Cdc7 kinase complex: A key regulator in the initiation of DNA replication

Journal of Cellular Physiology

Volumn 190, Issue 3, 2002, Pages 287-296

  Masai, Hisao ^a,b   Arai, Ken Ichi ^a,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 7; MINICHROMOSOME MAINTENANCE PROTEIN;

ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CHROMOSOME STRUCTURE; COMPLEX FORMATION; DNA REPAIR; DNA REPLICATION; ENZYME REGULATION; ENZYME SUBUNIT; MAMMAL; MEIOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; SIGNAL TRANSDUCTION; YEAST;

ANIMALS; CELL CYCLE; CELL CYCLE PROTEINS; DNA REPLICATION; FUNGAL PROTEINS; HUMANS; MEIOSIS; MULTIGENE FAMILY; PROTEIN-SERINE-THREONINE KINASES; SACCHAROMYCES CEREVISIAE PROTEINS;

EUKARYOTA; MAMMALIA; SACCHAROMYCETALES;

EID: 0036154983     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.10070     Document Type: Article

References (99)

1. A globular complex formation by Ndal and the other five members of the MCM protein family in fission yeast
2. Components and dynamics of DNA replication complexes in S. cerevisae: Redistribution of MCM proteins and Cdc45p during S phase
3. Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint
4. ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex
5. The Cdc7 protein kinase is required for origin firing during S phase
6. Duplex opening by DnaA protein at novel sequences in initiation of replication at the origin of E. coli
7. A model for initiation at origins of DNA replication
8. Purification of Hsk1, a minichromosome maintenance protein kinase from fission yeast
9. Cell cycle regulation of Dfp1, an activator of the Hsk1 protein kinase
10. CDC7 protein kinase activity is required for mitosis and meiosis in Saccharomyces cerevisiae
11. Animal virus DNA replication
12. The yeast gene, DBF4, essential for entry into S phase is cell cycle regulated
13. Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage
14. Cdc 7 is required throughout the yeast S phase to activate replication origins
15. Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo
16. Cell cycle: Will the real Cdk-activating kinase please stand up
17. Dbf4p, an essential S phase-promoting factor, is targeted for degradation by the anaphase-promoting complex
18. hCDC47, a human member of the MCM family. Dissociation of the nucleus-bound form during S phase
19. Cell cycle- and chromatin binding state-dependent phosphorylation of human MCM heterohexameric complexes. A role for cdc2 kinase
20. Enzymatic replication of the origin of the Escherichia coli chromosome
21. Premature structural changes at replication origins in a yeast minichromosome maintenance (MCM) mutant
22. Cloning and characterization of Chinese hamster homologue of yeast DBF4 (ChDBF4)
23. The protein kinase family: Conserved features and deduced phylogeny of the catalytic domains
24. A novel role for Cdc5p in DNA replication
25. MCM5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p
26. Genetic control of the cell cycle in yeast II. Genes controlling DNA replication and its initiation
27. Three additional genes required for DNA synthesis in S. cerevisiae
28. Saccharomyces cerevisiae cell cycle
29. Phosphorylation of MCM4 by Cdc2 protein kinase inhibits the activity of the minichromosome maintenance complex
30. A group of interacting yeast DNA replication genes
31. Molecular genetic studies of the Cdc7 protein kinase and induced mutagenesis in yeast
32. Cdc45p assembles into a complex with Cdc46p/MCM5p, is required for minichromosome maintenance, and is essential for chromosomal DNA replication
33. Identification of a preinitiation step in DNA replication that is independent of origin recognition complex and cdc6, but dependent on cdk2
34. A DNA helicase activity is associated with an MCM4, -6 and -7 protein complex
35. Phosphorylation of MCM4 at specific sites by cyclin-dependent kinase leads to loss of MCM4,6,7 helicase activity
36. Biochemical function of mouse minichromosome maintenance 2 protein
37. Inhibition of MCM4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2
38. Biochemical activities associated with mouse MCM2 protein
39. Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF
40. Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein
41. nimO an aspergillus gene related to budding yeast DBF4, is required for DNA synthesis and mitotic checkpoint control
42. Xenopus Cdc7 function is dependent on licensing but not on XORC, XCdc6, or CDK activity and is required for XCdc45 loading
43. The Cdc7/Dbf4 protein kinase: Target of the S phase checkpoint?
44. Identification and characterization of a human protein kinase related to budding yeast Cdc7p
45. Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication
46. A further two mutants defective in initiation of the S phase in the yeast Saccharomyces cerevisiae
47. The isolation of new DNA synthesis mutants in the yeast Saccharomyces cerevisiae
48. First the CDKs, now the DDKs
49. Replication initiated at the origin oriC of the E. coli chromosome reconstituted with purified enzymes
50. Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication
51. Characterization of the yeast Cdc7p/Dbf4p complex purified from insect cells. Its protein kinase activity is regulated by Rad53p
52. Growth regulation of the expression of mouse cDNA and gene encoding a serine/threonine kinase related to Saccharomyces cerevisiae CDC7 essential for G1/S transition: Structure, chromosomal localization, and expression of mouse gene for S. cerevisiae Cdc7-related kinase
53. Temperature-sensitive cdc7 mutations of Saccharomyces cerevisiae are suppressed by the DBF4 gene, which is required for the G1/S cell cycle transition
54. Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor
55. A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells
56. The Drosophila chiffon gene is required for chorion gene amplification, and is related to the yeast Dbf4 regulator of DNA replication and cell cycle
57. Processive DNA helicase activity of the minichromosome maintenance proteins 4, 6, and 7 complex requires forked DNA structures
58. MCM2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis
59. Identification, characterization and chromosomal localization of the cognate human and murine DBF4 genes
60. Mutants of S. cerevisiae defective in the maintenance of minichromosomes
61. Dbf4 motifs: Conserved motifs in activation subunits for Cdc7 kinases essential for S-phase
62. Regulation of DNA replication during the cell cycle: Roles of Cdc7 kinase and coupling of replication, recombination, and repair in response to replication fork arrest
63. +, a Schizosaccharomyces pombe gene related to Saccharomyces cerevisiae CDC7, is required for chromosomal replication
64. CDC7 kinase complex as a molecular switch for DNA replication
65. Human Cdc7-related kinase complex: In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a critical threonine residue of Cdc7 by Cdks
66. Dpb11 controls the association between DNA palymerases alpha and epsilon and the autonomously replicating sequence region of budding yeast
67. Cold-sensitive cell-division-cycle mutants of yeast: Isolation, properties, and pseudoreversion studies
68. SW16 is a regulatory subunit of two different cell cycle START-dependent transcription factors in Saccharomyces cerevisiae
69. + gene encoding a nuclear protein with sequence similarity to budding yeast Dbf4 is required for meiotic second division and sporulation
70. Novel fission yeast Cdc7-Dbf4 kinase complex required for the initiation and progression of meiotic second division
71. Hierarchy of S-phase-promoting factors: Yeast Dbf4-cdc7 kinase requires prior Sphase cyclin-dependent kinase activation
72. Bipartite binding of a kinase activator activates Cdc7-related kinase essential for S phase
73. Analyses of Saccharomyces cerevisiae Cdc7 kinase point mutants: Dominant-negative inhibition of DNA replication on overexpression of kinase-negative Cdc7 proteins
74. Cell cycle control of Cdc7p kinase activity through regulation of Dbf4p stability
75. Molecular characterization of cell cycle gene CDC7 from Saccharomyces cerevisiae
76. DNA replication in vertebrates requires a homolog of the Cdc7 protein kinase
77. Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: In vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7
78. Electron microscopic obervation and single-stranded DNA binding activity of the MCM4,6,7 complex
79. Interactions between two catalytically distinct MCM subgroups are essential for coordinated ATP hydrolysis and DNA replication
80. Differential regulation of the yeast CDC7 gene during mitosis and meiosis
81. Oligomers of the CdcT/Dbf4 protein kinase exist in the yeast cell
82. G1 phase progression: Cycling on cue
83. A mutant that affects the function of autonomously replicating sequences in yeast
84. Schizosaccharomyces pombe Hsk1p is a potential Cdslp target required for genome integrity
85. Cell cycle control of DNA replication
86. +, encoding a regulatory subunit for Hsk1 kinase, plays essential roles in S-phase initiation as well as in S-phase checkpoint control and recovery from DNA damage
87. Regulation of initiation of S phase, replication checkpoint signaling, and maintenance of mitotic chromosome structures during S phase by hsk1 kinase in the fission yeast
88. Association of RPA with chromosomal replication origins requires an MCM protein, and is regulated by Rad53, and cyclin- and Dbf4-dependent kinases
89. The RLF-M component of the replication licensing system forms complexes containing all six MCM/P1 polypeptides
90. MCM proteins in DNA replication
91. goal, a novel mutation causing G1/S arrest in fission yeast, is defective in a CDC45 homologue and interacts genetically with polalpha
92. Essential role of Sna41/Cdc45 in loading of DNA polymerase alpha onto minichromosome maintenance proteins in fission yeast
93. Evidence for sequential action of cdc7 and cdk2 protein kinases during initiation of DNA replication in Xenopus egg extracts
94. Initiation of eukaryotic DNA replication: Origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha
95. Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway
96. The CDC7 protein of Saccharomyces cerevisiae is a phosphoprotein that contains protein kinase activity
97. Regulation of Saccharomyces cerevisiae CDC7 function during the cell cycle
98. Assembly of a complex containing Cdc45p, replication protein A, and MCM2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase