메뉴 건너뛰기




Volumn 8, Issue 4 SUPPL., 2002, Pages

Complexities in the development of cyclin-dependent kinase inhibitor drugs

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR;

EID: 0036220822     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4914(02)02308-0     Document Type: Review
Times cited : (155)

References (54)
  • 2
    • 0032146274 scopus 로고    scopus 로고
    • The regulation of E2F by pRB-family proteins
    • (1998) Genes Dev. , vol.12 , pp. 2245-2262
    • Dyson, N.1
  • 7
    • 0033920260 scopus 로고    scopus 로고
    • Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal omain during Human Immunodeficiency Virus Type 1 transcription
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 5077-5086
    • Zhou, M.1
  • 8
    • 0032110627 scopus 로고    scopus 로고
    • Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases
    • (1998) Mol. Cell , vol.2 , pp. 43-53
    • Hengartner, C.J.1
  • 9
    • 15144348173 scopus 로고    scopus 로고
    • Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitro
    • (1997) Genes Dev. , vol.11 , pp. 2622-2632
    • Zhu, Y.1
  • 10
    • 0032127436 scopus 로고    scopus 로고
    • Transcription elongation factor P-TEFb mediate Tat activation of HIV-1 transcription at multiple stages
    • (1998) EMBO J. , vol.17 , pp. 3681-3691
    • Zhou, Q.1
  • 11
    • 0032031706 scopus 로고    scopus 로고
    • Identification of multiple cyclin subunits of human P-TEFb
    • (1998) Genes Dev. , vol.12 , pp. 755-762
    • Peng, J.1
  • 12
    • 0029959881 scopus 로고    scopus 로고
    • Control of RNA polymerase II elongation potential by a novel carboxyl-terminal domain kinase
    • (1996) J. Biol. Chem. , vol.271 , pp. 27176-27183
    • Marshall, N.F.1
  • 13
    • 0032542282 scopus 로고    scopus 로고
    • Upregulation of cyclin T1/CDK9 complexes during T cell activation
    • (1998) Oncogene , vol.17 , pp. 3093-3102
    • Garriga, J.1
  • 14
    • 0035891288 scopus 로고    scopus 로고
    • 7SK small nuclear RNA binds to and inhibit the activity of CDK9/cyclin T complexes
    • (2001) Nature , vol.414 , pp. 322-325
    • Nguyen, V.T.1
  • 15
    • 0035891271 scopus 로고    scopus 로고
    • The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription
    • (2001) Nature , vol.414 , pp. 317-322
    • Yang, Z.1
  • 16
    • 0033798031 scopus 로고    scopus 로고
    • Paullones are potent inhibitors of glycogen synthase kinase-3β and cyclin-dependent kinase 5/p25
    • (2000) Eur. J. Biochem. , vol.267 , pp. 5983-5994
    • Leost, M.1
  • 17
    • 0035823630 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 promotes insulin exocytosis
    • (2001) J. Biol. Chem. , vol.276 , pp. 34199-34205
    • Lilja, L.1
  • 18
    • 0035808457 scopus 로고    scopus 로고
    • Indirubins inhibit glycogen synthase kinase-3β and CDK5/P25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's Disease
    • (2001) J. Biol. Chem. , vol.276 , pp. 251-260
    • Leclerc, S.1
  • 20
    • 0026452974 scopus 로고
    • Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275
    • (1992) J. Natl. Cancer Inst. , vol.84 , pp. 1736-1740
    • Kaur, G.1
  • 21
    • 0033568521 scopus 로고    scopus 로고
    • Down-regulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol
    • (1999) Cancer Res. , vol.59 , pp. 4634-4641
    • Carlson, B.1
  • 22
  • 24
    • 0002557555 scopus 로고    scopus 로고
    • Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol
    • (2001) Genome Biol. , vol.2 , pp. 1-11
    • Lam, L.T.1
  • 25
    • 0031963058 scopus 로고    scopus 로고
    • Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol
    • (1998) Blood , vol.91 , pp. 458-465
    • Parker, B.W.1
  • 26
    • 0032212885 scopus 로고    scopus 로고
    • Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis
    • (1998) J. Clin. Invest. , vol.102 , pp. 1674-1681
    • Patel, V.1
  • 27
    • 0040932434 scopus 로고    scopus 로고
    • The novel cyclin-dependent kinase inhibitor flavopiridol downregulates Bcl-2 and induces growth arrest and apoptosis in chronic B-cell leukemia lines
    • (1997) Blood , vol.90 , pp. 4307-4312
    • Konig, A.1
  • 28
    • 0034661538 scopus 로고    scopus 로고
    • Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocyctic leukemia
    • (2000) Blood , vol.96 , pp. 393-397
    • Kitada, S.1
  • 29
    • 0034721195 scopus 로고    scopus 로고
    • Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles
    • (2000) J. Med. Chem. , vol.43 , pp. 2797-2804
    • Arris, C.E.1
  • 30
    • 0034597571 scopus 로고    scopus 로고
    • Thio- and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: Synthesis and biological effects
    • (2000) J. Med. Chem. , vol.43 , pp. 4126-4134
    • Kim, K.S.1
  • 31
    • 0035818942 scopus 로고    scopus 로고
    • Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): Design, synthesis, enzymatic activities, and X-ray crystallographic analysis
    • (2001) J. Med. Chem. , vol.44 , pp. 4339-4358
    • Bramson, H.N.1
  • 32
    • 0035925574 scopus 로고    scopus 로고
    • Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 436-446
    • Soni, R.1
  • 35
    • 0034910933 scopus 로고    scopus 로고
    • Inhibition of human immunodeficiency virus type 1 transcription by chemical cyclin-dependent kinase inhibitors
    • (2001) J. Virol. , vol.75 , pp. 7266-7279
    • Dai Wang, C.1
  • 36
    • 0032804733 scopus 로고    scopus 로고
    • Sequential dependent enhancement of caspase activation and apoptosis by flavopiridol on paclitaxel-treated human gastric and breast cancer cells
    • (1999) Clin. Cancer Res. , vol.5 , pp. 1876-1883
    • Motwani, M.1
  • 37
    • 0035808599 scopus 로고    scopus 로고
    • Prevention of chemotherapy-reduced alopecia in rats by CDK inhibitors
    • (2001) Science , vol.291 , pp. 134-137
    • Davis, S.T.1
  • 41
    • 0035963435 scopus 로고    scopus 로고
    • Specific protection against breast cancers by cyclin D1 ablation
    • (2001) Nature , vol.411 , pp. 1017-1021
    • Yu, Q.1
  • 43
  • 44
    • 0032491579 scopus 로고    scopus 로고
    • Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway
    • (1998) J. Biol. Chem. , vol.273 , pp. 29864-29872
    • Muise-Helmericks, R.C.1
  • 45
    • 0035810047 scopus 로고    scopus 로고
    • Cdk 10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity
    • (2001) Oncogene , vol.20 , pp. 1832-1838
    • Kasten, M.1    Giordano, A.2
  • 47
    • 0033152760 scopus 로고    scopus 로고
    • Proteasome inhibitors: A novel class of potent and effective antitumor agents
    • (1999) Cancer Res. , vol.59 , pp. 2615-2622
    • Adams, J.1
  • 48
    • 0023647143 scopus 로고
    • Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2
    • (1987) Nature , vol.327 , pp. 31-35
    • Lee, M.G.1    Nurse, P.2
  • 49
    • 0025885070 scopus 로고
    • Isolation of the human cdk2 gene that encodes the cyclin A and adenovirus E1A-associated p33 kinase
    • (1991) Nature , vol.353 , pp. 174-177
    • Tsai, L.-H.1
  • 51
    • 0025286104 scopus 로고
    • Molecular cloning and expression of glycogen synthase kinase-3/factor A
    • (1990) EMBO J. , vol.9 , pp. 2431-2438
    • Woodgett, J.R.1
  • 53
    • 0026721068 scopus 로고
    • A family of human cdc2-related protein kinases
    • (1992) EMBO J. , vol.11 , pp. 2909-2917
    • Meyerson, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.