Mitotic kinases: The key to duplication, segregation, and cytokinesis errors, chromosomal instability, and oncogenesis

Pharmacology and Therapeutics

Volumn 111, Issue 3, 2006, Pages 974-984

  Li, Jonathan J ^a   Li, Sara Antonia ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Aneuploidy; Cancer; Centrosome amplification; Chromosomal instability; Mitotic kinases; Mitotic spindle checkpoint

Indexed keywords

ANTINEOPLASTIC AGENT; AURORA A KINASE; AURORA B KINASE; CYCLOPROPANECARBOXYLIC ACID [4 [4 (4 METHYL 1 PIPERAZINYL) 6 (5 METHYL 2H PYRAZOL 3 YLAMINO) 2 PYRIMIDINYLTHIO]PHENYL]AMIDE; ENZYME; ESTROGEN; HESPERADIN; N [4 [6 METHOXY 7 (3 MORPHOLINOPROPOXY) 4 QUINAZOLINYLAMINO]PHENYL] BENZAMIDE; N [4 [6 METHOXY 7 (3 MORPHOLINOPROPOXY) 4 QUINAZOLINYLAMINO]PHENYL]BENZAMIDE; NEVER IN MITOSIS A KINASE; PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE INHIBITOR; POLO LIKE KINASE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANEUPLOIDY; BREAST CANCER; CANCER; CANCER INHIBITION; CANCER PREVENTION; CANCER THERAPY; CARCINOGENESIS; CENTROMERE; CENTROSOME; CHROMATIN CONDENSATION; CHROMOSOMAL INSTABILITY; CHROMOSOME CONDENSATION; CHROMOSOME DUPLICATION; CHROMOSOME SEGREGATION; COLON CANCER; CYTOKINESIS; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; MICROTUBULE; MITOSIS SPINDLE; NEUTROPENIA; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REVIEW; SYNTHESIS; TUMOR GROWTH; WEIGHT REDUCTION;

ANEUPLOIDY; ANIMALS; CELL CYCLE PROTEINS; CENTROSOME; CHROMOSOMAL INSTABILITY; CHROMOSOME SEGREGATION; CYTOKINESIS; HUMANS; MITOSIS; MITOTIC SPINDLE APPARATUS; NEOPLASMS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS;

EID: 33746508429     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2006.02.006     Document Type: Review

References (108)

1. Acquaviva C., Herzog F., Kraft C., and Pines J. The anaphase promoting complex/cyclosome is recruited to centromeres by the spindle assembly checkpoint. Nat Cell Biol 6 (2004) 892-898
2. Adams R.R., Carmena M., and Earnshaw W.C. Chromosomal passengers and the (Aurora) ABC of mitosis. Trends Cell Biol 11 (2001) 49-54
3. Andrews P.D. Aurora kinases: shining lights on the therapeutic horizon?. Oncogene 24 (2005) 5005-5015
4. Andrews P.D., Knatko E., Moore W.J., and Swedlow J.R. Mitotic mechanics: the auroras come into view. Curr Opin Cell Biol 15 (2003) 672-683
5. Arnerlov C., Emdin S.O., Cajander S., Bengtsson N.O., Tavelin B., and Roos G. Intratumoral variations in DNA ploidy and s-phase fraction in human breast cancer. Anal Cell Pathol 23 (2001) 21-28
6. Bahn D.K., Silverman P., Lee Sr. F., Badalament R., Bahn E.D., and Rewcastle J.C. In treating localized prostate cancer the efficacy of cryoablation independent of DNA ploidy type. Technol Cancer Res Treat 3 (2004) 253-257
7. Baker D.J., Chen J., and van Deursen J.M. The mitotic checkpoint in cancer and aging: what have mice taught us?. Curr Opin Cell Biol 17 (2005) 583-589
8. Barr F.A., Sillje H.H., and Nigg E.A. Polo-like kinases and the orchestration of cell division. Nat Rev Mol Cell Biol 5 (2004) 429-440
9. Belham C., Roig J., Caldwell J.A., Aoyama Y., Kemp B.E., Comb M., et al. A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases. J Biol Chem 278 (2003) 34897-34909
10. Bischoff J.R., Anderson L., Zhu Y., Mossie K., Ng L., Souza B., et al. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J 17 (1998) 3052-3065
11. Bolanos-Garcia V.M. Aurora kinases. Int J Biochem Cell Biol 37 (2005) 1572-1577
12. Bocsi J., Berczi C., Balazs G., and Lapis K. Flow cytometric studies on the relationship between DNA content and clinicopathologic features of pancreatic cancers. Anticancer Res 18 (1998) 1839-1843
13. Boveri T. Zur Frageder. Enstehung Maligner Tumoran vol. 1 (1914), Gustav Fisher Verlag
14. Bowers A.J., and Boylan J.F. Nek8, a NIMA family kinase member, is over-expressed in primary human breast tumors. Gene 328 (2004) 135-142
15. Brinker D.A., Ross J.S., Tran T.A., Jones D.M., and Epstein J.I. Can ploidy of prostate carcinoma diagnosed on needle biopsy predict radical prostatectomy stage and grade?. J Urol 162 (1999) 2036-2039
16. Brinkley B.R. Managing the centrosome numbers game: from chaos to stability in cancer cell division. Trends Cell Biol 11 (2001) 18-21
17. Carmena M., and Earnshaw W.C. The cellular geography of aurora kinases. Nat Rev Mol Cell Biol 4 (2003) 842-854
18. Chen Y., Riley D.J., Zheng L., Chen P.L., and Lee W.H. Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation. J Biol Chem 277 (2002) 49408-49416
19. Cochran J.C., Sontag C.A., Maliga Z., Kapoor T.M., Correia J.J., and Gilbert S.P. Mechanistic analysis of the mitotic kinesin Eg5. J Biol Chem 279 (2004) 38861-38870
20. Conte N., Charafe-Jauffret E., Delaval B., Adelaide J., Ginestier C., Geneix J., et al. Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators. Oncogene 21 (2002) 5619-5630
21. Crosio C., Fimia G.M., Loury R., Kimura M., Okano Y., Zhou H., et al. Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases. Mol Cell Biol 22 (2002) 874-885
22. Ditchfield C., Johnson V.L., Tighe A., Ellston R., Haworth C., Johnson T., et al. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J Cell Biol 161 (2003) 267-280
23. Du J., and Hannon G.J. The centrosomal kinase AuroraA/STK15 interacts with a putative tumor suppressor NM23-H1. Nucleic Acid Res 30 (2002) 5465-5475
24. Eckerdt F., Yuan J., and Strebhardt K. Polo-like kinases and oncogenesis. Oncogene 24 (2005) 267-276
25. Ehara H., Yokoi S., Tamaki M., Nishino Y., Takahashi Y., Deguchi T., et al. Expression of mitotic Aurora/Ipl1p-related kinases in renal cell carcinomas: an immunohistochemical study. Urol Res 31 (2003) 382-386
26. El-Rayes B.F., Norton C.S., Sakr W., Maciorowski Z., Smith D., Pietraszkiewicz H., et al. Cellular DNA content parameters as prognostic indicators in human astrocytomas. J Neurooncol 71 (2005) 85-89
27. Eyers P.A., Erikson E., Chen L.G., and Maller J.L. A novel mechanism for activation of the protein kinase Aurora A. Curr Biol 13 (2003) 691-697
28. Fry A.M., Meraldi P., and Nigg E.A. A centrosomal function for the human Nek2 protein kinase, a member of the NIMA-family of cell cycle regulators. EMBO J 17 (1998) 470-481
29. Fry A.M., Mayor T., Meraldi P., Stierhof Y.D., Tanaka K., and Nigg E.A. C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2. J Cell Biol 141 (1998) 1563-1574
30. Gergely F. Centrosomal TACCtics. BioEssays 24 (2002) 915-925
31. Giet R., Petretti C., and Prigent C. Aurora kinases, aneuploidy and cancer, a coincidence or a real link?. Trends Cell Biol 15 (2005) 241-250
32. Glover D.M., Leibowitz M.H., McLean D.A., and Parry H. Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. Cell 81 (1995) 95-105
33. Goh K.C., Wang H., Yu N., Zhou Y., Zheng Y., Lim Z.Y., et al. PLK1 as a potential drug target in cancer therapy. Drug Dev Res 62 (2004) 349-361
34. Greene D.R., Taylor S.R., Whealer T.M., and Scardino P.T. DNA ploidy by image analysis of individual foci of prostate cancer: a preliminary report. Cancer Res 51 (1991) 4084-4089
35. Gritsko T.M., Coppola D., Paciga J.E., Yang L., Sun M., Shelley S.A., et al. Activation and over-expression of centrosome kinase BTAK/Aurora-A in human ovarian cancer. Clin Cancer Res 9 (2003) 1420-1426
36. Hames R.S., and Fry A.M. Alternative splice variants of the human centrosome Nek2 exhibit distinct patterns of expression in mitosis. Biochem J 361 (2002) 77-85
37. Harrington E.A., Bebbington D., Moore J., Rasmussen R.K., Ajose-Adeogun A.O., Nakayama T., et al. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat Med 10 (2004) 262-267
38. Hayward D.G., Clarke R.B., Faragher A.J., Pillai M.R., Hagan I.M., and Fry A.M. The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancer. Cancer Res 64 (2004) 7370-7376
39. Hernando E., Nahle Z., Juan G., Diaz-Rodriguez E., Alaminos M., Hemann M., et al. Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control. Nature 430 (2004) 797-802
40. Hoque A., Carter J., Xia W., Hung M.C., Sahin A.A., Sen S., et al. Loss of aurora A/STK15/BTAK over-expression correlates with transition of in situ to invasive ductal carcinoma of the breast. Cancer Epidemiol Biomarkers Prev 12 (2003) 1518-1522
41. Jeng Y.-M., Peng S.-Y., Lin C.-Y., and Hsu H.C. Over-expression and amplification of Aurora-A in hepatocellular carcinoma. Clin Cancer Res 10 (2004) 2065-2071
42. Jiang F., Caraway N.P., Sabichi A.L., Zhang H.Z., Ruitrok A., Grossman H.B., et al. Centrosomal abnormality is common in and a potential biomarker for bladder cancer. Int J Cancer 106 (2003) 661-665
43. Katayama H., Zhou H., Li Q., Tatsuka M., and Sen S. Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle. J Biol Chem 276 (2001) 46219-46224
44. Katayama H., Brinkley W.R., and Sen S. The Aurora kinases: role in cell transformation and tumorigenesis. Cancer Metastasis Rev 22 (2003) 451-464
45. Kildal W., Kaern J., Kraggerud S.M., Abeler V.M., Sudbo J., Trope C.G., et al. Evaluation of genomic changes in a large series of malignant ovarian germ cell tumors-relation to clinicopathologic variables. Cancer Genet Cytogenet 155 (2004) 25-32
46. Kops G.J., Weaver B.A., and Cleveland D.W. On the road to cancer: aneuploidy and mitotic checkpoint. Nat Rev Cancer 5 (2005) 773-785
47. Krause S., Feil G., Beiter T., Pressler H., Schrott K.M., and Bichler K.H. Examination of tumorigenesis of precursor lesions in bladder cancer by in situ hybridization. Urol Int 72 (2004) 118-122
48. Kunitoku N., Sasayama T., Marumoto T., Zhang D., Honda S., Kobayashi O., et al. CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function. Dev Cell 5 (2003) 853-864
49. Leal C.B., Schmitt F.C., Bento M.J., Maia N.C., and Lopes C.S. Ductal carcinoma in situ of the breast. Histologic categorization and its relationship to ploidy and immunohistochemical expression of hormone receptors, p53, and c-erbB-2 protein. Cancer 75 (1995) 2123-2131
50. Lew D.J., and Burke D.J. The spindle assembly and spindle position checkpoints. Annu Rev Genet 37 (2003) 251-282
51. Li G., Cottier M., Sabido O., Gentil-Perret A., Lambert C., Passebosc-Faure K., et al. The in vivo DNA aneuploidization during expansion of conventional renal cell carcinoma. In Vivo 16 (2002) 341-344
52. Li J.J., Papa D., Davis M.F., Weroha S.J., Aldaz C.M., El-Bayoumy K., et al. Ploidy differences between hormone- and chemical carcinogen-induced rat mammary neoplasms: comparison to invasive human ductal breast cancer. Mol Carcinog 33 (2002) 56-65
53. Li D., Zhu J., Firozi P.F., Abbruzzese J.L., Evans D.B., Clearly K., et al. Over-expression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer. Clin Cancer Res 9 (2003) 991-997
54. Li J.J., Weroha S.J., Lingle W.L., Papa D., Salisbury J.L., and Li S.A. Estrogen mediates Aurora A over-expression, centrosome amplification, chromosomal instability, and breast cancer in female ACI rats. Proc Natl Acad Sci U S A 101 (2004) 18123-18128
55. Li J., Tan M., Li L., Pamarthy D., Lawrence T.S., and Sun Y. SAK, a new polo-like kinase is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencing. Neoplasia 7 (2005) 312-323
56. Lin L.W., Lin X.Y., He Y.M., Gao S.D., and Lin X.D. Biological characteristics of HCC by ultrasound-guided aspiration biopsy and its clinical application. World J Gastroenterol 9 (2003) 941-945
57. Lingle W.L., and Salisbury J.L. Altered centrosome structure is associated with abnormal mitoses in human breast tumors. Am J Pathol 155 (1999) 1941-1951
58. Lingle W.L., Lutz W.H., Ingle J.N., Maihle N.J., and Salisbury J.L. Centrosome hypertrophy in human breast tumors: implications for genomic stability and cell polarity. Proc Natl Acad Sci U S A 95 (1998) 2950-2955
59. Lingle W.L., Barrett S.L., Negron V.C., D'Assoro A.B., Boeneman K., Liu W., et al. Centrosome amplification drives chromosomal instability in breast tumor development. Proc Natl Acad Sci U S A 99 (2002) 1978-1983
60. Marumoto T., Zhang D., and Saya H. Aurora-A-a guardian of poles. Nat Rev Cancer 5 (2005) 42-50
61. Mayor T., Hacker U., Stierhof Y.D., and Nigg E.A. The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles. J Cell Sci 115 (2002) 3275-3284
62. Meraldi P., Honda R., and Nigg E.A. Aurora kinases link chromosome segregation and cell division to cancer susceptibility. Curr Opin Genet Dev 14 (2004) 29-36
63. Miyoshi Y., Iwao K., Egawa C., and Noguchi S. Association of centrosomal kinase STK15/BTAK mRNA expression with chromosomal instability in human breast cancers. Int J Cancer 92 (2001) 370-373
64. Mortlock A.A., Keen N.J., Jung F.H., Heron N.M., Foote K.M., Wilkinson R.W., et al. Progress in the development of selective inhibitors of Aurora kinases. Curr Top Med Chem 5 (2005) 807-821
65. Muleris M., Salmon R.J., Dutrillaux A.M., Vielh P., Zafrani B., Girodet J., et al. Characteristic chromosomal imbalances in 18 near-diploid colorectal tumors. Cancer Genet Cytogenet 29 (1987) 289-301
66. Nigg E.A. Mitotic kinases as regulators of cell division and its checkpoints. Nat Rev Mol Cell Biol 2 (2001) 21-32
67. Osmani A.H., McGuire S.L., and Osmani S.A. Parallel activation of the NIMA and p34 cdc2 cell cycle-regulated protein kinases is required to initiate mitosis in A. nidulans. Cell 67 (1991) 283-291
68. Ottesen G.L., Christensen I.J., Larsen J.K., Hansen B., and Andersen A.J. Flow cytometric DNA analysis of breast cancers with predominance of carcinoma in situ: a comparison of the premalignant and malignant components. Clin Cancer Res 1 (1995) 881-888
69. Ouchi M., Fujiuchi N., Sasai K., Katayama H., Minamishima Y.A., Ongusaha P.P., et al. BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition. J Biol Chem 279 (2004) 19643-19648
70. Ozalp S., Yalcin O.T., Gulbas Z., Tanir H.M., and Minsin T. Effect of cellular DNA content on the prognosis of epithelial ovarian cancers. Gynecol Obstet Invest 52 (2001) 93-97
71. Pascreau G., Arlot-Bonnemains Y., and Prigent C. Phosphorylation of histone and histone-like proteins by aurora kinases during mitosis. Prog Cell Cycle Res 5 (2003) 369-374
72. Pepe S., Ruggiero A., D'Acquisto M., De Laurentiis M., De Placido S., Sandomenico C., et al. Nuclear DNA content-derived parameters correlated with heterogeneous expression of p53 and bcl-2 proteins in clear cell renal carcinomas. Cancer 89 (2000) 1065-1075
73. Peters J.M. The anaphase-promoting complex: proteolysis in mitosis and beyond. Mol Cell 9 (2002) 931-943
74. Pihan G.A., Purohit A., Wallace J., Knecht H., Woda B., Quesenberry P., et al. Centrosome defects and genetic instability in malignant tumors. Cancer Res 58 (1998) 3974-3985
75. Pihan G.A., Wallace J., Zhou Y., and Doxsey S.J. Centrosome abnormalities and chromosome instability occur together in pre-invasive carcinomas. Cancer Res 63 (2003) 1398-1404
76. Quintyne N.J., Reing J.E., Hoffelder D.R., Gollin S.M., and Saunders W.S. Spindle multipolarity is prevented by centrosomal clustering. Science 307 (2005) 127-129
77. Raff J.W. Centrosomes and cancer: lessons from a TACC. Trends Cell Biol 12 (2002) 222-225
78. Reichardt W., Jung V., Brunner C., Klein A., Wemmert S., Romeike B.F., et al. The putative serine/threonine kinase gene STK15 on chromosome 20q13.2 is amplified in human gliomas. Oncol Rep 10 (2003) 1275-1279
79. Royce M.E., Xia W., Sahin A.A., Katayama H., Johnston D.A., Hortobagyi G., et al. STK15/Aurora-A expression in primary breast tumors is correlated with nuclear grade but not with prognosis. Cancer 100 (2004) 12-19
80. Russo A., Bazan V., Migliavacca M., Tubiolo C., Macaluso M., Zanna I., et al. DNA aneuploidy and high proliferative activity but not K-ras-2 mutations as independent predictors of clinical outcome in operable gastric carcinoma: results of a 5-year Gruppo Oncologico dell'Italia Meridonale (GDIM) prospective study. Cancer 92 (2001) 294-302
81. Sasai K., Katayama H., Stenoien D.L., Fujii S., Honda R., Kimura M., et al. Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. Cell Motil Cytoskeleton 59 (2004) 249-263
82. Sato N., Mizumoto K., Nakamura M., Nakamura K., Kusumoto M., Niiyama H., et al. Centrosome abnormalities in pancreatic ductal carcinoma. Clin Cancer Res 5 (1999) 963-970
83. Schuendeln M.M., Piekorz R.P., Wichmann C., Lee Y., McKinnon P.J., Boyd K., et al. The centrosomal putative tumor suppressor protein TACC2 is dispensable for normal development and deficiency does not lead to cancer. Mol Cell Biol 24 (2004) 6403-6409
84. Sen S., Zhou H., Zhang R.-D., Yoon D.S., Vakar-Lopez F., Ito S., et al. Amplification/over-expression of a mitotic kinase gene in human bladder cancer. J Nat Cancer Inst 94 (2002) 1320-1329
85. Smith M.R., Wilson M.L., Hamanaka R., Chase D., Kung H., Longo D.L., et al. Malignant transformation of mammalian cells initiated by constitutive expression of the polo-like kinase. Biochem Biophys Res Commun 234 (1997) 397-405
86. Stenoien D.L., Sen S., Mancini M.A., and Brinkley B.R. Dynamic association of a tumor amplified kinase, Aurora-A, with the centrosome and mitotic spindle. Cell Motil Cytoskeleton 55 (2003) 134-146
87. Swallow C.J., Ko M.A., Siddiqui N.U., Hudson J.W., and Dennis J.W. Sak/Plk4 and mitotic fidelity. Oncogene 24 (2005) 306-312
88. Takai N., Hamanaka R., Yoshimatsu J., and Miyakawa I. Polo-like kinases (Plks) and cancer. Oncogene 24 (2005) 287-291
89. Tanaka E., Hashimoto Y., Ito T., Okumura T., Kan T., Watanabe G., Imamura M., Inazawa J., and Shimada Y. The clinical significance of Aurora-A/STK15/BTAK expression in human esophageal squamous cell carcinoma. Clin Cancer Res 11 (2005) 1827-1834
90. Tanaka T., Kimura M., Matsunaga K., Fukada D., Mori H., and Okano Y. Centrosomal kinase AIK1 is over-expressed in invasive ductal carcinoma of the breast. Cancer Res 59 (1999) 2041-2044
91. Tatsuka M., Katayama H., Ota T., Tanaka T., and Odashima S. Multinuclearity and increased ploidy caused by over-expression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells. Cancer Res 58 (1998) 4811-4816
92. Taylor S.S., Scott M.I., and Holland A.J. The spindle checkpoint: a quality control mechanism which ensures accurate chromosome segregation. Chromosome Res 12 (2004) 599-616
93. Tighe A., Johnson V.L., Albertella M., and Taylor S.S. Aneuploid colon cancer cells have a robust spindle checkpoint. EMBO Rep 2 (2001) 609-614
94. Toji S., Yabuta N., Hosomi T., Nishihara S., Kobayashi T., Suzuki S., et al. The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. Genes Cells 9 (2004) 383-397
95. Tong T., Zhong Y., Kong J., Dong L., Song Y., Fu M., et al. Over-expression of Aurora-A contributes to malignant development of human esophageal squamous cell carcinoma. Clin Cancer Res 10 (2004) 7010-7304
96. Tsai M.Y., Wiese C., Cao K., Martin O., Donovan P., Ruderman J., et al. A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly. Nat Cell Biol 5 (2003) 242-248
97. 2 to M transition. J Biol Chem 279 (2000) 19643-19648
98. van Vugt M.A., and Medema R.H. Getting in and out of mitosis with Polo-like kinase-1. Oncogene 24 (2005) 2844-2859
99. Visscher D.W., Wallis T.L., and Crissman J.D. Evaluation of chromosome aneuploidy in tissue sections of preinvasive breast carcinomas using interphase cytogenetics. Cancer 77 (1996) 315-320
100. Wang Q., Xie S., Chen J., Fukasawa K., Naik U., Traganos F., et al. Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity. Mol Cell Biol 22 (2002) 3450-3459
101. Warnke S., Kemmler S., Hames R.S., Tsai H.L., Hoffmann-Rohrer U., Fry A.M., et al. Polo-like kinase-2 is required for centriole duplication in mammalian cells. Curr Biol 13 14 (2004) 1200-1207
102. Weroha S.J., Li S.A., Tawfik O., and Li J.J. Over-expression of cyclin D1 and D3 during estrogen-induced breast oncogenesis in female ACI rats. Carcinogenesis 27 (2006) 491-498
103. Wiesener B., Hauser-Kronberger C.E., Zipperer E., Dietze O., Menzel C., and Hacker G.W. p34cdc2 in invasive breast cancer: relationship to DNA content, Ki67 index and c-erbB-2 expression. Histopathology 33 (1998) 522-530
104. Wolf G., Hildenbrand R., Schwar C., Grobholz R., Kaufmann M., Stutte H.J., et al. Polo-like kinase: a novel marker of proliferation: correlation with estrogen-receptor expression in human breast cancer. Pathol Res Pract 196 (2000) 753-759
105. Xie S., Xie B., Lee M.Y., and Dai W. Regulation of cell cycle checkpoints by polo-like kinases. Oncogene 24 (2005) 277-286
106. Yamamoto Y., Matsuyama H., Furuya T., Oga A., Yoshihiro S., Okuda M., et al. Centrosome hyperamplification predicts progression and tumor recurrence in bladder cancer. Clin Cancer Res 10 (2004) 6449-6455
107. Yasa M.H., Bektas A., Yukselen V., Akbulut H., Camci C., and Ormeci N. DNA analysis and DNA ploidy in gastric cancer and gastric precancerous lesions. Int J Clin Pract 59 (2005) 1029-1033
108. Zhou H., Kuang J., Zhong L., Kuo W.L., Gray J.W., Sahin A., et al. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat Genet 20 (1998) 189-193