
Pilch D.R., Sedelnikova O.A., Redon C., Celeste A., Nussenzweig A., Bonner W.M. Characteristics of gamma-H2AX foci at DNA double-strand breaks sites. Biochem. Cell Biol. 81:2003;123-129
-
(2003)
Biochem. Cell Biol.
, vol.81
, pp. 123-129
-
-
Pilch, D.R.1
Sedelnikova, O.A.2
Redon, C.3
Celeste, A.4
Nussenzweig, A.5
Bonner, W.M.6
-
73
-
-
10744233286
-
Involvement of histone H1.2 in apoptosis induced by DNA double-strand breaks
-
Konishi A., Shimizu S., Hirota J., Takao T., Fan Y., Matsuoka Y., Zhang L., Yoneda Y., Fujii Y., Skoultchi A.I., Tsujimoto Y. Involvement of histone H1.2 in apoptosis induced by DNA double-strand breaks. Cell. 114:2003;673-688
-
(2003)
Cell
, vol.114
, pp. 673-688
-
-
Konishi, A.1
Shimizu, S.2
Hirota, J.3
Takao, T.4
Fan, Y.5
Matsuoka, Y.6
Zhang, L.7
Yoneda, Y.8
Fujii, Y.9
Skoultchi, A.I.10
Tsujimoto, Y.11
-
74
-
-
0141538129
-
The secret life of histones
-
Gillespie D.A., Vousden K.H. The secret life of histones. Cell. 114:2003;655-656
-
(2003)
Cell
, vol.114
, pp. 655-656
-
-
Gillespie, D.A.1
Vousden, K.H.2
-
75
-
-
0942268167
-
Repair of DNA double strand breaks by nonhomologous end joining
-
Lees-Miller S.P., Meek K. Repair of DNA double strand breaks by nonhomologous end joining. Biochimie. 85:2003;1161-1173
-
(2003)
Biochimie
, vol.85
, pp. 1161-1173
-
-
Lees-Miller, S.P.1
Meek, K.2
-
76
-
-
0141757504
-
P53 and radiation responses
-
Fei P., El-Deiry W.S. P53 and radiation responses. Oncogene. 22:2003;5774-5783
-
(2003)
Oncogene
, vol.22
, pp. 5774-5783
-
-
Fei, P.1
El-Deiry, W.S.2
-
77
-
-
0036479241
-
Requirement of ATM in UVA-induced signaling and apoptosis
-
Zhang Y., Ma W.Y., Kaji A., Bode A.M., Dong Z. Requirement of ATM in UVA-induced signaling and apoptosis. J. Biol. Chem. 277:2002;3124-3131
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 3124-3131
-
-
Zhang, Y.1
Ma, W.Y.2
Kaji, A.3
Bode, A.M.4
Dong, Z.5
-
78
-
-
0035939844
-
Activation of p53 transcriptional activity requires ATM's kinase domain and multiple N-terminal serine residues of p53
-
Turenne G.A., Paul P., Laflair L., Price B.D. Activation of p53 transcriptional activity requires ATM's kinase domain and multiple N-terminal serine residues of p53. Oncogene. 20:2001;5100-5110
-
(2001)
Oncogene
, vol.20
, pp. 5100-5110
-
-
Turenne, G.A.1
Paul, P.2
Laflair, L.3
Price, B.D.4
-
79
-
-
0027500246
-
Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents
-
Fritsche M., Haessler C., Brandner G. Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents. Oncogene. 8:1993;307-318
-
(1993)
Oncogene
, vol.8
, pp. 307-318
-
-
Fritsche, M.1
Haessler, C.2
Brandner, G.3
-
80
-
-
0037066686
-
ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53
-
Tang D., Wu D., Hirao A., Lahti J.M., Liu L., Mazza B., Kidd V.J., Mak T.W., Ingram A.J. ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53. J. Biol. Chem. 277:2002;12710-12717
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 12710-12717
-
-
Tang, D.1
Wu, D.2
Hirao, A.3
Lahti, J.M.4
Liu, L.5
Mazza, B.6
Kidd, V.J.7
Mak, T.W.8
Ingram, A.J.9
-
81
-
-
0034003005
-
Stress signals utilize multiple pathways to stabilize p53
-
Ashcroft M., Taya Y., Vousden K.H. Stress signals utilize multiple pathways to stabilize p53. Mol. Cell Biol. 20:2000;3224-3233
-
(2000)
Mol. Cell Biol.
, vol.20
, pp. 3224-3233
-
-
Ashcroft, M.1
Taya, Y.2
Vousden, K.H.3
-
82
-
-
7344231094
-
Differential p53 phosphorylation and activation of apoptosis-promoting genes Bax and Fas/APO-1 by irradiation and ara-C treatment
-
Kobayashi T., Ruan S., Jabbur J.R., Consoli U., Clodi K., Shiku H., Owen-Schaub L.B., Andreeff M., Reed J.C., Zhang W. Differential p53 phosphorylation and activation of apoptosis-promoting genes Bax and Fas/APO-1 by irradiation and ara-C treatment. Cell Death Differ. 5:1998;584-591
-
(1998)
Cell Death Differ.
, vol.5
, pp. 584-591
-
-
Kobayashi, T.1
Ruan, S.2
Jabbur, J.R.3
Consoli, U.4
Clodi, K.5
Shiku, H.6
Owen-Schaub, L.B.7
Andreeff, M.8
Reed, J.C.9
Zhang, W.10
-
84
-
-
0037064053
-
ATM is activated in response to N-methyl-N′-nitro-N- nitrosoguanidine-induced DNA alkylation
-
Adamson A.W., Kim W.J., Shangary S., Baskaran R., Brown K.D. ATM is activated in response to N-methyl-N′-nitro-N-nitrosoguanidine-induced DNA alkylation. J. Biol. Chem. 277:2002;38222-38229
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 38222-38229
-
-
Adamson, A.W.1
Kim, W.J.2
Shangary, S.3
Baskaran, R.4
Brown, K.D.5
-
85
-
-
0035895606
-
Downregulation of MDM2 stabilizes p53 by inhibiting p53 ubiquitination in response to specific alkylating agents
-
Inoue T., Geyer R.K., Yu Z.K., Maki C.G. Downregulation of MDM2 stabilizes p53 by inhibiting p53 ubiquitination in response to specific alkylating agents. FEBS Lett. 490:2001;196-201
-
(2001)
FEBS Lett.
, vol.490
, pp. 196-201
-
-
Inoue, T.1
Geyer, R.K.2
Yu, Z.K.3
Maki, C.G.4
-
86
-
-
0037139178
-
S(N)2 DNA-alkylating agent-induced phosphorylation of p53 and activation of p21 gene expression
-
Jaiswal A.S., Narayan S. S(N)2 DNA-alkylating agent-induced phosphorylation of p53 and activation of p21 gene expression. Mutat. Res. 500:2002;17-30
-
(2002)
Mutat. Res.
, vol.500
, pp. 17-30
-
-
Jaiswal, A.S.1
Narayan, S.2
-
87
-
-
0035093544
-
Cisplatinum and taxol induce different patterns of p53 phosphorylation
-
Damia G., Filiberti L., Vikhanskaya F., Carrassa L., Taya Y., D'Incalci M., Broggini M. Cisplatinum and taxol induce different patterns of p53 phosphorylation. Neoplasia. 3:2001;10-16
-
(2001)
Neoplasia
, vol.3
, pp. 10-16
-
-
Damia, G.1
Filiberti, L.2
Vikhanskaya, F.3
Carrassa, L.4
Taya, Y.5
D'Incalci, M.6
Broggini, M.7
-
88
-
-
0033660679
-
Downregulation of p53 by sustained JNK activation during apoptosis
-
Wang J., Friedman E. Downregulation of p53 by sustained JNK activation during apoptosis. Mol. Carcinog. 29:2000;179-188
-
(2000)
Mol. Carcinog.
, vol.29
, pp. 179-188
-
-
Wang, J.1
Friedman, E.2
-
89
-
-
0038146962
-
ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to re-oxygenation
-
Hammond E.M., Dorie M.J., Giaccia A.J. ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to re-oxygenation. J. Biol. Chem. 278:2003;12207-12213
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 12207-12213
-
-
Hammond, E.M.1
Dorie, M.J.2
Giaccia, A.J.3
-
90
-
-
0035877581
-
The Ataxia telangiectasia gene product is required for oxidative stress-induced G1 and G2 checkpoint function in human fibroblasts
-
Shackelford R.E., Innes C.L., Sieber S.O., Heinloth A.N., Leadon S.A., Paules R.S. The Ataxia telangiectasia gene product is required for oxidative stress-induced G1 and G2 checkpoint function in human fibroblasts. J. Biol. Chem. 276:2001;21951-21959
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 21951-21959
-
-
Shackelford, R.E.1
Innes, C.L.2
Sieber, S.O.3
Heinloth, A.N.4
Leadon, S.A.5
Paules, R.S.6
-
91
-
-
0141891251
-
Activation of p53 by oxidative stress involves PDGFbeta receptor-mediated ATM kinase activation
-
Chen K., Albano A., Ho A., Keaney J.F. Jr. Activation of p53 by oxidative stress involves PDGFbeta receptor-mediated ATM kinase activation. J. Biol. Chem. 278:2003;39527-39533
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 39527-39533
-
-
Chen, K.1
Albano, A.2
Ho, A.3
Keaney Jr., J.F.4
-
92
-
-
0037422535
-
Nitric oxide-induced cellular stress and p53 activation in chronic inflammation
-
Hofseth L.J., Saito S., Hussain S.P., Espey M.G., Miranda K.M., Araki Y., Jhappan C., Higashimoto Y., He P., Linke S.P., Quezado M.M., Zurer I., Rotter V., Wink D.A., Appella E., Harris C.C. Nitric oxide-induced cellular stress and p53 activation in chronic inflammation. Proc. Natl. Acad. Sci. U.S.A. 100:2003;143-148
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 143-148
-
-
Hofseth, L.J.1
Saito, S.2
Hussain, S.P.3
Espey, M.G.4
Miranda, K.M.5
Araki, Y.6
Jhappan, C.7
Higashimoto, Y.8
He, P.9
Linke, S.P.10
Quezado, M.M.11
Zurer, I.12
Rotter, V.13
Wink, D.A.14
Appella, E.15
Harris, C.C.16
-
93
-
-
0036170228
-
Inhibition of protein phosphatase-1 is linked to phosphorylation of p53 and apoptosis
-
Long X., Wu G., Gaa S.T., Rogers T.B. Inhibition of protein phosphatase-1 is linked to phosphorylation of p53 and apoptosis. Apoptosis. 7:2002;31-39
-
(2002)
Apoptosis
, vol.7
, pp. 31-39
-
-
Long, X.1
Wu, G.2
Gaa, S.T.3
Rogers, T.B.4
-
94
-
-
0033677082
-
Arsenite induces p53 accumulation through an ATM-dependent pathway in human fibroblasts
-
Yih L.H., Lee T.C. Arsenite induces p53 accumulation through an ATM-dependent pathway in human fibroblasts. Cancer Res. 60:2000;6346-6352
-
(2000)
Cancer Res.
, vol.60
, pp. 6346-6352
-
-
Yih, L.H.1
Lee, T.C.2
-
95
-
-
0642333820
-
Genetic predisposition to the cytotoxicity of arsenic: The role of DNA damage and ATM
-
Mei N., Lee J., Sun X., Xing J.Z., Hanson J., Le C., Weinfeld M. Genetic predisposition to the cytotoxicity of arsenic: the role of DNA damage and ATM. FASEB J. 17:2003;2310-2312
-
(2003)
FASEB J.
, vol.17
, pp. 2310-2312
-
-
Mei, N.1
Lee, J.2
Sun, X.3
Xing, J.Z.4
Hanson, J.5
Le, C.6
Weinfeld, M.7
-
96
-
-
0038381451
-
Chromium (VI) activates ataxia telangiectasia mutated (ATM) protein. Requirement of ATM for both apoptosis and recovery from terminal growth arrest
-
Ha L., Ceryak S., Patierno S.R. Chromium (VI) activates ataxia telangiectasia mutated (ATM) protein. Requirement of ATM for both apoptosis and recovery from terminal growth arrest. J. Biol. Chem. 278:2003;17885-17894
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 17885-17894
-
-
Ha, L.1
Ceryak, S.2
Patierno, S.R.3
-
97
-
-
0037809254
-
Single-stranded DNA induces ataxia telangiectasia mutant (ATM)/p53-dependent DNA damage and apoptotic signals
-
Nur-E-Kamal A., Li T.K., Zhang A., Qi H., Hars E.S., Liu L.F. Single-stranded DNA induces ataxia telangiectasia mutant (ATM)/p53-dependent DNA damage and apoptotic signals. J. Biol. Chem. 278:2003;12475-12481
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 12475-12481
-
-
Nur-E-Kamal, A.1
Li, T.K.2
Zhang, A.3
Qi, H.4
Hars, E.S.5
Liu, L.F.6
-
98
-
-
0041836256
-
Metabolic labeling of human cells with tritiated nucleosides results in activation of the ATM-dependent p53 signaling pathway and acceleration of DNA repair
-
Mirzayans R., Pollock S., Scott A., Gao C.Q., Murray D. Metabolic labeling of human cells with tritiated nucleosides results in activation of the ATM-dependent p53 signaling pathway and acceleration of DNA repair. Oncogene. 22:2003;5562-5571
-
(2003)
Oncogene
, vol.22
, pp. 5562-5571
-
-
Mirzayans, R.1
Pollock, S.2
Scott, A.3
Gao, C.Q.4
Murray, D.5
-
99
-
-
0030801002
-
Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
-
Altschul S.F., Madden T.L., Schaffer A.A., Zhang J., Zhang Z., Miller W., Lipman D.J. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25:1997;3389-3402
-
(1997)
Nucleic Acids Res.
, vol.25
, pp. 3389-3402
-
-
Altschul, S.F.1
Madden, T.L.2
Schaffer, A.A.3
Zhang, J.4
Zhang, Z.5
Miller, W.6
Lipman, D.J.7
-
101
-
-
0142072174
-
ATM's leucine-rich domain and adjacent sequences are essential for ATM to regulate the DNA damage response
-
Chen S., Paul P., Price B.D. ATM's leucine-rich domain and adjacent sequences are essential for ATM to regulate the DNA damage response. Oncogene. 22:2003;6332-6339
-
(2003)
Oncogene
, vol.22
, pp. 6332-6339
-
-
Chen, S.1
Paul, P.2
Price, B.D.3
-
102
-
-
0036134979
-
A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival
-
Yamane K., Wu X., Chen J. A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival. Mol. Cell Biol. 22:2002;555-566
-
(2002)
Mol. Cell Biol.
, vol.22
, pp. 555-566
-
-
Yamane, K.1
Wu, X.2
Chen, J.3
-
103
-
-
2342618116
-
Phosphatidyl inositol 3-kinase like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32-kDa subunit of replication protein a at threonine 21
-
Block W.D., Yu Y., Lees-Miller S.P. Phosphatidyl inositol 3-kinase like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32-kDa subunit of replication protein A at threonine 21. Nucleic Acids Res. 32:2004;997-1005
-
(2004)
Nucleic Acids Res.
, vol.32
, pp. 997-1005
-
-
Block, W.D.1
Yu, Y.2
Lees-Miller, S.P.3
-
104
-
-
0033615547
-
Sensing of ionizing radiation-induced DNA damage by ATM through interaction with histone deacetylase
-
Kim G.D., Choi Y.H., Dimtchev A., Jeong S.J., Dritschilo A., Jung M. Sensing of ionizing radiation-induced DNA damage by ATM through interaction with histone deacetylase. J. Biol. Chem. 274:1999;31127-31130
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 31127-31130
-
-
Kim, G.D.1
Choi, Y.H.2
Dimtchev, A.3
Jeong, S.J.4
Dritschilo, A.5
Jung, M.6
-
105
-
-
0037102708
-
Neocarzinostatin induces Mre11 phosphorylation and focus formation through an ATM- and NBS1-dependent mechanism
-
Yuan S.S., Chang H.L., Hou M.F., Chan T.F., Kao Y.H., Wu Y.C., Su J.H. Neocarzinostatin induces Mre11 phosphorylation and focus formation through an ATM- and NBS1-dependent mechanism. Toxicology. 177:2002;123-130
-
(2002)
Toxicology
, vol.177
, pp. 123-130
-
-
Yuan, S.S.1
Chang, H.L.2
Hou, M.F.3
Chan, T.F.4
Kao, Y.H.5
Wu, Y.C.6
Su, J.H.7
-
106
-
-
0037040920
-
BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs
-
Fan W., Jin S., Tong T., Zhao H., Fan F., Antinore M.J., Rajasekaran B., Wu M., Zhan Q. BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs. J. Biol. Chem. 277:2002;8061-8067
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 8061-8067
-
-
Fan, W.1
Jin, S.2
Tong, T.3
Zhao, H.4
Fan, F.5
Antinore, M.J.6
Rajasekaran, B.7
Wu, M.8
Zhan, Q.9
-
107
-
-
0038054343
-
The Chk2 tumor suppressor is not required for p53 responses in human cancer cells
-
Jallepalli P.V., Lengauer C., Vogelstein B., Bunz F. The Chk2 tumor suppressor is not required for p53 responses in human cancer cells. J. Biol. Chem. 278:2003;20475-20479
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 20475-20479
-
-
Jallepalli, P.V.1
Lengauer, C.2
Vogelstein, B.3
Bunz, F.4
-
108
-
-
0038392762
-
Questioning the role of checkpoint kinase 2 in the p53 DNA damage response
-
Ahn J., Urist M., Prives C. Questioning the role of checkpoint kinase 2 in the p53 DNA damage response. J. Biol. Chem. 278:2003;20480-20489
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 20480-20489
-
-
Ahn, J.1
Urist, M.2
Prives, C.3
-
109
-
-
18644375649
-
Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription
-
Takai H., Naka K., Okada Y., Watanabe M., Harada N., Saito S., Anderson C.W., Appella E., Nakanishi M., Suzuki H., Nagashima K., Sawa H., Ikeda K., Motoyama N. Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO J. 21:2002;5195-5205
-
(2002)
EMBO J.
, vol.21
, pp. 5195-5205
-
-
Takai, H.1
Naka, K.2
Okada, Y.3
Watanabe, M.4
Harada, N.5
Saito, S.6
Anderson, C.W.7
Appella, E.8
Nakanishi, M.9
Suzuki, H.10
Nagashima, K.11
Sawa, H.12
Ikeda, K.13
Motoyama, N.14
-
110
-
-
0141730324
-
Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1
-
Krause D.R., Jonnalagadda J.C., Gatei M.H., Sillje H.H., Zhou B.B., Nigg E.A., Khanna K. Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1. Oncogene. 22:2003;5927-5937
-
(2003)
Oncogene
, vol.22
, pp. 5927-5937
-
-
Krause, D.R.1
Jonnalagadda, J.C.2
Gatei, M.H.3
Sillje, H.H.4
Zhou, B.B.5
Nigg, E.A.6
Khanna, K.7
-
111
-
-
0037386947
-
Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint
-
Groth A., Lukas J., Nigg E.A., Sillje H.H., Wernstedt C., Bartek J., Hansen K. Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint. EMBO J. 22:2003;1676-1687
-
(2003)
EMBO J.
, vol.22
, pp. 1676-1687
-
-
Groth, A.1
Lukas, J.2
Nigg, E.A.3
Sillje, H.H.4
Wernstedt, C.5
Bartek, J.6
Hansen, K.7
-
112
-
-
0037427194
-
Ionizing radiation-induced Rad51 nuclear focus formation is cell cycle-regulated and defective in both ATM(-/-) and c-Abl(-/-) cells
-
Yuan S.S., Chang H.L., Lee E.Y. Ionizing radiation-induced Rad51 nuclear focus formation is cell cycle-regulated and defective in both ATM(-/-) and c-Abl(-/-) cells. Mutat. Res. 525:2003;85-92
-
(2003)
Mutat. Res.
, vol.525
, pp. 85-92
-
-
Yuan, S.S.1
Chang, H.L.2
Lee, E.Y.3
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