CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation

Journal of Biological Chemistry

Volumn 272, Issue 46, 1997, Pages 29207-29211

  Brooks, Eric E ^a   Gray, Nathanael S ^b   Joly, Alison ^a   Kerwar, Suresh S ^a   Lum, Robert ^a   Mackman, Richard L ^a   Norman, Thea C ^b   Rosete, Jose ^a   Rowe, Michael ^a   Schow, Steven R ^a   Schultz, Peter G ^b   Wang, Xingbo ^a   Wick, Michael M ^a   Shiffman, Dov ^a  

^a CV THERAPEUTICS INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 BIS(2 HYDROXYETHYL)AMINO 9 ISOPROPYL 6 (4 METHOXYBENZYLAMINO)PURINE; ADENOSINE TRIPHOSPHATE; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; BINDING, COMPETITIVE; CDC2-CDC28 KINASES; CELL CYCLE; CELL DIVISION; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASES; ENZYME INHIBITORS; HUMANS; MICE; MUSCLE, SMOOTH, VASCULAR; PROTEIN-SERINE-THREONINE KINASES; PURINES; RATS; RECOMBINANT PROTEINS; SPODOPTERA;

ANIMALIA; MAMMALIA;

EID: 15444355744     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.46.29207     Document Type: Article

References (16)

1. Pines, J. (1994) Semin. Cancer Biol. 5, 305-313
2. Morgan, D. O. (1995) Nature 374, 131-134
3. Sherr C. J. (1996) Science 274, 1672-1677
4. Tsai, L. H., Lees, E. Faha, B. Harlow, E., and Riabowol, K. (1993) Oncogene 8, 1593-1602
5. Pagano, M., Pepperkok, R., Verde, F., Ansorge, W., and Draetta, G. (1992) EMBO J. 11, 961-971
6. van den Heuvel, S., and Harlow, E. (1993) Science 262, 2050-2054
7. Ross, R., (1993) Nature 362, 801-809
8. Wei, G. L., Kransinski, K., Kearney, M., Isner, J. M., Walsh, K., and André, V. (1997) Circ. Res. 80, 418-426
9. Morishita, R., Gibbons, G. H., Ellison, K. E., Nakajima, M., von der Leyen, H., Zhang, L., Kaneda, Y., Ogihara, T., and Dzau, V. J. (1994) J. Clin. Invest. 93, 1458-1464
10. Abe, J., Zhou, W., Taguchi, J., Takuwa, N., Miki, K., Okazaki, H., Hurokawa, K., Kumada, M., and Takuwa, Y. (1994) Biocham. Biophys. Res. Commun. 198, 16-24
11. Vesely, J., Havlicek, L., Strand, M., Blow, J. J., Donella-Deana, A., Pinna, L., Letham, D. S., Kato, J., Detivaud, L., Leclerc, S., and Meijer, L. (1994) Eur. J. Biochem. 224, 771-786
12. De Bondt, H. L., Rosenblatt, J., Jancarick, J., Jones, H. D., Morgan, D. O., and Kim, S. (1993) Nature 363, 595-602
13. Norman, T. C., Gray, N. S., Koh, J. T., and Schultz, P. G. (1996) J. Am. Chem. Soc. 118, 7430-7431
14. Nugiel, D. A., Cornelius, L. A. M., and Corbett. J. W. (1997) J. Org. Chem. 62, 201-203
15. Fisher, R. P., and Morgan D. O. (1994) Cell 78, 713-724
16. Weinberg, R. A. (1995) Cell 18, 323-330