Dawn of Aurora kinase inhibitors as anticancer drugs

Expert Opinion on Investigational Drugs

Volumn 13, Issue 9, 2004, Pages 1199-1201

  Doggrell, Sheila A ^a  

^a Doggrell Biomedical Communications   (New Zealand)

Author keywords

Acute myelogenous leukaemia; Aurora kinase; FMS like tyrosine kinase 3; VX 680

Indexed keywords

ANTINEOPLASTIC AGENT; AURORA KINASE INHIBITOR; CISPLATIN; CYCLOPROPANECARBOXYLIC ACID [4 [4 (4 METHYL 1 PIPERAZINYL) 6 (5 METHYL 2H PYRAZOL 3 YLAMINO) 2 PYRIMIDINYLTHIO]PHENYL]AMIDE; HESPERADI; HISTONE H3; N [4 [6 METHOXY 7 (3 MORPHOLINOPROPOXY) 4 QUINAZOLINYLAMINO]PHENYL]BENZAMIDE; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CHEMOTHERAPY; CANCER INHIBITION; CANCER PREVENTION; CANCER SURVIVAL; COLORECTAL CANCER; DRUG POTENCY; DRUG SYNTHESIS; DRUG TARGETING; DRUG TOLERABILITY; ENZYME INHIBITION; GENE OVEREXPRESSION; HUMAN; MELANOMA; NONHUMAN; PANCREAS CANCER; PROSTATE CANCER; STRUCTURE ACTIVITY RELATION; UTERINE CERVIX CANCER;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZAMIDES; ENZYME INHIBITORS; HUMANS; INDOLES; MOLECULAR STRUCTURE; PIPERAZINES; PROTEIN-SERINE-THREONINE KINASES; QUINAZOLINES; SULFONAMIDES;

EID: 4544277193     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.13.9.1199     Document Type: Article

References (5)

1. HARRINGTON EA, BEBBINGTON D, MOORE J et al.: VX-680, a potent and select small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat. Med. (2004) 10:262-267.
2. KATAYAMA H, BRINKLEY WR, SEN S: The Aurora kinases; role in cell transformation and tumorigenesis. Cancer Metastasis Rev. (2003) 22:451-464.
3. GEORGE P, BALI P, COHEN P et al.: Cotreatment with 17-allkylamino-demethoxygeldanamycin and FLT-3 kinase inhibitor PKC412 is highly effective against human acute myelogenous leukemia cells with mutant FLT-3. Cancer Res. (2004) 64:3645-3652.
4. HAUF S, COLE RW, LATERRA S et al.: The small molecule Hesparadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoints. J. Cell Biol. (2003) 161:281-294.
5. DITCHFIELD C, JOHNSON VL, TIGHE A et al.: Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J. Cell Biol. (2003) 161:267-280.