Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis

Genes and Development

Volumn 14, Issue 18, 2000, Pages 2277-2282

  Kalitsis, P ^a   Earle, E ^a   Fowler, K J ^a   Choo, K H A ^a  

^a ROYAL CHILDREN'S HOSPITAL   (Australia)

Author keywords

Chromosome missegregation; Kinetochore; Mitotic checkpoint; Mouse transgenic

Indexed keywords

ARTICLE; CHROMATIN; CHROMOSOME DISORDER; CONTROLLED STUDY; DEPOLYMERIZATION; EMBRYO; EMBRYO DEVELOPMENT; GENE DISRUPTION; METAPHASE; MICRONUCLEUS; MITOSIS INHIBITION; MITOSIS SPINDLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SURVIVAL;

ANIMAL; CHIMERA; EMBRYO AND FETAL DEVELOPMENT; MICE; MICE, INBRED C57BL; MITOSIS; MITOTIC SPINDLE APPARATUS; MUTAGENESIS, INSERTIONAL; NOCODAZOLE; PROTEINS; SUPPORT, NON-U.S. GOV'T;

EID: 0034665634     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.827500     Document Type: Article

References (28)

1. The spindle checkpoint
2. Localization of the Drosophila checkpoint control protein Bub3 to the kinetochore requires Bubl but not Zw10 or Rod
3. Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila
4. Complex formation between Madlp, Bublp and Bub3p is crucial for spindle checkpoint function
5. Mutations of mitotic checkpoint genes in human cancers
6. Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC
7. Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores
8. Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores
9. Defective chromosome segregation, microtubule bundling and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice
10. Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2
11. A functional neo-centromere formed through activation of a latent human centromere and consisting of non-alpha-satellite DNA
12. A screen for dynein synthetic lethals in Aspergillus nidulans identifies spindle assembly checkpoint genes and other genes involved in mitosis
13. Bub1p kinase activates the Saccharomyces cerevisiae spindle assembly checkpoint
14. Microinjection of antibody to Mad2 protein into mammalian cells in mitosis induces premature anaphase
15. Early disruption of centromeric chromatin organization in centromere protein A (Cenpa) null mice
16. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function
17. Targeted disruption of mouse centromere protein C gene leads to mitotic disarray and early embryo death
18. Feedback control of mitosis in budding yeast
19. Identification of a human mitotic checkpoint gene: hsMAD2
20. Retention of the BUB3 checkpoint protein on lagging chromosomes
21. The ancient regulatory-protein family of WD-repeat proteins
22. The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase
23. Kinetochores and the checkpoint mechanism that monitors for defects in the chromosome segregation machinery
24. Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage
25. The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase
26. Localization of Mad2 to kinetochores depends on microtubule attachment, not tension
27. The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint
28. The spindle checkpoint