Aurora kinases link chromosome segregation and cell division to cancer susceptibility

Current Opinion in Genetics and Development

Volumn 14, Issue 1, 2004, Pages 29-36

  Meraldi, Patrick ^a   Honda, Reiko ^b   Nigg, Erich A ^b  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA A KINASE; AURORA B KINASE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

BINDING AFFINITY; CANCER; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CELL CYCLE; CELL DIVISION; CENTROMERE; CENTROSOME; CHROMOSOME CONDENSATION; CHROMOSOME SEGREGATION; CYTOKINE PRODUCTION; ENZYME PHOSPHORYLATION; HUMAN; MICROTUBULE; MITOSIS; MITOSIS SPINDLE; NONHUMAN; POLYPLOIDY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVIEW; UBIQUITINATION;

EID: 0842281498     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gde.2003.11.006     Document Type: Review

References (62)

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7. ••]). Most interestingly, mutation of a serine residue within this motif (serine 53 in Xenopus) to aspartic acid blocks degradation, suggesting that dephosphorylation of this site may contribute to control the timing of Aurora A destruction.
8. ••]). It also shows that the mutation of a conserved lysine (169) to arginine, a mutation frequently used to generate 'inactive' versions of kinases, still retains ∼10% of wild-type activity.
9. ••]).
10. ••]).
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13. •]).
14. •]). In addition, overexpression of Aurora A was shown to transform NIH 3T3 cells.
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16. •]).
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19. ••]).
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40. ••] ).
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44. ••]).
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48. Murata-Hori M., Wang Y.L. Both midzone and astral microtubules are involved in the delivery of cytokinesis signals: insights from the mobility of aurora B. J Cell Biol. 159:2002;45-53 This study on the dynamics of Aurora B, using photobleaching experiments, indicates that Aurora B may reach the MT midzone by both centromere-dependent and independent pathways. It is inferred that the signaling pathways for cytokinesis may utilize both central spindle MTs and astral MTs.
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50. ••]).
51. ••]).
52. •]).
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58. 1 tetraploidy checkpoint arrests and/or eliminates those cells that arise through faulty division processes. Although the molecular mechanisms underlying the latter checkpoint remain poorly understood, both the p53 and pRb tumor suppressor proteins appear to be involved.
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62. Hirota T., Kunitoku N., Sasayama T., Marumoto T., Zhang D., Nitta M., Hatakeyama K., Saya H. Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell. 114:2003;585-598 The LIM protein Ajuba is described as a binding partner of Aurora A at the centrosomes in human cells. Binding of Ajuba is reported to stimulate autophosphorylation and activation of Aurora A both in vivo and in vitro. Furthermore, the data suggest that the Aurora-A-Ajuba complex is required for both centrosome maturation and entry into mitosis.