VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

Nature Medicine

Volumn 10, Issue 3, 2004, Pages 262-267

  Harrington, Elizabeth A ^a   Bebbington, David ^a   Moore, Jeff ^a   Rasmussen, Richele K ^a   Ajose Adeogun, Abi O ^a   Nakayama, Tomoko ^a   Graham, Joanne A ^a,c   Demur, Cecile ^b   Hercend, Thierry ^a,d   Diu Hercend, Anita ^a,d   Su, Michael ^a   Golec, Julian M C ^a   Miller, Karen M ^a  

^a VERTEX PHARMACEUTICALS   (United States)

^b INSERM   (France)

^c Decision Resources Intl   (United Kingdom)

^d SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA KINASE; CYCLOPROPANECARBOXYLIC ACID [4 [4 (4 METHYL 1 PIPERAZINYL) 6 (5 METHYL 2H PYRAZOL 3 YLAMINO) 2 PYRIMIDINYLTHIO]PHENYL]AMIDE; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG; ENZYME INHIBITOR; HISTONE; PIPERAZINE DERIVATIVE;

ANEUPLOIDY; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL STRAIN HL 60; CELL STRAIN MCF 7; CHROMOSOME SEGREGATION; COLON TUMOR; CONTROLLED STUDY; CYTOKINESIS; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LEUKEMIA REMISSION; MOUSE; NONHUMAN; PANCREAS TUMOR; PRIORITY JOURNAL; XENOGRAFT; ANIMAL; CELL CYCLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; METABOLISM; NEOPLASM; NUDE MOUSE; PHYSIOLOGY; RAT; TUMOR CELL LINE;

ANIMALIA; MINK CELL FOCUS-FORMING VIRUS;

ANIMALS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; ENZYME INHIBITORS; FEMALE; HISTONES; HUMANS; MICE; MICE, NUDE; MOLECULAR STRUCTURE; NEOPLASMS; PIPERAZINES; PROTEIN-SERINE-THREONINE KINASES; RATS;

EID: 2342639645     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1003     Document Type: Article

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