Cdc7 inhibition reveals a p53-dependent replication checkpoint that is defective in cancer cells

Cancer Research

Volumn 64, Issue 19, 2004, Pages 7110-7116

  Montagnoli, Alessia ^a   Tenca, Pierluigi ^a   Sola, Francesco ^a   Carpani, Daniela ^a   Brotherton, Deborah ^a   Albanese, Clara ^a   Santocanale, Corrado ^a  

^a Nerviano Medical Science ^*  (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CDC7 KINASE; CELL CYCLE PROTEIN; PROTEIN KINASE; PROTEIN P53; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE S PHASE; CELL DEATH; CELL DIVISION; CELL VIABILITY; CONTROLLED STUDY; DNA REPLICATION; DNA SYNTHESIS; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; FIBROBLAST; HELA CELL; HUMAN; HUMAN CELL; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN DEPLETION; RNA INTERFERENCE; TUMOR CELL LINE;

APOPTOSIS; CELL CYCLE; CELL CYCLE PROTEINS; DISEASE PROGRESSION; DOWN-REGULATION; HELA CELLS; HUMANS; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; S PHASE; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 4944256913     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-1547     Document Type: Article

References (44)

1. Diffley JF, Labib K. The chromosome replication cycle. J Cell Sci 2002;115:869-72.
2. Bell SP, Dutta A. DNA replication in eukaryotic cells. Annu Rev Biochem 2002;71:333-74.
3. Hartwell LH, Culotti J, Pringle JR, Reid BJ. Genetic control of the cell division cycle in yeast. Science 1974;183:46-51.
4. Hartwell LH. Sequential function of gene products relative to DNA synthesis in the yeast cell cycle. J Mol Biol 1976;104:803-17.
5. Donaldson AD, Fangman WL, Brewer BJ. Cdc7 is required throughout the yeast S phase to activate replication origins. Genes Dev 1998;12:491-501.
6. Bousset K, Diffley JF. The Cdc7 protein kinase is required for origin firing during S phase. Genes Dev 1998;12:480-90.
7. Jiang W, McDonald D, Hope TJ, Hunter T. Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication. EMBO J 1999;18:5703-13.
8. Kim JM, Nakao K, Nakamura K, et al. Inactivation of Cdc7 kinase in mouse ES cells results in S-phase arrest and p53-dependent cell death. EMBO J 2002;21:2168-79.
9. Sclafani RA. Cdc7p-Dbf4p becomes famous in the cell cycle. J Cell Sci 2000;113:2111-7.
10. Johnston LH, Masai H, Sugino A. A Cdc7p-Dbf4p protein kinase activity is conserved from yeast to humans. Prog Cell Cycle Res 2000;4:61-9.
11. Kumagai H, Sato N, Yamada M, et al. A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells. Mol Cell Biol 1999;19:5083-95.
12. Montagnoli A, Bosotti R, Villa F, et al. Drf1, a novel regulatory subunit for human Cdc7 kinase. EMBO J 2002;21:3171-81.
13. Kim JM, Yamada M, Masai H. Functions of mammalian Cdc7 kinase in initiation/ monitoring of DNA replication and development. Mutat Res 2003;532:29-40.
14. Duncker BP, Brown GW. Cdc7 kinases (DDKs) and checkpoint responses: lessons from two yeasts. Mutat Res 2003;532:21-7.
15. Costanzo V, Shechter D, Lupardus PJ, Cimprich KA, Gottesman M, Gautier J. An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Mol Cell 2003;11:203-13.
16. Yanow SK, Gold DA, Yoo HY, Dunphy WG. Xenopus Drf1, a regulator of Cdc7, displays checkpoint-dependent accumulation on chromatin during an S-phase arrest. J Biol Chem 2003;278:41083-92.
17. Chabner BA, Ryan DP, Paz-Arez L, Garcia-Carbonero R, Calabresi P. Antineoplastic agents. In: Hardman JG, Limbird LE, Gilman AG, editors. The pharmacological basis of therapeutics, 10th edition. New York: McGraw-Hill, 2001. p. 1389-1460.
18. Santocanale C, Diffley JF. A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication. Nature 1998;395:615-8.
19. Shirahige K, Hori Y, Shiraishi K, et al. Regulation of DNA-replication origins during cell-cycle progression. Nature (Lond) 1998;395:618-21.
20. Tercero JA, Diffley JF. Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint. Nature 2001;412:553-7.
21. Lopes M, Cotta-Ramusino C, Pellicioli A, et al. The DNA replication checkpoint response stabilizes stalled replication forks. Nature (Lond) 2001;412:557-61.
22. Dimitrova DS, Gilbert DM. Temporally coordinated assembly and disassembly of replication factories in the absence of DNA synthesis. Nat Cell Biol 2000;2:686-94.
23. Zhou BB, Elledge SJ. The DNA damage response: putting checkpoints in perspective. Nature (Lond) 2000;408:433-9.
24. Vaze MB, Pellicioli A, Lee SE, et al. Recovery from checkpoint-mediated arrest after repair of a double-strand break requires Srs2 helicase. Mol Cell 2002;10:373-85.
25. Lindahl T, Wood RD. Quality control by DNA repair. Science 1999;286:1897-905.
26. Sogo JM, Lopes M, Foiani M. Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects. Science (Wash DC) 2002;297:599-602.
27. Vousden KH, Lu X. Live or let die: the cell's response to p53. Nat Rev Cancer 2002;2:594-604.
28. Gottifredi V, Shieh S, Taya Y, Prives C. p53 accumulates but is functionally impaired when DNA synthesis is blocked. Proc Nad Acad Sci USA 2001;98:1036-41.
29. Taylor WR, Agarwal ML, Agarwal A, Stacey DW. Stark GR. p53 inhibits entry into mitosis when DNA synthesis is blocked. Oncogene 1999;18:283-95.
30. Rialland M, Sola F, Santocanale C. Essential rote of human CDT1 in DNA replication and chromatin licensing. J Cell Sci 2002;115:1435-40.
31. Borel F, Lacroix FB, Margolis RL. Prolonged arrest of mammalian cells at the G1/S boundary results in permanent S phase stasis. J Cell Sci 2002;115:2829-38.
32. Liu Q, Guntuku S, Cui XS, et al. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev 2000;14:1448-59.
33. Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ. Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc Natl Acad Sci USA 2000;97:10389-94.
34. Busino L, Donzelli M, Chiesa M, et al. Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. Nature (Lond) 2003;426:87-91.
35. Jin J, Shirogane T, Xu L, et al. SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes Dev 2003;17:3062-74.
36. Mailand N, Falck J, Lukas C, et al. Rapid destruction of human Cdc25A in response to DNA damage. Science 2000;288:1425-9.
37. Kanda T, Sullivan KF, Wahl GM. Histone-GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells. Curr Biol 1998;8:377-85.
38. Ward IM, Chen J. Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J Biol Chem 2001;276:47759-62.
39. Rogakou EP, Nieves-Neira W, Boon C, Pommier Y, Bonner WM. Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139. J Biol Chem 2000;275:9390-5.
40. Masai H, Arai K. Cdc7 kinase complex: a key regulator in the initiation of DNA replication. J Cell Physiol 2002;190:287-96.
41. Bailis JM, Bernard P, Antonelli R, Allshire RC, Forsburg SL. Hsk1-Dfp1 is required for heterochromatin-mediated cohesion at centromeres. Nat Cell Biol 2003;5:1111-6.
42. Shreeram S, Sparks A, Lane DP, Blow JJ. Cell type-specific responses of human cells to inhibition of replication licensing. Oncogene 2002;21:6624-32.
43. Feng D, Tu Z, Wu W, Liang C. Inhibiting the expression of DNA replication-initiation proteins induces apoptosis in human cancer cells. Cancer Res 2003;63:7356-64.
44. Sato N, Sato M, Nakayama M, Saitoh R, Arai K, Masai H. Cell cycle regulation of chromatin binding and nuclear localization of human Cdc7-ASK kinase complex. Genes Cells 2003;8:451-63.