-
2
-
-
0001769577
-
Über mehrpolige Mitosen als Mittel zur analyse des zellkerns
-
Boveri, T. Über mehrpolige Mitosen als Mittel zur analyse des zellkerns. Verh. d. phys.med. Ges. Würzburg N. F. 35, 67-90 (1902).
-
(1902)
Verh. D. Phys.med. Ges. Würzburg N. F.
, vol.35
, pp. 67-90
-
-
Boveri, T.1
-
3
-
-
33646065584
-
Ueber asymmetrische Zellheilteilung in epithelkrebsen und deren biologische bedeutung
-
von Hansemann, D. Ueber asymmetrische Zellheilteilung in epithelkrebsen und deren biologische bedeutung. Virschows Arch. Pathol. Anat. 119, 299-326 (1890).
-
(1890)
Virschows Arch. Pathol. Anat.
, vol.119
, pp. 299-326
-
-
Von Hansemann, D.1
-
6
-
-
0031004175
-
Genetic instability in colorectal cancers
-
Lengauer, C., Kinzler, K. W. & Vogelstein, B. Genetic instability in colorectal cancers. Nature 386, 623-627 (1997).
-
(1997)
Nature
, vol.386
, pp. 623-627
-
-
Lengauer, C.1
Kinzler, K.W.2
Vogelstein, B.3
-
7
-
-
2942567685
-
Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint
-
Kops, G. J., Foltz, D. R. & Cleveland, D. W. Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint. Proc. Natl Acad. Sci. USA 101, 8699-8704 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 8699-8704
-
-
Kops, G.J.1
Foltz, D.R.2
Cleveland, D.W.3
-
8
-
-
1842533070
-
Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells
-
Michel, L. et al. Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells. Proc. Natl Acad. Sci. USA 101, 4459-4464 (2004). References 7 and 8 show that the complete inhibition of the mitotic checkpoint causes death in human tumour cells.
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 4459-4464
-
-
Michel, L.1
-
9
-
-
0033396407
-
How aneuploidy may cause cancer and genetic instability
-
Duesberg, P. et al. How aneuploidy may cause cancer and genetic instability. Anticancer Res. 19, 4887-4906 (1999).
-
(1999)
Anticancer Res.
, vol.19
, pp. 4887-4906
-
-
Duesberg, P.1
-
10
-
-
0030799909
-
Somatic mutations of PTEN in glioblastoma multiforme
-
Wang, S. I. et al. Somatic mutations of PTEN in glioblastoma multiforme. Cancer Res. 57, 4183-4186 (1997).
-
(1997)
Cancer Res.
, vol.57
, pp. 4183-4186
-
-
Wang, S.I.1
-
11
-
-
0037174667
-
Cancer biology. A matter of dosage
-
Fodde, R. & Smits, R. Cancer biology. A matter of dosage. Science 298, 761-763 (2002).
-
(2002)
Science
, vol.298
, pp. 761-763
-
-
Fodde, R.1
Smits, R.2
-
12
-
-
12144290775
-
Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients
-
Wang, T. L. et al. Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients. Proc. Natl Acad. Sci. USA 101, 3089-3094 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 3089-3094
-
-
Wang, T.L.1
-
13
-
-
0035976571
-
Research on resistance to cancer drug Gleevec
-
Sawyers, C. L. Research on resistance to cancer drug Gleevec. Science 294, 1834 (2001).
-
(2001)
Science
, vol.294
, pp. 1834
-
-
Sawyers, C.L.1
-
14
-
-
0347762556
-
From polyploidy to aneuploidy, genome instability and cancer
-
Storchova, Z. & Pellman, D. From polyploidy to aneuploidy, genome instability and cancer. Nature Rev. Mol. Cell Biol. 5, 45-54 (2004).
-
(2004)
Nature Rev. Mol. Cell Biol.
, vol.5
, pp. 45-54
-
-
Storchova, Z.1
Pellman, D.2
-
15
-
-
0036831681
-
Centrosome aberrations: Cause or consequence of cancer progression?
-
Nigg, E. A. Centrosome aberrations: cause or consequence of cancer progression? Nature Rev. Cancer 2, 815-825 (2002).
-
(2002)
Nature Rev. Cancer
, vol.2
, pp. 815-825
-
-
Nigg, E.A.1
-
16
-
-
0031714080
-
Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
-
Zhou, H. et al. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nature Genet. 20, 189-193 (1998).
-
(1998)
Nature Genet.
, vol.20
, pp. 189-193
-
-
Zhou, H.1
-
17
-
-
0029881977
-
Abnormal centrosome amplification in the absence of p53
-
Fukasawa, K., Choi, T., Kuriyama, R., Rulong, S. & Vande Woude, G. F. Abnormal centrosome amplification in the absence of p53. Science 271, 1744-1747 (1996).
-
(1996)
Science
, vol.271
, pp. 1744-1747
-
-
Fukasawa, K.1
Choi, T.2
Kuriyama, R.3
Rulong, S.4
Vande Woude, G.F.5
-
18
-
-
0037048290
-
Roles of BRCA1 in centrosome duplication
-
Deng, C. X. Roles of BRCA1 in centrosome duplication. Oncogene 21, 6222-6227 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 6222-6227
-
-
Deng, C.X.1
-
19
-
-
0030910680
-
Isolation and characterization of a pituitary tumor-transforming gene (PTTG)
-
Pei, L. & Melmed, S. Isolation and characterization of a pituitary tumor-transforming gene (PTTG). Mol. Endocrinol 11, 433-441 (1997).
-
(1997)
Mol. Endocrinol
, vol.11
, pp. 433-441
-
-
Pei, L.1
Melmed, S.2
-
20
-
-
0027059021
-
Requirement for ESP1 in the nuclear division of Saccharomyces cerevisiae
-
McGrew, J. T., Goetsch, L., Byers, B. & Baum, P. Requirement for ESP1 in the nuclear division of Saccharomyces cerevisiae. Mol. Biol. Cell 3, 1443-1454 (1992).
-
(1992)
Mol. Biol. Cell
, vol.3
, pp. 1443-1454
-
-
McGrew, J.T.1
Goetsch, L.2
Byers, B.3
Baum, P.4
-
21
-
-
0025078529
-
The fission yeast cut1+ gene regulates spindle pole body duplication and has homology to the budding yeast ESP1 gene
-
Uzawa, S., Samejima, I., Hirano, T., Tanaka, K. & Yanagida, M. The fission yeast cut1+ gene regulates spindle pole body duplication and has homology to the budding yeast ESP1 gene. Cell 62, 913-925 (1990).
-
(1990)
Cell
, vol.62
, pp. 913-925
-
-
Uzawa, S.1
Samejima, I.2
Hirano, T.3
Tanaka, K.4
Yanagida, M.5
-
22
-
-
0029997447
-
Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae
-
Yamamoto, A., Guacci, V. & Koshland, D. Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae. J. Cell Biol. 133, 85-97 (1996).
-
(1996)
J. Cell Biol.
, vol.133
, pp. 85-97
-
-
Yamamoto, A.1
Guacci, V.2
Koshland, D.3
-
23
-
-
0035906989
-
Securin is required for chromosomal stability in human cells
-
Jallepalli, P. V. et al. Securin is required for chromosomal stability in human cells. Cell 105, 445-457 (2001).
-
(2001)
Cell
, vol.105
, pp. 445-457
-
-
Jallepalli, P.V.1
-
24
-
-
0032894720
-
Structure, expression, and function of human pituitary tumor-transforming gene (PTTG)
-
Zhang, X. et al. Structure, expression, and function of human pituitary tumor-transforming gene (PTTG). Mol. Endocrinol. 13, 156-166 (1999).
-
(1999)
Mol. Endocrinol.
, vol.13
, pp. 156-166
-
-
Zhang, X.1
-
25
-
-
0033018670
-
Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas
-
Zhang, X. et al. Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas. J. Clin. Endocrinol. Metab. 84, 761-767 (1999).
-
(1999)
J. Clin. Endocrinol. Metab.
, vol.84
, pp. 761-767
-
-
Zhang, X.1
-
26
-
-
0035972237
-
Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells
-
Cimini, D. et al. Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells. J. Cell Biol. 153, 517-527 (2001).
-
(2001)
J. Cell Biol.
, vol.153
, pp. 517-527
-
-
Cimini, D.1
-
27
-
-
3342887700
-
Borealin: A nova chromosomal passenger required for stability of the bipolar mitotic spindle
-
Gassmann, R. et al. Borealin: a nova chromosomal passenger required for stability of the bipolar mitotic spindle. J. Cell Biol. 166, 179-191 (2004).
-
(2004)
J. Cell Biol.
, vol.166
, pp. 179-191
-
-
Gassmann, R.1
-
28
-
-
0035067391
-
A role for the adenomatous polyposis coli protein in chromosome segregation
-
Kaplan, K. B. et al. A role for the adenomatous polyposis coli protein in chromosome segregation. Nature Cell Biol. 3, 429-432 (2001).
-
(2001)
Nature Cell Biol.
, vol.3
, pp. 429-432
-
-
Kaplan, K.B.1
-
29
-
-
0035070046
-
Mutations in the APC tumour suppressor gene cause chromosomal instability
-
Fodde, R. et al. Mutations in the APC tumour suppressor gene cause chromosomal instability. Nature Cell Biol. 3, 433-438 (2001).
-
(2001)
Nature Cell Biol.
, vol.3
, pp. 433-438
-
-
Fodde, R.1
-
30
-
-
0035496104
-
APC, signal transduction and genetic instability in colorectal cancer
-
Fodde, R., Smits, R. & Clevers, H. APC, signal transduction and genetic instability in colorectal cancer Nature Rev. Cancer 1, 55-67 (2001).
-
(2001)
Nature Rev. Cancer
, vol.1
, pp. 55-67
-
-
Fodde, R.1
Smits, R.2
Clevers, H.3
-
31
-
-
0346849717
-
Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC
-
Green, R. A. & Kaplan, K. B. Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC. J. Cell Biol 163, 949-961 (2003).
-
(2003)
J. Cell Biol
, vol.163
, pp. 949-961
-
-
Green, R.A.1
Kaplan, K.B.2
-
32
-
-
9144242386
-
Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability
-
Shin, H. J. et al. Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability. Cancer Cell 4, 483-497 (2003).
-
(2003)
Cancer Cell
, vol.4
, pp. 483-497
-
-
Shin, H.J.1
-
33
-
-
0030687987
-
Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage
-
Taylor, S. S. & McKeon, F. Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage. Cell 89, 727-735 (1997).
-
(1997)
Cell
, vol.89
, pp. 727-735
-
-
Taylor, S.S.1
McKeon, F.2
-
34
-
-
0036284778
-
The anaphase-promoting complex: Proteolysis in mitosis and beyond
-
Peters, J. M. The anaphase-promoting complex: proteolysis in mitosis and beyond. Mol. Cell 9, 931-943 (2002).
-
(2002)
Mol. Cell
, vol.9
, pp. 931-943
-
-
Peters, J.M.1
-
35
-
-
0037459109
-
Centromeres and kinetochores. from epigenetics to mitotic checkpoint signaling
-
Cleveland, D. W., Mao, Y. & Sullivan, K. F. Centromeres and kinetochores. From epigenetics to mitotic checkpoint signaling. Cell 112, 407-421 (2003).
-
(2003)
Cell
, vol.112
, pp. 407-421
-
-
Cleveland, D.W.1
Mao, Y.2
Sullivan, K.F.3
-
36
-
-
0027942033
-
Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle
-
Rieder, C. L., Schultz, A., Cole, R. & Sluder, G. Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle. J. Cell Biol. 127, 1301-1310 (1994).
-
(1994)
J. Cell Biol.
, vol.127
, pp. 1301-1310
-
-
Rieder, C.L.1
Schultz, A.2
Cole, R.3
Sluder, G.4
-
37
-
-
0030066347
-
The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint
-
Weiss, E. & Winey, M. The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint. J. Cell Biol. 132, 111-123 (1996).
-
(1996)
J. Cell Biol.
, vol.132
, pp. 111-123
-
-
Weiss, E.1
Winey, M.2
-
38
-
-
0026009964
-
Feedback control of mitosis in budding yeast
-
Li, R. & Murray, A. W. Feedback control of mitosis in budding yeast. Cell 66, 519-531 (1991).
-
(1991)
Cell
, vol.66
, pp. 519-531
-
-
Li, R.1
Murray, A.W.2
-
39
-
-
0025941405
-
S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function
-
Hoyt, M. A., Totis, L. & Roberts, B. T. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell 66, 507-517 (1991). References 38 and 39 reported the identification of the molecular components of the mitotic checkpoint in budding yeast.
-
(1991)
Cell
, vol.66
, pp. 507-517
-
-
Hoyt, M.A.1
Totis, L.2
Roberts, B.T.3
-
40
-
-
0035854379
-
Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint
-
Abrieu, A. et al. Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint. Cell 106, 83-93 (2001).
-
(2001)
Cell
, vol.106
, pp. 83-93
-
-
Abrieu, A.1
-
41
-
-
0032478547
-
Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1
-
Jin, D. Y., Spencer, F. & Jeang, K. T. Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1. Cell 93, 81-91 (1998).
-
(1998)
Cell
, vol.93
, pp. 81-91
-
-
Jin, D.Y.1
Spencer, F.2
Jeang, K.T.3
-
42
-
-
10244251532
-
Identification of a human mitotic checkpoint gene: HsMAD2
-
Li, Y. & Benezra, R. Identification of a human mitotic checkpoint gene: hsMAD2. Science 274, 246-248 (1996).
-
(1996)
Science
, vol.274
, pp. 246-248
-
-
Li, Y.1
Benezra, R.2
-
43
-
-
0032514260
-
The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1 -related protein kinase
-
Taylor, S. S., Ha, E. & McKeon, F. The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1 -related protein kinase. J. Cell Biol. 142, 1-11 (1998).
-
(1998)
J. Cell Biol.
, vol.142
, pp. 1-11
-
-
Taylor, S.S.1
Ha, E.2
McKeon, F.3
-
44
-
-
0034664766
-
CENP-E as an essential component of the mitotic checkpoint in vitro
-
Abrieu, A., Kahana, J. A., Wood, K. W. & Cleveland, D. W. CENP-E as an essential component of the mitotic checkpoint in vitro. Cell 102, 817-826 (2000).
-
(2000)
Cell
, vol.102
, pp. 817-826
-
-
Abrieu, A.1
Kahana, J.A.2
Wood, K.W.3
Cleveland, D.W.4
-
45
-
-
0032846338
-
Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC
-
Chan, G. K., Jablonski, S. A., Sudakin, V., Hittle, J. C. & Yen, T. J. Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC. J. Cell Biol. 146, 941-954 (1999).
-
(1999)
J. Cell Biol.
, vol.146
, pp. 941-954
-
-
Chan, G.K.1
Jablonski, S.A.2
Sudakin, V.3
Hittle, J.C.4
Yen, T.J.5
-
46
-
-
0033672239
-
Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores
-
Chan, G. K., Jablonski, S. A., Starr, D. A., Goldberg, M. L. & Yen, T. J. Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores. Nature Cell Biol. 2, 944-947 (2000).
-
(2000)
Nature Cell Biol.
, vol.2
, pp. 944-947
-
-
Chan, G.K.1
Jablonski, S.A.2
Starr, D.A.3
Goldberg, M.L.4
Yen, T.J.5
-
47
-
-
0038446875
-
Activating and silencing the mitotic checkpoint through CENP-E-dependent activation/inactivation of BubR1
-
Mao, Y., Abrieu, A. & Cleveland, D. W. Activating and silencing the mitotic checkpoint through CENP-E-dependent activation/inactivation of BubR1. Cell 114, 87-98 (2003). This study shows how a lack of attachment at the kinetochore can be converted into a catalytic activity that sustains mitotic checkpoint signalling. The microtubule-binding protein CENPE, when unbound by microtubules, directly activates the checkpoint kinase BUBR1, which is an essential mediator of the mitotic checkpoint response.
-
(2003)
Cell
, vol.114
, pp. 87-98
-
-
Mao, Y.1
Abrieu, A.2
Cleveland, D.W.3
-
48
-
-
0028134981
-
A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts
-
Minshull, J., Sun, H., Tonks, N. K. & Murray, A. W. A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts. Cell 79, 475-486 (1994).
-
(1994)
Cell
, vol.79
, pp. 475-486
-
-
Minshull, J.1
Sun, H.2
Tonks, N.K.3
Murray, A.W.4
-
49
-
-
2642549143
-
Dynamics of centromere and kinetochore proteins; implications for checkpoint signaling and silencing
-
Shah, J. V. et al. Dynamics of centromere and kinetochore proteins; implications for checkpoint signaling and silencing. Curr. Biol. 14, 942-952 (2004).
-
(2004)
Curr. Biol.
, vol.14
, pp. 942-952
-
-
Shah, J.V.1
-
50
-
-
2642546649
-
Spindle checkpoint protein dynamics at kinetochores in living cells
-
Howell, B. J. et al. Spindle checkpoint protein dynamics at kinetochores in living cells. Curr. Biol. 14, 953-964 (2004).
-
(2004)
Curr. Biol.
, vol.14
, pp. 953-964
-
-
Howell, B.J.1
-
51
-
-
0032525783
-
The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation
-
Fang, G., Yu, H. & Kirschner, M. W. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. Genes Dev. 12, 1871-1883 (1998).
-
(1998)
Genes Dev.
, vol.12
, pp. 1871-1883
-
-
Fang, G.1
Yu, H.2
Kirschner, M.W.3
-
52
-
-
1842420626
-
The Mad2 spindle checkpoint protein has two distinct natively folded states
-
Luo, X. et al. The Mad2 spindle checkpoint protein has two distinct natively folded states. Nature Struct. Mol. Biol. 11, 338-345 (2004).
-
(2004)
Nature Struct. Mol. Biol.
, vol.11
, pp. 338-345
-
-
Luo, X.1
-
53
-
-
13444288299
-
The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint
-
De Antoni, A. et al. The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint. Curr. Biol. 15, 214-225 (2005).
-
(2005)
Curr. Biol.
, vol.15
, pp. 214-225
-
-
De Antoni, A.1
-
54
-
-
0036199862
-
Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex
-
Fang, G. Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex. Mol. Biol. Cell 13, 755-766 (2002).
-
(2002)
Mol. Biol. Cell
, vol.13
, pp. 755-766
-
-
Fang, G.1
-
55
-
-
0035435063
-
Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1
-
Tang, Z., Bharadwaj, R., Li, B. & Yu, H. Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1. Dev. Cell 1, 227-237 (2001).
-
(2001)
Dev. Cell
, vol.1
, pp. 227-237
-
-
Tang, Z.1
Bharadwaj, R.2
Li, B.3
Yu, H.4
-
56
-
-
0035802122
-
Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2
-
Sudakin, V., Chan, G. K. & Yen, T. J. Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2. J. Cell Biol. 154, 925-936 (2001). References 55 and 56 challenged the view that MAD2 alone was the APC/C inhibitor. Although reference 55 showed BUBR1 could directly inhibit the APC/C better than MAD2 could, reference 56 showed that in mitotic HeLa cells, both BUBR1 and MAD2, together with BUB3, were found in complex with CDC20, and that this complex was a very potent inhibitor of the APC/C.
-
(2001)
J. Cell Biol.
, vol.154
, pp. 925-936
-
-
Sudakin, V.1
Chan, G.K.2
Yen, T.J.3
-
57
-
-
0032512748
-
Budding yeast Cdc20: A target of the spindle checkpoint
-
Hwang, L. H. et al. Budding yeast Cdc20: a target of the spindle checkpoint. Science 279, 1041-1044 (1998).
-
(1998)
Science
, vol.279
, pp. 1041-1044
-
-
Hwang, L.H.1
-
58
-
-
0032526415
-
Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events
-
Kallio, M., Weinstein, J., Daum, J. R., Burke, D. J. & Gorbsky, G. J. Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events. J. Cell Biol. 141, 1393-1406 (1998).
-
(1998)
J. Cell Biol.
, vol.141
, pp. 1393-1406
-
-
Kallio, M.1
Weinstein, J.2
Daum, J.R.3
Burke, D.J.4
Gorbsky, G.J.5
-
59
-
-
4143069361
-
Phosphorylation and activation of Bub1 on unattached chromosomes facilitate the spindle checkpoint
-
Chen, R. H. Phosphorylation and activation of Bub1 on unattached chromosomes facilitate the spindle checkpoint. EMBO J. 23, 3113-3121 (2004).
-
(2004)
EMBO J.
, vol.23
, pp. 3113-3121
-
-
Chen, R.H.1
-
60
-
-
0013057087
-
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores
-
Ditchfield, C. et al. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J. Cell Biol. 161, 267-280 (2003).
-
(2003)
J. Cell Biol.
, vol.161
, pp. 267-280
-
-
Ditchfield, C.1
-
61
-
-
0041669463
-
The CCT chaperonin promotes activation of the anaphase-promoting complex through the generation of functional Cdc20
-
Camasses, A., Bogdanova, A., Shevchenko, A. & Zachariae, W. The CCT chaperonin promotes activation of the anaphase-promoting complex through the generation of functional Cdc20. Mol. Cell 12, 87-100 (2003).
-
(2003)
Mol. Cell
, vol.12
, pp. 87-100
-
-
Camasses, A.1
Bogdanova, A.2
Shevchenko, A.3
Zachariae, W.4
-
62
-
-
0038376119
-
Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension
-
Lens, S. M. et al. Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension. EMBO J. 22, 2934-2947 (2003).
-
(2003)
EMBO J.
, vol.22
, pp. 2934-2947
-
-
Lens, S.M.1
-
63
-
-
0033106322
-
Regulation of Saccharomyces cerevisiae kinetochores by the type 1 phosphatase Glc7p
-
Sassoon, I. et al. Regulation of Saccharomyces cerevisiae kinetochores by the type 1 phosphatase Glc7p. Genes Dev. 13, 545-555 (1999).
-
(1999)
Genes Dev.
, vol.13
, pp. 545-555
-
-
Sassoon, I.1
-
64
-
-
0038746733
-
The small molecule hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint
-
Hauf, S. et al. The small molecule hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J. Cell Biol. 161, 281-294 (2003).
-
(2003)
J. Cell Biol.
, vol.161
, pp. 281-294
-
-
Hauf, S.1
-
65
-
-
0036178929
-
Evidence that the lpl1-Sli15 (aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections
-
Tanaka, T. U. et al. Evidence that the lpl1-Sli15 (aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections. Cell 108, 317-329 (2002).
-
(2002)
Cell
, vol.108
, pp. 317-329
-
-
Tanaka, T.U.1
-
66
-
-
12344266713
-
The human mitotic checkpoint protein BubR1 regulates chromosome-spindle attachments
-
Lampson, M. A. & Kapoor, T. M. The human mitotic checkpoint protein BubR1 regulates chromosome-spindle attachments. Nature Cell Biol. 7, 93-98 (2005).
-
(2005)
Nature Cell Biol.
, vol.7
, pp. 93-98
-
-
Lampson, M.A.1
Kapoor, T.M.2
-
67
-
-
0036744787
-
Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E
-
Putkey, F. R. et al. Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E. Dev. Cell 3, 351-365 (2002).
-
(2002)
Dev. Cell
, vol.3
, pp. 351-365
-
-
Putkey, F.R.1
-
68
-
-
0042978646
-
Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss
-
Weaver, B. A. et al. Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss. J. Cell Biol. 162, 551-563 (2003).
-
(2003)
J. Cell Biol.
, vol.162
, pp. 551-563
-
-
Weaver, B.A.1
-
69
-
-
0037011119
-
Identification of a MAD2-binding protein, CMT2, and its role in mitosis
-
Habu, T., Kim, S. H., Weinstein, J. & Matsumoto, T. Identification of a MAD2-binding protein, CMT2, and its role in mitosis. EMBO J. 21, 6419-6428 (2002).
-
(2002)
EMBO J.
, vol.21
, pp. 6419-6428
-
-
Habu, T.1
Kim, S.H.2
Weinstein, J.3
Matsumoto, T.4
-
70
-
-
4143076016
-
Conformation-specific binding of p31 (comet) antagonizes the function of Mad2 in the spindle checkpoint
-
Xia, G. et al. Conformation-specific binding of p31 (comet) antagonizes the function of Mad2 in the spindle checkpoint. EMBO J. 23, 3133-3143 (2004).
-
(2004)
EMBO J.
, vol.23
, pp. 3133-3143
-
-
Xia, G.1
-
71
-
-
20544463659
-
Partial downregulation of MAD1 causes spindle checkpoint inactivation and aneuploidy, but does not confer resistance towards taxol
-
Kienitz, A., Vogel, C., Morales, I., Muller, R. & Bastians, H. Partial downregulation of MAD1 causes spindle checkpoint inactivation and aneuploidy, but does not confer resistance towards taxol. Oncogene 24, 4301-4310 (2005).
-
(2005)
Oncogene
, vol.24
, pp. 4301-4310
-
-
Kienitz, A.1
Vogel, C.2
Morales, I.3
Muller, R.4
Bastians, H.5
-
72
-
-
0032546360
-
Mutations of mitotic checkpoint genes in human cancers
-
Cahill, D. P. et al. Mutations of mitotic checkpoint genes in human cancers. Nature 392, 300-303 (1998). First study to identify mutant alleles of the mitotic checkpoint proteins BUB1 and BUBR1 in human colorectal cancer cell lines.
-
(1998)
Nature
, vol.392
, pp. 300-303
-
-
Cahill, D.P.1
-
73
-
-
9144253124
-
Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency
-
Dai, W. et al. Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency. Cancer Res. 64, 440-445 (2004).
-
(2004)
Cancer Res.
, vol.64
, pp. 440-445
-
-
Dai, W.1
-
74
-
-
0037415605
-
Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation
-
Babu, J. R. et al. Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. J. Cell Biol. 160, 341-353 (2003).
-
(2003)
J. Cell Biol.
, vol.160
, pp. 341-353
-
-
Babu, J.R.1
-
75
-
-
0035905811
-
MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells
-
Michel, M. L. et al. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature 409, 355-359 (2001). References 74 and 75 provided proof-of-principle that reduced levels of a mitotic checkpoint protein can cause checkpoint malfunction and CIN, and thereby contribute to tumour formation.
-
(2001)
Nature
, vol.409
, pp. 355-359
-
-
Michel, M.L.1
-
76
-
-
3042761646
-
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
-
Baker, D. J. et al. BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nature Genet. 36, 744-749 (2004).
-
(2004)
Nature Genet.
, vol.36
, pp. 744-749
-
-
Baker, D.J.1
-
77
-
-
0038581888
-
Inhibition of BUB1 results in genomic instability and anchorage-independent growth of normal human fibroblasts
-
Musio, A. et al. Inhibition of BUB1 results in genomic instability and anchorage-independent growth of normal human fibroblasts. Cancer Res. 63, 2855-2863 (2003).
-
(2003)
Cancer Res.
, vol.63
, pp. 2855-2863
-
-
Musio, A.1
-
78
-
-
10744222603
-
BUBR1 deficiency results in abnormal megakaryopoiesis
-
Wang, Q. et al. BUBR1 deficiency results in abnormal megakaryopoiesis. Blood 103, 1278-1285 (2004).
-
(2004)
Blood
, vol.103
, pp. 1278-1285
-
-
Wang, Q.1
-
79
-
-
8644251877
-
Mitotic checkpoint function in the formation of gross chromosomal rearrangements in Saccharomyces cerevisiae
-
Myung, K., Smith, S. & Kolodner, R. D. Mitotic checkpoint function in the formation of gross chromosomal rearrangements in Saccharomyces cerevisiae. Proc. Natl Acad. Sci. USA 101, 15980-15985 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 15980-15985
-
-
Myung, K.1
Smith, S.2
Kolodner, R.D.3
-
80
-
-
0037049550
-
The yeast nuclear pore complex functionally interacts with components of the spindle assembly checkpoint
-
Iouk, T., Kerscher, O., Scott, R. J., Basrai, M. A. & Wozniak, R. W. The yeast nuclear pore complex functionally interacts with components of the spindle assembly checkpoint. J. Cell Biol. 159, 807-819 (2002).
-
(2002)
J. Cell Biol.
, vol.159
, pp. 807-819
-
-
Iouk, T.1
Kerscher, O.2
Scott, R.J.3
Basrai, M.A.4
Wozniak, R.W.5
-
81
-
-
0035063690
-
Mitotic checkpoint proteins HsMAD1 and HsMAD2 are associated with nuclear pore complexes in interphase
-
Campbell, M. S., Chan, G. K. & Yen, T. J. Mitotic checkpoint proteins HsMAD1 and HsMAD2 are associated with nuclear pore complexes in interphase. J. Cell. Sci. 114, 953-963 (2001).
-
(2001)
J. Cell. Sci.
, vol.114
, pp. 953-963
-
-
Campbell, M.S.1
Chan, G.K.2
Yen, T.J.3
-
82
-
-
15444370589
-
Min/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability
-
Min/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability. Proc. Natl Acad. Sci. USA 102, 4365-4370 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 4365-4370
-
-
Rao, C.V.1
-
83
-
-
0030659153
-
Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation
-
Connor, F. et al. Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation. Nature Genet. 17, 423-430 (1997).
-
(1997)
Nature Genet.
, vol.17
, pp. 423-430
-
-
Connor, F.1
-
84
-
-
0032054158
-
Thymic lymphomas in mice with a truncating mutation in Brca2
-
Friedman, L. S. et al. Thymic lymphomas in mice with a truncating mutation in Brca2. Cancer Res. 58, 1338-1343 (1998).
-
(1998)
Cancer Res.
, vol.58
, pp. 1338-1343
-
-
Friedman, L.S.1
-
85
-
-
0033166981
-
Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2
-
Lee, H. et al. Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2. Mol. Cell 4, 1-10 (1999).
-
(1999)
Mol. Cell
, vol.4
, pp. 1-10
-
-
Lee, H.1
-
86
-
-
7744233719
-
Stuck in division or passing through: What happens when cells cannot satisfy the spindle assembly checkpoint
-
Rieder, C. L. & Maiato, H. Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint. Dev. Cell 7, 637-651 (2004).
-
(2004)
Dev. Cell
, vol.7
, pp. 637-651
-
-
Rieder, C.L.1
Maiato, H.2
-
87
-
-
0036223590
-
Mechanisms of aneuploidy in thyroid cancer cell lines and tissues: Evidence for mitotic checkpoint dysfunction without mutations in BUB1 and BUBR1
-
Ouyang, B., Knauf, J. A., Ain, K., Nacev, B. & Fagin, J. A. Mechanisms of aneuploidy in thyroid cancer cell lines and tissues: evidence for mitotic checkpoint dysfunction without mutations in BUB1 and BUBR1. Clin. Endocrinol. (Oxford) 56, 341-350 (2002).
-
(2002)
Clin. Endocrinol. (Oxford)
, vol.56
, pp. 341-350
-
-
Ouyang, B.1
Knauf, J.A.2
Ain, K.3
Nacev, B.4
Fagin, J.A.5
-
88
-
-
0033614936
-
Identification of frequent impairment of the mitotic checkpoint and molecular analysis of the mitotic checkpoint genes, hsMAD2 and p55CDC, in human lung cancers
-
Takahashi, T. et al. Identification of frequent impairment of the mitotic checkpoint and molecular analysis of the mitotic checkpoint genes, hsMAD2 and p55CDC, in human lung cancers. Oncogene 18, 4295-4300 (1999).
-
(1999)
Oncogene
, vol.18
, pp. 4295-4300
-
-
Takahashi, T.1
-
89
-
-
0037085936
-
Significance of MAD2 expression to mitotic checkpoint control in ovarian cancer cells
-
Wang, X. et al. Significance of MAD2 expression to mitotic checkpoint control in ovarian cancer cells. Cancer Res. 62, 1662-1668 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 1662-1668
-
-
Wang, X.1
-
90
-
-
0034906435
-
Aneuploid colon cancer cells have a robust spindle checkpoint
-
Tighe, A., Johnson, V. L., Albertella, M. & Taylor, S. S., Aneuploid colon cancer cells have a robust spindle checkpoint. EMBO Rep. 2, 609-614 (2001).
-
(2001)
EMBO Rep.
, vol.2
, pp. 609-614
-
-
Tighe, A.1
Johnson, V.L.2
Albertella, M.3
Taylor, S.S.4
-
91
-
-
0036534146
-
Frequent impairment of the spindle assembly checkpoint in hepatocellular carcinoma
-
Saeki, A. et al. Frequent impairment of the spindle assembly checkpoint in hepatocellular carcinoma. Cancer 94, 2047-2054 (2002).
-
(2002)
Cancer
, vol.94
, pp. 2047-2054
-
-
Saeki, A.1
-
92
-
-
0036969268
-
Variable levels of chromosomal instability and mitotic spindle checkpoint defects in breast cancer
-
Yoon, D. S. et al. Variable levels of chromosomal instability and mitotic spindle checkpoint defects in breast cancer. Am. J. Pathol. 161, 391-397 (2002).
-
(2002)
Am. J. Pathol.
, vol.161
, pp. 391-397
-
-
Yoon, D.S.1
-
93
-
-
2642574942
-
Possible causes of chromosome instability: Comparison of chromosomal abnormalities in cancer cell lines with mutations in BRCA1, BRCA2, CHK2 and BUB1
-
Grigorova, M., Staines, J. M., Ozdag, H., Caldas, C. & Edwards, P. A. Possible causes of chromosome instability: comparison of chromosomal abnormalities in cancer cell lines with mutations in BRCA1, BRCA2, CHK2 and BUB1. Cytogenet. Genome Res. 104, 333-340 (2004).
-
(2004)
Cytogenet. Genome Res.
, vol.104
, pp. 333-340
-
-
Grigorova, M.1
Staines, J.M.2
Ozdag, H.3
Caldas, C.4
Edwards, P.A.5
-
94
-
-
0033800018
-
Somatic mutation of the hBUB1 mitotic checkpoint gene in primary lung cancer
-
Gemma, A. et al. Somatic mutation of the hBUB1 mitotic checkpoint gene in primary lung cancer. Genes Chromosomes Cancer 29, 213-218 (2000).
-
(2000)
Genes Chromosomes Cancer
, vol.29
, pp. 213-218
-
-
Gemma, A.1
-
95
-
-
0037389466
-
A double missense variation of the BUB1 gene and a defective mitotic spindle checkpoint in the pancreatic cancer cell line Hs766T
-
Hempen, P. M., Kurpad, H., Calhoun, E. S., Abraham, S. & Kern, S. E. A double missense variation of the BUB1 gene and a defective mitotic spindle checkpoint in the pancreatic cancer cell line Hs766T. Hum. Mutat. 21, 445 (2003).
-
(2003)
Hum. Mutat.
, vol.21
, pp. 445
-
-
Hempen, P.M.1
Kurpad, H.2
Calhoun, E.S.3
Abraham, S.4
Kern, S.E.5
-
96
-
-
0035919860
-
Molecular analyses of the mitotic checkpoint components hsMAD2, hBUB1 and hBUB3 in human cancer
-
Hernando, E. et al. Molecular analyses of the mitotic checkpoint components hsMAD2, hBUB1 and hBUB3 in human cancer. Int. J. Cancer 95, 223-227 (2001).
-
(2001)
Int. J. Cancer
, vol.95
, pp. 223-227
-
-
Hernando, E.1
-
97
-
-
0032850288
-
Mutational inactivation of mitotic checkpoint genes, hsMAD2 and hBUB1, is rare in sporadic digestive tract cancers
-
Imai, Y., Shiratori, Y., Kato, N., Inoue, T. & Omata, M. Mutational inactivation of mitotic checkpoint genes, hsMAD2 and hBUB1, is rare in sporadic digestive tract cancers. Jpn. J. Cancer Res. 90, 837-840 (1999).
-
(1999)
Jpn. J. Cancer Res.
, vol.90
, pp. 837-840
-
-
Imai, Y.1
Shiratori, Y.2
Kato, N.3
Inoue, T.4
Omata, M.5
-
98
-
-
0034308209
-
Mutation analysis of mitotic checkpoint genes (hBUB1 and hBUBR1) and microsatellite instability in adult T-cell leukemia/lymphoma
-
Ohshima, K. et al. Mutation analysis of mitotic checkpoint genes (hBUB1 and hBUBR1) and microsatellite instability in adult T-cell leukemia/lymphoma. Cancer Lett. 158, 141-150 (2000).
-
(2000)
Cancer Lett.
, vol.158
, pp. 141-150
-
-
Ohshima, K.1
-
99
-
-
0033604452
-
Search for in vivo somatic mutations in the mitotic checkpoint gene, hMAD1, in human lung cancers
-
Nomoto, S. et al. Search for in vivo somatic mutations in the mitotic checkpoint gene, hMAD1, in human lung cancers. Oncogene 18, 7180-7183 (1999).
-
(1999)
Oncogene
, vol.18
, pp. 7180-7183
-
-
Nomoto, S.1
-
100
-
-
0033758034
-
Expression and mutational analyses of the human MAD2L1 gene in breast cancer cells
-
Percy, M. J. et al. Expression and mutational analyses of the human MAD2L1 gene in breast cancer cells. Genes Chromosomes Cancer 29, 356-362 (2000).
-
(2000)
Genes Chromosomes Cancer
, vol.29
, pp. 356-362
-
-
Percy, M.J.1
-
101
-
-
0034968482
-
Mutations in the mitotic check point gene, MAD1L1, in human cancers
-
Tsukasaki, K. et al. Mutations in the mitotic check point gene, MAD1L1, in human cancers. Oncogene 20, 3301-3305 (2001).
-
(2001)
Oncogene
, vol.20
, pp. 3301-3305
-
-
Tsukasaki, K.1
-
102
-
-
0036141441
-
Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival
-
Shichiri, M., Yoshinaga, K., Hisatomi, H., Sugihara, K. & Hirata, Y. Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival. Cancer Res. 62, 13-17 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 13-17
-
-
Shichiri, M.1
Yoshinaga, K.2
Hisatomi, H.3
Sugihara, K.4
Hirata, Y.5
-
103
-
-
2342557921
-
Three classes of genes mutated in colorectal cancers with chromosomal instability
-
Wang, Z. et al. Three classes of genes mutated in colorectal cancers with chromosomal instability. Cancer Res. 64, 2998-3001 (2004).
-
(2004)
Cancer Res.
, vol.64
, pp. 2998-3001
-
-
Wang, Z.1
-
104
-
-
10644258336
-
Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B
-
Hanks, S. et al. Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B. Nature Genet. 36, 1159-1161 (2004).
-
(2004)
Nature Genet.
, vol.36
, pp. 1159-1161
-
-
Hanks, S.1
-
105
-
-
0035951697
-
Molecular analysis of the mitotic checkpoint genes BUB1, BUBR1 and BUB3 in human lung cancers
-
Haruki, N. et al. Molecular analysis of the mitotic checkpoint genes BUB1, BUBR1 and BUB3 in human lung cancers. Cancer Lett. 162, 201-205 (2001).
-
(2001)
Cancer Lett.
, vol.162
, pp. 201-205
-
-
Haruki, N.1
-
106
-
-
0035031228
-
Mitotic checkpoint genes hBUB1, hBUB1B, hBUB3 and TTK in human bladder cancer, screening for mutations and loss of heterozygosity
-
Olesen, S. H., Thykjaer, T. & Orntoft, T. F. Mitotic checkpoint genes hBUB1, hBUB1B, hBUB3 and TTK in human bladder cancer, screening for mutations and loss of heterozygosity. Carcinogenesis 22, 813-815 (2001).
-
(2001)
Carcinogenesis
, vol.22
, pp. 813-815
-
-
Olesen, S.H.1
Thykjaer, T.2
Orntoft, T.F.3
-
107
-
-
0033152810
-
Characterization of MAD2B and other mitotic spindle checkpoint genes
-
Cahill, D. P. et al. Characterization of MAD2B and other mitotic spindle checkpoint genes. Genomics 58, 181-187 (1999).
-
(1999)
Genomics
, vol.58
, pp. 181-187
-
-
Cahill, D.P.1
-
108
-
-
0034193627
-
Mutation and expression analysis of human BUB1 and BUB1B in aneuploid breast cancer cell lines
-
Myrie, K. A., Percy, M. J., Azim, J. N., Neeley, C. K. & Petty, E. M. Mutation and expression analysis of human BUB1 and BUB1B in aneuploid breast cancer cell lines. Cancer Lett. 152, 193-199 (2000).
-
(2000)
Cancer Lett.
, vol.152
, pp. 193-199
-
-
Myrie, K.A.1
Percy, M.J.2
Azim, J.N.3
Neeley, C.K.4
Petty, E.M.5
-
109
-
-
0034721154
-
Chfr defines a mitotic stress checkpoint that delays entry into metaphase
-
Scolnick, D. M. & Halazonetis, T. D. Chfr defines a mitotic stress checkpoint that delays entry into metaphase. Nature 406, 430-135 (2000).
-
(2000)
Nature
, vol.406
, pp. 430-1135
-
-
Scolnick, D.M.1
Halazonetis, T.D.2
-
110
-
-
0032954260
-
Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity
-
Tao, W. et al. Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. Nature Genet. 21, 177-181 (1999).
-
(1999)
Nature Genet.
, vol.21
, pp. 177-181
-
-
Tao, W.1
-
111
-
-
1642602695
-
The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex
-
Song, M. S. et al. The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex. Nature Cell Biol. 6, 129-137 (2004).
-
(2004)
Nature Cell Biol.
, vol.6
, pp. 129-137
-
-
Song, M.S.1
-
112
-
-
0037649987
-
Overexpression of the mitotic checkpoint genes BUB1, BUBR1, and BUB3 in gastric cancer - Association with tumour cell proliferation
-
Grabsch, H. et al. Overexpression of the mitotic checkpoint genes BUB1, BUBR1, and BUB3 in gastric cancer - association with tumour cell proliferation. J. Pathol. 200, 16-22 (2003).
-
(2003)
J. Pathol.
, vol.200
, pp. 16-22
-
-
Grabsch, H.1
-
113
-
-
4043093341
-
Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control
-
Hernando, E. et al. Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control. Nature 430, 797-802 (2004). This study shows how a tumour suppressor can manipulate the mitotic checkpoint to create CIN. Aneuploidy occurs in RB-negative tumor cells via increased levels of MAD2. MAD2L1 is a target gene of the RB-controlled transcription factor E2F.
-
(2004)
Nature
, vol.430
, pp. 797-802
-
-
Hernando, E.1
-
114
-
-
13944278802
-
Mitotic arrest deficient 2 expression induces chemosensitization to a DNA-damaging agent, cisplatin, in nasopharyngeal carcinoma cells
-
Cheung, H. W. et al. Mitotic arrest deficient 2 expression induces chemosensitization to a DNA-damaging agent, cisplatin, in nasopharyngeal carcinoma cells. Cancer Res. 65, 1450-1458 (2005).
-
(2005)
Cancer Res.
, vol.65
, pp. 1450-1458
-
-
Cheung, H.W.1
-
115
-
-
10344230981
-
A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle heckpoint
-
Wang, R. H., Yu, H. & Deng, C. X. A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle heckpoint. Proc. Natl Acad. Sci. USA 101, 17108-17113 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 17108-17113
-
-
Wang, R.H.1
Yu, H.2
Deng, C.X.3
-
116
-
-
18244409687
-
Gene expression profiling predicts clinical outcome of breast cancer
-
van 't Veer, L. J. et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 415, 530-536 (2002).
-
(2002)
Nature
, vol.415
, pp. 530-536
-
-
Van 't Veer, L.J.1
-
117
-
-
0037080483
-
E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints
-
Ren, B. et al. E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. Genes Dev. 16, 245-256 (2002).
-
(2002)
Genes Dev.
, vol.16
, pp. 245-256
-
-
Ren, B.1
-
118
-
-
0141733191
-
Transcriptional regulation of mitotic checkpoint gene MAD1 by p53
-
Chun, A. C. & Jin, D. Y. Transcriptional regulation of mitotic checkpoint gene MAD1 by p53. J. Biol. Chem. 278, 37439-37450 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 37439-37450
-
-
Chun, A.C.1
Jin, D.Y.2
-
119
-
-
0036569942
-
Expression of mitotic spindle checkpoint protein hsMAD1 correlates with cellular proliferation and is activated by a gain-of-function p53 mutant
-
Iwanaga, Y. & Jeang, K. T. Expression of mitotic spindle checkpoint protein hsMAD1 correlates with cellular proliferation and is activated by a gain-of-function p53 mutant. Cancer Res. 62, 2618-2624 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 2618-2624
-
-
Iwanaga, Y.1
Jeang, K.T.2
-
120
-
-
0345304252
-
Breast cancer-specific gene 1 interacts with the mitotic checkpoint kinase BubR1
-
Gupta, A., Inaba, S., Wong, O. K., Fang, G. & Liu, J. Breast cancer-specific gene 1 interacts with the mitotic checkpoint kinase BubR1. Oncogene 22, 7593-7599 (2003).
-
(2003)
Oncogene
, vol.22
, pp. 7593-7599
-
-
Gupta, A.1
Inaba, S.2
Wong, O.K.3
Fang, G.4
Liu, J.5
-
121
-
-
1942438028
-
Microtubules as a target for anticancer drugs
-
Jordan, M. A. & Wilson, L. Microtubules as a target for anticancer drugs. Nature Rev. Cancer 4, 253-265 (2004).
-
(2004)
Nature Rev. Cancer
, vol.4
, pp. 253-265
-
-
Jordan, M.A.1
Wilson, L.2
-
122
-
-
10344236486
-
Aurora-kinase inhibitors as anticancer agents
-
Keen, N. & Taylor, S. Aurora-kinase inhibitors as anticancer agents. Nature Rev. Cancer 4, 927-936 (2004).
-
(2004)
Nature Rev. Cancer
, vol.4
, pp. 927-936
-
-
Keen, N.1
Taylor, S.2
-
123
-
-
2342639645
-
VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo
-
Harrington, E. A. et al. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nature Med. 10, 262-267 (2004).
-
(2004)
Nature Med.
, vol.10
, pp. 262-267
-
-
Harrington, E.A.1
-
124
-
-
20144381969
-
A small-molecule inhibitor of Mps1 blocks the spindle-checkpoint response to a lack of tension on mitotic chromosomes
-
Dorer, R. K. et al. A small-molecule inhibitor of Mps1 blocks the spindle-checkpoint response to a lack of tension on mitotic chromosomes. Curr. Biol. 15, 1070-1076 (2005).
-
(2005)
Curr. Biol.
, vol.15
, pp. 1070-1076
-
-
Dorer, R.K.1
-
125
-
-
8544242697
-
Crystal structure of the spindle assembly checkpoint protein Bub3
-
Larsen, N. A. & Harrison, S. C. Crystal structure of the spindle assembly checkpoint protein Bub3. J. Mol. Biol. 344, 885-892 (2004).
-
(2004)
J. Mol. Biol.
, vol.344
, pp. 885-892
-
-
Larsen, N.A.1
Harrison, S.C.2
-
126
-
-
17644396387
-
ZW10 links mitotic checkpoint signaling to the structural kinetochore
-
Kops, G. J. et al. ZW10 links mitotic checkpoint signaling to the structural kinetochore. J. Cell Biol. 169, 49-60 (2005).
-
(2005)
J. Cell Biol.
, vol.169
, pp. 49-60
-
-
Kops, G.J.1
-
127
-
-
0343986407
-
Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20
-
Luo, X. et al. Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20. Nature Struct. Biol. 7, 224-229 (2000).
-
(2000)
Nature Struct. Biol.
, vol.7
, pp. 224-229
-
-
Luo, X.1
-
128
-
-
7744230752
-
Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint
-
Tang, Z., Shu, H., Oncel, D., Chen, S. & Yu, H. Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint. Mol. Cell 16, 387-397 (2004).
-
(2004)
Mol. Cell
, vol.16
, pp. 387-397
-
-
Tang, Z.1
Shu, H.2
Oncel, D.3
Chen, S.4
Yu, H.5
-
129
-
-
0032547733
-
Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores
-
Chen, R. H., Shevchenko, A., Mann, M. & Murray, A. W. Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores. J. Cell Biol. 143, 283-295 (1998).
-
(1998)
J. Cell Biol.
, vol.143
, pp. 283-295
-
-
Chen, R.H.1
Shevchenko, A.2
Mann, M.3
Murray, A.W.4
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