메뉴 건너뛰기




Volumn 4, Issue 12, 2004, Pages 927-936

Aurora-kinase inhibitors as anticancer agents

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; AURORA A KINASE; AURORA B KINASE; AURORA C KINASE; AURORA KINASE INHIBITOR; CYCLOPROPANECARBOXYLIC ACID [4 [4 (4 METHYL 1 PIPERAZINYL) 6 (5 METHYL 2H PYRAZOL 3 YLAMINO) 2 PYRIMIDINYLTHIO]PHENYL]AMIDE; HESPERIDIN; N [4 [6 METHOXY 7 (3 MORPHOLINOPROPOXY) 4 QUINAZOLINYLAMINO]PHENYL]BENZAMIDE; PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 10344236486     PISSN: 1474175X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrc1502     Document Type: Review
Times cited : (613)

References (52)
  • 1
    • 0032542364 scopus 로고    scopus 로고
    • Genetic instabilities in human cancers
    • Lengauer, C., Kinzler, K.W. & Vogelstein, B. Genetic instabilities in human cancers. Nature 396, 643-649 (1998).
    • (1998) Nature , vol.396 , pp. 643-649
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 2
    • 0035252654 scopus 로고    scopus 로고
    • Chromosomal passengers and the (aurora) ABCs of mitosis
    • Adams, R. R., Camnena, M. & Earnshaw, W. C. Chromosomal passengers and the (aurora) ABCs of mitosis. Trends Cell Biol. 11, 49-54 (2001).
    • (2001) Trends Cell Biol. , vol.11 , pp. 49-54
    • Adams, R.R.1    Camnena, M.2    Earnshaw, W.C.3
  • 4
    • 0035235736 scopus 로고    scopus 로고
    • Mitotic kinases as regulators of cell division and its checkpoints
    • Nigg, E. A. Mitotic kinases as regulators of cell division and its checkpoints. Nature Rev. Mol. Cell Biol. 2, 21-32 (2001).
    • (2001) Nature Rev. Mol. Cell Biol. , vol.2 , pp. 21-32
    • Nigg, E.A.1
  • 5
    • 0032100685 scopus 로고    scopus 로고
    • A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers
    • Bischoff, J. R. et al. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J. 17, 3052-3065 (1998). Describes the identification of the mammalian Aurora-A and -B proteins, demonstrates that both are overexpressed in human tumours and that Aurora-A is an oncogene.
    • (1998) EMBO J. , vol.17 , pp. 3052-3065
    • Bischoff, J.R.1
  • 6
    • 0030962953 scopus 로고    scopus 로고
    • A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines
    • Sen, S., Zhou, H. & White, R. A. A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines. Oncogene 14, 2195-2200 (1997).
    • (1997) Oncogene , vol.14 , pp. 2195-2200
    • Sen, S.1    Zhou, H.2    White, R.A.3
  • 8
    • 0038746733 scopus 로고    scopus 로고
    • The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint
    • Hauf, S. et al. The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J. Cell Biol. 161, 281-294 (2003). First description of Hesperadin, including a careful analysis showing how inhibition of Aurora-kinase activity in human cells results in syntelic orientation of chromosomes.
    • (2003) J. Cell Biol. , vol.161 , pp. 281-294
    • Hauf, S.1
  • 9
    • 0013057087 scopus 로고    scopus 로고
    • Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores
    • Ditchfield, C. et al. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J. Cell Biol. 161, 267-280 (2003). First description of ZM447439, including a careful analysis showing how inhibition of Aurora-kinase activity in human cells compromises the spindle checkpoint and induces endoreduplication in p53-deficient cells.
    • (2003) J. Cell Biol. , vol.161 , pp. 267-280
    • Ditchfield, C.1
  • 10
    • 2342639645 scopus 로고    scopus 로고
    • VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo
    • Harrington, E. A. et al. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nature Med. 10, 262-267 (2004). First description of VX-680, including a demonstration of the antitumour activity of an Aurora-kinase inhibitor in rodent xenograft models.
    • (2004) Nature Med. , vol.10 , pp. 262-267
    • Harrington, E.A.1
  • 11
    • 0141429171 scopus 로고    scopus 로고
    • Aurora-A and an Interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells
    • Hirota, T. et al. Aurora-A and an Interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell. 114, 585-598 (2003).
    • (2003) Cell. , vol.114 , pp. 585-598
    • Hirota, T.1
  • 12
    • 0037586498 scopus 로고    scopus 로고
    • AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol
    • Anand, S., PenrhynLowe, S. & Venkitaraman, A. R. AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol. Cancer Cell 3, 51-62 (2003).
    • (2003) Cancer Cell , vol.3 , pp. 51-62
    • Anand, S.1    PenrhynLowe, S.2    Venkitaraman, A.R.3
  • 13
    • 0037084163 scopus 로고    scopus 로고
    • -/- cells
    • -/- cells. EMBO J. 21, 483-492 (2002). Many tumour cells, including ones with p53 deficiencies, have abnormal numbers of centrosomes. This paper shows that this is not necessarily because the mechanisms that control centrosome amplification are dysregulated, but because cytokinesis often fails when mitotic regulators, including Aurora-A, are overexpressed, leading to a tetraploid cell with four centrosomes.
    • (2002) EMBO J. , vol.21 , pp. 483-492
    • Meraldi, P.1    Honda, R.2    Nigg, E.A.3
  • 14
    • 0033548619 scopus 로고    scopus 로고
    • Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3
    • Kimura, M., Matsuda, Y., Yoshioka, T. & Okano, Y. Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3. J. Biol. Chem. 274, 7334-7340 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 7334-7340
    • Kimura, M.1    Matsuda, Y.2    Yoshioka, T.3    Okano, Y.4
  • 15
    • 8744313990 scopus 로고    scopus 로고
    • Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C
    • 16 Aug (doi: 10.1074/jbc.M 403029200)
    • Li, X. et al. Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C. J. Biol. Chem. 16 Aug 2004 (doi: 10.1074/jbc.M403029200).
    • (2004) J. Biol. Chem.
    • Li, X.1
  • 16
    • 0842281498 scopus 로고    scopus 로고
    • Aurora kinases link chromosome segregation and cell division to cancer susceptibility
    • Meraldi, P., Honda, R. & Nigg, E. A. Aurora kinases link chromosome segregation and cell division to cancer susceptibility. Curr. Opin. Genet. Dev. 14, 29-36 (2004).
    • (2004) Curr. Opin. Genet. Dev. , vol.14 , pp. 29-36
    • Meraldi, P.1    Honda, R.2    Nigg, E.A.3
  • 17
    • 3342887700 scopus 로고    scopus 로고
    • Borealin: A novel chromosomal passenger required for stability of the bipolar mitotic spindle
    • Gassmann, R. et al. Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. J. Cell Biol. 166, 179-191 (2004).
    • (2004) J. Cell Biol. , vol.166 , pp. 179-191
    • Gassmann, R.1
  • 18
    • 0037386929 scopus 로고    scopus 로고
    • Activation and overexpression of centrosome kinase BTAK/Aurora-A in human ovarian cancer
    • Gritsko, T. M. et al. Activation and overexpression of centrosome kinase BTAK/Aurora-A in human ovarian cancer. Clin. Cancer Res. 9, 1420-1426 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , pp. 1420-1426
    • Gritsko, T.M.1
  • 19
    • 0033532869 scopus 로고    scopus 로고
    • Mitotic kinase expression and colorectal cancer progression
    • Katayama, H. et al. Mitotic kinase expression and colorectal cancer progression. J. Natl Cancer Inst. 91, 1160-1162 (1999).
    • (1999) J. Natl. Cancer Inst. , vol.91 , pp. 1160-1162
    • Katayama, H.1
  • 20
    • 0037343237 scopus 로고    scopus 로고
    • Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer
    • Li, D. et al. Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer. Clin. Cancer Res.. 9, 991-997 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , pp. 991-997
    • Li, D.1
  • 21
    • 0035342595 scopus 로고    scopus 로고
    • Association of centrosomal kinase STK15/BTAK mRNA expression with chromosomal instability in human breast cancers
    • Miyoshi, Y., Iwao, K., Egawa, C. & Noguchi, S. Association of centrosomal kinase STK15/BTAK mRNA expression with chromosomal instability in human breast cancers. Int. J. Cancer 92, 370-373 (2001).
    • (2001) Int. J. Cancer , vol.92 , pp. 370-373
    • Miyoshi, Y.1    Iwao, K.2    Egawa, C.3    Noguchi, S.4
  • 22
    • 17744384260 scopus 로고    scopus 로고
    • Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation
    • Sakakura, C. et al. Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation. Br. J. Cancer 84, 824-831 (2001).
    • (2001) Br. J. Cancer , vol.84 , pp. 824-831
    • Sakakura, C.1
  • 23
    • 0037019736 scopus 로고    scopus 로고
    • Amplification/overexpression of a mitotic kinase gene in human bladder cancer
    • Sen, S. et al. Amplification/overexpression of a mitotic kinase gene in human bladder cancer. J. Natl Cancer Inst. 94, 1320-1329 (2002).
    • (2002) J. Natl. Cancer Inst. , vol.94 , pp. 1320-1329
    • Sen, S.1
  • 24
    • 0037373258 scopus 로고    scopus 로고
    • G1 tetraploidy checkpoint and the suppression of tumorigenesis
    • Margolis, R. L., Lohez, O. D. & Andreassen, P. R. G1 tetraploidy checkpoint and the suppression of tumorigenesis. J. Cell. Biochem. 88, 673-683 (2003).
    • (2003) J. Cell. Biochem. , vol.88 , pp. 673-683
    • Margolis, R.L.1    Lohez, O.D.2    Andreassen, P.R.3
  • 25
    • 0036178929 scopus 로고    scopus 로고
    • Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections
    • Tanaka, T. U. et al. Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections. Cell 108, 317-329 (2002). Demonstrates that the budding yeast Aurora kinase Ipl1 destabilizes kinetochore-microtubule interactions that do not yield tension across the centromere.
    • (2002) Cell , vol.108 , pp. 317-329
    • Tanaka, T.U.1
  • 26
    • 14444267778 scopus 로고    scopus 로고
    • How cells get the right chromosomes
    • Nicklas, R.B. How cells get the right chromosomes. Science 275, 632-637 (1997).
    • (1997) Science , vol.275 , pp. 632-637
    • Nicklas, R.B.1
  • 27
    • 0036789555 scopus 로고    scopus 로고
    • The spindle checkpoint: Structural insights into dynamic signalling
    • Musacchio, A. & Hardwick, K. G. The spindle checkpoint: structural insights into dynamic signalling. Nature Rev. Mol. Cell Biol. 3, 731-741 (2002).
    • (2002) Nature Rev. Mol. Cell Biol. , vol.3 , pp. 731-741
    • Musacchio, A.1    Hardwick, K.G.2
  • 28
    • 10344241869 scopus 로고    scopus 로고
    • The spindle checkpoint: A quality control mechanism which ensures accurate chromosome segregation
    • Taylor, S. S., Scott, M. I. & Holland, A. J. The spindle checkpoint: a quality control mechanism which ensures accurate chromosome segregation. Chromosome Res. 12, 599-616 (2004).
    • (2004) Chromosome Res. , vol.12 , pp. 599-616
    • Taylor, S.S.1    Scott, M.I.2    Holland, A.J.3
  • 29
    • 0035577762 scopus 로고    scopus 로고
    • The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint
    • Biggins, S. & Murray, A. W. The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint. Genes Dev. 15, 3118-3129 (2001). Demonstrates that the budding yeast Aurora kinase Ipl1 activates the spindle checkpoint in the absence of tension across the centromere.
    • (2001) Genes Dev. , vol.15 , pp. 3118-3129
    • Biggins, S.1    Murray, A.W.2
  • 30
    • 0031938231 scopus 로고    scopus 로고
    • The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involved in bipolar mitotic spindle assembly
    • Roghi, C. et al. The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involved in bipolar mitotic spindle assembly. J. Cell Sci. 111, 557-572 (1998).
    • (1998) J. Cell Sci. , vol.111 , pp. 557-572
    • Roghi, C.1
  • 31
    • 0028938482 scopus 로고
    • Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles
    • Glover, D. M., Leibowitz, M. H., McLean, D. A. & Parry, H. Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. Cell 81, 95-105 (1995).
    • (1995) Cell , vol.81 , pp. 95-105
    • Glover, D.M.1    Leibowitz, M.H.2    McLean, D.A.3    Parry, H.4
  • 32
    • 0347324949 scopus 로고    scopus 로고
    • Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells
    • Marumoto, T. et al. Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells. J. Biol. Chem. 278, 51786-51795 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 51786-51795
    • Marumoto, T.1
  • 33
    • 0037018843 scopus 로고    scopus 로고
    • The kinase activity of aurora B is required for kinetochore-microtubule interactions during mitosis
    • MurataHori, M. & Wang, Y. L. The kinase activity of aurora B is required for kinetochore-microtubule interactions during mitosis. Curr. Biol. 12, 894-899 (2002).
    • (2002) Curr. Biol. , vol.12 , pp. 894-899
    • MurataHori, M.1    Wang, Y.L.2
  • 34
    • 0037018844 scopus 로고    scopus 로고
    • Inhibition of aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis
    • Kallio, M. J., McCleland, M. L., Stukenberg, P. T. & Gorbsky, G. J. Inhibition of aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis. Curr. Biol. 12, 900-905 (2002).
    • (2002) Curr. Biol. , vol.12 , pp. 900-905
    • Kallio, M.J.1    McCleland, M.L.2    Stukenberg, P.T.3    Gorbsky, G.J.4
  • 35
    • 0042170180 scopus 로고    scopus 로고
    • Survivin is required for stable checkpoint activation in taxol-treated HeLa cells
    • Carvalho, A., Carmena, M., Sambade, C., Earnshaw, W. C. & Wheatley, S. P. Survivin is required for stable checkpoint activation in taxol-treated HeLa cells. J. Cell Sci. 116, 14-98 (2003).
    • (2003) J. Cell Sci. , vol.116 , pp. 14-98
    • Carvalho, A.1    Carmena, M.2    Sambade, C.3    Earnshaw, W.C.4    Wheatley, S.P.5
  • 36
    • 0038376119 scopus 로고    scopus 로고
    • Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension
    • Lens, S. M. et al. Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension. EMBO J. 22, 2934-2947 (2003). References 35 and 36 show that repression of the Aurora-B binding partner survivin results in a similar phenotype to that induced by Hesperadin and ZM447439.
    • (2003) EMBO J. , vol.22 , pp. 2934-2947
    • Lens, S.M.1
  • 37
    • 2342439525 scopus 로고    scopus 로고
    • Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression
    • Johnson, V. L., Scott, M. I., Holt, S. V., Hussein, D. & Taylor, S. S. Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression. J. Cell Sci. 117, 8-89 (2004).
    • (2004) J. Cell Sci. , vol.117 , pp. 8-89
    • Johnson, V.L.1    Scott, M.I.2    Holt, S.V.3    Hussein, D.4    Taylor, S.S.5
  • 38
    • 2342624020 scopus 로고    scopus 로고
    • Aurora-A overexpression leads to override of the microtubule-kinetochore attachment checkpoint
    • Dutertre, S. & Prigent, C. Aurora-A overexpression leads to override of the microtubule-kinetochore attachment checkpoint. Mol. Interv. 3, 127-130 (2003).
    • (2003) Mol. Interv. , vol.3 , pp. 127-130
    • Dutertre, S.1    Prigent, C.2
  • 39
    • 0035858865 scopus 로고    scopus 로고
    • Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation
    • Adams, R. R., Maiato, H., Earnshaw, W. C. & Carmena, M. Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation. J. Cell Biol. 153, 866-880 (2001).
    • (2001) J. Cell Biol. , vol.153 , pp. 866-880
    • Adams, R.R.1    Maiato, H.2    Earnshaw, W.C.3    Carmena, M.4
  • 40
    • 0035911159 scopus 로고    scopus 로고
    • Drosophla aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis
    • Giet, R. & Glover, D. M. Drosophla aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis. J. Cell Biol. 152, 669-682 (2001).
    • (2001) J. Cell Biol. , vol.152 , pp. 669-682
    • Giet, R.1    Glover, D.M.2
  • 41
    • 0032472915 scopus 로고    scopus 로고
    • AIM-1: A mammalian midbody-associated protein required for cytokinesis
    • Terada, Y. et al. AIM-1: a mammalian midbody-associated protein required for cytokinesis. EMBO J. 17, 667-676 (1998).
    • (1998) EMBO J. , vol.17 , pp. 667-676
    • Terada, Y.1
  • 42
    • 0038015849 scopus 로고    scopus 로고
    • Aurora2/BTAK/STK15 is involved in cell cycle checkpoint and cell survival of aggressive non-Hodgkin's lymphoma
    • Hamada, M. et al. Aurora2/BTAK/STK15 is involved in cell cycle checkpoint and cell survival of aggressive non-Hodgkin's lymphoma. Br. J. Haematol. 121, 439-447 (2003).
    • (2003) Br. J. Haematol. , vol.121 , pp. 439-447
    • Hamada, M.1
  • 43
    • 0031714080 scopus 로고    scopus 로고
    • Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
    • Zhou, H. et al. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nature Genet. 20, 189-193 (1998). Reports that overexpression of Aurora-A in mouse fibroblasts induces centrosome duplication-distribution abnormalities, aneuploidy and transformation. Furthermore, overexpression of Aurora-A in human breast epithelial cells revealed similar centrosome abnormalities, as well as induction of aneuploidy.
    • (1998) Nature Genet. , vol.20 , pp. 189-193
    • Zhou, H.1
  • 44
    • 0042093747 scopus 로고    scopus 로고
    • Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human
    • EwartToland, A. et al. Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Nature Genet. 34, 403-412 (2003). Quantitative trait loci mapping of a locus that confers susceptibility to skin tumours in mice identifies Aurora-A. Comparative analysis of human samples identifies a polymorphism in Aurora-A.
    • (2003) Nature Genet. , vol.34 , pp. 403-412
    • EwartToland, A.1
  • 45
    • 9144251019 scopus 로고    scopus 로고
    • Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53
    • Katayama, H. et al. Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. Nature Genet. 36, 55-62 (2004).
    • (2004) Nature Genet. , vol.36 , pp. 55-62
    • Katayama, H.1
  • 46
    • 0034609753 scopus 로고    scopus 로고
    • The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation
    • Walter, A. O., Seghezzi, W., Korver, W., Sheung, J. & Lees, E. The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation. Oncogene 19, 4906-4916 (2000).
    • (2000) Oncogene , vol.19 , pp. 4906-4916
    • Walter, A.O.1    Seghezzi, W.2    Korver, W.3    Sheung, J.4    Lees, E.5
  • 47
    • 0036797682 scopus 로고    scopus 로고
    • Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool
    • Sitnicka, E. et al. Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool. Immunity 17, 463-472 (2002).
    • (2002) Immunity , vol.17 , pp. 463-472
    • Sitnicka, E.1
  • 48
    • 0033615357 scopus 로고    scopus 로고
    • Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen
    • Mayer, T. U. et al. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science 286, 971-974 (1999).
    • (1999) Science , vol.286 , pp. 971-974
    • Mayer, T.U.1
  • 49
    • 2342563857 scopus 로고    scopus 로고
    • Antitumor activity of a kinesin inhibitor
    • Sakowicz, R. et al. Antitumor activity of a kinesin inhibitor. Cancer Res. 64, 3276-3280 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 3276-3280
    • Sakowicz, R.1
  • 50
    • 0037017398 scopus 로고    scopus 로고
    • Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules
    • Giet, R. et al. Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules. J. Cell Biol. 156, 437-451 (2002).
    • (2002) J. Cell Biol. , vol.156 , pp. 437-451
    • Giet, R.1
  • 51
    • 0345256340 scopus 로고    scopus 로고
    • TACC1-chTOG-Aurora A protein complex in breast cancer
    • Conte, N. et al. TACC1-chTOG-Aurora A protein complex in breast cancer. Oncogene 22, 8102-8116 (2003).
    • (2003) Oncogene , vol.22 , pp. 8102-8116
    • Conte, N.1
  • 52
    • 3042667646 scopus 로고    scopus 로고
    • Aurora B-TACC1 protein complex in cytokinesis
    • Delavai, B. et al. Aurora B-TACC1 protein complex in cytokinesis. Oncogene 23, 4516-4522 (2004).
    • (2004) Oncogene , vol.23 , pp. 4516-4522
    • Delavai, B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.