Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice

Genes and Development

Volumn 14, Issue 12, 2000, Pages 1439-1447

  Takai, Hiroyuki ^a   Tominaga, Kaoru ^a,e   Motoyama, Noboru ^a   Minamishima, Yohji A ^b,c   Nagahama, Hiroyasu ^b,c   Tsukiyama, Tadasuke ^b,c   Ikeda, Kyoji ^a   Nakayama, Keiko ^b,c   Nakanishi, Makoto ^a,d   Nakayama, Kei Ichi ^b,c  

^a NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Abnormal nuclei; Apoptosis; Chk1; Embryonic lethality; G2 checkpoints

Indexed keywords

ARTICLE; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; DNA DAMAGE; EMBRYO; EMBRYO DEATH; GENETIC CONSERVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ALLELES; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; BLASTOCYST; CELL DIVISION; CELL NUCLEUS; CELLS, CULTURED; CROSSES, GENETIC; DNA; DNA DAMAGE; EMBRYO; FIBROBLASTS; G2 PHASE; GENOTYPE; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MICE; MICE, INBRED C57BL; MICE, INBRED ICR; MICE, TRANSGENIC; MODELS, GENETIC; MUTAGENESIS; PROTEIN KINASES; STEM CELLS;

MAMMALIA;

EID: 0034659341     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Ajiro, K., K. Yoda, K. Utsumi, and Y. Nishikawa. 1996. Alteration of cell cycle-dependent histone phosphorylations by okadaic acid. Induction of mitosis-specific H3 phosphorylation and chromatin condensation in mammalian interphase cells. J. Biol. Chem. 271: 13197-13201.
2. Al-Khodairy, F. and A.M. Carr. 1992. DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe. EMBO J. 11: 1343-1350.
3. Brondello, J.M., M.N. Boddy, B. Furnari, and P. Russell. 1999. Basis for the checkpoint signal specificity that regulates Chk1 and Cds1 protein kinases. Mol. Cell. Biol. 19: 4262-4269.
4. Brown, A.L., C.H. Lee, J.K. Schwarz, N. Mitiku, H. Piwnica-Worms, and J.H. Chung. 1999. A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage. Proc. Natl. Acad. Sci. 96: 3745-3750.
5. Brown, E.J. and D. Baltimore. 2000. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes & Dev. 14: 397-402.
6. Carr, A.M. 1996. Checkpoints take the next step. Science 271: 314-315.
7. Chaturvedi, P., W.K. Eng, Y. Zhu, M.R. Mattern, R. Mishra, M.R. Hurle, X. Zhang, R.S. Annan, Q. Lu, L.F. Faucette et al. 1999. Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway. Oncogene 18: 4047-4054.
8. Cliby, W.A., C.J. Roberts, K.A. Cimprich, C.M. Stringer, J.R. Lamb, S.L. Schreiber, and S.H. Friend. 1998. Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO J. 17: 159-169.
9. Dalal, S.N., C.M. Schweitzer, J. Gan, and J.A. DeCaprio. 1999. Cytoplasmic localization of human cdc25c during interphase requires an intact 14-3-3 binding site. Mol. Cell. Biol. 19: 4465-4479.
10. Elledge, S.J. 1996. Cell cycle checkpoints: Preventing an identity crisis. Science 274: 1664-1672.
11. Enoch, T. and P. Nurse. 1990. Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication. Cell 60: 665-673.
12. Furnari, B., N. Rhind, and P. Russell. 1997. Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase. Science 277: 1495-1497.
13. Hakem, R., J.L. de la Pompa, C. Sirard, R. Mo, M. Woo, A. Hakem, A. Wakeham, J. Potter, A. Reitmair, F. Billia et al. 1996. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell 85: 1009-1023.
14. Hartwell, L.H. and T.A. Weinert. 1989. Checkpoints: Controls that ensure the order of cell cycle events. Science 246: 629-634.
15. Heald, R., M. McLoughlin, and F. McKeon. 1993. Human weel maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase. Cell 74: 463-474.
16. Kaneko, Y., N. Watanabe, H. Morisaki, H. Akita, A. Fujimoto, K. Tominaga, M. Terasawa, A. Tachibana, K. Ikeda, and M. Nakanishi. 1999. Cell-cycle-dependent and ATM-independent expression of human Chk1 kinase. Oncogene 18: 3673-3681.
17. Kumagai, A. and W.G. Dunphy. 1999. Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the meiotic inducer Cdc25. Genes & Dev. 13: 1067-1072.
18. Lee, J., K.M. Collins, A.L. Brown, C. Lee, and J.H. Chung. 2000. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature 404: 201-204.
19. Lindsay, H.D., D.J. Griffiths, R.J. Edwards, P.U. Christensen, J.M. Murray, F. Osman, N. Walworth, and A.M. Carr. 1998. S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe. Genes & Dev. 12: 382-395.
20. Lopez-Girona, A., B. Furnari, O. Mondesert, and P. Russel. 1999. Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein. Nature 397: 172-175.
21. Matsuoka, S., M. Huang, and S.J. Elledge. 1998. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282: 1893-1897.
22. Nakayama, K., K. Nakayama, I. Negishi, K. Kuida, Y. Shinkai, M.C. Louie, L.E. Fields, P.J. Lucas, V. Stewart, F.W. Atl, and D.Y. Loh. 1993. Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice. Science 261: 1584-1588.
23. Nakanishi, M., G.R. Adami, R.S. Robetorye, A. Noda, S.F. Venable, D. Dimitrov, O.M. Pereira-Smith, and J.R. Smith. 1995. Exit from G0 and entry into the cell cycle of cells expressing p21Sdi1 antisense RNA. Proc. Natl. Acad. Sci. 92: 4352-4356.
24. Nurse, P. 1994. Ordering S phase and M phase in the cell cycle. Cell 79: 547-550.
25. Peng, C.Y., P.R. Graves, R.S. Thoma, Z. Wu, A.S. Shaw, and H. Piwnica-Worms. 1997. Mitotic and G2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science 277: 1501-1505.
26. Sanchez, Y., C. Wong, R.S. Thoma, R. Richman, Z. Wu, H. Piwnica-Worms, and S.J. Elledge. 1997. Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25. Science 277: 1497-1501.
27. Sanchez, Y., J. Bachant, H. Wang, F. Hu, D. Liu, M. Tetzlaff, and S.J. Elledge. 1999. Control of the DNA damage checkpoint by Chk1 and Rad53 protein kinases through distinct mechanisms. Science 286: 1166-1171.
28. Sarkaria, J.N., E.C. Busby, R.S. Tibbetts, P. Roos, Y. Taya, L.M. Karnitz, and R.T. Abraham. 1999. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res. 59: 4375-4382.
29. Savitsky, K., A. Bar-Shira, S. Gilad, G. Rotman, Y. Ziv, L. Vanagaite, D.A. Tagle, S. Smith, T. Uziel, S. Sfez et al. 1995. A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268: 1749-1753.
30. Sibon, O.C., V.A. Stevenson, and W.E. Theurkauf. 1997. DNA-replication checkpoint control at the Drosophila midblastula transition. Nature 388: 93-97.
31. Sibon, O.C., A. Laurencon, R. Hawley, and W.E. Theurkauf. 1999. The Drosophila ATM homologue Mei-41 has an essential checkpoint function at the midblastula transition. Curr. Biol. 9: 302-312.
32. Sharan, S.K., M. Morimatsu, U. Albrecht, D.S. Lim, E. Regel, C. Dinh, A. Sands, G. Eichele, P. Hasty, and A. Bradley. 1997. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature 386: 804-810.
33. Suzuki, A., J.L. de la Pompa, R. Hakem, A. Elia, R. Yoshida, R. Mo, H. Nishina, T. Chuang, A. Wakeham, A. Itie et al. 1997. Brca2 is required for embryonic cellular proliferation in the mouse. Genes & Dev. 11: 1242-1252.
34. Tominaga, K., H. Morosaki, Y. Raneko, A. Fujimoto, T. Tanaka, M. Ohtsubo, M. Hirai, H. Okayama, K. Ikeda, and M. Nakanishi. 1999. Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53. J. Biol. Chem. 274: 31463-31467.
35. Tybulewicz, V.L., C.E. Crawford, P.K. Jackson, R.T. Bronson, and R.C. Mulligan. 1991. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-ab1 protooncogene. Cell 65: 1153-1163.
36. Walworth, N., S. Davey, and D. Beach. 1993. Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2. Nature 363: 368-371.
37. Walworth, N.C. and R. Bernards. 1996. rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint. Science 271: 353-356.
38. Zeng, Y., K.C. Forbes, Z. Wu, S. Moreno, H. Piwnica-Worms, and T. Enoch. 1998. Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1. Nature 395: 507-510.