The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint

Journal of Cell Biology

Volumn 161, Issue 2, 2003, Pages 281-294

  Hauf, Silke ^a   Cole, Richard W ^b   LaTerra, Sabrina ^b   Zimmer, Christine ^a   Schnapp, Gisela ^c   Walter, Rainer ^c   Heckel, Armin ^c   Van Meel, Jacques ^d   Rieder, Conly L ^b   Peters, Jan Michael ^a  

^a RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^b WADSWORTH CENTER   (United States)

^c BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^d BOEHRINGER INGELHEIM RCV GMBH AND CO KG   (Austria)

Author keywords

Chemical biology; Chromosome segregation; Kinetochores; Mitosis; Spindle assembly checkpoint

Indexed keywords

ANTIMITOTIC AGENT; AURORA B KINASE; HESPERADIN; NOCODAZOLE; PACLITAXEL; PROTEIN KINASE; UNCLASSIFIED DRUG;

ANAPHASE; ARTICLE; CENTROMERE; CHROMOSOME; CHROMOSOME SEGREGATION; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MAMMAL CELL; MICROTUBULE ASSEMBLY; MITOSIS SPINDLE; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SISTER CHROMATID;

ANAPHASE; ANEUGENS; ANIMALS; CELL CYCLE PROTEINS; CHROMOSOME SEGREGATION; ENDOPEPTIDASES; EUKARYOTIC CELLS; GENES, CDC; HELA CELLS; HUMANS; INDOLES; KINETOCHORES; MICROTUBULES; MITOSIS; MITOTIC SPINDLE APPARATUS; NOCODAZOLE; PACLITAXEL; PHENOTYPE; POLYPLOIDY; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PYRIMIDINES; RNA, SMALL INTERFERING; SULFONAMIDES; THIONES;

MAMMALIA;

EID: 0038746733     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200208092     Document Type: Article

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