메뉴 건너뛰기




Volumn 2, Issue 3, 2003, Pages 236-241

Targeting the kinetochore for mitosis-specific inhibitors

Author keywords

Drug target; Kinetochore; Mitosis

Indexed keywords

ANTINEOPLASTIC AGENT; MICROTUBULE ASSOCIATED PROTEIN;

EID: 0642306010     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.2.3.384     Document Type: Review
Times cited : (9)

References (47)
  • 1
    • 0141774441 scopus 로고    scopus 로고
    • (ed. Meijer, L., Jezequel, A., and Roberge, M.) Editions "Life in Progress", Roscoff, France
    • Hadfield JA, Ducki S, Hirst N, McGown AT. in Progress in Cell Cycle Research (ed. Meijer, L., Jezequel, A., and Roberge, M.) 309-325 (Editions "Life in Progress", Roscoff, France, 2003).
    • (2003) Progress in Cell Cycle Research , pp. 309-325
    • Hadfield, J.A.1    Ducki, S.2    Hirst, N.3    McGown, A.T.4
  • 2
    • 0037303101 scopus 로고    scopus 로고
    • Paclitaxel resistance: Molecular mechanisms and pharmacologic manipulation
    • DOI 10.2174/1568009033333754
    • Yusuf RZ, Duan Z, Lamendola DE, Penson RT, Seiden MV. Paclitaxel resistance: molecular mechanisms and pharmacologic manipulation. Curr Cancer Drug Targets 2003; 3:1-19. (Pubitemid 36119417)
    • (2003) Current Cancer Drug Targets , vol.3 , Issue.1 , pp. 1-19
    • Yusuf, R.Z.1    Duan, Z.2    Lamendola, D.E.3    Penson, R.T.4    Seiden, M.V.5
  • 3
    • 0020333277 scopus 로고
    • The formation, structure, and composition of the mammalian kinetochore and kinetochore fiber
    • Rieder CL. The formation, structure, and composition of the mammalian kinetochore and kinetochore fiber. Int Rev Cytol 1982; 79:1-58. (Pubitemid 13178584)
    • (1982) International Review of Cytology , vol.79 , pp. 1-58
    • Rieder, C.L.1
  • 4
    • 0037459109 scopus 로고    scopus 로고
    • Centromeres and kinetochores: From epigenetics to mitotic checkpoint signaling
    • DOI 10.1016/S0092-8674(03)00115-6
    • Cleveland DW, Mao Y, Sullivan KF. Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling. Cell 2003; 112:407-21. (Pubitemid 36263076)
    • (2003) Cell , vol.112 , Issue.4 , pp. 407-421
    • Cleveland, D.W.1    Mao, Y.2    Sullivan, K.F.3
  • 6
    • 0032146974 scopus 로고    scopus 로고
    • The vertebrate cell kinetochore and its roles during mitosis
    • Rieder CL, Salmon ED. The vertebrate cell kinetochore and its roles during mitosis. Trends Cell Biol 1998; 8:310-8.
    • (1998) Trends Cell Biol , vol.8 , pp. 310-318
    • Rieder, C.L.1    Salmon, E.D.2
  • 7
    • 0026767624 scopus 로고
    • CENP-E is a putative kinetochore motor that accumulates just before mitosis
    • Yen TJ, Li G, Schaar BT, Szilak I, Cleveland DW. CENP-E is a putative kinetochore motor that accumulates just before mitosis. Nature 1992; 359:536-9.
    • (1992) Nature , vol.359 , pp. 536-539
    • Yen, T.J.1    Li, G.2    Schaar, B.T.3    Szilak, I.4    Cleveland, D.W.5
  • 8
    • 0025320820 scopus 로고
    • Localization of cytoplasmic dynein to mitotic spindles and kinetochores
    • Steuer ER, Wordeman L, Schroer TA, Sheetz MP. Localization of cytoplasmic dynein to mitotic spindles and kinetochores. Nature 1990; 345:266-8.
    • (1990) Nature , vol.345 , pp. 266-268
    • Steuer, E.R.1    Wordeman, L.2    Schroer, T.A.3    Sheetz, M.P.4
  • 9
    • 0025304455 scopus 로고
    • Cytoplasmic dynein is localized to kinetochores during mitosis
    • Pfarr CM, et al. Cytoplasmic dynein is localized to kinetochores during mitosis. Nature 1990; 345:263-5.
    • (1990) Nature , vol.345 , pp. 263-265
    • Pfarr, C.M.1
  • 10
    • 0028887847 scopus 로고
    • Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosis
    • Wordeman L, Mitchison TJ. Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosis. J Cell Biol 1995; 128:95-104.
    • (1995) J Cell Biol , vol.128 , pp. 95-104
    • Wordeman, L.1    Mitchison, T.J.2
  • 12
  • 14
    • 0031468113 scopus 로고    scopus 로고
    • CENP-E function at kinetochores is essential for chromosome alignment
    • DOI 10.1083/jcb.139.6.1373
    • Schaar BT, Chan GKT, Maddox P, Salmon ED, Yen TJ. CENP-E function at kinetochores is essential for chromosome alignment. J Cell Biol 1997; 139:1373-82. (Pubitemid 28013659)
    • (1997) Journal of Cell Biology , vol.139 , Issue.6 , pp. 1373-1382
    • Schaar, B.T.1    Chan, G.K.T.2    Maddox, P.3    Salmon, E.D.4    Yen, T.J.5
  • 15
    • 0035172929 scopus 로고    scopus 로고
    • CENP-E is essential for reliable bioriented spindle attachment, but chromosome alignment can be achieved via redundant mechanisms in mammalian cells
    • McEwen BF, et al. CENP-E is essential for reliable bioriented spindle attachment, but chromosome alignment can be achieved via redundant mechanisms in mammalian cells. Mol Biol Cell 2001; 12, 2776-89. (Pubitemid 33051942)
    • (2001) Molecular Biology of the Cell , vol.12 , Issue.9 , pp. 2776-2789
    • McEwen, B.F.1    Chan, G.K.T.2    Zubrowski, B.3    Savoian, M.S.4    Sauer, M.T.5    Yen, T.J.6
  • 16
    • 0036744787 scopus 로고    scopus 로고
    • Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E
    • Putkey FR, et al. Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E. Dev Cell 2002; 3:351-65.
    • (2002) Dev Cell , vol.3 , pp. 351-365
    • Putkey, F.R.1
  • 17
    • 0037292454 scopus 로고    scopus 로고
    • The kinesin-related protein MCAK is a microtubule depolymerase that forms an ATP-hydrolyzing complex at microtubule ends
    • DOI 10.1016/S1097-2765(03)00049-2
    • Hunter AW, et al. The kinesin-related protein MCAK is a microtubule depolymerase that forms an ATP-hydrolyzing complex at microtubule ends. Mol Cell 2003; 11:445-57. (Pubitemid 36293838)
    • (2003) Molecular Cell , vol.11 , Issue.2 , pp. 445-457
    • Hunter, A.W.1    Caplow, M.2    Coy, D.L.3    Hancock, W.O.4    Diez, S.5    Wordeman, L.6    Howard, J.7
  • 18
    • 0033534575 scopus 로고    scopus 로고
    • Kin I kinesins are microtubule-destabilizing enzymes
    • DOI 10.1016/S0092-8674(00)80960-5
    • Desai A, Verma S, Mitchison TJ, Walczak CE. Kin I kinesins are microtubule-destabilizing enzymes. Cell 1999; 96:69-78. (Pubitemid 29044154)
    • (1999) Cell , vol.96 , Issue.1 , pp. 69-78
    • Desai, A.1    Verma, S.2    Mitchison, T.J.3    Walczak, C.E.4
  • 19
    • 0642347850 scopus 로고    scopus 로고
    • (ed. Meijer, L., Jezequel, A., and Roberge, M.) Editions "Life in Progress", Roscoff, France
    • Chan GK, Yen TJ. in Progress in Cell Cycle Research (ed. Meijer, L., Jezequel, A., and Roberge, M.) 431-439 (Editions "Life in Progress", Roscoff, France, 2003).
    • (2003) Progress in Cell Cycle Research , pp. 431-439
    • Chan, G.K.1    Yen, T.J.2
  • 20
    • 0038581888 scopus 로고    scopus 로고
    • Inhibition of BUB1 Results in Genomic Instability and Anchorage-independent Growth of Normal Human Fibroblasts
    • Musio A, et al. Inhibition of BUB1 Results in Genomic Instability and Anchorage-independent Growth of Normal Human Fibroblasts. Cancer Res 63, 2855-63 (2003).
    • (2003) Cancer Res , vol.63 , pp. 2855-2863
    • Musio, A.1
  • 21
    • 0034625268 scopus 로고    scopus 로고
    • Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2
    • Dobles M, Liberal V, Scott ML, Benezra R, Sorger PK. Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2. Cell 2000; 101:635-45.
    • (2000) Cell , vol.101 , pp. 635-645
    • Dobles, M.1    Liberal, V.2    Scott, M.L.3    Benezra, R.4    Sorger, P.K.5
  • 22
    • 0026009964 scopus 로고
    • Feedback control of mitosis in budding yeast
    • Li R, Murray AW. Feedback control of mitosis in budding yeast. Cell 1991; 66:519-31. (Pubitemid 121001388)
    • (1991) Cell , vol.66 , Issue.3 , pp. 519-531
    • Li, R.1    Murray, A.W.2
  • 23
    • 0025941405 scopus 로고
    • S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function
    • Hoyt MA, Totis L, Roberts BT. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell 1991; 66:507-17. (Pubitemid 121001387)
    • (1991) Cell , vol.66 , Issue.3 , pp. 507-517
    • Hoyt, M.A.1    Totis, L.2    Roberts, B.T.3
  • 24
    • 0030066347 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint
    • Weiss E, Winey M. The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint. J Cell Biol 1996; 132:111-23. (Pubitemid 26035079)
    • (1996) Journal of Cell Biology , vol.132 , Issue.1-2 , pp. 111-123
    • Weiss, E.1    Winey, M.2
  • 25
    • 0036800379 scopus 로고    scopus 로고
    • Anaphase onset does not require the microtubule-dependent depletion of kinetochore and centromere-binding proteins
    • DOI 10.1242/jcs.00057
    • Canman JC, et al. Anaphase onset does not require the microtubule-dependent depletion of kinetochore and centromere-binding proteins. J Cell Sci 2002; 115:3787-95. (Pubitemid 35203605)
    • (2002) Journal of Cell Science , vol.115 , Issue.19 , pp. 3787-3795
    • Canman, J.C.1    Sharma, N.2    Straight, A.3    Shannon, K.B.4    Fang, G.5    Salmon, E.D.6
  • 27
    • 0029096822 scopus 로고
    • CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis
    • Liao H, Winkfein RJ, Mack G, Rattner JB, Yen TJ. CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis. J Cell Biol 1995; 130:507-18.
    • (1995) J Cell Biol , vol.130 , pp. 507-518
    • Liao, H.1    Winkfein, R.J.2    Mack, G.3    Rattner, J.B.4    Yen, T.J.5
  • 28
    • 0032415592 scopus 로고    scopus 로고
    • The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis
    • DOI 10.1007/s004120050322
    • Jablonski SA, Chan GK, Cooke CA, Earnshaw WC, Yen TJ. The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis. Chromosoma 1998; 107:386-96. (Pubitemid 29057531)
    • (1998) Chromosoma , vol.107 , Issue.6-7 , pp. 386-396
    • Jablonski, S.A.1    Chan, G.K.T.2    Cooke, C.A.3    Earnshaw, W.C.4    Yen, T.J.5
  • 29
    • 0037385783 scopus 로고    scopus 로고
    • Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis
    • Liu ST, et al. Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis. Nat Cell Biol 2003; 5:341-5.
    • (2003) Nat Cell Biol , vol.5 , pp. 341-345
    • Liu, S.T.1
  • 30
    • 0031469851 scopus 로고    scopus 로고
    • Mis6, a fission yeast inner centromere protein, acts during G1/S and forms specialized chromatin required for equal segregation
    • DOI 10.1016/S0092-8674(00)80320-7
    • Saitoh S, Takahashi K, Yanagida M. Mis6, a fission yeast inner centromere protein, acts during G1/S and forms specialized chromatin required for equal segregation. Cell 1997; 90:131-43. (Pubitemid 28009425)
    • (1997) Cell , vol.90 , Issue.1 , pp. 131-143
    • Saitoh, S.1    Takahashi, K.2    Yanagida, M.3
  • 33
    • 0037964265 scopus 로고    scopus 로고
    • 2 phase as defined by CENP-F localization
    • DOI 10.1667/0033-7587(2003)159[0604:DDIHCI]2.0.CO;2
    • Fletcher L, Yen TJ, Muschel RJ. DNA damage in HeLa cells induced arrest at a discrete point in G2 phase as defined by CENP-F localization. Radiat Res 2003; 159:604-11. (Pubitemid 36539239)
    • (2003) Radiation Research , vol.159 , Issue.5 , pp. 604-611
    • Fletcher, L.1    Yen, T.J.2    Muschel, R.J.3
  • 34
    • 0037183886 scopus 로고    scopus 로고
    • Role of hec1 in spindle checkpoint signaling and kinetochore recruitment of mad1/mad2
    • Martin-Lluesma S, Stucke VM, Nigg EA. Role of hec1 in spindle checkpoint signaling and kinetochore recruitment of mad1/mad2. Science 2002; 297:2267-70.
    • (2002) Science , vol.297 , pp. 2267-2270
    • Martin-Lluesma, S.1    Stucke, V.M.2    Nigg, E.A.3
  • 35
    • 0037175401 scopus 로고    scopus 로고
    • HNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells
    • DeLuca JG, Moree B, Hickey JM, Kilmartin JV, Salmon ED. hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells. J Cell Biol 2002; 159:549-55.
    • (2002) J Cell Biol , vol.159 , pp. 549-555
    • DeLuca, J.G.1    Moree, B.2    Hickey, J.M.3    Kilmartin, J.V.4    Salmon, E.D.5
  • 36
    • 0035931755 scopus 로고    scopus 로고
    • The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation
    • DOI 10.1083/jcb.152.2.349
    • Wigge PA, Kilmartin JV, The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation. J Cell Biol 2001; 152:349-60. (Pubitemid 34285604)
    • (2001) Journal of Cell Biology , vol.152 , Issue.2 , pp. 349-360
    • Wigge, P.A.1    Kilmartin, J.V.2
  • 37
    • 0040471693 scopus 로고    scopus 로고
    • (ed. El-Deiry, W. S.) Humana Press Inc., Totowa, New Jersey
    • Simon JA, Yen TJ. in Methods in Molecular Biology (ed. El-Deiry, W. S.) 555-576 (Humana Press Inc., Totowa, New Jersey, 2003).
    • (2003) Methods in Molecular Biology , pp. 555-576
    • Simon, J.A.1    Yen, T.J.2
  • 38
    • 0034730625 scopus 로고    scopus 로고
    • Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules
    • Ashar HR, et al. Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules. J Biol Chem 2000; 275:30451-7.
    • (2000) J Biol Chem , vol.275 , pp. 30451-30457
    • Ashar, H.R.1
  • 39
    • 0035844247 scopus 로고    scopus 로고
    • The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells
    • Crespo NC, Ohkanda J, Yen TJ, Hamilton AD, Sebti SM. The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells. J Biol Chem 2001; 276:16161-7.
    • (2001) J Biol Chem , vol.276 , pp. 16161-16167
    • Crespo, N.C.1    Ohkanda, J.2    Yen, T.J.3    Hamilton, A.D.4    Sebti, S.M.5
  • 40
    • 0036714596 scopus 로고    scopus 로고
    • Farnesylation of Cenp-F is required for G2/M progression and degradation after mitosis
    • Hussein D, Taylor SS. Farnesylation of Cenp-F is required for G2/M progression and degradation after mitosis. J Cell Sci 2002; 115:3403-14. (Pubitemid 34994030)
    • (2002) Journal of Cell Science , vol.115 , Issue.17 , pp. 3403-3414
    • Hussein, D.1    Taylor, S.S.2
  • 41
    • 0037046861 scopus 로고    scopus 로고
    • Chromosome dynamics: New light on Aurora B kinase function
    • Shannon KB, Salmon ED. Chromosome dynamics: new light on Aurora B kinase function. Curr Biol 2002; 12:R458-60.
    • (2002) Curr Biol , vol.12
    • Shannon, K.B.1    Salmon, E.D.2
  • 42
    • 0033231927 scopus 로고    scopus 로고
    • The Aurora/Ipl1p kinase family: Regulators of chromosome segregation and cytokinesis
    • Bischoff JR, Plowman GD. The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis. Trends Cell Biol1999; 9:454-9.
    • (1999) Trends Cell Biol , vol.9 , pp. 454-459
    • Bischoff, J.R.1    Plowman, G.D.2
  • 44
    • 0038746733 scopus 로고    scopus 로고
    • The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint
    • In Press
    • Hauf S, et al. The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J Cell Biol 2003; In Press.
    • (2003) J Cell Biol
    • Hauf, S.1
  • 45
    • 0035252654 scopus 로고    scopus 로고
    • Chromosomal passengers and the (aurora) ABCs of mitosis
    • DOI 10.1016/S0962-8924(00)01880-8, PII S0962892400018808
    • Adams RR, Carmena M, Earnshaw WC. Chromosomal passengers and the (aurora) ABCs of mitosis. Trends Cell Biol 2001; 11:49-54. (Pubitemid 32144751)
    • (2001) Trends in Cell Biology , vol.11 , Issue.2 , pp. 49-54
    • Adams, R.R.1    Carmena, M.2    Earnshaw, W.C.3
  • 46
    • 0036178929 scopus 로고    scopus 로고
    • Evidence that the Ipl1-Sli15 (Aurora Kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections
    • DOI 10.1016/S0092-8674(02)00633-5
    • Tanaka TU, et al. Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections. Cell 2002; 108:317-29. (Pubitemid 34178397)
    • (2002) Cell , vol.108 , Issue.3 , pp. 317-329
    • Tanaka, T.U.1    Rachidi, N.2    Janke, C.3    Pereira, G.4    Galova, M.5    Schiebel, E.6    Stark, M.J.R.7    Nasmyth, K.8
  • 47
    • 0032101688 scopus 로고    scopus 로고
    • Localization of Mad 2 to kinetochores depends on microtubule attachment, not tension
    • Waters JC, Chen RH, Murray AW, Salmon ED. Localization of Mad 2 to kinetochores depends on microtubule attachment, not tension. J Cell Biol 1998; 141:1181-91.
    • (1998) J Cell Biol , vol.141 , pp. 1181-1191
    • Waters, J.C.1    Chen, R.H.2    Murray, A.W.3    Salmon, E.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.