A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry

Science

Volumn 306, Issue 5697, 2004, Pages 885-888

  Matsumoto, Yutaka ^a   Maller, James L ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; DNA; GENES; MUTAGENESIS; POLYPEPTIDES; SYNTHESIS (CHEMICAL); TUMORS;

CENTROSOMAL LOCALIZATION SIGNAL (CLS); CENTROSOMAL TARGETING; GENOMIC INSTABILITY; POLYPLOIDY; S PHASE;

PROTEINS;

AMINO ACID; CYCLIN A; CYCLIN DEPENDENT KINASE 2; CYCLIN E; MUTANT PROTEIN;

BIOLOGY;

ARTICLE; CELL CYCLE S PHASE; CENTROSOME; CHO CELL; DNA SYNTHESIS; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TARGETING;

AMINO ACID SEQUENCE; ANIMALS; CDC2-CDC28 KINASES; CENTROSOME; CHO CELLS; CRICETINAE; CYCLIN E; CYCLIN-DEPENDENT KINASE 2; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN KINASES; PROTEIN SORTING SIGNALS; RATS; S PHASE; TRANSFECTION;

EID: 7444229923     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1103544     Document Type: Article

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24. We thank M. Winey (University of Colorado, Boulder) for providing antibody to centrin, and members of this laboratory for helpful discussions and support, especially P. Eyers and C. Conn. We also thank E. Erikson for a critical reading of the manuscript and L. Chen for assistance in construction of truncated cyclin E mutants. This work was supported by HHMI. Y.M. is an Associate and J.L.M. an Investigator of HHMI.