AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol

Cancer Cell

Volumn 3, Issue 1, 2003, Pages 51-62

  Anand, Shubha ^a   Penrhyn Lowe, Sue ^a   Venkitaraman, Ashok R ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PACLITAXEL; PROTEIN; PROTEIN BUB; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; AURORA KINASE; BUB1 SPINDLE CHECKPOINT PROTEIN; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE;

ANAPHASE; ANIMAL CELL; APOPTOSIS; ARTICLE; AURORA A GENE; CANCER RESISTANCE; CELL ACTIVITY; CELL COUNT; CENTROMERE; CONTROLLED STUDY; CYTOKINESIS; DISEASE ASSOCIATION; EMBRYO; GENE; GENE AMPLIFICATION; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC STRAIN; MITOSIS; MITOSIS SPINDLE; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; ANIMAL; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECT; DRUG RESISTANCE; FIBROBLAST; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC TRANSFECTION; GENETICS; HELA CELL; HUMAN; MUTATION; PHYSIOLOGY; WESTERN BLOTTING;

ANIMALIA;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BLOTTING, WESTERN; CELLS, CULTURED; DRUG RESISTANCE, NEOPLASM; EMBRYO; FIBROBLASTS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENE AMPLIFICATION; GENES, CDC; HELA CELLS; HUMANS; MICE; MITOSIS; MITOTIC SPINDLE APPARATUS; MUTATION; PACLITAXEL; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; TRANSFECTION;

EID: 0037586498     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1535-6108(02)00235-0     Document Type: Article

References (52)

1. Adams R.R., Wheatleya S.P., Gouldsworthy A.M., Kandels-Lewis S.E., Carmena M., Smythe C., Gerloff D.L., Earnshaw W.C. INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow. Curr. Biol. 10:2000;1075-1078.
2. Adams R.R., Maiato H., Earnshaw W.C., Carmena M. Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation. J. Cell Biol. 153:2001;865-880.
3. Biggins S., Murray A.W. The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint. Genes Dev. 15:2001;3118-3129.
4. Biggins S., Severin F.F., Bhalla N., Sassoon I., Hyman A.A., Murray A.W. The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast. Genes Dev. 13:1999;532-544.
5. Bischoff J.R., Plowman G.D. The Aurora/Ipl1p kinase family. regulators of chromosome segregation and cytokinesis Trends Cell Biol. 9:1999;454-459.
6. Bischoff J.R., Anderson L., Zhu Y., Mossie K., Ng L., Souza B., Schryver B., Flanagan P., Clairvoyant F., Ginther C., et al. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J. 17:1998;3052-3065.
7. Cahill D.P., Lengauer C., Yu J., Riggins G.J., Willson J.K., Markowitz S.D., Kinzler K.W., Vogelstein B. Mutations of mitotic checkpoint genes in human cancers. Nature. 392:1998;300-303.
8. Cahill D.P., da Costa L.T., Carson-Walter E.B., Kinzler K.W., Vogelstein B., Lengauer C. Characterization of MAD2B and other mitotic spindle checkpoint genes. Genomics. 58:1999;181-187.
9. Chan C.S., Botstein D. Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast. Genetics. 135:1993;677-691.
10. Crosio C., Fimia G.M., Loury R., Kimura M., Okano Y., Zhou H., Sen S., Allis C.D., Sassone-Corsi P. Mitotic phosphorylation of histone H3. spatio-temporal regulation by mammalian Aurora kinases Mol. Cell. Biol. 22:2002;874-885.
11. Furuno N., den Elzen N., Pines J. Human cyclin A is required for mitosis until mid prophase. J. Cell Biol. 147:1999;295-306.
12. Giet R., Prigent C. Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases. J. Cell Sci. 112:1999;3591-3601.
13. Giet R., Glover D.M. Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis. J. Cell Biol. 152:2001;669-682.
14. Giet R., McLean D., Descamps S., Lee M.J., Raff J.W., Prigent C., Glover D.M. Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules. J. Cell Biol. 156:2002;437-451.
15. Gopalan G., Chan C.S., Donovan P.J. A novel mammalian, mitotic spindle-associated kinase is related to yeast and fly chromosome segregation regulators. J. Cell Biol. 138:1997;643-656.
16. Hannak E., Kirkham M., Hyman A.A., Oegema K. Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans. J. Cell Biol. 155:2001;1109-1116.
17. Haruki N., Saito H., Harano T., Nomoto S., Takahashi T., Osada H., Fujii Y. Molecular analysis of the mitotic checkpoint genes BUB1, BUBR1 and BUB3 in human lung cancers. Cancer Lett. 162:2001;201-205.
18. He X., Rines D.R., Espelin C.W., Sorger P.K. Molecular analysis of kinetochore-microtubule attachment in budding yeast. Cell. 106:2001;195-206.
19. Hoffman D.B., Pearson C.G., Yen T.J., Howell B.J., Salmon E.D. Microtubule-dependent changes in assembly of microtubule motor proteins and mitotic spindle checkpoint proteins at PtK1 kinetochores. Mol. Biol. Cell. 12:2001;1995-2009.
20. Hsu J.Y., Sun Z.W., Li X., Reuben M., Tatchell K., Bishop D.K., Grushcow J.M., Brame C.J., Caldwell J.A., Hunt D.F., et al. Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes. Cell. 102:2000;279-291.
21. Hugo P., Kappler J.W., Godfrey D.I., Marrack P.C. A cell line that can induce thymocyte positive selection. Nature. 360:1992;679-682.
22. Kaitna S., Mendoza M., Jantsch-Plunger V., Glotzer M. Incenp and an aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis. Curr. Biol. 10:2000;1172-1181.
23. Kallio M.J., McCleland M.L., Stukenberg P.T., Gorbsky G.J. Inhibition of aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis. Curr. Biol. 12:2002;900-905.
24. Kallioniemi A., Kallioniemi O.P., Piper J., Tanner M., Stokke T., Chen L., Smith H.S., Pinkel D., Gray J.W., Waldman F.M. Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization. Proc. Natl. Acad. Sci. USA. 91:1994;2156-2160.
25. Katayama H., Ota T., Jisaki F., Ueda Y., Tanaka T., Odashima S., Suzuki F., Terada Y., Tatsuka M. Mitotic kinase expression and colorectal cancer progression. J. Natl. Cancer Inst. 91:1999;1160-1162.
26. Kim J.H., Kang J.S., Chan C.S. Sli15 associates with the ipl1 protein kinase to promote proper chromosome segregation in Saccharomyces cerevisiae. J. Cell Biol. 145:1999;1381-1394.
27. Kimura M., Kotani S., Hattori T., Sumi N., Yoshioka T., Todokoro K., Okano Y. Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ipl1. J. Biol. Chem. 272:1997;13766-13771.
28. Lee H., Trainer A.H., Friedman L.S., Thistlethwaite F.C., Evans M.J., Ponder B.A., Venkitaraman A.R. Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2. Mol. Cell. 4:1999;1-10.
29. Li Y., Bachant J., Alcasabas A.A., Wang Y., Qin J., Elledge S.J. The mitotic spindle is required for loading of the DASH complex onto the kinetochore. Genes Dev. 16:2002;183-197.
30. Meraldi P., Honda R., Nigg E.A. Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells. EMBO J. 21:2002;483-492.
31. Miyoshi Y., Iwao K., Egawa C., Noguchi S. Association of centrosomal kinase STK15/BTAK mRNA expression with chromosomal instability in human breast cancers. Int. J. Cancer. 92:2001;370-373.
32. Murata-Hori M., Wang Y. The kinase activity of Aurora B is required for kinetochore-microtubule interactions during mitosis. Curr. Biol. 12:2002;894-899.
33. Myrie K.A., Percy M.J., Azim J.N., Neeley C.K., Petty E.M. Mutation and expression analysis of human BUB1 and BUB1B in aneuploid breast cancer cell lines. Cancer Lett. 152:2000;193-199.
34. Nigg E.A. Mitotic kinases as regulators of cell division and its checkpoints. Nat. Rev. Mol. Cell Biol. 2:2001;21-32.
35. Patel K.J., Yu V.P., Lee H., Corcoran A., Thistlethwaite F.C., Evans M.J., Colledge W.H., Friedman L.S., Ponder B.A., Venkitaraman A.R. Involvement of Brca2 in DNA repair. Mol. Cell. 1:1998;347-357.
36. Rowinsky E.K., Donehower R.C. The clinical pharmacology and use of antimicrotubule agents in cancer chemotherapeutics. Pharmacol. Ther. 52:1991;35-84.
37. Sakakura C., Hagiwara A., Yasuoka R., Fujita Y., Nakanishi M., Masuda K., Shimomura K., Nakamura Y., Inazawa J., Abe T., Yamagishi H. Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation. Br. J. Cancer. 84:2001;824-831.
38. Schumacher J.M., Golden A., Donovan P.J. AIR-2. An aurora/ipl1-related protein kinase associated with chromosomes and midbody microtubules is required for polar body extrusion and cytokinesis in caenorhabditis elegans embryos J. Cell Biol. 143:1998;1635-1646.
39. Scrittori L., Hans F., Angelov D., Charra M., Prigent C., Dimitrov S. pEg2 aurora-A kinase, histone H3 phosphorylation, and chromosome assembly in Xenopus egg extract. J. Biol. Chem. 276:2001;30002-30010.
40. Sen S., Zhou H., White R.A. A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines. Oncogene. 14:1997;2195-2200.
41. Serrano M., Lin A.W., McCurrach M.E., Beach D., Lowe S.W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell. 88:1997;593-602.
42. Skoufias D.A., Andreassen P.R., Lacroix F.B., Wilson L., Margolis R.L. Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints. Proc. Natl. Acad. Sci. USA. 98:2001;4492-4497.
43. Takahashi T., Futamura M., Yoshimi N., Sano J., Katada M., Takagi Y., Kimura M., Yoshioka T., Okano Y., Saji S. Centrosomal kinases, HsAIRK1 and HsAIRK3, are overexpressed in primary colorectal cancers. Jpn. J. Cancer Res. 91:2000;1007-1014.
44. Tanaka T.U., Rachidi N., Janke C., Pereira G., Galova M., Schiebel E., Stark M.J.R., Nasmyth K. Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections. Cell. 108:2002;317-329.
45. Tanner M.M., Grenman S., Koul A., Johannsson O., Meltzer P., Pejovic T., Borg A., Isola J.J. Frequent amplification of chromosomal region 20q12-q13 in ovarian cancer. Clin. Cancer Res. 6:2000;1833-1839.
46. Taylor S.S., McKeon F. Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage. Cell. 89:1997;727-735.
47. Terada Y., Tatsuka M., Suzuki F., Yasuda Y., Fujita S., Otsu M. AIM-1. a mammalian midbody-associated protein required for cytokinesis EMBO J. 17:1998;667-676.
48. Vaughan P.S., Miura P., Henderson M., Byrne B., Vaughan K.T. A role for regulated binding of p150(Glued) to microtubule plus ends in organelle transport. J. Cell Biol. 158:2002;305-319.
49. Wang T.H., Wang H.S., Soong Y.K. Paclitaxel-induced cell death. where the cell cycle and apoptosis come together Cancer. 88:2000;2619-2628.
50. Yamaguchi K., Okami K., Hibi K., Wehage S.L., Jen J., Sidransky D. Mutation analysis of hBUB1 in aneuploid HNSCC and lung cancer cell lines. Cancer Lett. 139:1999;183-187.
51. Zhou H., Kuang J., Zhong L., Kuo W.L., Gray J.W., Sahin A., Brinkley B.R., Sen S. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat. Genet. 20:1998;189-193.
52. Zhou J., Panda D., Landen J.W., Wilson L., Joshi H.C. Minor alteration of microtubule dynamics causes loss of tension across kinetochore pairs and activates the spindle checkpoint. J. Biol. Chem. 277:2002;17200-17208.