Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase

Chemistry and Biology

Volumn 12, Issue 1, 2005, Pages 99-107

  Liu, Yongsheng ^a   Shreder, Kevin R ^a   Gai, Wenzhi ^a   Corral, Sergio ^a   Ferris, Douglas K ^b   Rosenblum, Jonathan S ^a  

^a ACTIVX BIOSCIENCES INC   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANE DERIVATIVE; AX 7503; CELL CYCLE PROTEIN; FUSED HETEROCYCLIC RINGS; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; POLO LIKE KINASE 1; POLO-LIKE KINASE 1; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; RHODAMINE; WORTMANNIN;

ARTICLE; CHEMISTRY; CONFORMATION; DRUG ANTAGONISM; GENETICS; HUMAN; LEUKEMIA CELL LINE; METABOLISM; SYNTHESIS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; CELL CYCLE PROTEINS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; JURKAT CELLS; MOLECULAR CONFORMATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; RHODAMINES;

MAMMALIA;

EID: 12344256951     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2004.11.009     Document Type: Article

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